SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'D16'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 LYS A  77
ILE A 108
LEU A 192
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
ALA A 312
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.70A 1axwA-1hvyA:
39.1		 1axwA-1hvyA:
51.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.90A 1axwA-4iqqA:
36.2		 1axwA-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 194
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.16A 1axwA-4iqqA:
36.2		 1axwA-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 ILE A 132
LEU A 216
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.07A 1axwA-5h3aA:
36.3		 1axwA-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 11 LYS A  77
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.67A 1axwB-1hvyA:
38.9		 1axwB-1hvyA:
51.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 11 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.89A 1axwB-4iqqA:
36.3		 1axwB-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 110
TRP A 111
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.05A 1axwB-4iqqA:
36.3		 1axwB-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 11 LYS A  79
ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 ( 4.5A)
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 1.06A 1axwB-4iqqA:
36.3		 1axwB-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.89A 1axwB-5h3aA:
36.5		 1axwB-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 ILE A 132
TRP A 133
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.99A 1axwB-5h3aA:
36.5		 1axwB-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 11 ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.67A 1b02A-1hvyA:
34.9		 1b02A-1hvyA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.80A 1b02A-4iqqA:
31.7		 1b02A-4iqqA:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 110
LEU A 194
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 1.08A 1b02A-4iqqA:
31.7		 1b02A-4iqqA:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		8 / 12 GLU A  89
ILE A 110
ASN A 114
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 None
D16  A 402 (-4.0A)
None
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.77A 1hvyA-4iqqA:
12.9		 1hvyA-4iqqA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
TRP A 111
ASN A 114
PHE A 227
 None
D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.2A)
 0.68A 1hvyA-4iqqA:
12.9		 1hvyA-4iqqA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		8 / 12 PHE A 104
GLU A 111
ILE A 132
ASN A 136
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.76A 1hvyA-5h3aA:
21.0		 1hvyA-5h3aA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 PHE A 104
GLU A 111
ILE A 132
TRP A 133
ASN A 136
PHE A 249
 D16  A 401 (-3.6A)
D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
None
D16  A 401 (-3.4A)
 0.63A 1hvyA-5h3aA:
21.0		 1hvyA-5h3aA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		8 / 12 GLU A  89
ILE A 110
ASN A 114
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 None
D16  A 402 (-4.0A)
None
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.80A 1hvyB-4iqqA:
42.2		 1hvyB-4iqqA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
TRP A 111
ASN A 114
PHE A 227
 None
D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.2A)
 0.72A 1hvyB-4iqqA:
42.2		 1hvyB-4iqqA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 12 GLU A 111
ILE A 132
ASN A 136
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.78A 1hvyB-5h3aA:
43.0		 1hvyB-5h3aA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
TRP A 133
ASN A 136
PHE A 249
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
None
D16  A 401 (-3.4A)
 0.64A 1hvyB-5h3aA:
43.0		 1hvyB-5h3aA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		8 / 11 GLU A  89
ILE A 110
ASN A 114
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 None
D16  A 402 (-4.0A)
None
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.61A 1hvyC-4iqqA:
13.1		 1hvyC-4iqqA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 GLU A  89
ILE A 110
TRP A 111
ASN A 114
PHE A 227
 None
D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.2A)
 0.66A 1hvyC-4iqqA:
13.1		 1hvyC-4iqqA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		8 / 11 PHE A 104
GLU A 111
ILE A 132
ASN A 136
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.62A 1hvyC-5h3aA:
21.3		 1hvyC-5h3aA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 11 PHE A 104
GLU A 111
ILE A 132
TRP A 133
ASN A 136
PHE A 249
 D16  A 401 (-3.6A)
D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
None
D16  A 401 (-3.4A)
 0.62A 1hvyC-5h3aA:
21.3		 1hvyC-5h3aA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 GLU A  89
ILE A 110
ASN A 114
LEU A 194
LEU A 223
GLY A 224
PHE A 227
 None
D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 0.84A 1hvyD-4iqqA:
42.3		 1hvyD-4iqqA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 GLU A  89
ILE A 110
ASN A 114
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 None
D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.73A 1hvyD-4iqqA:
42.3		 1hvyD-4iqqA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 GLU A  89
ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.70A 1hvyD-4iqqA:
42.3		 1hvyD-4iqqA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 GLU A  89
ILE A 110
TRP A 111
ASN A 114
LEU A 194
LEU A 223
PHE A 227
 None
D16  A 402 (-4.0A)
None
None
None
D16  A 402 (-3.7A)
D16  A 402 (-3.2A)
 0.94A 1hvyD-4iqqA:
42.3		 1hvyD-4iqqA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 12 GLU A 111
ILE A 132
ASN A 136
LEU A 216
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.73A 1hvyD-5h3aA:
43.1		 1hvyD-5h3aA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 GLU A 111
ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.56A 1hvyD-5h3aA:
43.1		 1hvyD-5h3aA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 GLU A 111
ILE A 132
TRP A 133
ASN A 136
LEU A 216
PHE A 249
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
None
None
D16  A 401 (-3.4A)
 0.69A 1hvyD-5h3aA:
43.1		 1hvyD-5h3aA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 9 PHE A  80
GLU A  87
ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.53A 1i00A-1hvyA:
43.9		 1i00A-1hvyA:
98.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 9 PHE A  80
GLU A  87
ILE A 108
TRP A 109
PHE A 225
 D16  A 414 (-3.7A)
D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.6A)
 0.62A 1i00A-1hvyA:
43.9		 1i00A-1hvyA:
98.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		8 / 9 GLU A  89
ILE A 110
TRP A 111
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 None
D16  A 402 (-4.0A)
None
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.42A 1i00A-4iqqA:
42.1		 1i00A-4iqqA:
62.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		8 / 9 PHE A 104
GLU A 111
ILE A 132
TRP A 133
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.35A 1i00A-5h3aA:
21.2		 1i00A-5h3aA:
70.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 9 PHE A  80
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
 0.65A 1i00B-1hvyA:
44.0		 1i00B-1hvyA:
98.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 9 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.29A 1i00B-4iqqA:
12.8		 1i00B-4iqqA:
62.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 9 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.21A 1i00B-5h3aA:
21.0		 1i00B-5h3aA:
70.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 9 PHE A 104
TRP A 133
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
None
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.90A 1i00B-5h3aA:
21.0		 1i00B-5h3aA:
70.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE
(Streptococcus
pneumoniae) 		5 / 11 VAL D 161
CYH D 163
TYR D 121
TRP D 373
TYR D  88
 None
None
None
OAN  D1627 (-3.7A)
None
 1.50A 1jkhA-5a6bD:
undetectable
1jkhB-5a6bD:
1.4		 1jkhA-5a6bD:
22.66
1jkhB-5a6bD:
19.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		11 / 11 PHE A  80
ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.78A 1ju6A-1hvyA:
46.8		 1ju6A-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 110
ASN A 114
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.03A 1ju6A-4iqqA:
41.7		 1ju6A-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 11 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.91A 1ju6A-4iqqA:
41.7		 1ju6A-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 PHE A 104
ILE A 132
ASN A 136
GLY A 246
PHE A 249
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
 1.17A 1ju6A-5h3aA:
42.3		 1ju6A-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 11 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.95A 1ju6A-5h3aA:
42.3		 1ju6A-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 PHE A 104
ILE A 132
TRP A 133
ASN A 136
PHE A 249
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
None
D16  A 401 (-3.4A)
 0.86A 1ju6A-5h3aA:
42.3		 1ju6A-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 9 LYS A  77
ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.66A 1ju6B-1hvyA:
46.8		 1ju6B-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 9 ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.75A 1ju6B-4iqqA:
41.8		 1ju6B-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 10 ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.81A 1ju6C-1hvyA:
46.8		 1ju6C-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 ILE A 110
ASN A 114
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.04A 1ju6C-4iqqA:
41.8		 1ju6C-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.91A 1ju6C-4iqqA:
41.8		 1ju6C-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 10 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.96A 1ju6C-5h3aA:
42.3		 1ju6C-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		11 / 11 LYS A  77
PHE A  80
ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
ALA A 312
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.67A 1ju6D-1hvyA:
46.8		 1ju6D-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.76A 1ju6D-4iqqA:
41.8		 1ju6D-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 PHE A 104
ILE A 132
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.66A 1ju6D-5h3aA:
42.3		 1ju6D-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.84A 1jujA-1hvyA:
45.3		 1jujA-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 LYS A  77
ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.63A 1jujA-1hvyA:
45.3		 1jujA-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 ILE A 110
ASN A 114
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.16A 1jujA-4iqqA:
41.3		 1jujA-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.95A 1jujA-4iqqA:
41.3		 1jujA-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 LYS A  79
ILE A 110
ASP A 220
GLY A 224
TYR A 260
 D16  A 402 ( 4.5A)
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.91A 1jujA-4iqqA:
41.3		 1jujA-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 10 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.03A 1jujA-5h3aA:
41.6		 1jujA-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.84A 1jujB-1hvyA:
45.3		 1jujB-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 LYS A  77
ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.63A 1jujB-1hvyA:
45.3		 1jujB-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 ILE A 110
ASN A 114
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.16A 1jujB-4iqqA:
41.3		 1jujB-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.95A 1jujB-4iqqA:
41.3		 1jujB-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 LYS A  79
ILE A 110
ASP A 220
GLY A 224
TYR A 260
 D16  A 402 ( 4.5A)
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.91A 1jujB-4iqqA:
41.3		 1jujB-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 10 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.03A 1jujB-5h3aA:
41.5		 1jujB-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.84A 1jujC-1hvyA:
45.2		 1jujC-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 LYS A  77
ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.63A 1jujC-1hvyA:
45.2		 1jujC-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 ILE A 110
ASN A 114
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.16A 1jujC-4iqqA:
41.3		 1jujC-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.95A 1jujC-4iqqA:
41.3		 1jujC-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 LYS A  79
ILE A 110
ASP A 220
GLY A 224
TYR A 260
 D16  A 402 ( 4.5A)
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.91A 1jujC-4iqqA:
41.3		 1jujC-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 10 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.03A 1jujC-5h3aA:
41.6		 1jujC-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.84A 1jujD-1hvyA:
45.3		 1jujD-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 LYS A  77
ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.63A 1jujD-1hvyA:
45.3		 1jujD-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 ILE A 110
ASN A 114
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.16A 1jujD-4iqqA:
41.3		 1jujD-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.95A 1jujD-4iqqA:
41.3		 1jujD-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 LYS A  79
ILE A 110
ASP A 220
GLY A 224
TYR A 260
 D16  A 402 ( 4.5A)
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.91A 1jujD-4iqqA:
41.3		 1jujD-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 10 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.03A 1jujD-5h3aA:
41.6		 1jujD-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 8 ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.60A 1rtsA-1hvyA:
45.1		 1rtsA-1hvyA:
92.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 8 PHE A  80
ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.50A 1rtsA-1hvyA:
45.1		 1rtsA-1hvyA:
92.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 8 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.24A 1rtsA-4iqqA:
42.7		 1rtsA-4iqqA:
63.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 8 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.26A 1rtsA-5h3aA:
43.7		 1rtsA-5h3aA:
70.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 7 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.39A 1rtsB-1hvyA:
45.9		 1rtsB-1hvyA:
92.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 7 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.30A 1rtsB-4iqqA:
43.2		 1rtsB-4iqqA:
63.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 7 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.21A 1rtsB-5h3aA:
43.8		 1rtsB-5h3aA:
70.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 ILE A 108
TRP A 109
LEU A 192
LEU A 221
GLY A 222
PHE A 225
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.85A 1tlsA-1hvyA:
39.5		 1tlsA-1hvyA:
51.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.93A 1tlsA-4iqqA:
36.2		 1tlsA-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
TRP A 111
LEU A 194
LEU A 223
PHE A 227
 D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
D16  A 402 (-3.2A)
 1.14A 1tlsA-4iqqA:
36.2		 1tlsA-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
TRP A 133
LEU A 216
GLY A 246
PHE A 249
 D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
 1.08A 1tlsA-5h3aA:
36.3		 1tlsA-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 ILE A 108
TRP A 109
LEU A 192
LEU A 221
GLY A 222
PHE A 225
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.78A 1tlsB-1hvyA:
39.5		 1tlsB-1hvyA:
51.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 194
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.14A 1tlsB-4iqqA:
36.3		 1tlsB-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.86A 1tlsB-4iqqA:
36.3		 1tlsB-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
LEU A 216
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.09A 1tlsB-5h3aA:
36.5		 1tlsB-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
TRP A 133
LEU A 216
GLY A 246
PHE A 249
 D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
 1.06A 1tlsB-5h3aA:
36.5		 1tlsB-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 ILE A 108
TRP A 109
LEU A 192
LEU A 221
GLY A 222
PHE A 225
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.86A 1tsnA-1hvyA:
39.3		 1tsnA-1hvyA:
51.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.93A 1tsnA-4iqqA:
36.1		 1tsnA-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
TRP A 111
LEU A 194
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.10A 1tsnA-4iqqA:
36.1		 1tsnA-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
LEU A 216
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.08A 1tsnA-5h3aA:
36.3		 1tsnA-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
TRP A 133
LEU A 216
GLY A 246
PHE A 249
 D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
 1.01A 1tsnA-5h3aA:
36.3		 1tsnA-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 GLU A  87
TRP A 109
LEU A 192
ASP A 218
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.49A 2kceA-1hvyA:
39.6		 2kceA-1hvyA:
51.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 TRP A 109
LEU A 192
ASP A 218
GLY A 222
PHE A 225
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.83A 2kceA-1hvyA:
39.6		 2kceA-1hvyA:
51.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
LEU A 216
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.77A 2kceA-5h3aA:
36.3		 2kceA-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 LEU A 216
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.28A 2kceA-5h3aA:
36.3		 2kceA-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.57A 2kceB-1hvyA:
39.5		 2kceB-1hvyA:
51.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 LEU A 216
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.85A 2kceB-5h3aA:
36.6		 2kceB-5h3aA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 7 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.57A 2tsrA-1hvyA:
44.0		 2tsrA-1hvyA:
92.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 7 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.22A 2tsrA-4iqqA:
43.0		 2tsrA-4iqqA:
63.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 7 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.23A 2tsrA-5h3aA:
43.9		 2tsrA-5h3aA:
70.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 8 ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.51A 2tsrB-1hvyA:
44.9		 2tsrB-1hvyA:
92.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 PHE A  80
GLU A  87
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.60A 2tsrC-1hvyA:
43.8		 2tsrC-1hvyA:
92.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 10 GLU A  89
ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.33A 2tsrC-4iqqA:
42.9		 2tsrC-4iqqA:
63.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 10 PHE A 104
GLU A 111
ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.30A 2tsrC-5h3aA:
43.9		 2tsrC-5h3aA:
70.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 10 PHE A 104
GLU A 111
ILE A 132
TRP A 133
PHE A 249
 D16  A 401 (-3.6A)
D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 (-3.4A)
 0.75A 2tsrC-5h3aA:
43.9		 2tsrC-5h3aA:
70.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 9 PHE A  80
ILE A 108
PHE A 225
TYR A 258
THR A 306
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
None
 0.72A 2tsrD-1hvyA:
21.0		 2tsrD-1hvyA:
92.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 9 PHE A  80
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.54A 2tsrD-1hvyA:
21.0		 2tsrD-1hvyA:
92.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 9 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.19A 2tsrD-4iqqA:
12.9		 2tsrD-4iqqA:
63.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 9 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.31A 2tsrD-5h3aA:
20.7		 2tsrD-5h3aA:
70.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 9 PHE A 104
ILE A 132
ASP A 242
GLY A 246
TYR A 282
THR A 330
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
None
 0.63A 2tsrD-5h3aA:
20.7		 2tsrD-5h3aA:
70.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A  87
ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.66A 3k2hA-1hvyA:
19.4		 3k2hA-1hvyA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 ILE A 108
TRP A 109
LEU A 192
GLY A 222
PHE A 225
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.98A 3k2hA-1hvyA:
19.4		 3k2hA-1hvyA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 194
LEU A 223
GLY A 224
 None
D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
 0.98A 3k2hA-4iqqA:
12.4		 3k2hA-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.86A 3k2hA-4iqqA:
12.4		 3k2hA-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
TRP A 111
LEU A 194
LEU A 223
 None
D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
 0.92A 3k2hA-4iqqA:
12.4		 3k2hA-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 1.11A 3k2hA-4iqqA:
12.4		 3k2hA-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
LEU A 216
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.95A 3k2hA-5h3aA:
19.3		 3k2hA-5h3aA:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A  87
ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.71A 3k2hB-1hvyA:
20.5		 3k2hB-1hvyA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
PHE A 225
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.97A 3k2hB-1hvyA:
20.5		 3k2hB-1hvyA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 194
LEU A 223
GLY A 224
 None
D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
 0.97A 3k2hB-4iqqA:
13.0		 3k2hB-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.87A 3k2hB-4iqqA:
13.0		 3k2hB-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
TRP A 111
LEU A 194
LEU A 223
 None
D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
 0.88A 3k2hB-4iqqA:
13.0		 3k2hB-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 1.10A 3k2hB-4iqqA:
13.0		 3k2hB-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
LEU A 216
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.96A 3k2hB-5h3aA:
20.4		 3k2hB-5h3aA:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
TRP A 133
LEU A 216
GLY A 246
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
 0.81A 3k2hB-5h3aA:
20.4		 3k2hB-5h3aA:
32.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE
(Streptococcus
pneumoniae) 		5 / 12 ARG D  94
HIS D 169
TRP D 306
TYR D 308
TRP D 373
 OAN  D1627 (-2.8A)
OAN  D1627 ( 4.9A)
OAN  D1627 (-3.6A)
OAN  D1627 (-4.3A)
OAN  D1627 (-3.7A)
 0.67A 3lmyA-5a6bD:
27.3		 3lmyA-5a6bD:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE
(Streptococcus
pneumoniae) 		6 / 12 ARG D  94
HIS D 169
TRP D 266
TRP D 306
TYR D 308
TRP D 373
 OAN  D1627 (-2.8A)
OAN  D1627 ( 4.9A)
OAN  D1627 (-3.6A)
OAN  D1627 (-3.6A)
OAN  D1627 (-4.3A)
OAN  D1627 (-3.7A)
 0.70A 3lmyB-5a6bD:
27.3		 3lmyB-5a6bD:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A  87
ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.51A 3nrrA-1hvyA:
19.9		 3nrrA-1hvyA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 ILE A 108
TRP A 109
ASN A 112
ASP A 218
GLY A 222
PHE A 225
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.88A 3nrrA-1hvyA:
19.9		 3nrrA-1hvyA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
ASN A 114
LEU A 223
GLY A 224
 None
D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
 0.86A 3nrrA-4iqqA:
14.7		 3nrrA-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 GLU A  89
ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.71A 3nrrA-4iqqA:
14.7		 3nrrA-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
ASN A 114
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.21A 3nrrA-4iqqA:
14.7		 3nrrA-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 1.01A 3nrrA-4iqqA:
14.7		 3nrrA-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.65A 3nrrA-5h3aA:
undetectable		 3nrrA-5h3aA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 GLU A  87
ILE A 108
TRP A 109
ASN A 112
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.50A 3nrrB-1hvyA:
20.0		 3nrrB-1hvyA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 ILE A 108
TRP A 109
ASN A 112
ASP A 218
GLY A 222
PHE A 225
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.88A 3nrrB-1hvyA:
20.0		 3nrrB-1hvyA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
ASN A 114
LEU A 223
GLY A 224
 None
D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
 0.84A 3nrrB-4iqqA:
14.8		 3nrrB-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 GLU A  89
ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.70A 3nrrB-4iqqA:
14.8		 3nrrB-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
ASN A 114
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.21A 3nrrB-4iqqA:
14.8		 3nrrB-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 1.02A 3nrrB-4iqqA:
14.8		 3nrrB-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
ASN A 136
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.88A 3nrrB-5h3aA:
undetectable		 3nrrB-5h3aA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.64A 3nrrB-5h3aA:
undetectable		 3nrrB-5h3aA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 ILE A 108
LEU A 192
GLY A 222
PHE A 225
ASN A 226
TYR A 258
 D16  A 414 (-3.7A)
None
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
 1.08A 3uwlB-1hvyA:
39.5		 3uwlB-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 ILE A 108
LEU A 192
LEU A 221
GLY A 222
ASN A 226
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.89A 3uwlB-1hvyA:
39.5		 3uwlB-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 ILE A 108
TRP A 109
LEU A 192
GLY A 222
ASN A 226
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.82A 3uwlB-1hvyA:
39.5		 3uwlB-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 ILE A 108
TRP A 109
LEU A 192
HIS A 196
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
UMP  A 314 (-3.9A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 1.09A 3uwlB-1hvyA:
39.5		 3uwlB-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
HIS A 198
LEU A 223
GLY A 224
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
UMP  A 401 ( 4.7A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.74A 3uwlB-4iqqA:
35.8		 3uwlB-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 1.07A 3uwlB-4iqqA:
35.8		 3uwlB-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 ILE A 110
TRP A 111
LEU A 194
HIS A 198
LEU A 223
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
UMP  A 401 ( 4.7A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.77A 3uwlB-4iqqA:
35.8		 3uwlB-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 192
LEU A 221
GLY A 222
ASN A 226
TYR A 258
ALA A 312
 None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.95A 3uwlD-1hvyA:
38.7		 3uwlD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 192
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
 None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
 1.15A 3uwlD-1hvyA:
38.7		 3uwlD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 TRP A 109
LEU A 192
GLY A 222
ASN A 226
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
None
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.82A 3uwlD-1hvyA:
38.7		 3uwlD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 HIS A 198
LEU A 223
GLY A 224
ASN A 228
TYR A 260
 UMP  A 401 ( 4.7A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.83A 3uwlD-4iqqA:
35.0		 3uwlD-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 TRP A 111
LEU A 194
HIS A 198
LEU A 223
GLY A 224
ASN A 228
 None
None
UMP  A 401 ( 4.7A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.78A 3uwlD-4iqqA:
35.0		 3uwlD-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 LEU A 216
HIS A 220
GLY A 246
ASN A 250
TYR A 282
 None
UMP  A 402 (-3.9A)
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.83A 3uwlD-5h3aA:
34.8		 3uwlD-5h3aA:
45.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 TRP A 133
LEU A 216
HIS A 220
GLY A 246
ASN A 250
 None
None
UMP  A 402 (-3.9A)
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.84A 3uwlD-5h3aA:
34.8		 3uwlD-5h3aA:
45.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		12 / 12 PHE A  80
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
LYS A 308
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
None
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.59A 4eb4A-1hvyA:
47.8		 4eb4A-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.42A 4eb4A-4iqqA:
41.6		 4eb4A-4iqqA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 12 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.40A 4eb4A-5h3aA:
42.5		 4eb4A-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		11 / 12 PHE A  80
ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
LYS A 308
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
None
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.62A 4eb4B-1hvyA:
47.7		 4eb4B-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		11 / 12 PHE A  80
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.48A 4eb4B-1hvyA:
47.7		 4eb4B-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.46A 4eb4B-4iqqA:
41.7		 4eb4B-4iqqA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 12 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.45A 4eb4B-5h3aA:
42.2		 4eb4B-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 9 PHE A  80
ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
 0.48A 4eb4C-1hvyA:
44.0		 4eb4C-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 9 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.26A 4eb4C-4iqqA:
42.6		 4eb4C-4iqqA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 9 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.22A 4eb4C-5h3aA:
43.2		 4eb4C-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 10 PHE A  80
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
LYS A 308
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
None
 0.84A 4eb4D-1hvyA:
45.6		 4eb4D-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 10 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.23A 4eb4D-4iqqA:
42.8		 4eb4D-4iqqA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 10 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.25A 4eb4D-5h3aA:
43.1		 4eb4D-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 10 PHE A 104
ILE A 132
TRP A 133
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.71A 4eb4D-5h3aA:
43.1		 4eb4D-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 11 ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.79A 4fogA-1hvyA:
38.0		 4fogA-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 11 LYS A  77
ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
TYR A 258
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.47A 4fogA-1hvyA:
38.0		 4fogA-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 110
LEU A 194
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
None
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 1.16A 4fogA-4iqqA:
36.2		 4fogA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 110
TRP A 111
LEU A 194
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
None
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.08A 4fogA-4iqqA:
36.2		 4fogA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 LYS A  79
ILE A 110
LEU A 194
GLY A 224
TYR A 260
 D16  A 402 ( 4.5A)
D16  A 402 (-4.0A)
None
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 1.15A 4fogA-4iqqA:
36.2		 4fogA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 LYS A  79
ILE A 110
TRP A 111
LEU A 194
GLY A 224
 D16  A 402 ( 4.5A)
D16  A 402 (-4.0A)
None
None
D16  A 402 ( 3.1A)
 1.03A 4fogA-4iqqA:
36.2		 4fogA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 ILE A 132
LEU A 216
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.77A 4fogA-5h3aA:
35.9		 4fogA-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 11 ILE A 132
TRP A 133
LEU A 216
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.04A 4fogA-5h3aA:
35.9		 4fogA-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 11 ILE A 108
LEU A 192
ASP A 218
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.93A 4fogC-1hvyA:
38.7		 4fogC-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 11 ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.61A 4fogC-1hvyA:
38.7		 4fogC-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 ILE A 132
TRP A 133
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.10A 4fogC-5h3aA:
35.9		 4fogC-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 ILE A 132
TRP A 133
LEU A 216
GLY A 246
TYR A 282
 D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.70A 4fogC-5h3aA:
35.9		 4fogC-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 11 ILE A 108
LEU A 192
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.86A 4fogD-1hvyA:
39.4		 4fogD-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 11 LYS A  77
ILE A 108
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.65A 4fogD-1hvyA:
39.4		 4fogD-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 11 LYS A  77
ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.57A 4fogD-1hvyA:
39.4		 4fogD-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 11 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.95A 4fogD-4iqqA:
36.0		 4fogD-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 110
TRP A 111
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.06A 4fogD-4iqqA:
36.0		 4fogD-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 ILE A 132
LEU A 216
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.88A 4fogD-5h3aA:
36.0		 4fogD-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 ILE A 132
TRP A 133
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.03A 4fogD-5h3aA:
36.0		 4fogD-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 ILE A 132
TRP A 133
LEU A 216
GLY A 246
TYR A 282
 D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.81A 4fogD-5h3aA:
36.0		 4fogD-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A  87
ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.31A 4foxA-1hvyA:
38.6		 4foxA-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.73A 4foxA-1hvyA:
38.6		 4foxA-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 GLU A  89
ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.70A 4foxA-4iqqA:
36.2		 4foxA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 194
LEU A 223
GLY A 224
 None
D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
 0.80A 4foxA-4iqqA:
36.2		 4foxA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
TRP A 111
LEU A 194
LEU A 223
 None
D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
 0.90A 4foxA-4iqqA:
36.2		 4foxA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.95A 4foxA-4iqqA:
36.2		 4foxA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 GLU A 111
ILE A 132
LEU A 216
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.78A 4foxA-5h3aA:
36.1		 4foxA-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 ILE A 132
LEU A 216
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.18A 4foxA-5h3aA:
36.1		 4foxA-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A  87
ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.25A 4foxB-1hvyA:
38.6		 4foxB-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.82A 4foxB-1hvyA:
38.6		 4foxB-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 GLU A  89
ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.66A 4foxB-4iqqA:
36.3		 4foxB-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 194
LEU A 223
GLY A 224
 None
D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
 0.80A 4foxB-4iqqA:
36.3		 4foxB-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 1.04A 4foxB-4iqqA:
36.3		 4foxB-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 GLU A 111
ILE A 132
LEU A 216
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.75A 4foxB-5h3aA:
36.3		 4foxB-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
TRP A 133
LEU A 216
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
None
UMP  A 402 (-4.5A)
 0.75A 4foxB-5h3aA:
36.3		 4foxB-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
TRP A 133
LEU A 216
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
None
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.20A 4foxB-5h3aA:
36.3		 4foxB-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 11 GLU A  87
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.32A 4foxC-1hvyA:
38.3		 4foxC-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 11 TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.79A 4foxC-1hvyA:
38.3		 4foxC-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 GLU A  89
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.70A 4foxC-4iqqA:
36.1		 4foxC-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 GLU A 111
LEU A 216
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.82A 4foxC-5h3aA:
36.1		 4foxC-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A  87
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.56A 4foxD-1hvyA:
39.6		 4foxD-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.80A 4foxD-1hvyA:
39.6		 4foxD-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.74A 4foxD-4iqqA:
35.9		 4foxD-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.94A 4foxD-4iqqA:
35.9		 4foxD-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.63A 4foxD-5h3aA:
35.8		 4foxD-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 ILE A 108
TRP A 109
ASP A 218
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.80A 4foxE-1hvyA:
38.6		 4foxE-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 LYS A  77
GLU A  87
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
TYR A 258
 D16  A 414 ( 4.3A)
D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.28A 4foxE-1hvyA:
38.6		 4foxE-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.61A 4foxE-4iqqA:
36.5		 4foxE-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.62A 4foxE-4iqqA:
36.5		 4foxE-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.99A 4foxE-4iqqA:
36.5		 4foxE-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 LYS A  79
GLU A  89
ILE A 110
GLY A 224
TYR A 260
 D16  A 402 ( 4.5A)
None
D16  A 402 (-4.0A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 1.00A 4foxE-4iqqA:
36.5		 4foxE-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.64A 4foxE-5h3aA:
36.2		 4foxE-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
TRP A 133
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.69A 4foxE-5h3aA:
36.2		 4foxE-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
TRP A 133
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.20A 4foxE-5h3aA:
36.2		 4foxE-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 11 GLU A  87
ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
TYR A 258
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.33A 4foxF-1hvyA:
38.5		 4foxF-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 11 ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.75A 4foxF-1hvyA:
38.5		 4foxF-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 GLU A  89
ILE A 110
ASP A 220
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.71A 4foxF-4iqqA:
36.1		 4foxF-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 11 GLU A 111
ILE A 132
LEU A 216
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.90A 4foxF-5h3aA:
36.0		 4foxF-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 ILE A 132
LEU A 216
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.25A 4foxF-5h3aA:
36.0		 4foxF-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A  87
ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.33A 4foxG-1hvyA:
38.4		 4foxG-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.78A 4foxG-1hvyA:
38.4		 4foxG-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 GLU A  89
ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.74A 4foxG-4iqqA:
36.3		 4foxG-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 194
LEU A 223
GLY A 224
 None
D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
 0.86A 4foxG-4iqqA:
36.3		 4foxG-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
TRP A 111
LEU A 194
LEU A 223
 None
D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
 0.89A 4foxG-4iqqA:
36.3		 4foxG-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 1.00A 4foxG-4iqqA:
36.3		 4foxG-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 GLU A 111
ILE A 132
LEU A 216
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.78A 4foxG-5h3aA:
36.0		 4foxG-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
LEU A 216
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.23A 4foxG-5h3aA:
36.0		 4foxG-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 11 GLU A  87
ILE A 108
TRP A 109
ASP A 218
GLY A 222
TYR A 258
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.35A 4foxH-1hvyA:
38.1		 4foxH-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 11 ILE A 108
TRP A 109
ASP A 218
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.68A 4foxH-1hvyA:
38.1		 4foxH-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 110
ASP A 220
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.94A 4foxH-4iqqA:
36.0		 4foxH-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 GLU A 111
ILE A 132
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.74A 4foxH-5h3aA:
35.7		 4foxH-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 1.02A 4foxH-5h3aA:
35.7		 4foxH-5h3aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A  87
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.63A 4fqsA-1hvyA:
39.4		 4fqsA-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.88A 4fqsA-1hvyA:
39.4		 4fqsA-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.82A 4fqsA-4iqqA:
35.9		 4fqsA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.85A 4fqsA-4iqqA:
35.9		 4fqsA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 1.05A 4fqsA-4iqqA:
35.9		 4fqsA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A  87
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.65A 4fqsB-1hvyA:
39.3		 4fqsB-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 ILE A 108
TRP A 109
LEU A 221
GLY A 222
PHE A 225
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.93A 4fqsB-1hvyA:
39.3		 4fqsB-1hvyA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.84A 4fqsB-4iqqA:
35.8		 4fqsB-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
TRP A 111
LEU A 223
GLY A 224
 None
D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
 0.85A 4fqsB-4iqqA:
35.8		 4fqsB-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.87A 4fqsB-4iqqA:
35.8		 4fqsB-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 1.06A 4fqsB-4iqqA:
35.8		 4fqsB-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
TRP A 111
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.22A 4fqsB-4iqqA:
35.8		 4fqsB-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 7 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.57A 4iqqA-1hvyA:
42.1		 4iqqA-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 7 ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.55A 4iqqB-1hvyA:
41.2		 4iqqB-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		4 / 7 ILE A 108
LEU A 221
GLY A 222
PHE A 225
 D16  A 414 (-3.7A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
 0.60A 4iqqB-1hvyA:
41.2		 4iqqB-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 7 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.34A 4iqqB-5h3aA:
41.5		 4iqqB-5h3aA:
58.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 7 ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.55A 4iqqC-1hvyA:
41.4		 4iqqC-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 7 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
 0.61A 4iqqC-1hvyA:
41.4		 4iqqC-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 7 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.36A 4iqqC-5h3aA:
42.1		 4iqqC-5h3aA:
58.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 8 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.59A 4iqqD-1hvyA:
40.8		 4iqqD-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 8 LYS A  77
ILE A 108
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 1.07A 4iqqD-1hvyA:
40.8		 4iqqD-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 11 PHE A  80
ILE A 108
TRP A 109
ASN A 112
LEU A 192
ASP A 218
GLY A 222
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.71A 5fctA-1hvyA:
48.1		 5fctA-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 11 PHE A  80
ILE A 108
TRP A 109
ASN A 112
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.58A 5fctA-1hvyA:
48.1		 5fctA-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 11 PHE A  80
ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
TYR A 258
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.66A 5fctA-1hvyA:
48.1		 5fctA-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 11 PHE A  80
ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.58A 5fctA-1hvyA:
48.1		 5fctA-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 PHE A 104
ILE A 132
LEU A 216
GLY A 246
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.99A 5fctA-5h3aA:
42.8		 5fctA-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 PHE A 104
LEU A 216
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 (-3.6A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.98A 5fctA-5h3aA:
42.8		 5fctA-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		12 / 12 LYS A  77
VAL A  79
PHE A  80
ILE A 108
TRP A 109
LEU A 192
CYH A 195
LEU A 221
TYR A 258
MET A 309
MET A 311
ALA A 312
 D16  A 414 ( 4.3A)
None
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
UMP  A 314 (-1.8A)
D16  A 414 (-4.0A)
UMP  A 314 ( 4.4A)
None
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.61A 5fctB-1hvyA:
48.2		 5fctB-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 LYS A  79
ILE A 110
CYH A 197
LEU A 223
TYR A 260
 D16  A 402 ( 4.5A)
D16  A 402 (-4.0A)
UMP  A 401 (-3.3A)
D16  A 402 (-3.7A)
D16  A 402 ( 4.2A)
 1.18A 5fctB-4iqqA:
42.3		 5fctB-4iqqA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 VAL A  81
ILE A 110
CYH A 197
LEU A 223
TYR A 260
 None
D16  A 402 (-4.0A)
UMP  A 401 (-3.3A)
D16  A 402 (-3.7A)
D16  A 402 ( 4.2A)
 0.84A 5fctB-4iqqA:
42.3		 5fctB-4iqqA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 VAL A  81
ILE A 110
TRP A 111
LEU A 194
LEU A 223
 None
D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
 0.92A 5fctB-4iqqA:
42.3		 5fctB-4iqqA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 VAL A 103
PHE A 104
ILE A 132
CYH A 219
TYR A 282
 None
D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
UMP  A 402 (-3.4A)
UMP  A 402 (-4.5A)
 0.73A 5fctB-5h3aA:
43.0		 5fctB-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 VAL A 103
PHE A 104
ILE A 132
LEU A 216
TYR A 282
 None
D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
UMP  A 402 (-4.5A)
 0.83A 5fctB-5h3aA:
43.0		 5fctB-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 VAL A 103
PHE A 104
ILE A 132
TRP A 133
LEU A 216
 None
D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
None
 0.70A 5fctB-5h3aA:
43.0		 5fctB-5h3aA:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		3 / 3 ASN A 112
ASP A 218
GLY A 222
 D16  A 414 ( 4.0A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
 0.44A 5fctB-1hvyA:
48.2		 5fctB-1hvyA:
93.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_A_D16A401_1
(ORF70)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 7 PHE A  80
ILE A 108
ASP A 218
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.56A 5h3aA-1hvyA:
43.2		 5h3aA-1hvyA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_A_D16A401_1
(ORF70)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 7 ILE A 110
ASP A 220
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.19A 5h3aA-4iqqA:
42.4		 5h3aA-4iqqA:
58.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_B_D16B401_1
(ORF70)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 7 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.64A 5h3aB-1hvyA:
43.8		 5h3aB-1hvyA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_B_D16B401_1
(ORF70)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 7 PHE A  80
ILE A 108
ASP A 218
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.53A 5h3aB-1hvyA:
43.8		 5h3aB-1hvyA:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_B_D16B401_1
(ORF70)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 7 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.26A 5h3aB-4iqqA:
12.7		 5h3aB-4iqqA:
58.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 12 ASP A 218
LEU A 221
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.54A 5j7wC-1hvyA:
39.3		 5j7wC-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 GLU A  87
ILE A 108
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.67A 5j7wC-1hvyA:
39.3		 5j7wC-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A  87
ILE A 108
LEU A 192
ASP A 218
LEU A 221
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.85A 5j7wD-1hvyA:
39.0		 5j7wD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 GLU A  87
ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.77A 5j7wD-1hvyA:
39.0		 5j7wD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 ILE A 108
LEU A 192
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 1.05A 5j7wD-1hvyA:
39.0		 5j7wD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.86A 5j7wD-4iqqA:
35.3		 5j7wD-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
TRP A 111
LEU A 223
GLY A 224
 None
D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
 0.76A 5j7wD-4iqqA:
35.3		 5j7wD-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
TRP A 111
LEU A 194
LEU A 223
GLY A 224
 None
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
 0.87A 5j7wD-4iqqA:
35.3		 5j7wD-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.88A 5j7wD-4iqqA:
35.3		 5j7wD-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 GLU A 111
ILE A 132
TRP A 133
LEU A 216
GLY A 246
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 0.89A 5j7wD-5h3aA:
35.3		 5j7wD-5h3aA:
45.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
LEU A 216
ASP A 242
GLY A 246
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-4.5A)
 1.08A 5j7wD-5h3aA:
35.3		 5j7wD-5h3aA:
45.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 7 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.58A 5nooA-1hvyA:
42.1		 5nooA-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 7 TYR A  82
ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-3.6A)
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.15A 5nooA-4iqqA:
47.3		 5nooA-4iqqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 7 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.22A 5nooA-5h3aA:
42.7		 5nooA-5h3aA:
58.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 7 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.68A 5nooB-1hvyA:
41.7		 5nooB-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 7 TYR A  82
ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-3.6A)
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.28A 5nooB-4iqqA:
46.2		 5nooB-4iqqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 7 ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.28A 5nooB-5h3aA:
42.2		 5nooB-5h3aA:
58.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 6 ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.55A 5nooC-1hvyA:
41.3		 5nooC-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 6 TYR A  82
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-3.6A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.16A 5nooC-4iqqA:
13.5		 5nooC-4iqqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		4 / 6 ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.15A 5nooC-5h3aA:
41.9		 5nooC-5h3aA:
58.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 8 ARG A  78
ILE A 108
ASP A 218
GLY A 222
PHE A 225
TYR A 258
 None
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.85A 5nooD-1hvyA:
20.8		 5nooD-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 8 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.64A 5nooD-1hvyA:
20.8		 5nooD-1hvyA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 GLU A  87
ILE A 108
LEU A 221
GLY A 222
PHE A 225
MET A 311
ALA A 312
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.99A 5x5qB-1hvyA:
47.1		 5x5qB-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 GLU A  87
ILE A 108
PHE A 225
THR A 306
MET A 311
ALA A 312
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.6A)
None
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.99A 5x5qB-1hvyA:
47.1		 5x5qB-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 GLU A  87
ILE A 108
PHE A 225
TYR A 258
THR A 306
MET A 309
MET A 311
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
None
None
D16  A 414 (-3.4A)
 0.71A 5x5qB-1hvyA:
47.1		 5x5qB-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 12 GLU A  87
ILE A 108
TRP A 109
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
MET A 309
MET A 311
 D16  A 414 (-3.8A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
None
D16  A 414 (-3.4A)
 0.49A 5x5qB-1hvyA:
47.1		 5x5qB-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 GLU A  89
ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.38A 5x5qB-4iqqA:
42.7		 5x5qB-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 12 GLU A 111
ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
THR A 330
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
None
 0.58A 5x5qB-5h3aA:
43.6		 5x5qB-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 GLU A 111
ILE A 132
TRP A 133
PHE A 249
TYR A 282
 D16  A 401 ( 4.7A)
D16  A 401 ( 4.0A)
None
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.74A 5x5qB-5h3aA:
43.6		 5x5qB-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 7 PHE A  80
ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.47A 5x5qC-1hvyA:
44.8		 5x5qC-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 7 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.23A 5x5qC-4iqqA:
42.8		 5x5qC-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 7 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.26A 5x5qC-5h3aA:
43.8		 5x5qC-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 8 PHE A  80
ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.47A 5x5qD-1hvyA:
44.9		 5x5qD-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 8 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.24A 5x5qD-4iqqA:
13.0		 5x5qD-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 8 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.30A 5x5qD-5h3aA:
43.7		 5x5qD-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 6 PHE A  80
ILE A 108
ASP A 218
LEU A 221
GLY A 222
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.44A 5x5qE-1hvyA:
44.7		 5x5qE-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 6 ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.24A 5x5qE-4iqqA:
42.7		 5x5qE-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 8 PHE A  80
ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
 0.49A 5x5qF-1hvyA:
44.6		 5x5qF-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 8 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.24A 5x5qF-4iqqA:
42.6		 5x5qF-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 8 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
 0.30A 5x5qF-5h3aA:
43.5		 5x5qF-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 12 PHE A  80
ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.64A 5x66A-1hvyA:
47.4
5x66B-1hvyA:
47.7		 5x66A-1hvyA:
100.00
5x66B-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASP A 220
LEU A 223
GLY A 224
ASN A 228
TYR A 260
 D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.79A 5x66A-4iqqA:
43.3
5x66B-4iqqA:
13.2		 5x66A-4iqqA:
62.54
5x66B-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
ASP A 220
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.38A 5x66A-4iqqA:
43.3
5x66B-4iqqA:
13.2		 5x66A-4iqqA:
62.54
5x66B-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 12 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.32A 5x66A-5h3aA:
44.1
5x66B-5h3aA:
29.5		 5x66A-5h3aA:
71.73
5x66B-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 9 ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.49A 5x66C-1hvyA:
47.7		 5x66C-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 9 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.61A 5x66C-4iqqA:
43.1		 5x66C-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 9 ILE A 132
ASP A 242
GLY A 246
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.34A 5x66C-5h3aA:
44.0		 5x66C-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 PHE A  80
ILE A 108
ASP A 218
GLY A 222
PHE A 225
ASN A 226
TYR A 258
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.41A 5x66D-1hvyA:
47.1		 5x66D-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 ILE A 110
ASP A 220
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.39A 5x66D-4iqqA:
42.9		 5x66D-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 10 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.35A 5x66D-5h3aA:
43.5		 5x66D-5h3aA:
71.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 LYS A  77
ASP A 218
GLY A 222
TYR A 258
THR A 306
MET A 311
ALA A 312
VAL A 313
 D16  A 414 ( 4.3A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
None
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
None
 1.13A 5x66F-1hvyA:
47.3		 5x66F-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 12 LYS A  77
ASP A 218
LEU A 221
GLY A 222
TYR A 258
MET A 311
ALA A 312
VAL A 313
 D16  A 414 ( 4.3A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
None
 1.09A 5x66F-1hvyA:
47.3		 5x66F-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 12 LYS A  77
PHE A  80
ILE A 108
ASP A 218
GLY A 222
PHE A 225
TYR A 258
THR A 306
MET A 311
ALA A 312
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
None
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.60A 5x66F-1hvyA:
47.3		 5x66F-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 12 LYS A  77
PHE A  80
ILE A 108
ASP A 218
LEU A 221
GLY A 222
PHE A 225
TYR A 258
MET A 311
ALA A 312
 D16  A 414 ( 4.3A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.53A 5x66F-1hvyA:
47.3		 5x66F-1hvyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 LYS A  79
ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 ( 4.5A)
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.93A 5x66F-4iqqA:
42.9		 5x66F-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 12 PHE A 104
ILE A 132
ASP A 242
GLY A 246
PHE A 249
TYR A 282
THR A 330
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-4.5A)
None
 0.47A 5x66F-5h3aA:
43.5		 5x66F-5h3aA:
71.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE
(Streptococcus
pneumoniae) 		4 / 6 TYR D 308
VAL D 368
VAL D 370
THR D 371
 OAN  D1627 (-4.3A)
None
None
None
 1.33A 6f32B-5a6bD:
undetectable		 6f32B-5a6bD:
23.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		7 / 12 ILE A 108
LEU A 192
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
 D16  A 414 (-3.7A)
None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
 1.10A 6qxsB-1hvyA:
38.5		 6qxsB-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 ILE A 108
TRP A 109
LEU A 192
GLY A 222
ASN A 226
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
 0.77A 6qxsB-1hvyA:
38.5		 6qxsB-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 1.08A 6qxsB-4iqqA:
35.0		 6qxsB-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
TRP A 111
LEU A 223
GLY A 224
PHE A 227
ASN A 228
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
 1.13A 6qxsB-4iqqA:
35.0		 6qxsB-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 TRP A 111
LEU A 194
LEU A 223
GLY A 224
ASN A 228
 None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.83A 6qxsB-4iqqA:
35.0		 6qxsB-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
LEU A 216
GLY A 246
ASN A 250
TYR A 282
 D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.95A 6qxsB-5h3aA:
34.8		 6qxsB-5h3aA:
45.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
TRP A 133
LEU A 216
GLY A 246
ASN A 250
 D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.68A 6qxsB-5h3aA:
34.8		 6qxsB-5h3aA:
45.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 108
ASP A 218
GLY A 222
ASN A 226
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.6A)
 0.63A 6qxsD-1hvyA:
38.4		 6qxsD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 108
ASP A 218
LEU A 221
GLY A 222
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
 0.79A 6qxsD-1hvyA:
38.4		 6qxsD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
ASN A 226
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
 0.73A 6qxsD-1hvyA:
38.4		 6qxsD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
TRP A 133
LEU A 216
GLY A 246
ASN A 250
 D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.55A 6qxsD-5h3aA:
34.7		 6qxsD-5h3aA:
45.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 108
LEU A 221
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.72A 6qyaB-1hvyA:
37.9		 6qyaB-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 108
TRP A 109
LEU A 192
GLY A 222
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
 0.69A 6qyaB-1hvyA:
37.9		 6qyaB-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 1.09A 6qyaB-4iqqA:
34.6		 6qyaB-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 108
GLY A 222
ASN A 226
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.59A 6qyaD-1hvyA:
37.9		 6qyaD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 108
LEU A 221
GLY A 222
TYR A 258
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.6A)
 0.73A 6qyaD-1hvyA:
37.9		 6qyaD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		6 / 12 ILE A 108
TRP A 109
LEU A 192
GLY A 222
ASN A 226
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
 0.69A 6qyaD-1hvyA:
37.9		 6qyaD-1hvyA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
HIS A 198
GLY A 224
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
UMP  A 401 ( 4.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.57A 6qyaD-4iqqA:
34.6		 6qyaD-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
TRP A 111
HIS A 198
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
UMP  A 401 ( 4.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.49A 6qyaD-4iqqA:
34.6		 6qyaD-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 TRP A 111
LEU A 194
HIS A 198
GLY A 224
ASN A 228
 None
None
UMP  A 401 ( 4.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.61A 6qyaD-4iqqA:
34.6		 6qyaD-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
TRP A 133
LEU A 216
GLY A 246
ASN A 250
 D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.62A 6qyaD-5h3aA:
34.5		 6qyaD-5h3aA:
45.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 ILE A 132
TRP A 133
LEU A 216
HIS A 220
ASN A 250
 D16  A 401 ( 4.0A)
None
None
UMP  A 402 (-3.9A)
UMP  A 402 (-3.2A)
 0.78A 6qyaD-5h3aA:
34.5		 6qyaD-5h3aA:
45.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 12 PHE A  80
ILE A 108
ASN A 112
LEU A 192
ASP A 218
LEU A 221
GLY A 222
PHE A 225
ASN A 226
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
 0.88A 6r2eA-1hvyA:
47.3		 6r2eA-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 PHE A  80
ILE A 108
LEU A 192
ASP A 218
GLY A 222
PHE A 225
ASN A 226
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.97A 6r2eA-1hvyA:
47.3		 6r2eA-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 12 PHE A  80
ILE A 108
TRP A 109
ASN A 112
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
TYR A 258
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
 0.69A 6r2eA-1hvyA:
47.3		 6r2eA-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 PHE A  80
ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
ASN A 226
TYR A 258
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
UMP  A 314 ( 4.4A)
D16  A 414 (-3.4A)
 0.76A 6r2eA-1hvyA:
47.3		 6r2eA-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASP A 220
LEU A 223
GLY A 224
ASN A 228
TYR A 260
 D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.76A 6r2eA-4iqqA:
41.7		 6r2eA-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.97A 6r2eA-4iqqA:
41.7		 6r2eA-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 ILE A 110
TRP A 111
ASN A 114
LEU A 194
GLY A 224
PHE A 227
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
 1.18A 6r2eA-4iqqA:
41.7		 6r2eA-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 ILE A 110
TRP A 111
LEU A 194
LEU A 223
GLY A 224
PHE A 227
ASN A 228
 D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
 1.24A 6r2eA-4iqqA:
41.7		 6r2eA-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 ILE A 132
TRP A 133
ASN A 136
LEU A 216
PHE A 249
ASN A 250
 D16  A 401 ( 4.0A)
None
None
None
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
 1.10A 6r2eA-5h3aA:
42.5		 6r2eA-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 ILE A 132
TRP A 133
LEU A 216
GLY A 246
PHE A 249
ASN A 250
 D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
 1.18A 6r2eA-5h3aA:
42.5		 6r2eA-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 12 PHE A 104
ASP A 242
GLY A 246
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 0.60A 6r2eA-5h3aA:
42.5		 6r2eA-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 PHE A 104
ILE A 132
GLY A 246
PHE A 249
ASN A 250
TYR A 282
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
UMP  A 402 (-4.5A)
 1.18A 6r2eA-5h3aA:
42.5		 6r2eA-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 PHE A 104
ILE A 132
TRP A 133
ASN A 136
PHE A 249
ASN A 250
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
None
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
 1.22A 6r2eA-5h3aA:
42.5		 6r2eA-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 PHE A 104
ILE A 132
TRP A 133
GLY A 246
PHE A 249
ASN A 250
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
 1.24A 6r2eA-5h3aA:
42.5		 6r2eA-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 10 PHE A  80
ILE A 108
TRP A 109
ASN A 112
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
 0.71A 6r2eB-1hvyA:
46.6		 6r2eB-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 ILE A 110
TRP A 111
ASN A 114
LEU A 194
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.91A 6r2eB-4iqqA:
41.4		 6r2eB-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 ILE A 110
TRP A 111
LEU A 194
LEU A 223
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 1.03A 6r2eB-4iqqA:
41.4		 6r2eB-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 10 ILE A 132
TRP A 133
ASN A 136
LEU A 216
GLY A 246
ASN A 250
 D16  A 401 ( 4.0A)
None
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.85A 6r2eB-5h3aA:
42.1		 6r2eB-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 10 PHE A 104
ILE A 132
TRP A 133
GLY A 246
ASN A 250
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.84A 6r2eB-5h3aA:
42.1		 6r2eB-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 PHE A  80
ILE A 108
TRP A 109
ASN A 112
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
 0.59A 6r2eC-1hvyA:
47.3		 6r2eC-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 PHE A  80
ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
 0.76A 6r2eC-1hvyA:
47.3		 6r2eC-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 ILE A 110
TRP A 111
ASN A 114
LEU A 194
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.94A 6r2eC-4iqqA:
41.7		 6r2eC-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 ILE A 110
TRP A 111
LEU A 194
LEU A 223
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 1.04A 6r2eC-4iqqA:
41.7		 6r2eC-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 10 ILE A 132
TRP A 133
ASN A 136
LEU A 216
GLY A 246
ASN A 250
 D16  A 401 ( 4.0A)
None
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.85A 6r2eC-5h3aA:
42.5		 6r2eC-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 10 PHE A 104
ILE A 132
TRP A 133
GLY A 246
ASN A 250
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.85A 6r2eC-5h3aA:
42.5		 6r2eC-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 PHE A  80
ILE A 108
TRP A 109
ASN A 112
LEU A 192
ASP A 218
GLY A 222
ASN A 226
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
 0.74A 6r2eD-1hvyA:
46.7		 6r2eD-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 10 PHE A  80
ILE A 108
TRP A 109
ASN A 112
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
 0.62A 6r2eD-1hvyA:
46.7		 6r2eD-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 10 ILE A 110
TRP A 111
ASN A 114
LEU A 194
LEU A 223
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.93A 6r2eD-4iqqA:
41.5		 6r2eD-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 10 ILE A 132
TRP A 133
ASN A 136
LEU A 216
GLY A 246
ASN A 250
 D16  A 401 ( 4.0A)
None
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.79A 6r2eD-5h3aA:
42.2		 6r2eD-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 10 PHE A 104
ILE A 132
TRP A 133
GLY A 246
ASN A 250
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.85A 6r2eD-5h3aA:
42.2		 6r2eD-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 PHE A  80
ILE A 108
ASN A 112
TYR A 135
LEU A 192
GLY A 222
PHE A 225
ASN A 226
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
None
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
 1.02A 6r2eE-1hvyA:
47.2		 6r2eE-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 PHE A  80
ILE A 108
ASN A 112
TYR A 135
LEU A 192
LEU A 221
GLY A 222
PHE A 225
ASN A 226
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
 0.84A 6r2eE-1hvyA:
47.2		 6r2eE-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 PHE A  80
ILE A 108
TRP A 109
ASN A 112
TYR A 135
LEU A 192
GLY A 222
ASN A 226
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
None
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
 0.80A 6r2eE-1hvyA:
47.2		 6r2eE-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 PHE A  80
ILE A 108
TRP A 109
ASN A 112
TYR A 135
LEU A 192
LEU A 221
GLY A 222
ASN A 226
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
 0.60A 6r2eE-1hvyA:
47.2		 6r2eE-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 PHE A  80
ILE A 108
TRP A 109
TYR A 135
LEU A 192
GLY A 222
ASN A 226
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
None
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.84A 6r2eE-1hvyA:
47.2		 6r2eE-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 PHE A  80
ILE A 108
TRP A 109
TYR A 135
LEU A 192
LEU A 221
GLY A 222
ASN A 226
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.6A)
 0.76A 6r2eE-1hvyA:
47.2		 6r2eE-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 PHE A  80
ILE A 108
TYR A 135
LEU A 192
GLY A 222
PHE A 225
ASN A 226
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
None
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 1.06A 6r2eE-1hvyA:
47.2		 6r2eE-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 12 PHE A  80
ILE A 108
TYR A 135
LEU A 192
LEU A 221
GLY A 222
PHE A 225
ASN A 226
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
None
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.6A)
 0.98A 6r2eE-1hvyA:
47.2		 6r2eE-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
ASN A 114
GLY A 224
PHE A 227
ASN A 228
 D16  A 402 (-4.0A)
None
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
 1.10A 6r2eE-4iqqA:
41.6		 6r2eE-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
ASN A 114
TYR A 137
LEU A 194
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.83A 6r2eE-4iqqA:
41.6		 6r2eE-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
ASN A 228
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
 0.97A 6r2eE-4iqqA:
41.6		 6r2eE-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
TRP A 111
ASN A 114
PHE A 227
ASN A 228
 D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
 1.09A 6r2eE-4iqqA:
41.6		 6r2eE-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
TRP A 111
ASN A 114
TYR A 137
LEU A 194
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
None
UMP  A 401 (-3.3A)
 0.74A 6r2eE-4iqqA:
41.6		 6r2eE-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
TRP A 111
LEU A 223
PHE A 227
ASN A 228
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
 1.17A 6r2eE-4iqqA:
41.6		 6r2eE-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
TRP A 111
TYR A 137
LEU A 194
LEU A 223
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
D16  A 402 (-3.7A)
UMP  A 401 (-3.3A)
 0.90A 6r2eE-4iqqA:
41.6		 6r2eE-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
TYR A 137
LEU A 194
LEU A 223
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.90A 6r2eE-4iqqA:
41.6		 6r2eE-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 12 ILE A 132
TRP A 133
ASN A 136
LEU A 216
GLY A 246
PHE A 249
ASN A 250
 D16  A 401 ( 4.0A)
None
None
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
 1.13A 6r2eE-5h3aA:
42.5		 6r2eE-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 12 ILE A 132
TRP A 133
ASN A 136
TYR A 159
LEU A 216
GLY A 246
ASN A 250
 D16  A 401 ( 4.0A)
None
None
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.84A 6r2eE-5h3aA:
42.5		 6r2eE-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 PHE A 104
ILE A 132
TRP A 133
GLY A 246
PHE A 249
ASN A 250
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
 1.32A 6r2eE-5h3aA:
42.5		 6r2eE-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 PHE A 104
ILE A 132
TRP A 133
TYR A 159
GLY A 246
ASN A 250
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.93A 6r2eE-5h3aA:
42.5		 6r2eE-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 11 PHE A  80
ILE A 108
TRP A 109
ASN A 112
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
 0.79A 6r2eF-1hvyA:
46.9		 6r2eF-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 11 PHE A  80
ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.82A 6r2eF-1hvyA:
46.9		 6r2eF-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 11 ILE A 110
TRP A 111
ASN A 114
LEU A 194
LEU A 223
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.95A 6r2eF-4iqqA:
41.5		 6r2eF-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 11 ILE A 132
TRP A 133
ASN A 136
LEU A 216
GLY A 246
ASN A 250
 D16  A 401 ( 4.0A)
None
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.78A 6r2eF-5h3aA:
42.3		 6r2eF-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		5 / 11 PHE A 104
ILE A 132
TRP A 133
GLY A 246
ASN A 250
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.80A 6r2eF-5h3aA:
42.3		 6r2eF-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 11 PHE A  80
ILE A 108
ASN A 112
LEU A 192
ASP A 218
LEU A 221
GLY A 222
PHE A 225
ASN A 226
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
 0.84A 6r2eG-1hvyA:
47.1		 6r2eG-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 11 PHE A  80
ILE A 108
LEU A 192
ASP A 218
GLY A 222
PHE A 225
ASN A 226
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
D16  A 414 (-3.6A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
 1.00A 6r2eG-1hvyA:
47.1		 6r2eG-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		9 / 11 PHE A  80
ILE A 108
TRP A 109
ASN A 112
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
 0.61A 6r2eG-1hvyA:
47.1		 6r2eG-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		8 / 11 PHE A  80
ILE A 108
TRP A 109
LEU A 192
ASP A 218
GLY A 222
ASN A 226
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
 0.76A 6r2eG-1hvyA:
47.1		 6r2eG-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 11 ILE A 110
TRP A 111
ASN A 114
LEU A 194
LEU A 223
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.98A 6r2eG-4iqqA:
41.5		 6r2eG-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 11 ILE A 110
TRP A 111
ASN A 114
LEU A 223
GLY A 224
PHE A 227
ASN A 228
 D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
 1.13A 6r2eG-4iqqA:
41.5		 6r2eG-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 11 ILE A 132
TRP A 133
ASN A 136
LEU A 216
GLY A 246
PHE A 249
ASN A 250
 D16  A 401 ( 4.0A)
None
None
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
 1.11A 6r2eG-5h3aA:
42.6		 6r2eG-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 11 PHE A 104
ILE A 132
TRP A 133
GLY A 246
PHE A 249
ASN A 250
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
D16  A 401 ( 3.2A)
D16  A 401 (-3.4A)
UMP  A 402 (-3.2A)
 1.26A 6r2eG-5h3aA:
42.6		 6r2eG-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 12 PHE A  80
ILE A 108
TRP A 109
ASN A 112
TYR A 135
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 ( 4.0A)
None
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
 0.76A 6r2eH-1hvyA:
46.8		 6r2eH-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 12 PHE A  80
ILE A 108
TRP A 109
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
MET A 311
ALA A 312
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
D16  A 414 (-3.6A)
 0.87A 6r2eH-1hvyA:
46.8		 6r2eH-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens) 		10 / 12 PHE A  80
ILE A 108
TRP A 109
TYR A 135
LEU A 192
ASP A 218
LEU A 221
GLY A 222
ASN A 226
MET A 311
 D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
D16  A 414 (-3.7A)
None
None
D16  A 414 ( 3.6A)
D16  A 414 (-4.0A)
D16  A 414 (-3.3A)
UMP  A 314 (-3.0A)
D16  A 414 (-3.4A)
 0.89A 6r2eH-1hvyA:
46.8		 6r2eH-1hvyA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 ILE A 110
TRP A 111
ASN A 114
TYR A 137
LEU A 194
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
None
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.89A 6r2eH-4iqqA:
41.5		 6r2eH-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 ILE A 110
TRP A 111
TYR A 137
LEU A 194
LEU A 223
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.99A 6r2eH-4iqqA:
41.5		 6r2eH-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		7 / 12 ILE A 132
TRP A 133
ASN A 136
TYR A 159
LEU A 216
GLY A 246
ASN A 250
 D16  A 401 ( 4.0A)
None
None
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.89A 6r2eH-5h3aA:
42.3		 6r2eH-5h3aA:
71.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 5h3a ORF70
(Human
gammaherpesvirus
8) 		6 / 12 PHE A 104
ILE A 132
TRP A 133
TYR A 159
GLY A 246
ASN A 250
 D16  A 401 (-3.6A)
D16  A 401 ( 4.0A)
None
None
D16  A 401 ( 3.2A)
UMP  A 402 (-3.2A)
 0.87A 6r2eH-5h3aA:
42.3		 6r2eH-5h3aA:
71.38