SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DGT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		5 / 9 ALA A 234
GLU A 266
SER A 334
VAL A 333
GLY A 204
 None
DGT  A 701 (-4.2A)
None
None
None
 1.27A 1bcuH-6brkA:
undetectable		 1bcuH-6brkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		5 / 12 ILE A 872
LEU A 964
SER A 895
ILE A 974
THR A 823
 None
None
DGT  A1456 (-2.4A)
None
None
 1.13A 2bl9A-3f2bA:
undetectable		 2bl9A-3f2bA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		4 / 7 ALA A 394
TYR A 226
TYR A 390
MET A 258
 None
None
DGT  A1588 (-4.4A)
None
 1.47A 2pncA-2pyjA:
undetectable		 2pncA-2pyjA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		5 / 12 ILE A 222
ARG A 164
PHE A 217
ILE A 426
LEU A 422
 None
DGT  A 701 (-3.3A)
None
None
None
 1.09A 2w3bA-4zweA:
undetectable		 2w3bA-4zweA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 6 ASP A 311
HIS A 210
ASP A 218
HIS A 215
 DGT  A 701 (-2.4A)
DGT  A 701 (-4.5A)
None
DGT  A 701 (-3.6A)
 1.05A 3c0zC-4zweA:
undetectable		 3c0zC-4zweA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 6 HIS A 210
ASN A 207
ARG A 206
GLU A 234
 DGT  A 701 (-4.5A)
DGT  A 701 (-3.6A)
DGT  A 701 ( 4.2A)
None
 1.18A 3galA-4zweA:
undetectable		 3galA-4zweA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 6 HIS A 210
ASN A 207
ARG A 206
GLU A 234
 DGT  A 701 (-4.5A)
DGT  A 701 (-3.6A)
DGT  A 701 ( 4.2A)
None
 1.16A 3galB-4zweA:
undetectable		 3galB-4zweA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 8 ASP A 311
SER A 302
ASP A 506
TYR A 374
 DGT  A 701 (-2.4A)
None
None
DGT  A 701 (-3.5A)
 1.14A 3havA-4zweA:
undetectable		 3havA-4zweA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KD5_E_PPFE914_1
(DNA POLYMERASE)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		4 / 5 ASP A 249
LEU A 253
LYS A 383
ASP A 458
 MG  A9004 (-2.3A)
None
DGT  A1588 ( 2.7A)
MG  A9004 (-2.5A)
 0.62A 3kd5E-2pyjA:
9.9		 3kd5E-2pyjA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 6 HIS A 210
HIS A 233
HIS A 215
ASP A 311
 DGT  A 701 (-4.5A)
DGT  A 701 (-3.8A)
DGT  A 701 (-3.6A)
DGT  A 701 (-2.4A)
 1.13A 3nvcA-4zweA:
undetectable		 3nvcA-4zweA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 6 HIS A 233
HIS A 215
HIS A 210
ASP A 311
 DGT  A 701 (-3.8A)
DGT  A 701 (-3.6A)
DGT  A 701 (-4.5A)
DGT  A 701 (-2.4A)
 0.90A 3nvcA-4zweA:
undetectable		 3nvcA-4zweA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		4 / 6 HIS A 242
HIS A 265
HIS A 247
ASP A 343
 DGT  A 701 (-4.4A)
DGT  A 701 (-3.9A)
DGT  A 701 (-3.7A)
DGT  A 701 (-2.6A)
 1.18A 3nvcA-6brkA:
undetectable		 3nvcA-6brkA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 ASP A 973
ASP A 975
GLY A 894
GLN A 983
 DGT  A1456 ( 2.7A)
MG  A   5 ( 2.4A)
DGT  A1456 (-3.1A)
None
 0.93A 3s3mA-3f2bA:
undetectable		 3s3mA-3f2bA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 8 ASP A 973
ASP A 975
GLY A 894
GLN A 983
 DGT  A1456 ( 2.7A)
MG  A   5 ( 2.4A)
DGT  A1456 (-3.1A)
None
 0.95A 3s3nA-3f2bA:
undetectable		 3s3nA-3f2bA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 5 LEU A 150
GLY A 151
PHE A 157
ASN A 380
 None
None
DGT  A 702 (-3.5A)
None
 1.06A 3uq6B-4zweA:
undetectable		 3uq6B-4zweA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 5 LEU A 150
GLY A 152
PHE A 157
ASN A 380
 None
None
DGT  A 702 (-3.5A)
None
 1.29A 3uq6B-4zweA:
undetectable		 3uq6B-4zweA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 7 LEU A 150
TYR A 315
ASP A 319
HIS A 370
 None
DGT  A 701 (-3.6A)
DGT  A 701 (-3.2A)
DGT  A 701 (-4.6A)
 1.30A 4arcA-4zweA:
undetectable		 4arcA-4zweA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		4 / 7 LEU A 182
TYR A 347
ASP A 351
HIS A 413
 DGT  A 701 (-4.4A)
DGT  A 701 (-3.8A)
DGT  A 701 (-3.2A)
None
 1.32A 4arcA-6brkA:
undetectable		 4arcA-6brkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 7 SER A 214
ARG A 164
GLU A 234
ASP A 218
 None
DGT  A 701 (-3.3A)
None
None
 1.06A 4d33B-4zweA:
undetectable		 4d33B-4zweA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		5 / 12 THR A 457
THR A 441
ALA A 445
TYR A 454
TYR A 500
 DGT  A1588 ( 4.3A)
None
None
None
None
 1.43A 4dajB-2pyjA:
undetectable		 4dajB-2pyjA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		4 / 8 ASP A 343
ASP A 426
ASN A 239
GLU A 266
 DGT  A 701 (-2.6A)
DGT  A 701 ( 4.5A)
DGT  A 701 (-3.7A)
DGT  A 701 (-4.2A)
 0.93A 4feuD-6brkA:
undetectable		 4feuD-6brkA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		3 / 3 TYR A 315
ARG A 164
HIS A 215
 DGT  A 701 (-3.6A)
DGT  A 701 (-3.3A)
DGT  A 701 (-3.6A)
 1.16A 4fubA-4zweA:
undetectable		 4fubA-4zweA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		3 / 3 TYR A 347
ARG A 196
HIS A 247
 DGT  A 701 (-3.8A)
DGT  A 701 (-3.5A)
DGT  A 701 (-3.7A)
 1.18A 4fubA-6brkA:
undetectable		 4fubA-6brkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 2atz H. PYLORI PREDICTED
CODING REGION HP0184
(Helicobacter
pylori) 		5 / 10 TYR A  78
ASP A  77
PRO A 143
ALA A 139
GLY A  80
 None
DGT  A 201 (-2.9A)
None
None
None
 1.34A 4mmdA-2atzA:
undetectable		 4mmdA-2atzA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		5 / 12 HIS A 215
HIS A 210
GLY A 211
PHE A 217
GLY A 219
 DGT  A 701 (-3.6A)
DGT  A 701 (-4.5A)
None
None
None
 1.20A 4qa0A-4zweA:
undetectable		 4qa0A-4zweA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		5 / 12 HIS A 215
HIS A 210
GLY A 211
PHE A 217
GLY A 219
 DGT  A 701 (-3.6A)
DGT  A 701 (-4.5A)
None
None
None
 1.12A 4qa2A-4zweA:
undetectable		 4qa2A-4zweA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		5 / 12 HIS A 215
HIS A 210
GLY A 211
PHE A 217
GLY A 219
 DGT  A 701 (-3.6A)
DGT  A 701 (-4.5A)
None
None
None
 1.13A 4qa2B-4zweA:
undetectable		 4qa2B-4zweA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		5 / 12 HIS A 247
HIS A 242
GLY A 243
PHE A 249
GLY A 251
 DGT  A 701 (-3.7A)
DGT  A 701 (-4.4A)
None
None
None
 1.13A 4qa2B-6brkA:
undetectable		 4qa2B-6brkA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		5 / 12 VAL A 156
GLY A 151
TYR A 154
ILE A 147
ASN A 163
 DGT  A 703 ( 3.6A)
None
None
None
None
 1.42A 4xueB-4zweA:
undetectable		 4xueB-4zweA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2pyj DNA POLYMERASE
(Bacillus
virus
phi29) 		5 / 12 THR A 457
THR A 441
ALA A 445
TYR A 454
TYR A 500
 DGT  A1588 ( 4.3A)
None
None
None
None
 1.49A 5dsgA-2pyjA:
undetectable		 5dsgA-2pyjA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		5 / 12 HIS A 413
HIS A 242
HIS A 265
ASP A 343
TYR A 347
 None
DGT  A 701 (-4.4A)
DGT  A 701 (-3.9A)
DGT  A 701 (-2.6A)
DGT  A 701 (-3.8A)
 1.49A 5ef8A-6brkA:
undetectable		 5ef8A-6brkA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_1
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN
(Geobacillus
kaustophilus) 		4 / 4 ASP A1103
HIS A1186
SER A1182
GLU A1157
 None
DGT  A1456 (-4.1A)
None
None
 1.47A 5hfjG-3f2bA:
0.0		 5hfjG-3f2bA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 7 HIS A 210
ASN A 207
ARG A 206
GLU A 234
 DGT  A 701 (-4.5A)
DGT  A 701 (-3.6A)
DGT  A 701 ( 4.2A)
None
 1.13A 6b8kA-4zweA:
undetectable		 6b8kA-4zweA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 8 HIS A 210
ASN A 207
ARG A 206
GLU A 234
 DGT  A 701 (-4.5A)
DGT  A 701 (-3.6A)
DGT  A 701 ( 4.2A)
None
 1.13A 6b94A-4zweA:
undetectable		 6b94A-4zweA:
8.43