SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'D5M'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4cxo ENDONUCLEASE 2
(Arabidopsis
thaliana) 		5 / 12 ASP A 207
ASP A  73
ILE A 214
ASP A 219
THR A  62
 D5M  A 430 ( 4.7A)
None
None
None
None
 1.44A 1kijA-4cxoA:
undetectable		 1kijA-4cxoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 ASP A 404
HIS A 451
HIS A 362
 ZN  A 703 (-2.7A)
D5M  A 701 (-4.1A)
FE  A 702 ( 3.4A)
 0.66A 1oe1A-5iheA:
undetectable		 1oe1A-5iheA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 ASP A 404
HIS A 451
HIS A 362
 ZN  A 703 (-2.7A)
D5M  A 701 (-4.1A)
FE  A 702 ( 3.4A)
 0.64A 1oe3A-5iheA:
undetectable		 1oe3A-5iheA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3kie CAPSID PROTEIN VP1
(Adeno-associated
dependoparvoviru
s
A) 		5 / 10 GLY A 637
THR A 729
VAL A 612
GLU A 563
SER A 632
 None
None
None
None
D5M  A 999 ( 3.9A)
 1.07A 1z35A-3kieA:
undetectable		 1z35A-3kieA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 2g8g CAPSID
(Adeno-associated
dependoparvoviru
s
A) 		5 / 12 LEU A 597
GLY A 598
MET A 603
VAL A 604
HIS A 628
 None
None
None
None
D5M  A  21 (-4.0A)
 1.47A 1z95A-2g8gA:
undetectable		 1z95A-2g8gA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 2g8g CAPSID
(Adeno-associated
dependoparvoviru
s
A) 		5 / 12 SER A 630
GLY A 634
HIS A 628
ILE A 478
MET A 523
 D5M  A  21 ( 4.3A)
None
D5M  A  21 (-4.0A)
None
None
 1.17A 2b25B-2g8gA:
undetectable		 2b25B-2g8gA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 ASP A 404
HIS A 451
HIS A 362
 ZN  A 703 (-2.7A)
D5M  A 701 (-4.1A)
FE  A 702 ( 3.4A)
 0.67A 2xxgA-5iheA:
undetectable		 2xxgA-5iheA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 ASP A 404
HIS A 451
HIS A 362
 ZN  A 703 (-2.7A)
D5M  A 701 (-4.1A)
FE  A 702 ( 3.4A)
 0.69A 2xxgC-5iheA:
undetectable		 2xxgC-5iheA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3sz4 EXONUCLEASE
(Laribacter
hongkongensis) 		4 / 5 SER A  19
THR A  17
GLU A 112
ASP A 151
 D5M  A 218 (-2.2A)
D5M  A 218 (-3.4A)
MG  A 217 (-3.0A)
None
 1.18A 3tm4A-3sz4A:
undetectable		 3tm4A-3sz4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3sz4 EXONUCLEASE
(Laribacter
hongkongensis) 		4 / 5 SER A  19
THR A  17
GLU A 112
ASP A 151
 D5M  A 218 (-2.2A)
D5M  A 218 (-3.4A)
MG  A 217 (-3.0A)
None
 1.18A 3tm4B-3sz4A:
undetectable		 3tm4B-3sz4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 2pau 5'-DEOXYNUCLEOTIDASE
YFBR
(Escherichia
coli) 		4 / 8 ARG A  18
HIS A  33
VAL A  37
VAL A  40
 D5M  A 301 (-3.3A)
CO  A 201 ( 3.2A)
None
None
 0.71A 3uy4A-2pauA:
undetectable		 3uy4A-2pauA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 THR A 584
HIS A 562
GLN A 587
HIS A 451
ASP A 404
 None
FE  A 702 ( 3.4A)
None
D5M  A 701 (-4.1A)
ZN  A 703 (-2.7A)
 1.25A 4rp8A-5iheA:
0.0		 4rp8A-5iheA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		4 / 4 ASP A 404
HIS A 497
HIS A 560
HIS A 451
 ZN  A 703 (-2.7A)
ZN  A 703 ( 3.5A)
ZN  A 703 ( 3.3A)
D5M  A 701 (-4.1A)
 1.49A 5ncdD-5iheA:
undetectable		 5ncdD-5iheA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 GLU A 502
HIS A 513
VAL A 561
 D5M  A 701 (-3.6A)
None
D5M  A 701 (-3.7A)
 0.81A 5trqB-5iheA:
undetectable		 5trqB-5iheA:
21.19