SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'D3T'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		3 / 3 ASP A 330
ARG A 418
ARG A 323
 NA  A 902 (-2.5A)
None
D3T  A 538 (-2.8A)
 0.99A 3k37A-2ihmA:
undetectable		 3k37A-2ihmA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		4 / 6 GLU A 445
GLY A 324
ARG A 322
GLY A 320
 None
None
None
D3T  A 538 (-3.7A)
 0.83A 5cdnA-2ihmA:
2.1
5cdnB-2ihmA:
undetectable		 5cdnA-2ihmA:
20.95
5cdnB-2ihmA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		5 / 12 HIS A 366
HIS A 329
PHE A 391
ASP A 330
ASP A 332
 None
D3T  A 538 (-3.9A)
None
NA  A 902 (-2.5A)
NA  A 902 (-3.2A)
 1.43A 5eenB-2ihmA:
undetectable		 5eenB-2ihmA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 2ihm DNA POLYMERASE MU
(Mus
musculus) 		5 / 12 HIS A 366
HIS A 329
PHE A 391
ASP A 330
ASP A 332
 None
D3T  A 538 (-3.9A)
None
NA  A 902 (-2.5A)
NA  A 902 (-3.2A)
 1.45A 5ef8A-2ihmA:
undetectable		 5ef8A-2ihmA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4p4o DNA POLYMERASE BETA
(Leishmania
infantum) 		5 / 12 ALA A 283
ASP A 271
PHE A 287
GLY A 183
SER A 184
 None
None
None
D3T  A 401 (-3.2A)
D3T  A 401 (-2.5A)
 1.10A 5hfjE-4p4oA:
undetectable		 5hfjE-4p4oA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 4p4o DNA POLYMERASE BETA
(Leishmania
infantum) 		4 / 7 GLY A 193
PHE A 191
SER A 158
ASN A 150
 D3T  A 401 (-3.7A)
None
None
None
 0.80A 5n5dB-4p4oA:
undetectable		 5n5dB-4p4oA:
21.75