SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DDZ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		3 / 3 LEU A  89
SER A  87
ASN A  85
 None
None
DDZ  A  64 ( 4.0A)
 0.74A 1bx4A-4uphA:
undetectable		 1bx4A-4uphA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 4 THR A  54
LEU A  58
VAL A 410
LEU A 414
 DDZ  A  51 ( 4.4A)
None
None
None
 0.88A 1fbmB-4cxkA:
undetectable		 1fbmB-4cxkA:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 2vqr PUTATIVE SULFATASE
(Rhizobium
leguminosarum) 		5 / 12 TYR A 215
ASN A  78
LEU A 125
PRO A  56
ASN A 141
 None
DDZ  A  57 ( 3.9A)
None
DDZ  A  57 ( 3.0A)
None
 1.46A 1mrlB-2vqrA:
undetectable
1mrlC-2vqrA:
undetectable		 1mrlB-2vqrA:
16.70
1mrlC-2vqrA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		5 / 12 PHE A  72
LEU A  86
ARG A  83
GLY A 365
LEU A 368
 None
None
DDZ  A  79 ( 4.2A)
None
None
 1.30A 2lbdA-4fdjA:
undetectable		 2lbdA-4fdjA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 7 TYR A 349
ARG A  84
ASN A  85
ALA A  67
 None
None
DDZ  A  64 ( 4.0A)
DDZ  A  64 ( 3.7A)
 1.39A 3frqB-4uphA:
undetectable		 3frqB-4uphA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2vqr PUTATIVE SULFATASE
(Rhizobium
leguminosarum) 		4 / 8 LEU A 128
GLY A  58
ALA A  62
THR A  66
 ACT  A1519 (-4.7A)
DDZ  A  57 ( 2.4A)
None
None
 0.63A 3jusA-2vqrA:
undetectable		 3jusA-2vqrA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2vqr PUTATIVE SULFATASE
(Rhizobium
leguminosarum) 		4 / 8 LEU A 128
GLY A  58
ALA A  62
THR A  66
 ACT  A1519 (-4.7A)
DDZ  A  57 ( 2.4A)
None
None
 0.63A 3jusA-2vqrA:
undetectable		 3jusA-2vqrA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2vqr PUTATIVE SULFATASE
(Rhizobium
leguminosarum) 		4 / 8 LEU A 128
GLY A  58
ALA A  62
THR A  66
 ACT  A1519 (-4.7A)
DDZ  A  57 ( 2.4A)
None
None
 0.74A 3jusB-2vqrA:
undetectable		 3jusB-2vqrA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 1e33 ARYLSULFATASE A
(Homo
sapiens) 		3 / 3 SER P 150
ASP P  29
ASN P 282
 DDZ  P  69 ( 4.9A)
MG  P 603 (-3.1A)
MG  P 603 (-2.9A)
 0.97A 3lsfB-1e33P:
0.0
3lsfE-1e33P:
0.2		 3lsfB-1e33P:
18.93
3lsfE-1e33P:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 1e33 ARYLSULFATASE A
(Homo
sapiens) 		4 / 8 ASP P 152
SER P 150
HIS P 229
GLU P 481
 None
DDZ  P  69 ( 4.9A)
None
None
 0.90A 3sg9B-1e33P:
undetectable		 3sg9B-1e33P:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN
(Agrobacterium
tumefaciens) 		4 / 8 HIS A 329
LYS A 341
TYR A 294
ASP A  24
 MG  A1001 (-3.1A)
DDZ  A  64 ( 4.6A)
None
MG  A1001 (-1.9A)
 1.08A 4l7iB-4uphA:
undetectable		 4l7iB-4uphA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4upi SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		4 / 5 ASN A  74
GLY A  54
ASP A 135
ASP A  13
 DDZ  A  53 ( 4.2A)
DDZ  A  53 ( 2.4A)
None
ZN  A1576 (-2.1A)
 1.01A 4n48A-4upiA:
undetectable		 4n48A-4upiA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4upi SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		4 / 5 ASN A  74
GLY A  54
ASP A 135
ASP A  13
 DDZ  A  53 ( 4.2A)
DDZ  A  53 ( 2.4A)
None
ZN  A1576 (-2.1A)
 1.03A 4n48B-4upiA:
undetectable		 4n48B-4upiA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4upi SULFATASE FAMILY
PROTEIN
(Ruegeria
pomeroyi) 		4 / 4 ASN A  74
GLY A  54
ASP A 135
ASP A  13
 DDZ  A  53 ( 4.2A)
DDZ  A  53 ( 2.4A)
None
ZN  A1576 (-2.1A)
 1.06A 4n49A-4upiA:
undetectable		 4n49A-4upiA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 317
ALA A  50
LYS A 375
THR A  47
 CA  A1528 (-2.0A)
DDZ  A  51 ( 3.1A)
SO4  A1529 (-2.8A)
None
 1.11A 4w5qA-4cxkA:
undetectable		 4w5qA-4cxkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 317
ALA A  50
LYS A 375
THR A  47
 CA  A1528 (-2.0A)
DDZ  A  51 ( 3.1A)
SO4  A1529 (-2.8A)
None
 1.05A 4w5rA-4cxkA:
undetectable		 4w5rA-4cxkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 317
ALA A  50
LYS A 375
THR A  47
 CA  A1528 (-2.0A)
DDZ  A  51 ( 3.1A)
SO4  A1529 (-2.8A)
None
 1.08A 4w5tA-4cxkA:
undetectable		 4w5tA-4cxkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 317
ALA A  50
LYS A 375
THR A  47
 CA  A1528 (-2.0A)
DDZ  A  51 ( 3.1A)
SO4  A1529 (-2.8A)
None
 1.07A 4z4cA-4cxkA:
undetectable		 4z4cA-4cxkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 317
ALA A  50
LYS A 375
THR A  47
 CA  A1528 (-2.0A)
DDZ  A  51 ( 3.1A)
SO4  A1529 (-2.8A)
None
 1.10A 4z4fA-4cxkA:
undetectable		 4z4fA-4cxkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 317
ALA A  50
LYS A 375
THR A  47
 CA  A1528 (-2.0A)
DDZ  A  51 ( 3.1A)
SO4  A1529 (-2.8A)
None
 1.10A 4z4iA-4cxkA:
undetectable		 4z4iA-4cxkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4cxk ARYLSULFATASE
(Pseudomonas
aeruginosa) 		4 / 9 PHE A 314
VAL A 407
THR A  54
ASN A 318
 None
None
DDZ  A  51 ( 4.4A)
CA  A1528 (-2.7A)
 1.07A 5lg3I-4cxkA:
undetectable		 5lg3I-4cxkA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1e33 ARYLSULFATASE A
(Homo
sapiens) 		5 / 12 HIS P 229
GLY P 303
ALA P 404
LEU P  68
PRO P  89
 None
None
None
DDZ  P  69 ( 3.7A)
None
 1.11A 6b3aA-1e33P:
undetectable		 6b3aA-1e33P:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1e33 ARYLSULFATASE A
(Homo
sapiens) 		5 / 12 HIS P 229
GLY P 303
ALA P 404
LEU P  68
PRO P  89
 None
None
None
DDZ  P  69 ( 3.7A)
None
 1.15A 6b3bA-1e33P:
2.1		 6b3bA-1e33P:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1e33 ARYLSULFATASE A
(Homo
sapiens) 		4 / 8 HIS P 125
HIS P 227
ASP P 281
GLU P 312
 DDZ  P  69 ( 3.9A)
None
MG  P 603 (-2.2A)
None
 1.18A 6mn4C-1e33P:
0.0		 6mn4C-1e33P:
21.14