SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DAO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		5 / 9 ILE A 229
PHE A 102
LEU A 149
GLY A 346
ALA A 233
 HEM  A 403 (-4.7A)
HEM  A 403 (-4.6A)
None
HEM  A 403 (-3.6A)
DAO  A 402 (-3.6A)
 1.04A 1e7bA-5cweA:
undetectable		 1e7bA-5cweA:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 1fk1 NON-SPECIFIC LIPID
TRANSFER PROTEIN
(Zea
mays) 		7 / 12 VAL A  33
ASN A  37
ARG A  46
ALA A  56
ILE A  71
ILE A  79
TYR A  81
 DAO  A 201 (-4.1A)
DAO  A 201 (-4.0A)
None
None
DAO  A 201 ( 4.0A)
DAO  A 201 ( 4.7A)
None
 1.08A 1fk6A-1fk1A:
21.7		 1fk6A-1fk1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 1fk1 NON-SPECIFIC LIPID
TRANSFER PROTEIN
(Zea
mays) 		12 / 12 VAL A  33
LEU A  36
ASN A  37
ALA A  40
ARG A  46
ALA A  49
LEU A  53
ALA A  57
ILE A  71
ILE A  79
TYR A  81
ILE A  83
 DAO  A 201 (-4.1A)
DAO  A 201 ( 4.6A)
DAO  A 201 (-4.0A)
DAO  A 201 ( 3.9A)
None
DAO  A 201 ( 4.0A)
None
None
DAO  A 201 ( 4.0A)
DAO  A 201 ( 4.7A)
None
FMT  A 205 ( 3.6A)
 0.36A 1fk6A-1fk1A:
21.7		 1fk6A-1fk1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4doo CHALCONE-FLAVANONE
ISOMERASE FAMILY
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 PHE A 130
SER A 110
LEU A 148
LEU A 180
TYR A 181
 None
DAO  A 301 (-2.8A)
None
None
None
 1.24A 1fm6X-4dooA:
undetectable		 1fm6X-4dooA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4doo CHALCONE-FLAVANONE
ISOMERASE FAMILY
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 PHE A 130
SER A 110
LEU A 148
LEU A 180
TYR A 181
 None
DAO  A 301 (-2.8A)
None
None
None
 1.13A 2prgB-4dooA:
undetectable		 2prgB-4dooA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4doo CHALCONE-FLAVANONE
ISOMERASE FAMILY
PROTEIN
(Arabidopsis
thaliana) 		4 / 7 TYR A 181
ILE A 177
ARG A  30
PHE A 134
 None
None
DAO  A 301 (-3.8A)
DAO  A 301 (-3.9A)
 1.05A 2vctD-4dooA:
undetectable		 2vctD-4dooA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A  85
GLY A 136
MET A 167
PHE A 161
LEU A 163
 None
None
DAO  A1285 (-4.2A)
None
None
 1.38A 2w8yA-5fusA:
undetectable		 2w8yA-5fusA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4doo CHALCONE-FLAVANONE
ISOMERASE FAMILY
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 PHE A 130
SER A 110
LEU A 148
LEU A 180
TYR A 181
 None
DAO  A 301 (-2.8A)
None
None
None
 1.39A 3adsA-4dooA:
undetectable		 3adsA-4dooA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		3 / 3 ALA A 233
THR A 237
CYH A 344
 DAO  A 402 (-3.6A)
HEM  A 403 ( 3.6A)
HEM  A 403 (-2.0A)
 0.37A 3e4eA-5cweA:
32.4		 3e4eA-5cweA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 5cwe CYTOCHROME P450
HYDROXYLASE
(Streptomyces
avermitilis) 		3 / 3 ALA A 233
THR A 237
CYH A 344
 DAO  A 402 (-3.6A)
HEM  A 403 ( 3.6A)
HEM  A 403 (-2.0A)
 0.31A 3e4eB-5cweA:
32.3		 3e4eB-5cweA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2agc GANGLIOSIDE GM2
ACTIVATOR
(Mus
musculus) 		5 / 12 ILE A 139
ALA A 157
LEU A 159
LEU A  72
VAL A  55
 None
DAO  A2055 ( 3.9A)
DAO  A2055 (-4.8A)
DAO  A2055 (-3.6A)
DAO  A2055 ( 4.8A)
 1.17A 3ix9A-2agcA:
undetectable		 3ix9A-2agcA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A 117
ALA A 139
ALA A 140
PHE A  68
TRP A  69
 GOL  A1280 ( 3.7A)
DAO  A1285 ( 4.0A)
None
None
None
 1.05A 3p2kC-5fusA:
undetectable		 3p2kC-5fusA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		4 / 8 HIS C 530
ASP C 297
GLU C 273
TRP C 274
 DAO  C 609 ( 3.3A)
None
None
FTT  C 611 (-4.9A)
 0.93A 3sg9B-5w7cC:
undetectable		 3sg9B-5w7cC:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 4doo CHALCONE-FLAVANONE
ISOMERASE FAMILY
PROTEIN
(Arabidopsis
thaliana) 		5 / 11 ILE A 146
ILE A 160
GLY A 162
PHE A 134
GLY A 166
 DAO  A 301 ( 4.9A)
None
None
DAO  A 301 (-3.9A)
None
 1.09A 4ac9B-4dooA:
undetectable
4ac9C-4dooA:
undetectable		 4ac9B-4dooA:
23.85
4ac9C-4dooA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		5 / 9 GLU A 129
GLY A 130
VAL A 152
GLU A 138
GLY A 155
 None
None
None
DAO  A1285 ( 4.6A)
None
 1.19A 4fimA-5fusA:
undetectable		 4fimA-5fusA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 163
PHE A  88
PRO A 165
ASP A  84
GLY A  82
 None
DAO  A1285 (-3.4A)
None
None
DAO  A1285 ( 4.6A)
 1.35A 4j7xF-5fusA:
2.1		 4j7xF-5fusA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		4 / 8 ALA A 139
PHE A  44
GLY A 136
ALA A 132
 DAO  A1285 ( 4.0A)
DAO  A1285 (-3.5A)
None
None
 0.65A 4zjzA-5fusA:
undetectable		 4zjzA-5fusA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens) 		5 / 10 GLY C 528
MET C 463
TYR C 448
PHE C 505
PHE C 423
 None
None
None
DAO  C 609 ( 4.9A)
DAO  C 609 ( 3.8A)
 1.24A 5lbtA-5w7cC:
3.3
5lbtB-5w7cC:
3.5		 5lbtA-5w7cC:
16.91
5lbtB-5w7cC:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4doo CHALCONE-FLAVANONE
ISOMERASE FAMILY
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 PHE A 130
SER A 110
LEU A 148
LEU A 180
TYR A 181
 None
DAO  A 301 (-2.8A)
None
None
None
 1.10A 5y2oA-4dooA:
undetectable		 5y2oA-4dooA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1fk1 NON-SPECIFIC LIPID
TRANSFER PROTEIN
(Zea
mays) 		4 / 8 GLY A  32
LEU A  36
VAL A  77
LEU A  53
 None
DAO  A 201 ( 4.6A)
None
None
 0.76A 6czmD-1fk1A:
undetectable
6czmF-1fk1A:
undetectable		 6czmD-1fk1A:
14.83
6czmF-1fk1A:
14.83