SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'D7V'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 PHE A 432
ILE A 438
LYS A 191
ALA A 195
 5EH  A1200 ( 4.3A)
None
PO4  A1202 (-3.0A)
D7V  A1201 ( 4.7A)
 1.18A 1hk2A-3rzeA:
undetectable		 1hk2A-3rzeA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 8 PHE A 116
LEU A 154
ILE A 160
THR A 112
 None
None
None
D7V  A1201 ( 4.0A)
 0.86A 1sbrA-3rzeA:
undetectable		 1sbrA-3rzeA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 PHE A 435
VAL A  76
TYR A 458
ASN A  84
VAL A  80
 D7V  A1201 ( 3.8A)
None
5EH  A1200 ( 4.4A)
None
None
 1.43A 1x70A-3rzeA:
undetectable		 1x70A-3rzeA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 8 TYR A 108
TYR A 431
PHE A 432
GLY A 457
 D7V  A1201 ( 3.7A)
5EH  A1200 (-4.4A)
5EH  A1200 ( 4.3A)
None
 1.14A 2ha4A-3rzeA:
undetectable		 2ha4A-3rzeA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 PHE A 435
VAL A  76
TYR A 458
ASN A  84
VAL A  80
 D7V  A1201 ( 3.8A)
None
5EH  A1200 ( 4.4A)
None
None
 1.43A 3bjmB-3rzeA:
undetectable		 3bjmB-3rzeA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 7 ASN A 198
ILE A 115
PHE A 424
PHE A 432
 D7V  A1201 (-4.6A)
D7V  A1201 (-3.8A)
None
5EH  A1200 ( 4.3A)
 0.94A 3tvxB-3rzeA:
undetectable		 3tvxB-3rzeA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 ASP A 107
TYR A 108
TRP A 103
 5EH  A1200 ( 2.6A)
D7V  A1201 ( 3.7A)
None
 1.40A 4p7nA-3rzeA:
undetectable		 4p7nA-3rzeA:
23.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ASP A 107
TYR A 108
SER A 111
TRP A 158
ALA A 195
 5EH  A1200 ( 2.6A)
D7V  A1201 ( 3.7A)
5EH  A1200 ( 3.7A)
5EH  A1200 ( 4.4A)
D7V  A1201 ( 4.7A)
 0.62A 4u15A-3rzeA:
37.0		 4u15A-3rzeA:
49.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		6 / 12 TYR A 108
SER A 111
TRP A 158
THR A 194
ALA A 195
TRP A 428
 D7V  A1201 ( 3.7A)
5EH  A1200 ( 3.7A)
5EH  A1200 ( 4.4A)
D7V  A1201 ( 4.6A)
D7V  A1201 ( 4.7A)
5EH  A1200 ( 3.4A)
 1.16A 4u15A-3rzeA:
37.0		 4u15A-3rzeA:
49.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ASP A 107
TYR A 108
SER A 111
ALA A 195
TRP A 428
 5EH  A1200 ( 2.6A)
D7V  A1201 ( 3.7A)
5EH  A1200 ( 3.7A)
D7V  A1201 ( 4.7A)
5EH  A1200 ( 3.4A)
 1.43A 4u15B-3rzeA:
36.1		 4u15B-3rzeA:
49.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 TYR A 108
SER A 111
THR A 194
ALA A 195
TRP A 428
 D7V  A1201 ( 3.7A)
5EH  A1200 ( 3.7A)
D7V  A1201 ( 4.6A)
D7V  A1201 ( 4.7A)
5EH  A1200 ( 3.4A)
 1.40A 4u15B-3rzeA:
36.1		 4u15B-3rzeA:
49.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 TYR A 108
SER A 111
THR A 194
ALA A 195
TYR A 431
 D7V  A1201 ( 3.7A)
5EH  A1200 ( 3.7A)
D7V  A1201 ( 4.6A)
D7V  A1201 ( 4.7A)
5EH  A1200 (-4.4A)
 1.12A 4u15B-3rzeA:
36.1		 4u15B-3rzeA:
49.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CXV_A_0HKA501_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		6 / 12 ASP A 107
TYR A 108
SER A 111
TRP A 158
ALA A 195
TRP A 428
 5EH  A1200 ( 2.6A)
D7V  A1201 ( 3.7A)
5EH  A1200 ( 3.7A)
5EH  A1200 ( 4.4A)
D7V  A1201 ( 4.7A)
5EH  A1200 ( 3.4A)
 1.16A 5cxvA-3rzeA:
23.4		 5cxvA-3rzeA:
55.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DSG_A_0HKA1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 TYR A 108
SER A 111
TRP A 158
THR A 194
TRP A 428
 D7V  A1201 ( 3.7A)
5EH  A1200 ( 3.7A)
5EH  A1200 ( 4.4A)
D7V  A1201 ( 4.6A)
5EH  A1200 ( 3.4A)
 1.22A 5dsgA-3rzeA:
34.1		 5dsgA-3rzeA:
48.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DSG_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 TYR A 108
SER A 111
TRP A 158
THR A 194
TRP A 428
 D7V  A1201 ( 3.7A)
5EH  A1200 ( 3.7A)
5EH  A1200 ( 4.4A)
D7V  A1201 ( 4.6A)
5EH  A1200 ( 3.4A)
 1.21A 5dsgB-3rzeA:
36.5		 5dsgB-3rzeA:
48.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		8 / 12 TRP A 103
SER A 111
THR A 112
ILE A 115
PHE A 424
TRP A 428
PHE A 432
TYR A 458
 None
5EH  A1200 ( 3.7A)
D7V  A1201 ( 4.0A)
D7V  A1201 (-3.8A)
None
5EH  A1200 ( 3.4A)
5EH  A1200 ( 4.3A)
5EH  A1200 ( 4.4A)
 0.53A 6a93A-3rzeA:
27.4		 6a93A-3rzeA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 TRP A 103
SER A 111
THR A 112
TRP A 428
PHE A 432
 None
5EH  A1200 ( 3.7A)
D7V  A1201 ( 4.0A)
5EH  A1200 ( 3.4A)
5EH  A1200 ( 4.3A)
 0.58A 6a93B-3rzeA:
29.1		 6a93B-3rzeA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 5 ASP A 107
ILE A 115
PHE A 424
TYR A 458
 5EH  A1200 ( 2.6A)
D7V  A1201 (-3.8A)
None
5EH  A1200 ( 4.4A)
 0.48A 6a93B-3rzeA:
29.1		 6a93B-3rzeA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 SER A 111
THR A 112
PHE A 424
TRP A 428
PHE A 432
 5EH  A1200 ( 3.7A)
D7V  A1201 ( 4.0A)
None
5EH  A1200 ( 3.4A)
5EH  A1200 ( 4.3A)
 0.43A 6a94B-3rzeA:
29.2		 6a94B-3rzeA:
28.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CM4_A_8NUA2001_0
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 THR A 112
PHE A 424
TRP A 428
PHE A 432
TYR A 458
 D7V  A1201 ( 4.0A)
None
5EH  A1200 ( 3.4A)
5EH  A1200 ( 4.3A)
5EH  A1200 ( 4.4A)
 0.55A 6cm4A-3rzeA:
37.3		 6cm4A-3rzeA:
58.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		6 / 12 TRP A 103
LEU A 104
SER A 111
THR A 112
TRP A 428
TYR A 458
 None
None
5EH  A1200 ( 3.7A)
D7V  A1201 ( 4.0A)
5EH  A1200 ( 3.4A)
5EH  A1200 ( 4.4A)
 0.79A 6drxA-3rzeA:
27.4		 6drxA-3rzeA:
27.81