SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DB8'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 6fdy -
(-) 		7 / 12 LEU U  20
VAL U  28
ALA U  42
PHE U  93
GLY U  97
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.83A 1iepA-6fdyU:
22.0		 1iepA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 6fdy -
(-) 		7 / 12 LEU U  20
VAL U  28
ALA U  42
PHE U  93
GLY U  97
LEU U 144
ALA U 156
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.73A 1iepA-6fdyU:
22.0		 1iepA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3soa CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER
(Homo
sapiens) 		6 / 12 LEU A  19
VAL A  27
ALA A  40
GLU A  60
GLY A  94
ALA A 155
 DB8  A 445 (-3.5A)
DB8  A 445 (-4.5A)
DB8  A 445 ( 4.2A)
DB8  A 445 ( 4.8A)
None
None
 1.03A 1iepB-3soaA:
19.5		 1iepB-3soaA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 6fdy -
(-) 		7 / 12 LEU U  20
VAL U  28
ALA U  42
PHE U  93
GLY U  97
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.88A 1iepB-6fdyU:
21.8		 1iepB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		6 / 12 LEU U  20
VAL U  28
ALA U  42
VAL U  75
PHE U  93
ALA U 156
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.2A)
 0.75A 1opjA-6fdyU:
21.7		 1opjA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		7 / 12 VAL U  28
ALA U  42
VAL U  75
PHE U  93
GLY U  97
ALA U 156
ASP U 157
 DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.99A 1opjB-6fdyU:
21.6		 1opjB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3soa CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER
(Homo
sapiens) 		5 / 9 LEU A  19
VAL A  27
LEU A  75
LEU A  87
LEU A  91
 DB8  A 445 (-3.5A)
DB8  A 445 (-4.5A)
None
None
None
 0.73A 1xkkA-3soaA:
19.3		 1xkkA-3soaA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 6fdy -
(-) 		6 / 12 VAL U  75
ASP U  98
ASN U 142
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 (-4.8A)
None
DB8  U 301 (-4.5A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.54A 2eufB-6fdyU:
26.7		 2eufB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		8 / 12 LEU U  20
ALA U  42
LYS U  44
VAL U  75
PHE U  93
GLY U  97
LEU U 144
ALA U 156
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.67A 2gqgA-6fdyU:
25.0		 2gqgA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		7 / 12 VAL U  28
ALA U  42
LYS U  44
VAL U  75
GLY U  97
LEU U 144
ALA U 156
 DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.64A 2gqgB-6fdyU:
25.0		 2gqgB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		6 / 12 VAL U  28
ALA U  42
PHE U  93
GLY U  97
ALA U 156
ASP U 157
 DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.83A 2hyyA-6fdyU:
22.1		 2hyyA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		6 / 12 VAL U  28
ALA U  42
PHE U  93
GLY U  97
LEU U 144
ALA U 156
 DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.73A 2hyyA-6fdyU:
22.1		 2hyyA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		6 / 12 VAL U  28
ALA U  42
PHE U  93
GLY U  97
LEU U 144
ALA U 156
 DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.71A 2hyyB-6fdyU:
22.2		 2hyyB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6fdy -
(-) 		8 / 12 LEU U  20
GLY U  21
VAL U  28
ALA U  42
LYS U  44
LEU U  89
GLY U  97
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.9A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
None
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 0.68A 2ityA-6fdyU:
22.6		 2ityA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6fdy -
(-) 		8 / 12 LEU U  20
GLY U  21
VAL U  28
ALA U  42
LYS U  44
LEU U  89
LEU U 144
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.9A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
None
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.83A 2ityA-6fdyU:
22.6		 2ityA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 6fdy -
(-) 		6 / 9 LEU U  20
VAL U  28
ALA U  42
GLY U  97
LEU U 144
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.64A 2xp2A-6fdyU:
5.4		 2xp2A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		5 / 10 LEU U  20
VAL U  28
LYS U  44
VAL U  75
PHE U  93
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
 0.69A 3cs9A-6fdyU:
21.8		 3cs9A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		5 / 10 LEU U  20
VAL U  28
VAL U  75
PHE U  93
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 (-3.6A)
 0.92A 3cs9A-6fdyU:
21.8		 3cs9A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 6fdy -
(-) 		7 / 11 LEU U  20
VAL U  28
ALA U  42
CYH U  94
GLY U  97
ASP U  98
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 (-4.2A)
DB8  U 301 ( 4.1A)
None
DB8  U 301 (-4.8A)
 0.75A 3g0fA-6fdyU:
21.6		 3g0fA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 6fdy -
(-) 		6 / 10 LEU U  20
VAL U  28
ALA U  42
CYH U  94
GLY U  97
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 (-4.2A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 0.73A 3g0fB-6fdyU:
21.9		 3g0fB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 6fdy -
(-) 		7 / 12 LEU U  20
VAL U  28
ALA U  42
VAL U  75
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.87A 3gvuA-6fdyU:
22.2		 3gvuA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		5 / 12 ALA U  42
VAL U  75
HIS U 135
LEU U 144
ALA U 156
 DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
None
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.64A 3ik3A-6fdyU:
21.8		 3ik3A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		5 / 12 ALA U  42
VAL U  75
HIS U 135
LEU U 144
ALA U 156
 DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
None
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.67A 3ik3B-6fdyU:
21.6		 3ik3B-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		6 / 12 VAL U  28
ALA U  42
PHE U  93
GLY U  97
LEU U 144
ALA U 156
 DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.75A 3k5vA-6fdyU:
21.6		 3k5vA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		6 / 12 VAL U  28
ALA U  42
PHE U  93
GLY U  97
LEU U 144
ALA U 156
 DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.72A 3k5vB-6fdyU:
21.3		 3k5vB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		6 / 12 LEU U  20
VAL U  28
ALA U  42
PHE U  93
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.68A 3ms9A-6fdyU:
21.7		 3ms9A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		6 / 12 LEU U  20
VAL U  28
ALA U  42
PHE U  93
LEU U 144
ALA U 156
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.70A 3ms9A-6fdyU:
21.7		 3ms9A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		6 / 12 LEU U  20
VAL U  28
ALA U  42
PHE U  93
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.69A 3mssA-6fdyU:
21.8		 3mssA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		6 / 12 LEU U  20
VAL U  28
ALA U  42
PHE U  93
LEU U 144
ALA U 156
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.72A 3mssA-6fdyU:
21.8		 3mssA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		6 / 12 LEU U  20
VAL U  28
ALA U  42
PHE U  93
GLY U  97
ALA U 156
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 ( 4.2A)
 0.71A 3mssB-6fdyU:
21.8		 3mssB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		6 / 12 LEU U  20
VAL U  28
ALA U  42
PHE U  93
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.72A 3mssC-6fdyU:
21.8		 3mssC-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		6 / 12 LEU U  20
VAL U  28
ALA U  42
PHE U  93
LEU U 144
ALA U 156
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.72A 3mssC-6fdyU:
21.8		 3mssC-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		6 / 12 LEU U  20
ALA U  42
PHE U  93
GLY U  97
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.86A 3mssD-6fdyU:
21.8		 3mssD-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		6 / 12 LEU U  20
ALA U  42
PHE U  93
GLY U  97
LEU U 144
ALA U 156
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.76A 3mssD-6fdyU:
21.8		 3mssD-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 6fdy -
(-) 		6 / 12 LEU U  20
VAL U  28
ALA U  42
VAL U  75
LEU U 144
ALA U 156
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.77A 3pyyB-6fdyU:
21.7		 3pyyB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		7 / 12 LEU U  20
ALA U  42
GLU U  62
VAL U  75
PHE U  93
GLY U  97
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
None
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 1.05A 3ue4A-6fdyU:
24.4		 3ue4A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		7 / 12 LEU U  20
ALA U  42
LYS U  44
VAL U  75
PHE U  93
GLY U  97
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 0.63A 3ue4A-6fdyU:
24.4		 3ue4A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		7 / 12 LEU U  20
VAL U  28
ALA U  42
VAL U  75
PHE U  93
GLY U  97
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 0.63A 3ue4B-6fdyU:
24.4		 3ue4B-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6fdy -
(-) 		7 / 12 LEU U  20
VAL U  28
ALA U  42
LYS U  44
LEU U  89
GLY U  97
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
None
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 0.49A 3ug2A-6fdyU:
23.3		 3ug2A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6fdy -
(-) 		7 / 12 LEU U  20
VAL U  28
ALA U  42
LYS U  44
LEU U  89
MET U  91
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
None
DB8  U 301 (-4.8A)
DB8  U 301 (-4.8A)
 0.62A 3ug2A-6fdyU:
23.3		 3ug2A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fdy -
(-) 		5 / 12 LEU U  20
VAL U  28
ALA U  42
CYH U  94
GLY U  97
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 (-4.2A)
DB8  U 301 ( 4.1A)
 0.48A 3wzdA-6fdyU:
21.4		 3wzdA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fdy -
(-) 		7 / 12 LEU U  20
VAL U  28
ALA U  42
LYS U  44
PHE U  93
GLY U  97
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 0.75A 4ag8A-6fdyU:
20.9		 4ag8A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fdy -
(-) 		7 / 11 LEU U  20
ALA U  42
VAL U  75
PHE U  93
CYH U  94
GLY U  97
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 (-4.2A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 0.76A 4agdA-6fdyU:
20.0		 4agdA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 6fdy -
(-) 		7 / 9 LEU U  20
VAL U  28
ALA U  42
GLY U  97
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.70A 4anqA-6fdyU:
22.3		 4anqA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 6fdy -
(-) 		7 / 9 LEU U  20
VAL U  28
ALA U  42
GLY U  97
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.72A 4ansA-6fdyU:
22.3		 4ansA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fdy -
(-) 		4 / 6 ILE U  69
VAL U  75
CYH U  94
LEU U 144
 None
DB8  U 301 (-4.8A)
DB8  U 301 (-4.2A)
DB8  U 301 (-4.8A)
 0.75A 4asdA-6fdyU:
20.8		 4asdA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6fdy -
(-) 		9 / 12 LEU U  20
GLY U  21
VAL U  28
ALA U  42
LYS U  44
LEU U  89
MET U  91
GLY U  97
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.9A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
None
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 0.86A 4i22A-6fdyU:
20.2		 4i22A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 6fdy -
(-) 		7 / 12 ALA U  42
ASP U  98
ASP U 137
LYS U 139
ASN U 142
LEU U 144
ASP U 157
 DB8  U 301 (-3.6A)
None
None
None
DB8  U 301 (-4.5A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.59A 4i41A-6fdyU:
27.6		 4i41A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 6fdy -
(-) 		7 / 12 VAL U  28
ALA U  42
ASP U  98
ASP U 137
LYS U 139
ASN U 142
LEU U 144
 DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
None
None
None
DB8  U 301 (-4.5A)
DB8  U 301 (-4.8A)
 0.74A 4i41A-6fdyU:
27.6		 4i41A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 6fdy -
(-) 		6 / 10 ALA U  42
VAL U  75
MET U  91
PHE U  93
GLY U  97
LEU U 144
 DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 0.69A 4ks8A-6fdyU:
28.3		 4ks8A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6fdy -
(-) 		9 / 12 LEU U  20
VAL U  28
ALA U  42
LYS U  44
VAL U  75
MET U  91
GLY U  97
LEU U 144
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.79A 4mxyA-6fdyU:
23.5		 4mxyA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6fdy -
(-) 		10 / 12 LEU U  20
VAL U  28
ALA U  42
LYS U  44
VAL U  75
MET U  91
GLY U  97
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.71A 4mxyB-6fdyU:
23.7		 4mxyB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6fdy -
(-) 		9 / 12 LEU U  20
VAL U  28
ALA U  42
LYS U  44
VAL U  75
MET U  91
GLY U  97
LEU U 144
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.79A 4mxzA-6fdyU:
23.5		 4mxzA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6fdy -
(-) 		10 / 12 LEU U  20
VAL U  28
ALA U  42
LYS U  44
VAL U  75
MET U  91
GLY U  97
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.71A 4mxzB-6fdyU:
23.7		 4mxzB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 6fdy -
(-) 		6 / 9 ALA U  42
CYH U  94
ASP U  98
ASN U 142
LEU U 144
ASP U 157
 DB8  U 301 (-3.6A)
DB8  U 301 (-4.2A)
None
DB8  U 301 (-4.5A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.68A 4ogrI-6fdyU:
25.7		 4ogrI-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 6fdy -
(-) 		7 / 12 LEU U  20
LYS U  44
VAL U  75
GLY U  97
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.80A 4otwA-6fdyU:
20.6		 4otwA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 6fdy -
(-) 		7 / 12 LEU U  20
VAL U  28
LYS U  44
VAL U  75
GLY U  97
LEU U 144
ALA U 156
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.73A 4otwA-6fdyU:
20.6		 4otwA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 6fdy -
(-) 		6 / 12 ALA U  42
GLU U  62
MET U  91
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 (-3.6A)
None
DB8  U 301 (-4.8A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.81A 4qmnA-6fdyU:
29.1		 4qmnA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		9 / 12 LEU U  20
VAL U  28
ALA U  42
LYS U  44
PHE U  93
GLY U  97
ASN U 142
LEU U 144
ALA U 156
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.5A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.98A 4twpA-6fdyU:
24.6		 4twpA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		9 / 12 VAL U  28
ALA U  42
LYS U  44
PHE U  93
GLY U  97
ASN U 142
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.5A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.92A 4twpA-6fdyU:
24.6		 4twpA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		9 / 12 LEU U  20
VAL U  28
ALA U  42
LYS U  44
PHE U  93
GLY U  97
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 1.05A 4twpB-6fdyU:
24.9		 4twpB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		9 / 12 LEU U  20
VAL U  28
ALA U  42
PHE U  93
GLY U  97
ASN U 142
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.5A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.88A 4twpB-6fdyU:
24.9		 4twpB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 6fdy -
(-) 		4 / 6 LEU U  20
VAL U  28
LYS U  44
ILE U 143
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 ( 4.0A)
None
 0.62A 4tyjA-6fdyU:
21.7		 4tyjA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		6 / 11 LEU U  20
ALA U  42
GLY U  97
ASN U 142
LEU U 144
ALA U 156
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.5A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.86A 4wa9A-6fdyU:
21.3		 4wa9A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		7 / 12 VAL U  28
ALA U  42
LYS U  44
PHE U  93
GLY U  97
LEU U 144
ALA U 156
 DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.98A 4wa9B-6fdyU:
23.8		 4wa9B-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		7 / 12 VAL U  28
ALA U  42
PHE U  93
GLY U  97
ASN U 142
LEU U 144
ALA U 156
 DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.5A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.82A 4wa9B-6fdyU:
23.8		 4wa9B-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		8 / 12 LEU U  20
VAL U  28
ALA U  42
VAL U  75
PHE U  93
GLY U  97
LEU U 144
ALA U 156
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.74A 4xeyB-6fdyU:
24.0		 4xeyB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 6fdy -
(-) 		6 / 9 LEU U  20
VAL U  28
ALA U  42
GLY U  97
LEU U 144
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.68A 5aaaA-6fdyU:
22.2		 5aaaA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 6fdy -
(-) 		7 / 10 LEU U  20
VAL U  28
ALA U  42
LYS U  44
GLY U  97
LEU U 144
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.78A 5aabA-6fdyU:
22.3		 5aabA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 6fdy -
(-) 		8 / 12 LEU U  20
ALA U  42
PHE U  93
CYH U  94
GLY U  97
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 (-4.2A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.57A 5ajqA-6fdyU:
21.1		 5ajqA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 6fdy -
(-) 		8 / 12 LEU U  20
GLY U  21
ALA U  42
PHE U  93
CYH U  94
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.9A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 (-4.2A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.84A 5ajqA-6fdyU:
21.1		 5ajqA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 6fdy -
(-) 		6 / 12 LYS U  44
CYH U  94
GLY U  97
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 ( 4.0A)
DB8  U 301 (-4.2A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.76A 5ajqA-6fdyU:
21.1		 5ajqA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 6fdy -
(-) 		4 / 6 LYS U  44
PHE U  80
VAL U  75
ASP U 157
 DB8  U 301 ( 4.0A)
None
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 1.11A 5hesA-6fdyU:
6.5		 5hesA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 6fdy -
(-) 		6 / 12 VAL U  28
ALA U  42
VAL U  75
ASP U  98
LEU U 144
ALA U 156
 DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
None
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.86A 5l2tA-6fdyU:
7.3		 5l2tA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 6fdy -
(-) 		4 / 5 LEU U  66
CYH U  94
LEU U 144
ASP U 157
 None
DB8  U 301 (-4.2A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.80A 5mafA-6fdyU:
28.6		 5mafA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		5 / 12 ALA U  42
VAL U  75
HIS U 135
LEU U 144
ALA U 156
 DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
None
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.60A 5mo4A-6fdyU:
15.5		 5mo4A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 6fdy -
(-) 		4 / 8 ALA U  42
CYH U  94
LEU U 144
ASP U 157
 DB8  U 301 (-3.6A)
DB8  U 301 (-4.2A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.30A 5owrA-6fdyU:
23.7		 5owrA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 6fdy -
(-) 		4 / 8 GLU U  62
CYH U  94
LEU U 144
ASP U 157
 None
DB8  U 301 (-4.2A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.33A 5owrA-6fdyU:
23.7		 5owrA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 6fdy -
(-) 		6 / 12 GLU U  18
ALA U  42
VAL U  75
PHE U  93
GLY U  97
LEU U 144
 None
DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 0.71A 5te0A-6fdyU:
25.3		 5te0A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 6fdy -
(-) 		6 / 12 GLU U  18
GLY U  21
ALA U  42
CYH U  94
GLY U  97
ASP U 157
 None
DB8  U 301 ( 4.9A)
DB8  U 301 (-3.6A)
DB8  U 301 (-4.2A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-3.6A)
 0.74A 5vc3A-6fdyU:
26.0		 5vc3A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 6fdy -
(-) 		6 / 12 LEU U  20
ALA U  42
LYS U  44
VAL U  75
LEU U  89
GLY U  97
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
None
DB8  U 301 ( 4.1A)
 1.37A 5vcvA-6fdyU:
24.8		 5vcvA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 6fdy -
(-) 		7 / 12 LEU U  20
VAL U  28
ALA U  42
LYS U  44
LEU U  89
CYH U  94
GLY U  96
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
None
DB8  U 301 (-4.2A)
None
 0.80A 5vcyA-6fdyU:
24.4		 5vcyA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 6fdy -
(-) 		6 / 12 LEU U  20
VAL U  28
ALA U  42
LYS U  44
LEU U  89
GLY U  97
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
None
DB8  U 301 ( 4.1A)
 0.99A 5vcyA-6fdyU:
24.4		 5vcyA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 6fdy -
(-) 		5 / 9 ALA U  42
VAL U  75
MET U  91
CYH U  94
GLY U  96
 DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
DB8  U 301 (-4.8A)
DB8  U 301 (-4.2A)
None
 1.05A 5w5vA-6fdyU:
4.1		 5w5vA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 6fdy -
(-) 		6 / 9 LEU U  20
ALA U  42
VAL U  75
MET U  91
CYH U  94
GLY U  97
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
DB8  U 301 (-4.8A)
DB8  U 301 (-4.2A)
DB8  U 301 ( 4.1A)
 0.74A 5w5vA-6fdyU:
4.1		 5w5vA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 6fdy -
(-) 		5 / 12 LEU U  20
GLY U  21
VAL U  28
ALA U  42
ALA U 156
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.9A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.2A)
 0.49A 5xv7A-6fdyU:
24.0		 5xv7A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6fdy -
(-) 		7 / 12 LEU U  20
VAL U  28
ALA U  42
LYS U  44
CYH U  94
GLY U  97
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.2A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 0.89A 5y7zA-6fdyU:
24.3		 5y7zA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6fdy -
(-) 		7 / 12 ALA U  42
LYS U  44
LEU U  89
CYH U  94
GLY U  97
LEU U 144
ASP U 157
 DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
None
DB8  U 301 (-4.2A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.94A 5y7zB-6fdyU:
17.6		 5y7zB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6fdy -
(-) 		7 / 12 LEU U  20
ALA U  42
LYS U  44
LEU U  89
CYH U  94
GLY U  97
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
None
DB8  U 301 (-4.2A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 0.93A 5y7zB-6fdyU:
17.6		 5y7zB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6fdy -
(-) 		6 / 12 LEU U  20
GLY U  21
VAL U  28
ALA U  42
LEU U  89
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.9A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
None
DB8  U 301 (-4.8A)
 0.58A 5yu9A-6fdyU:
20.0		 5yu9A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 6fdy -
(-) 		3 / 3 LYS U  44
LEU U 144
ASP U 157
 DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.89A 5zv2A-6fdyU:
21.5		 5zv2A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		7 / 12 VAL U  28
ALA U  42
LYS U  44
VAL U  75
PHE U  93
LEU U 144
ALA U 156
 DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.87A 6hd6A-6fdyU:
21.5		 6hd6A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 6fdy -
(-) 		7 / 12 LEU U  20
VAL U  28
ALA U  42
LYS U  44
VAL U  75
PHE U  93
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 (-4.8A)
 0.95A 6hd6B-6fdyU:
21.3		 6hd6B-6fdyU:
undetectable