SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DBO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		5 / 12 LEU A  46
ASP A  48
GLY A  50
ASN A  53
ILE A 134
 None
DBO  A1001 (-2.7A)
DBO  A1001 (-3.7A)
None
None
 0.78A 2f80B-2ewyA:
6.4		 2f80B-2ewyA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		5 / 12 LEU A  46
ASP A  48
GLY A  50
ASN A  53
ILE A 134
 None
DBO  A1001 (-2.7A)
DBO  A1001 (-3.7A)
None
None
 0.76A 2q64A-2ewyA:
6.7		 2q64A-2ewyA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		5 / 12 LEU A  46
ASP A  48
GLY A  50
ASN A  53
ILE A 134
 None
DBO  A1001 (-2.7A)
DBO  A1001 (-3.7A)
None
None
 0.78A 2q64B-2ewyA:
6.6		 2q64B-2ewyA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		5 / 12 LEU A  46
ASP A  48
GLY A  50
ASN A  53
ILE A 134
 None
DBO  A1001 (-2.7A)
DBO  A1001 (-3.7A)
None
None
 0.80A 2qakA-2ewyA:
6.6		 2qakA-2ewyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		5 / 12 LEU A  46
ASP A  48
GLY A  50
ASN A  53
ILE A 134
 None
DBO  A1001 (-2.7A)
DBO  A1001 (-3.7A)
None
None
 0.86A 2qakB-2ewyA:
6.6		 2qakB-2ewyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		6 / 12 ASP A  48
GLY A  50
SER A  51
TYR A  87
ASP A 241
GLY A 243
 DBO  A1001 (-2.7A)
DBO  A1001 (-3.7A)
DBO  A1001 (-4.1A)
DBO  A1001 (-3.8A)
DBO  A1001 (-3.2A)
DBO  A1001 (-4.2A)
 0.39A 2v0zC-2ewyA:
35.1		 2v0zC-2ewyA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		6 / 12 ASP A 241
GLY A 243
VAL A 344
ASP A  48
GLY A  50
SER A  52
 DBO  A1001 (-3.2A)
DBO  A1001 (-4.2A)
None
DBO  A1001 (-2.7A)
DBO  A1001 (-3.7A)
None
 1.19A 2v0zC-2ewyA:
35.1		 2v0zC-2ewyA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		6 / 12 ASP A 241
GLY A 243
VAL A 344
ASP A  48
GLY A  50
SER A  52
 DBO  A1001 (-3.2A)
DBO  A1001 (-4.2A)
None
DBO  A1001 (-2.7A)
DBO  A1001 (-3.7A)
None
 1.18A 2v0zO-2ewyA:
35.4		 2v0zO-2ewyA:
27.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		4 / 5 LEU A  46
ASP A  48
ILE A 134
GLY A 243
 None
DBO  A1001 (-2.7A)
None
DBO  A1001 (-4.2A)
 0.31A 3bufA-2ewyA:
51.6		 3bufA-2ewyA:
52.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		5 / 12 ASP A 241
GLY A 243
LEU A  46
ASP A  48
SER A  52
 DBO  A1001 (-3.2A)
DBO  A1001 (-4.2A)
None
DBO  A1001 (-2.7A)
None
 0.86A 3d91A-2ewyA:
17.1		 3d91A-2ewyA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		5 / 12 ASP A 241
GLY A 243
LEU A  46
ASP A  48
SER A  52
 DBO  A1001 (-3.2A)
DBO  A1001 (-4.2A)
None
DBO  A1001 (-2.7A)
None
 0.89A 3d91B-2ewyA:
35.1		 3d91B-2ewyA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		5 / 12 ASP A 241
GLY A 243
VAL A 344
LEU A  46
ASP A  48
 DBO  A1001 (-3.2A)
DBO  A1001 (-4.2A)
None
None
DBO  A1001 (-2.7A)
 1.01A 3d91B-2ewyA:
35.1		 3d91B-2ewyA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		5 / 8 GLY A  50
SER A  51
TYR A  87
ASP A 241
THR A 245
 DBO  A1001 (-3.7A)
DBO  A1001 (-4.1A)
DBO  A1001 (-3.8A)
DBO  A1001 (-3.2A)
DBO  A1001 (-3.8A)
 0.29A 3pwwA-2ewyA:
5.1		 3pwwA-2ewyA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		5 / 12 ILE A 239
ASP A 241
GLY A 243
ASP A  48
ILE A 134
 None
DBO  A1001 (-3.2A)
DBO  A1001 (-4.2A)
DBO  A1001 (-2.7A)
None
 0.77A 3tneA-2ewyA:
33.1		 3tneA-2ewyA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		4 / 6 SER A  51
TYR A  87
THR A 244
THR A 245
 DBO  A1001 (-4.1A)
DBO  A1001 (-3.8A)
DBO  A1001 (-3.8A)
DBO  A1001 (-3.8A)
 0.35A 3tneA-2ewyA:
33.1		 3tneA-2ewyA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		5 / 12 ILE A 239
ASP A 241
GLY A 243
ASP A  48
ILE A 134
 None
DBO  A1001 (-3.2A)
DBO  A1001 (-4.2A)
DBO  A1001 (-2.7A)
None
 0.77A 3tneB-2ewyA:
33.0		 3tneB-2ewyA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		5 / 7 SER A  51
TYR A  87
ILE A 134
THR A 244
THR A 245
 DBO  A1001 (-4.1A)
DBO  A1001 (-3.8A)
None
DBO  A1001 (-3.8A)
DBO  A1001 (-3.8A)
 0.54A 3tneB-2ewyA:
33.0		 3tneB-2ewyA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		3 / 3 ASP A 241
ASP A  48
ASN A  53
 DBO  A1001 (-3.2A)
DBO  A1001 (-2.7A)
None
 0.61A 4q5mA-2ewyA:
9.2		 4q5mA-2ewyA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		4 / 8 PHE A 124
PHE A 125
TRP A 131
ILE A 115
 DBO  A1001 (-4.2A)
None
None
None
 0.95A 4qoiA-2ewyA:
undetectable
4qoiB-2ewyA:
undetectable		 4qoiA-2ewyA:
22.28
4qoiB-2ewyA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		6 / 12 GLY A 243
GLY A  50
GLY A 136
ASN A  53
ALA A 347
THR A 348
 DBO  A1001 (-4.2A)
DBO  A1001 (-3.7A)
None
None
None
None
 1.14A 4uckA-2ewyA:
undetectable		 4uckA-2ewyA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		5 / 12 GLY A  50
GLY A 136
ASN A  53
ALA A 347
THR A 348
 DBO  A1001 (-3.7A)
None
None
None
None
 1.13A 4uckB-2ewyA:
undetectable		 4uckB-2ewyA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		4 / 7 ASP A  48
THR A  49
VAL A  85
TYR A  87
 DBO  A1001 (-2.7A)
None
None
DBO  A1001 (-3.8A)
 0.92A 5ov9A-2ewyA:
undetectable		 5ov9A-2ewyA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		3 / 3 GLY A  50
VAL A 355
MET A 168
 DBO  A1001 (-3.7A)
None
None
 0.65A 5ycpA-2ewyA:
undetectable		 5ycpA-2ewyA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ewy BETA-SECRETASE 2
(Homo
sapiens) 		3 / 3 GLY A 243
VAL A 355
MET A 168
 DBO  A1001 (-4.2A)
None
None
 0.59A 5ycpA-2ewyA:
undetectable		 5ycpA-2ewyA:
13.48