SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DD2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3bl9 SCAVENGER
MRNA-DECAPPING
ENZYME DCPS
(Homo
sapiens) 		4 / 5 VAL A  82
GLU A 185
LYS A  42
PHE A  44
 None
DD2  A 901 (-2.8A)
None
None
 1.49A 3rv5C-3bl9A:
undetectable
3rv5D-3bl9A:
undetectable		 3rv5C-3bl9A:
14.29
3rv5D-3bl9A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3bl9 SCAVENGER
MRNA-DECAPPING
ENZYME DCPS
(Homo
sapiens) 		5 / 12 ILE A 179
ASP A 205
SER A 272
HIS A 277
HIS A 279
 None
DD2  A 901 (-3.2A)
DD2  A 901 ( 3.7A)
None
None
 0.70A 5km9B-3bl9A:
10.6		 5km9B-3bl9A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 3bl9 SCAVENGER
MRNA-DECAPPING
ENZYME DCPS
(Homo
sapiens) 		6 / 12 VAL A 176
ILE A 179
ILE A 203
ASP A 205
HIS A 277
HIS A 279
 None
None
DD2  A 901 ( 4.2A)
DD2  A 901 (-3.2A)
None
None
 1.18A 5uvmB-3bl9A:
9.9		 5uvmB-3bl9A:
20.34