SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DAH'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FZG_A_SAMA300_0 (16S RRNA METHYLASE)	3teh	PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN (Thermus thermophilus)	5 / 12	SER A 180 THR A 179 GLY A 282 GLY A 316 VAL A 261	DAH A 351 (-2.9A) None DAH A 351 (-4.0A) DAH A 351 (-2.9A) DAH A 351 (-4.6A)	0.97A	3fzgA-3tehA: undetectable	3fzgA-3tehA: 19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TEG_A_DAHA416_1 (PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL)	3teh	PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN (Thermus thermophilus)	5 / 12	ARG A 204 GLN A 218 PHE A 258 GLY A 281 GLY A 316	DAH A 351 (-3.7A) DAH A 351 (-2.8A) DAH A 351 ( 3.8A) None DAH A 351 (-2.9A)	0.93A	3tegA-3tehA: 23.2	3tegA-3tehA: 24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TEG_A_DAHA416_1 (PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL)	3teh	PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN (Thermus thermophilus)	6 / 12	ARG A 204 GLN A 218 PHE A 258 PHE A 260 GLY A 282 GLY A 264	DAH A 351 (-3.7A) DAH A 351 (-2.8A) DAH A 351 ( 3.8A) DAH A 351 (-4.8A) DAH A 351 (-4.0A) None	1.38A	3tegA-3tehA: 23.2	3tegA-3tehA: 24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TEG_A_DAHA416_1 (PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL)	3teh	PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN (Thermus thermophilus)	10 / 12	SER A 180 ARG A 204 GLN A 218 GLU A 220 PHE A 258 PHE A 260 GLY A 282 GLY A 284 ALA A 314 GLY A 316	DAH A 351 (-2.9A) DAH A 351 (-3.7A) DAH A 351 (-2.8A) DAH A 351 (-3.3A) DAH A 351 ( 3.8A) DAH A 351 (-4.8A) DAH A 351 (-4.0A) DAH A 351 (-4.6A) DAH A 351 (-3.0A) DAH A 351 (-2.9A)	0.50A	3tegA-3tehA: 23.2	3tegA-3tehA: 24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TEG_A_DAHA416_1 (PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL)	3teh	PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN (Thermus thermophilus)	10 / 12	SER A 180 GLN A 183 ARG A 204 GLN A 218 PHE A 258 PHE A 260 GLY A 282 GLY A 284 ALA A 314 GLY A 316	DAH A 351 (-2.9A) DAH A 351 ( 4.3A) DAH A 351 (-3.7A) DAH A 351 (-2.8A) DAH A 351 ( 3.8A) DAH A 351 (-4.8A) DAH A 351 (-4.0A) DAH A 351 (-4.6A) DAH A 351 (-3.0A) DAH A 351 (-2.9A)	0.46A	3tegA-3tehA: 23.2	3tegA-3tehA: 24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4I41_A_MIXA500_2 (SERINE/THREONINE-PRO TEIN KINASE PIM-1)	3teh	PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN (Thermus thermophilus)	4 / 4	LEU A 110 LEU A 105 GLN A 218 GLU A 123	None None DAH A 351 (-2.8A) None	1.14A	4i41A-3tehA: 1.2	4i41A-3tehA: 23.24

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3FZG_A_SAMA300_0","16S RRNA METHYLASE","3teh","PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN","Thermus thermophilus",5,"SER A 180;THR A 179;GLY A 282;GLY A 316;VAL A 261","DAH A 351 (-2.9A);None;DAH A 351 (-4.0A);DAH A 351 (-2.9A);DAH A 351 (-4.6A)","0.97A","3fzgA-3tehA:undetectable",null],["3TEG_A_DAHA416_1","PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL","3teh","PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN","Thermus thermophilus",5,"ARG A 204;GLN A 218;PHE A 258;GLY A 281;GLY A 316","DAH A 351 (-3.7A);DAH A 351 (-2.8A);DAH A 351 ( 3.8A);None;DAH A 351 (-2.9A)","0.93A","3tegA-3tehA:23.2","3fzgA-3tehA:19.76"],["3TEG_A_DAHA416_1","PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL","3teh","PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN","Thermus thermophilus",6,"ARG A 204;GLN A 218;PHE A 258;PHE A 260;GLY A 282;GLY A 264","DAH A 351 (-3.7A);DAH A 351 (-2.8A);DAH A 351 ( 3.8A);DAH A 351 (-4.8A);DAH A 351 (-4.0A);None","1.38A","3tegA-3tehA:23.2","3tegA-3tehA:24.44"],["3TEG_A_DAHA416_1","PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL","3teh","PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN","Thermus thermophilus",10,"SER A 180;ARG A 204;GLN A 218;GLU A 220;PHE A 258;PHE A 260;GLY A 282;GLY A 284;ALA A 314;GLY A 316","DAH A 351 (-2.9A);DAH A 351 (-3.7A);DAH A 351 (-2.8A);DAH A 351 (-3.3A);DAH A 351 ( 3.8A);DAH A 351 (-4.8A);DAH A 351 (-4.0A);DAH A 351 (-4.6A);DAH A 351 (-3.0A);DAH A 351 (-2.9A)","0.50A","3tegA-3tehA:23.2","3tegA-3tehA:24.44"],["3TEG_A_DAHA416_1","PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL","3teh","PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN","Thermus thermophilus",10,"SER A 180;GLN A 183;ARG A 204;GLN A 218;PHE A 258;PHE A 260;GLY A 282;GLY A 284;ALA A 314;GLY A 316","DAH A 351 (-2.9A);DAH A 351 ( 4.3A);DAH A 351 (-3.7A);DAH A 351 (-2.8A);DAH A 351 ( 3.8A);DAH A 351 (-4.8A);DAH A 351 (-4.0A);DAH A 351 (-4.6A);DAH A 351 (-3.0A);DAH A 351 (-2.9A)","0.46A","3tegA-3tehA:23.2","3tegA-3tehA:24.44"],["4I41_A_MIXA500_2","SERINE\/THREONINE-PROTEIN KINASE PIM-1","3teh","PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN","Thermus thermophilus",4,"LEU A 110;LEU A 105;GLN A 218;GLU A 123","None;None;DAH A 351 (-2.8A);None","1.14A","4i41A-3tehA:1.2","3tegA-3tehA:24.44"]]