SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DEB'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		7 / 8 TYR A  75
PHE A  86
ILE A 174
LEU A 175
LEU A 240
GLU A 244
LEU A 391
 DEB  A 420 ( 4.8A)
None
DEB  A 420 (-4.8A)
None
DEB  A 420 ( 4.5A)
None
DEB  A 420 ( 4.8A)
 0.59A 1eupA-1jioA:
69.4		 1eupA-1jioA:
98.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		6 / 8 TYR A  75
PHE A  86
SER A 171
ILE A 174
LEU A 240
GLU A 244
 DEB  A 420 ( 4.8A)
None
DEB  A 420 ( 4.8A)
DEB  A 420 (-4.8A)
DEB  A 420 ( 4.5A)
None
 0.75A 1eupA-1jioA:
69.4		 1eupA-1jioA:
98.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 11 PHE A  72
ALA A  74
ALA A 245
THR A 292
LEU A 391
 None
DEB  A 420 (-3.8A)
HEM  A 410 (-3.5A)
None
DEB  A 420 ( 4.8A)
 1.02A 1jinA-1jioA:
68.3		 1jinA-1jioA:
98.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		6 / 11 PHE A  72
ALA A  74
TYR A  75
LEU A 240
THR A 292
LEU A 391
 None
DEB  A 420 (-3.8A)
DEB  A 420 ( 4.8A)
DEB  A 420 ( 4.5A)
None
DEB  A 420 ( 4.8A)
 0.93A 1jinA-1jioA:
68.3		 1jinA-1jioA:
98.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		10 / 11 SER A  59
ALA A  74
TYR A  75
THR A  92
VAL A 237
LEU A 240
ALA A 241
ALA A 245
THR A 292
LEU A 391
 HEM  A 410 ( 4.9A)
DEB  A 420 (-3.8A)
DEB  A 420 ( 4.8A)
DEB  A 420 (-4.2A)
DEB  A 420 ( 4.3A)
DEB  A 420 ( 4.5A)
DEB  A 420 ( 3.6A)
HEM  A 410 (-3.5A)
None
DEB  A 420 ( 4.8A)
 0.69A 1jinA-1jioA:
68.3		 1jinA-1jioA:
98.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		7 / 12 ALA A  74
GLY A  91
LEU A 175
ARG A 185
VAL A 237
ALA A 241
LEU A 391
 DEB  A 420 (-3.8A)
HEM  A 410 ( 3.1A)
None
DEB  A 420 ( 4.6A)
DEB  A 420 ( 4.3A)
DEB  A 420 ( 3.6A)
DEB  A 420 ( 4.8A)
 0.51A 1jipA-1jioA:
68.9		 1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		6 / 12 ALA A  74
LEU A 175
ARG A 185
ALA A 245
THR A 292
LEU A 391
 DEB  A 420 (-3.8A)
None
DEB  A 420 ( 4.6A)
HEM  A 410 (-3.5A)
None
DEB  A 420 ( 4.8A)
 1.26A 1jipA-1jioA:
68.9		 1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		9 / 12 ALA A  74
TYR A  75
GLY A  91
THR A  92
LEU A 175
ARG A 185
VAL A 237
THR A 292
LEU A 391
 DEB  A 420 (-3.8A)
DEB  A 420 ( 4.8A)
HEM  A 410 ( 3.1A)
DEB  A 420 (-4.2A)
None
DEB  A 420 ( 4.6A)
DEB  A 420 ( 4.3A)
None
DEB  A 420 ( 4.8A)
 0.21A 1jipA-1jioA:
68.9		 1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 12 ALA A  74
TYR A  75
LEU A 392
VAL A 237
LEU A 391
 DEB  A 420 (-3.8A)
DEB  A 420 ( 4.8A)
DEB  A 420 (-3.6A)
DEB  A 420 ( 4.3A)
DEB  A 420 ( 4.8A)
 1.29A 1jipA-1jioA:
68.9		 1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		7 / 12 GLY A  91
LEU A 175
ARG A 185
VAL A 237
LEU A 240
ALA A 241
LEU A 391
 HEM  A 410 ( 3.1A)
None
DEB  A 420 ( 4.6A)
DEB  A 420 ( 4.3A)
DEB  A 420 ( 4.5A)
DEB  A 420 ( 3.6A)
DEB  A 420 ( 4.8A)
 0.69A 1jipA-1jioA:
68.9		 1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		6 / 12 PHE A  72
ALA A  74
LEU A 175
ARG A 185
ALA A 245
LEU A 391
 None
DEB  A 420 (-3.8A)
None
DEB  A 420 ( 4.6A)
HEM  A 410 (-3.5A)
DEB  A 420 ( 4.8A)
 1.29A 1jipA-1jioA:
68.9		 1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		6 / 12 PHE A  72
ALA A  74
TYR A  75
LEU A 175
ARG A 185
LEU A 391
 None
DEB  A 420 (-3.8A)
DEB  A 420 ( 4.8A)
None
DEB  A 420 ( 4.6A)
DEB  A 420 ( 4.8A)
 0.75A 1jipA-1jioA:
68.9		 1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		6 / 12 PHE A  72
TYR A  75
LEU A 175
ARG A 185
LEU A 240
LEU A 391
 None
DEB  A 420 ( 4.8A)
None
DEB  A 420 ( 4.6A)
DEB  A 420 ( 4.5A)
DEB  A 420 ( 4.8A)
 0.76A 1jipA-1jioA:
68.9		 1jipA-1jioA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		8 / 12 TYR A  75
GLY A  91
THR A  92
LEU A 175
ARG A 185
VAL A 237
LEU A 240
LEU A 391
 DEB  A 420 ( 4.8A)
HEM  A 410 ( 3.1A)
DEB  A 420 (-4.2A)
None
DEB  A 420 ( 4.6A)
DEB  A 420 ( 4.3A)
DEB  A 420 ( 4.5A)
DEB  A 420 ( 4.8A)
 0.43A 1jipA-1jioA:
68.9		 1jipA-1jioA:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTU_A_BCZA801_0
(NEURAMINIDASE)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 12 GLU A 244
LEU A 392
ARG A 387
ILE A 250
GLU A 360
 None
DEB  A 420 (-3.6A)
None
None
None
 1.50A 2htuA-1jioA:
undetectable		 2htuA-1jioA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 10 LEU A 199
ALA A 235
VAL A 159
SER A 171
PHE A 195
 None
None
None
DEB  A 420 ( 4.8A)
None
 1.12A 2w9gA-1jioA:
undetectable		 2w9gA-1jioA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		5 / 11 LEU A 199
ALA A 235
VAL A 159
SER A 171
PHE A 195
 None
None
None
DEB  A 420 ( 4.8A)
None
 1.08A 3frbX-1jioA:
undetectable		 3frbX-1jioA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 1jio CYTOCHROME P450
107A1
(Saccharopolyspor
a
erythraea) 		3 / 3 ARG A 185
PHE A  78
PRO A  79
 DEB  A 420 ( 4.6A)
None
None
 0.63A 3zoaB-1jioA:
undetectable		 3zoaB-1jioA:
22.93