SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'D5E'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EII_A_RTLA135_1 (CELLULAR RETINOL-BINDING PROTEIN II)	6fd2	PUTATIVE APRAMYCIN BIOSYNTHETIC OXIDOREDUCTASE 4 (Streptoalloteich us tenebrarius)	4 / 7	TYR B 216 THR B 32 SER B 406 TYR B 26	D5E B 501 ( 4.5A) D5E B 501 (-3.4A) D5E B 501 ( 3.4A) D5E B 501 (-3.7A)	1.08A	1eiiA-6fd2B: undetectable	1eiiA-6fd2B: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S3Z_B_RIOB501_0 (AMINOGLYCOSIDE 6'-N-ACETYLTRANSFERA SE)	6fd2	PUTATIVE APRAMYCIN BIOSYNTHETIC OXIDOREDUCTASE 4 (Streptoalloteich us tenebrarius)	4 / 8	TYR B 26 GLU B 303 VAL B 342 GLU B 37	D5E B 501 (-3.7A) D5E B 501 (-3.1A) None D5E B 501 (-3.0A)	1.22A	1s3zA-6fd2B: undetectable 1s3zB-6fd2B: undetectable	1s3zA-6fd2B: undetectable 1s3zB-6fd2B: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TD2_A_PXLA288_1 (PYRIDOXAMINE KINASE)	6fd2	PUTATIVE APRAMYCIN BIOSYNTHETIC OXIDOREDUCTASE 4 (Streptoalloteich us tenebrarius)	5 / 10	SER B 425 VAL B 378 HIS B 407 THR B 405 ASP B 429	None None D5E B 501 ( 4.8A) None None	1.44A	1td2A-6fd2B: 3.3	1td2A-6fd2B: 13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XYT_B_TC9B1206_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	6fd2	PUTATIVE APRAMYCIN BIOSYNTHETIC OXIDOREDUCTASE 4 (Streptoalloteich us tenebrarius)	5 / 11	TYR B 382 TYR B 216 GLN B 23 SER B 85 SER B 111	5AD B 504 (-4.8A) D5E B 501 ( 4.5A) None None None	1.30A	2xytB-6fd2B: 0.0 2xytC-6fd2B: 0.0 2xytG-6fd2B: 0.0	2xytB-6fd2B: 17.86 2xytC-6fd2B: 17.86 2xytG-6fd2B: 17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YSH_B_GLYB401_0 (GLYCINE OXIDASE)	6fd2	PUTATIVE APRAMYCIN BIOSYNTHETIC OXIDOREDUCTASE 4 (Streptoalloteich us tenebrarius)	4 / 6	GLY B 29 TYR B 216 ALA B 27 ARG B 250	None D5E B 501 ( 4.5A) D5E B 501 (-4.0A) D5E B 501 (-4.5A)	1.22A	4yshB-6fd2B: undetectable	4yshB-6fd2B: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EII_A_RTLA135_1","CELLULAR RETINOL-BINDING PROTEIN II","6fd2","PUTATIVE APRAMYCIN BIOSYNTHETIC OXIDOREDUCTASE 4","Streptoalloteichus tenebrarius",4,"TYR B 216;THR B  32;SER B 406;TYR B  26","D5E B 501 ( 4.5A);D5E B 501 (-3.4A);D5E B 501 ( 3.4A);D5E B 501 (-3.7A)","1.08A","1eiiA-6fd2B:undetectable",null],["1S3Z_B_RIOB501_0","AMINOGLYCOSIDE 6'-N-ACETYLTRANSFERASE","6fd2","PUTATIVE APRAMYCIN BIOSYNTHETIC OXIDOREDUCTASE 4","Streptoalloteichus tenebrarius",4,"TYR B  26;GLU B 303;VAL B 342;GLU B  37","D5E B 501 (-3.7A);D5E B 501 (-3.1A);None;D5E B 501 (-3.0A)","1.22A","1s3zA-6fd2B:undetectable;1s3zB-6fd2B:undetectable","1eiiA-6fd2B:undetectable"],["1TD2_A_PXLA288_1","PYRIDOXAMINE KINASE","6fd2","PUTATIVE APRAMYCIN BIOSYNTHETIC OXIDOREDUCTASE 4","Streptoalloteichus tenebrarius",5,"SER B 425;VAL B 378;HIS B 407;THR B 405;ASP B 429","None;None;D5E B 501 ( 4.8A);None;None","1.44A","1td2A-6fd2B:3.3","1s3zA-6fd2B:undetectable;1s3zB-6fd2B:undetectable"],["2XYT_B_TC9B1206_1","SOLUBLE ACETYLCHOLINE RECEPTOR;SOLUBLE ACETYLCHOLINE RECEPTOR;SOLUBLE ACETYLCHOLINE RECEPTOR","6fd2","PUTATIVE APRAMYCIN BIOSYNTHETIC OXIDOREDUCTASE 4","Streptoalloteichus tenebrarius",5,"TYR B 382;TYR B 216;GLN B  23;SER B  85;SER B 111","5AD B 504 (-4.8A);D5E B 501 ( 4.5A);None;None;None","1.30A","2xytB-6fd2B:0.0;2xytC-6fd2B:0.0;2xytG-6fd2B:0.0","1td2A-6fd2B:13.81"],["4YSH_B_GLYB401_0","GLYCINE OXIDASE","6fd2","PUTATIVE APRAMYCIN BIOSYNTHETIC OXIDOREDUCTASE 4","Streptoalloteichus tenebrarius",4,"GLY B  29;TYR B 216;ALA B  27;ARG B 250","None;D5E B 501 ( 4.5A);D5E B 501 (-4.0A);D5E B 501 (-4.5A)","1.22A","4yshB-6fd2B:undetectable","2xytB-6fd2B:17.86;2xytC-6fd2B:17.86;2xytG-6fd2B:17.86"]]