SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DCA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN
(Propionibacteriu
m
freudenreichii) 		4 / 7 TYR A  89
GLN A 197
SER A 239
TYR A 243
 DCA  A 801 (-4.0A)
None
DCA  A 801 ( 4.1A)
B12  A 800 ( 4.6A)
 1.32A 1eiiA-1e1cA:
0.0		 1eiiA-1e1cA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN
(Propionibacteriu
m
freudenreichii) 		4 / 8 TYR A 243
SER A 362
GLN A 197
SER A 239
 B12  A 800 ( 4.6A)
DCA  A 801 (-3.4A)
None
DCA  A 801 ( 4.1A)
 1.00A 2xz5B-1e1cA:
0.0
2xz5E-1e1cA:
0.0		 2xz5B-1e1cA:
15.66
2xz5E-1e1cA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN
(Propionibacteriu
m
freudenreichii) 		5 / 10 ILE A 174
ILE A 196
PHE A 287
TYR A  89
ARG A 207
 None
None
DCA  A 801 ( 4.5A)
DCA  A 801 (-4.0A)
B12  A 800 (-3.9A)
 1.35A 3elzB-1e1cA:
0.0		 3elzB-1e1cA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN
(Propionibacteriu
m
freudenreichii) 		3 / 3 MET A 306
GLN A 361
TYR A  75
 None
None
DCA  A 801 (-3.9A)
 1.08A 4udcA-1e1cA:
0.0		 4udcA-1e1cA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN
(Propionibacteriu
m
freudenreichii) 		3 / 3 ARG A 305
PHE A 287
LEU A 301
 None
DCA  A 801 ( 4.5A)
None
 0.83A 5x1bC-1e1cA:
undetectable		 5x1bC-1e1cA:
16.48