SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DAS'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SBR_B_VIBB503_1 (YKOF)	5hra	ASPARTATE/GLUTAMATE RACEMASE (Escherichia coli)	4 / 7	PHE A 45 ILE A 157 ILE A 161 THR A 85	None None None DAS A 301 (-3.7A)	1.00A	1sbrB-5hraA: undetectable	1sbrB-5hraA: 22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4W5O_A_IPHA907_0 (PROTEIN ARGONAUTE-2)	5hra	ASPARTATE/GLUTAMATE RACEMASE (Escherichia coli)	4 / 5	LYS A 88 THR A 125 THR A 85 TYR A 127	None DAS A 301 ( 4.1A) DAS A 301 (-3.7A) None	1.46A	4w5oA-5hraA: 2.2	4w5oA-5hraA: 15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4W5T_A_IPHA905_0 (PROTEIN ARGONAUTE-2)	5hra	ASPARTATE/GLUTAMATE RACEMASE (Escherichia coli)	4 / 6	LYS A 88 THR A 125 THR A 85 TYR A 127	None DAS A 301 ( 4.1A) DAS A 301 (-3.7A) None	1.48A	4w5tA-5hraA: 3.6	4w5tA-5hraA: 15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4C_A_IPHA906_0 (PROTEIN ARGONAUTE-2)	5hra	ASPARTATE/GLUTAMATE RACEMASE (Escherichia coli)	4 / 6	LYS A 88 THR A 125 THR A 85 TYR A 127	None DAS A 301 ( 4.1A) DAS A 301 (-3.7A) None	1.45A	4z4cA-5hraA: 2.2	4z4cA-5hraA: 15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4D_A_IPHA905_0 (PROTEIN ARGONAUTE-2)	5hra	ASPARTATE/GLUTAMATE RACEMASE (Escherichia coli)	4 / 5	LYS A 88 THR A 125 THR A 85 TYR A 127	None DAS A 301 ( 4.1A) DAS A 301 (-3.7A) None	1.47A	4z4dA-5hraA: 2.2	4z4dA-5hraA: 15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4E_A_IPHA907_0 (PROTEIN ARGONAUTE-2)	5hra	ASPARTATE/GLUTAMATE RACEMASE (Escherichia coli)	4 / 5	LYS A 88 THR A 125 THR A 85 TYR A 127	None DAS A 301 ( 4.1A) DAS A 301 (-3.7A) None	1.47A	4z4eA-5hraA: 3.8	4z4eA-5hraA: 15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4F_A_IPHA904_0 (PROTEIN ARGONAUTE-2)	5hra	ASPARTATE/GLUTAMATE RACEMASE (Escherichia coli)	4 / 6	LYS A 88 THR A 125 THR A 85 TYR A 127	None DAS A 301 ( 4.1A) DAS A 301 (-3.7A) None	1.48A	4z4fA-5hraA: 2.2	4z4fA-5hraA: 15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IEO_A_VDYA206_1 (CDL2.3A)	5hra	ASPARTATE/GLUTAMATE RACEMASE (Escherichia coli)	5 / 12	TYR A 18 LEU A 81 LEU A 64 PHE A 45 THR A 198	None None None None DAS A 301 (-3.2A)	1.35A	5ieoA-5hraA: undetectable	5ieoA-5hraA: 19.20

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1SBR_B_VIBB503_1","YKOF","5hra","ASPARTATE\/GLUTAMATE RACEMASE","Escherichia coli",4,"PHE A  45;ILE A 157;ILE A 161;THR A  85","None;None;None;DAS A 301 (-3.7A)","1.00A","1sbrB-5hraA:undetectable",null],["4W5O_A_IPHA907_0","PROTEIN ARGONAUTE-2","5hra","ASPARTATE\/GLUTAMATE RACEMASE","Escherichia coli",4,"LYS A  88;THR A 125;THR A  85;TYR A 127","None;DAS A 301 ( 4.1A);DAS A 301 (-3.7A);None","1.46A","4w5oA-5hraA:2.2","1sbrB-5hraA:22.76"],["4W5T_A_IPHA905_0","PROTEIN ARGONAUTE-2","5hra","ASPARTATE\/GLUTAMATE RACEMASE","Escherichia coli",4,"LYS A  88;THR A 125;THR A  85;TYR A 127","None;DAS A 301 ( 4.1A);DAS A 301 (-3.7A);None","1.48A","4w5tA-5hraA:3.6","4w5oA-5hraA:15.56"],["4Z4C_A_IPHA906_0","PROTEIN ARGONAUTE-2","5hra","ASPARTATE\/GLUTAMATE RACEMASE","Escherichia coli",4,"LYS A  88;THR A 125;THR A  85;TYR A 127","None;DAS A 301 ( 4.1A);DAS A 301 (-3.7A);None","1.45A","4z4cA-5hraA:2.2","4w5tA-5hraA:15.56"],["4Z4D_A_IPHA905_0","PROTEIN ARGONAUTE-2","5hra","ASPARTATE\/GLUTAMATE RACEMASE","Escherichia coli",4,"LYS A  88;THR A 125;THR A  85;TYR A 127","None;DAS A 301 ( 4.1A);DAS A 301 (-3.7A);None","1.47A","4z4dA-5hraA:2.2","4z4cA-5hraA:15.56"],["4Z4E_A_IPHA907_0","PROTEIN ARGONAUTE-2","5hra","ASPARTATE\/GLUTAMATE RACEMASE","Escherichia coli",4,"LYS A  88;THR A 125;THR A  85;TYR A 127","None;DAS A 301 ( 4.1A);DAS A 301 (-3.7A);None","1.47A","4z4eA-5hraA:3.8","4z4dA-5hraA:15.56"],["4Z4F_A_IPHA904_0","PROTEIN ARGONAUTE-2","5hra","ASPARTATE\/GLUTAMATE RACEMASE","Escherichia coli",4,"LYS A  88;THR A 125;THR A  85;TYR A 127","None;DAS A 301 ( 4.1A);DAS A 301 (-3.7A);None","1.48A","4z4fA-5hraA:2.2","4z4eA-5hraA:15.56"],["5IEO_A_VDYA206_1","CDL2.3A","5hra","ASPARTATE\/GLUTAMATE RACEMASE","Escherichia coli",5,"TYR A  18;LEU A  81;LEU A  64;PHE A  45;THR A 198","None;None;None;None;DAS A 301 (-3.2A)","1.35A","5ieoA-5hraA:undetectable","4z4fA-5hraA:15.56"]]