SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DCK'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3PPO_A_DCKA401_0 (GLYCINE BETAINE/CARNITINE/CH OLINE-BINDING PROTEIN)	3ppo	GLYCINE BETAINE/CARNITINE/CH OLINE-BINDING PROTEIN (Bacillus subtilis)	9 / 9	GLN A 39 SER A 71 ASN A 72 TYR A 91 THR A 94 ASN A 135 TYR A 137 TYR A 217 TYR A 241	DCK A 401 (-3.0A) DCK A 401 (-4.4A) DCK A 401 (-4.2A) DCK A 401 (-3.8A) DCK A 401 (-3.7A) DCK A 401 (-4.2A) DCK A 401 (-3.5A) DCK A 401 (-3.9A) DCK A 401 (-4.1A)	0.00A	3ppoA-3ppoA: 49.0	3ppoA-3ppoA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3PPO_B_DCKB401_0 (GLYCINE BETAINE/CARNITINE/CH OLINE-BINDING PROTEIN)	3ppo	GLYCINE BETAINE/CARNITINE/CH OLINE-BINDING PROTEIN (Bacillus subtilis)	9 / 9	GLN A 39 SER A 71 ASN A 72 TYR A 91 THR A 94 ASN A 135 TYR A 137 TYR A 217 TYR A 241	DCK A 401 (-3.0A) DCK A 401 (-4.4A) DCK A 401 (-4.2A) DCK A 401 (-3.8A) DCK A 401 (-3.7A) DCK A 401 (-4.2A) DCK A 401 (-3.5A) DCK A 401 (-3.9A) DCK A 401 (-4.1A)	0.21A	3ppoB-3ppoA: 46.0	3ppoB-3ppoA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V4T_H_ACTH502_0 (UDP-N-ACETYLGLUCOSAM INE 1-CARBOXYVINYLTRANSF ERASE)	3ppo	GLYCINE BETAINE/CARNITINE/CH OLINE-BINDING PROTEIN (Bacillus subtilis)	3 / 3	SER A 71 GLY A 70 GLN A 39	DCK A 401 (-4.4A) None DCK A 401 (-3.0A)	0.55A	3v4tH-3ppoA: undetectable	3v4tH-3ppoA: 24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NTX_A_AMRA509_1 (ACID-SENSING ION CHANNEL 1 BASIC PHOSPHOLIPASE A2 HOMOLOG TX-BETA)	3ppo	GLYCINE BETAINE/CARNITINE/CH OLINE-BINDING PROTEIN (Bacillus subtilis)	4 / 6	GLU A 45 ASP A 282 ASP A 220 ASN A 135	None None None DCK A 401 (-4.2A)	1.25A	4ntxA-3ppoA: undetectable 4ntxC-3ppoA: undetectable	4ntxA-3ppoA: 22.49 4ntxC-3ppoA: 15.33

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3PPO_A_DCKA401_0","GLYCINE BETAINE\/CARNITINE\/CHOLINE-BINDING PROTEIN","3ppo","GLYCINE BETAINE\/CARNITINE\/CHOLINE-BINDING PROTEIN","Bacillus subtilis",9,"GLN A  39;SER A  71;ASN A  72;TYR A  91;THR A  94;ASN A 135;TYR A 137;TYR A 217;TYR A 241","DCK A 401 (-3.0A);DCK A 401 (-4.4A);DCK A 401 (-4.2A);DCK A 401 (-3.8A);DCK A 401 (-3.7A);DCK A 401 (-4.2A);DCK A 401 (-3.5A);DCK A 401 (-3.9A);DCK A 401 (-4.1A)","0.00A","3ppoA-3ppoA:49.0",null],["3PPO_B_DCKB401_0","GLYCINE BETAINE\/CARNITINE\/CHOLINE-BINDING PROTEIN","3ppo","GLYCINE BETAINE\/CARNITINE\/CHOLINE-BINDING PROTEIN","Bacillus subtilis",9,"GLN A  39;SER A  71;ASN A  72;TYR A  91;THR A  94;ASN A 135;TYR A 137;TYR A 217;TYR A 241","DCK A 401 (-3.0A);DCK A 401 (-4.4A);DCK A 401 (-4.2A);DCK A 401 (-3.8A);DCK A 401 (-3.7A);DCK A 401 (-4.2A);DCK A 401 (-3.5A);DCK A 401 (-3.9A);DCK A 401 (-4.1A)","0.21A","3ppoB-3ppoA:46.0","3ppoA-3ppoA:100.00"],["3V4T_H_ACTH502_0","UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE","3ppo","GLYCINE BETAINE\/CARNITINE\/CHOLINE-BINDING PROTEIN","Bacillus subtilis",3,"SER A  71;GLY A  70;GLN A  39","DCK A 401 (-4.4A);None;DCK A 401 (-3.0A)","0.55A","3v4tH-3ppoA:undetectable","3ppoB-3ppoA:100.00"],["4NTX_A_AMRA509_1","ACID-SENSING ION CHANNEL 1;BASIC PHOSPHOLIPASE A2 HOMOLOG TX-BETA","3ppo","GLYCINE BETAINE\/CARNITINE\/CHOLINE-BINDING PROTEIN","Bacillus subtilis",4,"GLU A  45;ASP A 282;ASP A 220;ASN A 135","None;None;None;DCK A 401 (-4.2A)","1.25A","4ntxA-3ppoA:undetectable;4ntxC-3ppoA:undetectable","3v4tH-3ppoA:24.19"]]