SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DGD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 8 PHE B 250
SER D 155
ILE D 159
LEU B 460
LEU D 291
 CLA  B1010 ( 3.7A)
CLA  D1004 ( 4.7A)
DGD  B1058 (-4.5A)
DGD  B1058 (-3.6A)
DGD  B1058 ( 4.6A)
 1.24A 1eupA-3a0hB:
undetectable		 1eupA-3a0hB:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN
(Pisum
sativum) 		4 / 8 TYR B 172
SER B 446
PRO B  54
THR B 452
 None
None
None
DGD  H 102 ( 4.7A)
 1.15A 2v0zO-5xnmB:
undetectable		 2v0zO-5xnmB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 3a0h PHOTOSYSTEM II CP43
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 6 ARG C 362
SER C 226
ASP C 232
TYR C 212
 None
DGD  C1055 (-3.1A)
None
None
 1.30A 3jqaC-3a0hC:
undetectable		 3jqaC-3a0hC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 3a0h PHOTOSYSTEM II CP43
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 6 ARG C 362
SER C 226
ASP C 232
TYR C 212
 None
DGD  C1055 (-3.1A)
None
None
 1.28A 3jqaD-3a0hC:
undetectable		 3jqaD-3a0hC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus;
Thermosynechococ
cus
vulcanus) 		4 / 4 VAL D 287
PHE B 453
PHE B 451
VAL B 252
 DGD  B1058 (-4.2A)
None
CLA  B1012 (-3.6A)
CLA  B1012 (-4.5A)
 1.41A 3rv5C-3a0hD:
1.5
3rv5D-3a0hD:
undetectable		 3rv5C-3a0hD:
13.82
3rv5D-3a0hD:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2c9e PERIDININ-CHLOROPHYL
L A PROTEIN
(Amphidinium
carterae) 		3 / 3 LYS A 143
ASN A  94
ASP A 140
 DGD  A1332 (-3.6A)
PID  A1331 (-3.9A)
DGD  A1332 ( 4.7A)
 0.57A 4o1eA-2c9eA:
undetectable		 4o1eA-2c9eA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 ALA D 290
GLY D 285
ILE D 284
VAL D 154
ILE D 159
 DGD  B1058 ( 4.4A)
None
None
DGD  B1058 (-4.7A)
DGD  B1058 (-4.5A)
 1.16A 6difA-3a0hD:
undetectable		 6difA-3a0hD:
17.26