SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'D71'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens) 		4 / 6 CYH D 111
ASP D 116
VAL D 113
GLY D 130
 ZN  D7121 (-2.3A)
None
ZN  D7121 ( 4.6A)
None
 1.21A 1ekjC-3dzuD:
undetectable
1ekjD-3dzuD:
undetectable		 1ekjC-3dzuD:
19.08
1ekjD-3dzuD:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 10 TYR A 325
HIS A 326
PHE A 506
GLN A 535
GLY A 537
PHE A 538
 None
D71  A 901 (-4.5A)
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
None
D71  A 901 (-3.9A)
 0.51A 1uhoA-3g4gA:
36.0		 1uhoA-3g4gA:
26.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 12 HIS A 330
MET A 439
LEU A 485
SER A 534
PHE A 538
 ZN  A 801 (-3.4A)
D71  A 901 ( 4.0A)
None
D71  A 901 (-3.4A)
D71  A 901 (-3.9A)
 1.38A 1xlxA-3g4gA:
51.0		 1xlxA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 12 HIS A 330
MET A 439
LEU A 485
THR A 499
GLN A 535
PHE A 538
 ZN  A 801 (-3.4A)
D71  A 901 ( 4.0A)
None
D71  A 901 (-3.6A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 1.35A 1xlxA-3g4gA:
51.0		 1xlxA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		8 / 12 HIS A 370
MET A 439
LEU A 485
ASN A 487
ILE A 502
MET A 503
SER A 534
PHE A 538
 None
D71  A 901 ( 4.0A)
None
D71  A 901 (-4.5A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-3.4A)
D71  A 901 (-3.9A)
 0.88A 1xlxA-3g4gA:
51.0		 1xlxA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		9 / 12 HIS A 370
MET A 439
LEU A 485
ASN A 487
THR A 499
ILE A 502
MET A 503
GLN A 535
PHE A 538
 None
D71  A 901 ( 4.0A)
None
D71  A 901 (-4.5A)
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.70A 1xlxA-3g4gA:
51.0		 1xlxA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		9 / 12 TYR A 325
HIS A 326
HIS A 370
LEU A 485
ASN A 487
ILE A 502
MET A 503
SER A 534
PHE A 538
 None
D71  A 901 (-4.5A)
None
None
D71  A 901 (-4.5A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-3.4A)
D71  A 901 (-3.9A)
 0.66A 1xlxA-3g4gA:
51.0		 1xlxA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		10 / 12 TYR A 325
HIS A 326
HIS A 370
LEU A 485
ASN A 487
THR A 499
ILE A 502
MET A 503
GLN A 535
PHE A 538
 None
D71  A 901 (-4.5A)
None
None
D71  A 901 (-4.5A)
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.47A 1xlxA-3g4gA:
51.0		 1xlxA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		10 / 12 TYR A 325
HIS A 326
HIS A 370
THR A 499
ILE A 502
MET A 503
PHE A 506
MET A 523
SER A 534
GLN A 535
 None
D71  A 901 (-4.5A)
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-4.8A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.4A)
D71  A 901 (-3.1A)
 0.70A 1xlxB-3g4gA:
51.1		 1xlxB-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		10 / 12 TYR A 325
HIS A 326
HIS A 370
THR A 499
ILE A 502
MET A 503
PHE A 506
SER A 534
GLN A 535
PHE A 538
 None
D71  A 901 (-4.5A)
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-4.8A)
D71  A 901 (-3.4A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.44A 1xlxB-3g4gA:
51.1		 1xlxB-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		10 / 12 TYR A 325
HIS A 370
MET A 439
THR A 499
ILE A 502
MET A 503
PHE A 506
SER A 534
GLN A 535
PHE A 538
 None
None
D71  A 901 ( 4.0A)
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-4.8A)
D71  A 901 (-3.4A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.62A 1xlxB-3g4gA:
51.1		 1xlxB-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		9 / 12 TYR A 325
HIS A 326
ASP A 484
LEU A 485
ILE A 502
PHE A 506
MET A 523
SER A 534
PHE A 538
 None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.4A)
D71  A 901 (-3.9A)
 0.97A 1xmuA-3g4gA:
51.2		 1xmuA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 325
HIS A 326
ASP A 484
LEU A 485
PRO A 488
TYR A 495
TRP A 498
ILE A 502
PHE A 506
MET A 523
PHE A 538
 None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
None
None
None
D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.9A)
 0.71A 1xmuA-3g4gA:
51.2		 1xmuA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 5 MET A 439
ASN A 487
THR A 499
MET A 503
GLN A 535
 D71  A 901 ( 4.0A)
D71  A 901 (-4.5A)
D71  A 901 (-3.6A)
D71  A 901 (-3.6A)
D71  A 901 (-3.1A)
 0.55A 1xmuA-3g4gA:
51.2		 1xmuA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 12 ASP A 484
LEU A 485
PRO A 488
TYR A 495
PHE A 196
 ZN  A 801 (-2.6A)
None
None
None
D71  A 901 (-3.9A)
 1.13A 1xmuB-3g4gA:
51.3		 1xmuB-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 12 MET A 439
ASP A 484
LEU A 485
ILE A 502
PHE A 506
SER A 534
 D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
D71  A 901 (-3.4A)
 0.93A 1xmuB-3g4gA:
51.3		 1xmuB-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		7 / 12 MET A 439
ASP A 484
LEU A 485
PRO A 488
TYR A 495
ILE A 502
PHE A 506
 D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
None
None
D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
 0.61A 1xmuB-3g4gA:
51.3		 1xmuB-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		7 / 12 TYR A 325
HIS A 326
ASP A 484
ILE A 502
PHE A 506
MET A 523
SER A 534
 None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.4A)
 1.05A 1xmuB-3g4gA:
51.3		 1xmuB-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		7 / 12 TYR A 325
HIS A 326
ASP A 484
LEU A 485
ILE A 502
PHE A 506
SER A 534
 None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
D71  A 901 (-3.4A)
 0.65A 1xmuB-3g4gA:
51.3		 1xmuB-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		9 / 12 TYR A 325
HIS A 326
ASP A 484
LEU A 485
PRO A 488
TYR A 495
TRP A 498
ILE A 502
PHE A 506
 None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
None
None
None
D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
 0.28A 1xmuB-3g4gA:
51.3		 1xmuB-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		9 / 12 TYR A 325
HIS A 326
ASP A 484
PRO A 488
TYR A 495
TRP A 498
ILE A 502
PHE A 506
MET A 523
 None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
None
None
D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
D71  A 901 ( 4.0A)
 0.69A 1xmuB-3g4gA:
51.3		 1xmuB-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 5 ASN A 487
THR A 499
MET A 503
GLN A 535
PHE A 538
 D71  A 901 (-4.5A)
D71  A 901 (-3.6A)
D71  A 901 (-3.6A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.34A 1xmuB-3g4gA:
51.3		 1xmuB-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 12 HIS A 330
MET A 439
LEU A 485
MET A 503
GLN A 535
PHE A 538
 ZN  A 801 (-3.4A)
D71  A 901 ( 4.0A)
None
D71  A 901 (-3.6A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 1.40A 1xomA-3g4gA:
52.9		 1xomA-3g4gA:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		10 / 12 TYR A 325
HIS A 326
MET A 439
ASP A 484
LEU A 485
ILE A 502
MET A 503
PHE A 506
GLN A 535
PHE A 538
 None
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.62A 1xomA-3g4gA:
52.9		 1xomA-3g4gA:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		10 / 12 TYR A 325
HIS A 326
MET A 439
ASP A 484
LEU A 485
ILE A 502
MET A 503
PHE A 506
SER A 534
PHE A 538
 None
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-4.8A)
D71  A 901 (-3.4A)
D71  A 901 (-3.9A)
 0.80A 1xomA-3g4gA:
52.9		 1xomA-3g4gA:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 12 TYR A 325
ILE A 502
MET A 503
MET A 523
GLN A 535
 None
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.1A)
 0.74A 1xomA-3g4gA:
52.9		 1xomA-3g4gA:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 12 TYR A 325
ILE A 502
MET A 503
MET A 523
SER A 534
 None
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.4A)
 1.09A 1xomA-3g4gA:
52.9		 1xomA-3g4gA:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		9 / 12 TYR A 325
HIS A 326
MET A 439
LEU A 485
ILE A 502
MET A 503
PHE A 506
SER A 534
PHE A 538
 None
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
None
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-4.8A)
D71  A 901 (-3.4A)
D71  A 901 (-3.9A)
 0.88A 1xomB-3g4gA:
52.8		 1xomB-3g4gA:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		10 / 12 TYR A 325
HIS A 326
MET A 439
LEU A 485
THR A 499
ILE A 502
MET A 503
PHE A 506
GLN A 535
PHE A 538
 None
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.66A 1xomB-3g4gA:
52.8		 1xomB-3g4gA:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 12 TYR A 325
ILE A 502
MET A 503
MET A 523
SER A 534
PHE A 538
 None
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.4A)
D71  A 901 (-3.9A)
 1.02A 1xomB-3g4gA:
52.8		 1xomB-3g4gA:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		7 / 12 TYR A 325
THR A 499
ILE A 502
MET A 503
MET A 523
GLN A 535
PHE A 538
 None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.70A 1xomB-3g4gA:
52.8		 1xomB-3g4gA:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		7 / 12 HIS A 326
MET A 439
ASP A 484
LEU A 485
MET A 523
SER A 534
PHE A 538
 D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
D71  A 901 ( 4.0A)
D71  A 901 (-3.4A)
D71  A 901 (-3.9A)
 0.98A 1xoqA-3g4gA:
53.0		 1xoqA-3g4gA:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 12 HIS A 330
MET A 439
LEU A 485
MET A 503
PHE A 538
 ZN  A 801 (-3.4A)
D71  A 901 ( 4.0A)
None
D71  A 901 (-3.6A)
D71  A 901 (-3.9A)
 1.21A 1xoqA-3g4gA:
53.0		 1xoqA-3g4gA:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 12 HIS A 330
MET A 439
LEU A 485
SER A 534
PHE A 538
 ZN  A 801 (-3.4A)
D71  A 901 ( 4.0A)
None
D71  A 901 (-3.4A)
D71  A 901 (-3.9A)
 1.22A 1xoqA-3g4gA:
53.0		 1xoqA-3g4gA:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 12 MET A 439
ASP A 484
LEU A 485
MET A 503
PHE A 538
 D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
D71  A 901 (-3.6A)
D71  A 901 (-3.9A)
 1.40A 1xoqA-3g4gA:
53.0		 1xoqA-3g4gA:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 325
HIS A 326
MET A 439
ASP A 484
LEU A 485
PRO A 488
TYR A 495
THR A 499
ILE A 502
MET A 523
PHE A 538
 None
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
None
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.9A)
 0.67A 1xoqA-3g4gA:
53.0		 1xoqA-3g4gA:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		3 / 3 ASN A 487
TRP A 498
GLN A 535
 D71  A 901 (-4.5A)
None
D71  A 901 (-3.1A)
 0.37A 1xoqA-3g4gA:
53.0		 1xoqA-3g4gA:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 12 HIS A 326
ASP A 484
LEU A 485
MET A 523
SER A 534
PHE A 538
 D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
D71  A 901 ( 4.0A)
D71  A 901 (-3.4A)
D71  A 901 (-3.9A)
 0.90A 1xoqB-3g4gA:
52.7		 1xoqB-3g4gA:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 325
HIS A 326
ASP A 484
LEU A 485
PRO A 488
TYR A 495
TRP A 498
THR A 499
ILE A 502
MET A 523
PHE A 538
 None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
None
None
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.9A)
 0.49A 1xoqB-3g4gA:
52.7		 1xoqB-3g4gA:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		3 / 3 MET A 439
ASN A 487
GLN A 535
 D71  A 901 ( 4.0A)
D71  A 901 (-4.5A)
D71  A 901 (-3.1A)
 0.58A 1xoqB-3g4gA:
52.7		 1xoqB-3g4gA:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 12 HIS A 330
MET A 439
LEU A 485
GLN A 535
PHE A 538
 ZN  A 801 (-3.4A)
D71  A 901 ( 4.0A)
None
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 1.13A 1xosA-3g4gA:
51.0		 1xosA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 12 MET A 439
LEU A 485
MET A 503
PHE A 506
GLN A 535
PHE A 538
 D71  A 901 ( 4.0A)
None
D71  A 901 (-3.6A)
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.85A 1xosA-3g4gA:
51.0		 1xosA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		9 / 12 TYR A 325
HIS A 326
ASP A 484
LEU A 485
MET A 503
PHE A 506
GLN A 535
PHE A 538
ILE A 542
 None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
D71  A 901 (-3.6A)
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
None
 0.52A 1xosA-3g4gA:
51.0		 1xosA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 12 TYR A 325
HIS A 326
ASP A 484
MET A 503
PHE A 506
SER A 521
 None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
D71  A 901 (-3.6A)
D71  A 901 (-4.8A)
None
 1.02A 1xosA-3g4gA:
51.0		 1xosA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 12 TYR A 325
HIS A 326
MET A 503
PHE A 506
MET A 523
GLN A 535
 None
D71  A 901 (-4.5A)
D71  A 901 (-3.6A)
D71  A 901 (-4.8A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.1A)
 0.77A 1xosA-3g4gA:
51.0		 1xosA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		7 / 12 TYR A 325
HIS A 326
ILE A 502
MET A 503
MET A 523
SER A 534
GLN A 535
 None
D71  A 901 (-4.5A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.4A)
D71  A 901 (-3.1A)
 0.89A 1xotA-3g4gA:
51.1		 1xotA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		8 / 12 TYR A 325
HIS A 326
LEU A 485
ILE A 502
MET A 503
SER A 521
GLN A 535
PHE A 538
 None
D71  A 901 (-4.5A)
None
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
None
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.72A 1xotA-3g4gA:
51.1		 1xotA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		9 / 12 TYR A 325
HIS A 326
LEU A 485
ILE A 502
MET A 503
SER A 534
GLN A 535
PHE A 538
ILE A 542
 None
D71  A 901 (-4.5A)
None
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-3.4A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
None
 0.55A 1xotA-3g4gA:
51.1		 1xotA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		8 / 12 TYR A 325
MET A 439
LEU A 485
ILE A 502
MET A 503
SER A 521
GLN A 535
PHE A 538
 None
D71  A 901 ( 4.0A)
None
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
None
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.84A 1xotA-3g4gA:
51.1		 1xotA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		8 / 12 TYR A 325
MET A 439
LEU A 485
ILE A 502
MET A 503
SER A 534
GLN A 535
PHE A 538
 None
D71  A 901 ( 4.0A)
None
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-3.4A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.78A 1xotA-3g4gA:
51.1		 1xotA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 12 HIS A 330
MET A 439
LEU A 485
GLN A 535
PHE A 538
 ZN  A 801 (-3.4A)
D71  A 901 ( 4.0A)
None
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 1.15A 1xotB-3g4gA:
51.2		 1xotB-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		9 / 12 MET A 439
LEU A 485
ASN A 487
ILE A 502
MET A 503
SER A 521
SER A 534
GLN A 535
PHE A 538
 D71  A 901 ( 4.0A)
None
D71  A 901 (-4.5A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
None
D71  A 901 (-3.4A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.81A 1xotB-3g4gA:
51.2		 1xotB-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		10 / 12 TYR A 325
HIS A 326
LEU A 485
ASN A 487
ILE A 502
MET A 503
SER A 521
SER A 534
GLN A 535
PHE A 538
 None
D71  A 901 (-4.5A)
None
D71  A 901 (-4.5A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
None
D71  A 901 (-3.4A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.68A 1xotB-3g4gA:
51.2		 1xotB-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		7 / 12 TYR A 325
ILE A 502
MET A 503
SER A 521
MET A 523
SER A 534
GLN A 535
 None
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
None
D71  A 901 ( 4.0A)
D71  A 901 (-3.4A)
D71  A 901 (-3.1A)
 1.15A 1xotB-3g4gA:
51.2		 1xotB-3g4gA:
66.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 11 TYR A 325
HIS A 326
PHE A 506
GLN A 535
PHE A 538
 None
D71  A 901 (-4.5A)
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.56A 2h42A-3g4gA:
35.8		 2h42A-3g4gA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 12 TYR A 325
LEU A 485
PHE A 506
GLN A 535
PHE A 538
 None
None
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.60A 2h42C-3g4gA:
35.5		 2h42C-3g4gA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 12 TYR A 325
HIS A 326
LEU A 485
GLU A 505
PHE A 506
PHE A 201
 None
D71  A 901 (-4.5A)
None
None
D71  A 901 (-4.8A)
D71  A 901 (-4.9A)
 1.35A 2weyA-3g4gA:
37.7		 2weyA-3g4gA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		8 / 12 TYR A 325
HIS A 326
LEU A 485
ILE A 502
GLU A 505
PHE A 506
GLN A 535
PHE A 538
 None
D71  A 901 (-4.5A)
None
D71  A 901 (-4.1A)
None
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.92A 2weyA-3g4gA:
37.7		 2weyA-3g4gA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 12 TYR A 325
HIS A 326
LEU A 485
ILE A 502
GLU A 505
PHE A 538
 None
D71  A 901 (-4.5A)
None
D71  A 901 (-4.1A)
None
D71  A 901 (-3.9A)
 1.49A 2weyA-3g4gA:
37.7		 2weyA-3g4gA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		4 / 8 ILE A 502
PHE A 506
GLN A 535
PHE A 538
 D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.84A 2weyB-3g4gA:
37.3		 2weyB-3g4gA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 12 TYR A 325
HIS A 326
LEU A 485
PHE A 506
GLN A 535
PHE A 538
 None
D71  A 901 (-4.5A)
None
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.71A 3b2rA-3g4gA:
31.2		 3b2rA-3g4gA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 11 TYR A 325
HIS A 326
LEU A 485
GLN A 535
PHE A 538
 None
D71  A 901 (-4.5A)
None
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.73A 3b2rB-3g4gA:
31.1		 3b2rB-3g4gA:
26.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 12 HIS A 326
MET A 439
MET A 523
SER A 534
PHE A 538
 D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.4A)
D71  A 901 (-3.9A)
 1.03A 3g4lA-3g4gA:
52.5		 3g4lA-3g4gA:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 325
HIS A 326
MET A 439
ASN A 487
PRO A 488
TYR A 495
TRP A 498
THR A 499
ILE A 502
MET A 523
PHE A 538
 None
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
D71  A 901 (-4.5A)
None
None
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.9A)
 0.61A 3g4lA-3g4gA:
52.5		 3g4lA-3g4gA:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		3 / 3 ASP A 484
LEU A 485
GLN A 535
 ZN  A 801 (-2.6A)
None
D71  A 901 (-3.1A)
 0.29A 3g4lA-3g4gA:
52.5		 3g4lA-3g4gA:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 12 HIS A 330
MET A 439
LEU A 485
MET A 503
PHE A 538
 ZN  A 801 (-3.4A)
D71  A 901 ( 4.0A)
None
D71  A 901 (-3.6A)
D71  A 901 (-3.9A)
 1.24A 3g4lB-3g4gA:
52.7		 3g4lB-3g4gA:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 325
HIS A 326
ASP A 484
LEU A 485
PRO A 488
TRP A 498
THR A 499
ILE A 502
MET A 503
MET A 523
PHE A 538
 None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
None
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.9A)
 0.58A 3g4lB-3g4gA:
52.7		 3g4lB-3g4gA:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 325
HIS A 326
MET A 439
ASP A 484
LEU A 485
PRO A 488
TRP A 498
THR A 499
ILE A 502
MET A 503
PHE A 538
 None
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
None
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-3.9A)
 0.59A 3g4lB-3g4gA:
52.7		 3g4lB-3g4gA:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 325
HIS A 326
MET A 439
ASP A 484
LEU A 485
ASN A 487
PRO A 488
TYR A 495
TRP A 498
THR A 499
ILE A 502
MET A 523
 None
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
D71  A 901 (-4.5A)
None
None
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 ( 4.0A)
 0.66A 3g4lC-3g4gA:
52.7		 3g4lC-3g4gA:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 12 HIS A 326
MET A 439
ASP A 484
LEU A 485
MET A 503
SER A 534
 D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
D71  A 901 (-3.6A)
D71  A 901 (-3.4A)
 0.91A 3g4lD-3g4gA:
52.7		 3g4lD-3g4gA:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 325
HIS A 326
MET A 439
ASP A 484
LEU A 485
PRO A 488
TRP A 498
THR A 499
ILE A 502
MET A 503
GLN A 535
 None
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
None
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-3.1A)
 0.57A 3g4lD-3g4gA:
52.7		 3g4lD-3g4gA:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		3 / 3 ASN A 487
MET A 523
PHE A 538
 D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.9A)
 0.67A 3g4lD-3g4gA:
52.7		 3g4lD-3g4gA:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		8 / 9 TYR A 325
MET A 439
ASN A 487
ILE A 502
PHE A 506
GLN A 535
PHE A 538
ILE A 542
 None
D71  A 901 ( 4.0A)
D71  A 901 (-4.5A)
D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
None
 0.44A 3iakA-3g4gA:
52.1		 3iakA-3g4gA:
81.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		4 / 7 TYR A 325
HIS A 326
GLN A 535
PHE A 538
 None
D71  A 901 (-4.5A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.58A 3jwqC-3g4gA:
38.8		 3jwqC-3g4gA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 11 TYR A 325
HIS A 326
PHE A 506
GLN A 535
PHE A 538
 None
D71  A 901 (-4.5A)
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.63A 3jwqA-3g4gA:
38.9
3jwqD-3g4gA:
38.6		 3jwqA-3g4gA:
25.94
3jwqD-3g4gA:
25.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		8 / 9 TYR A 325
LEU A 485
ASN A 487
PRO A 488
THR A 499
ILE A 502
GLN A 535
PHE A 538
 None
None
D71  A 901 (-4.5A)
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.42A 3tvxA-3g4gA:
51.2		 3tvxA-3g4gA:
70.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 7 TYR A 325
ASN A 487
ILE A 502
PHE A 506
GLN A 535
PHE A 538
 None
D71  A 901 (-4.5A)
D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.48A 3tvxB-3g4gA:
51.3		 3tvxB-3g4gA:
70.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		4 / 6 ILE A 502
THR A 499
VAL A 373
ASP A 322
 D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
None
None
 1.06A 4iaqA-3g4gA:
undetectable		 4iaqA-3g4gA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 8 GLU A 505
VAL A 323
HIS A 326
ASP A 367
HIS A 399
 None
None
D71  A 901 (-4.5A)
MG  A 802 ( 2.7A)
None
 1.20A 5f8yA-3g4gA:
undetectable		 5f8yA-3g4gA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 8 GLU A 505
VAL A 323
HIS A 326
ASP A 367
HIS A 399
 None
None
D71  A 901 (-4.5A)
MG  A 802 ( 2.7A)
None
 1.22A 5f8yB-3g4gA:
undetectable		 5f8yB-3g4gA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		4 / 8 HIS A 481
PHE A 538
PRO A 488
TYR A 325
 None
D71  A 901 (-3.9A)
None
None
 1.32A 5v4vA-3g4gA:
undetectable		 5v4vA-3g4gA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		4 / 8 HIS A 481
PHE A 538
PRO A 488
TYR A 325
 None
D71  A 901 (-3.9A)
None
None
 1.32A 5v4vB-3g4gA:
undetectable		 5v4vB-3g4gA:
20.82