SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DCM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 9 PHE A  47
ASP A 171
GLY A 175
ASN A 178
TYR A 218
 None
None
DCM  A 300 (-3.5A)
None
DCM  A 300 (-4.6A)
 1.49A 1i00B-1b5dA:
18.0		 1i00B-1b5dA:
22.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N3Z_A_ADNA126_1
(RIBONUCLEASE,
SEMINAL)		 5arl RIBONUCLEASE 4
(Sus
scrofa) 		5 / 9 ASN A  66
ASN A  70
ALA A 106
VAL A 115
HIS A 116
 None
None
None
None
DCM  A1120 (-3.3A)
 0.45A 1n3zA-5arlA:
19.3		 1n3zA-5arlA:
39.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		4 / 6 ASN A 170
LEU A 215
TRP A 210
PHE A  41
 DCM  A 300 (-3.9A)
None
None
None
 1.20A 1ru9H-1b5dA:
undetectable
1ru9L-1b5dA:
undetectable		 1ru9H-1b5dA:
20.82
1ru9L-1b5dA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		4 / 6 ASN A 170
LEU A 215
TRP A 210
PHE A  41
 DCM  A 300 (-3.9A)
None
None
None
 1.19A 1rukH-1b5dA:
undetectable
1rukL-1b5dA:
undetectable		 1rukH-1b5dA:
20.82
1rukL-1b5dA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		4 / 5 TYR A 104
GLU A 144
ASP A 152
ASP A  95
 DCM  A 401 (-4.6A)
None
None
None
 1.44A 2yqzA-5jp9A:
undetectable		 2yqzA-5jp9A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		4 / 5 TYR A 104
GLU A 144
ASP A 152
ASP A  95
 DCM  A 401 (-4.6A)
None
None
None
 1.43A 2yqzB-5jp9A:
undetectable		 2yqzB-5jp9A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 12 GLU A  60
TRP A  82
ASP A 171
GLY A 175
TYR A 218
 None
None
None
DCM  A 300 (-3.5A)
DCM  A 300 (-4.6A)
 0.80A 3k2hA-1b5dA:
0.0		 3k2hA-1b5dA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		5 / 12 ALA A  60
GLU A  68
ASP A 178
GLY A 182
TYR A 218
 None
None
None
DCM  A 401 ( 3.7A)
None
 1.15A 3k2hA-5jp9A:
22.9		 3k2hA-5jp9A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 12 GLU A  60
TRP A  82
ASP A 171
GLY A 175
TYR A 218
 None
None
None
DCM  A 300 (-3.5A)
DCM  A 300 (-4.6A)
 0.77A 3k2hB-1b5dA:
0.0		 3k2hB-1b5dA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		5 / 12 ALA A  60
GLU A  68
ASP A 178
GLY A 182
TYR A 218
 None
None
None
DCM  A 401 ( 3.7A)
None
 1.16A 3k2hB-5jp9A:
23.2		 3k2hB-5jp9A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 12 GLU A  60
TRP A  82
ASP A 171
GLY A 175
TYR A 218
 None
None
None
DCM  A 300 (-3.5A)
DCM  A 300 (-4.6A)
 1.00A 3nrrA-1b5dA:
6.4		 3nrrA-1b5dA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5jp9 CMP
5-HYDROXYMETHYLASE
(Streptomyces
rimofaciens) 		5 / 12 ALA A  60
GLU A  68
ASP A 178
GLY A 182
TYR A 218
 None
None
None
DCM  A 401 ( 3.7A)
None
 1.23A 3nrrB-5jp9A:
undetectable		 3nrrB-5jp9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5xpd SUGAR TRANSPORTER
(Arabidopsis
thaliana) 		5 / 11 ILE A  59
GLY A  79
GLU A  83
GLY A  16
ASN A 176
 None
None
None
None
DCM  A 301 (-4.1A)
 1.19A 4e47A-5xpdA:
undetectable		 4e47A-5xpdA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5xpd SUGAR TRANSPORTER
(Arabidopsis
thaliana) 		5 / 11 ILE A  59
GLY A  79
GLU A  83
GLY A  16
ASN A 176
 None
None
None
None
DCM  A 301 (-4.1A)
 1.17A 4e47B-5xpdA:
undetectable		 4e47B-5xpdA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5xpd SUGAR TRANSPORTER
(Arabidopsis
thaliana) 		5 / 11 ILE A  59
GLY A  79
GLU A  83
GLY A  16
ASN A 176
 None
None
None
None
DCM  A 301 (-4.1A)
 1.20A 4e47C-5xpdA:
undetectable		 4e47C-5xpdA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 12 GLU A  60
TRP A  82
ASP A 171
GLY A 175
TYR A 218
 None
None
None
DCM  A 300 (-3.5A)
DCM  A 300 (-4.6A)
 0.91A 4foxD-1b5dA:
18.8		 4foxD-1b5dA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 11 GLU A  60
TRP A  82
ASP A 171
GLY A 175
TYR A 218
 None
None
None
DCM  A 300 (-3.5A)
DCM  A 300 (-4.6A)
 0.99A 4foxF-1b5dA:
18.9		 4foxF-1b5dA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 11 GLU A  60
TRP A  82
ASP A 171
GLY A 175
TYR A 218
 None
None
None
DCM  A 300 (-3.5A)
DCM  A 300 (-4.6A)
 0.91A 4foxH-1b5dA:
19.0		 4foxH-1b5dA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 12 GLU A  60
TRP A  82
ASP A 171
GLY A 175
TYR A 218
 None
None
None
DCM  A 300 (-3.5A)
DCM  A 300 (-4.6A)
 0.86A 4fqsA-1b5dA:
18.9		 4fqsA-1b5dA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 12 GLU A  60
TRP A  82
ASP A 171
GLY A 175
TYR A 218
 None
None
None
DCM  A 300 (-3.5A)
DCM  A 300 (-4.6A)
 0.86A 4fqsB-1b5dA:
18.9		 4fqsB-1b5dA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5xpd SUGAR TRANSPORTER
(Arabidopsis
thaliana) 		5 / 11 ILE A  59
GLY A  79
GLU A  83
GLY A  16
ASN A 176
 None
None
None
None
DCM  A 301 (-4.1A)
 1.17A 4jdsA-5xpdA:
undetectable		 4jdsA-5xpdA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5xpd SUGAR TRANSPORTER
(Arabidopsis
thaliana) 		5 / 11 ILE A  59
GLY A  79
GLU A  83
GLY A  16
ASN A 176
 None
None
None
None
DCM  A 301 (-4.1A)
 1.17A 4jdsB-5xpdA:
undetectable		 4jdsB-5xpdA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5xpd SUGAR TRANSPORTER
(Arabidopsis
thaliana) 		5 / 11 ILE A  59
GLY A  79
GLU A  83
GLY A  16
ASN A 176
 None
None
None
None
DCM  A 301 (-4.1A)
 1.16A 4jdsC-5xpdA:
undetectable		 4jdsC-5xpdA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 12 GLU A  60
TRP A  82
ASP A 171
GLY A 175
TYR A 218
 None
None
None
DCM  A 300 (-3.5A)
DCM  A 300 (-4.6A)
 0.85A 5j7wD-1b5dA:
18.1		 5j7wD-1b5dA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 10 PHE A  47
ASP A 171
GLY A 175
ASN A 178
TYR A 218
 None
None
DCM  A 300 (-3.5A)
None
DCM  A 300 (-4.6A)
 1.45A 5x66D-1b5dA:
17.7		 5x66D-1b5dA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		4 / 5 ARG A 177
GLY A 175
ASN A 170
ASP A 171
 None
DCM  A 300 (-3.5A)
DCM  A 300 (-3.9A)
None
 1.34A 6dwjB-1b5dA:
0.0
6dwjD-1b5dA:
0.0		 6dwjB-1b5dA:
19.09
6dwjD-1b5dA:
19.09