SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'D10'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 8 PHE B 250
SER D 155
ILE D 159
LEU B 460
LEU D 291
 CLA  B1010 ( 3.7A)
CLA  D1004 ( 4.7A)
DGD  B1058 (-4.5A)
DGD  B1058 (-3.6A)
DGD  B1058 ( 4.6A)
 1.24A 1eupA-3a0hB:
undetectable		 1eupA-3a0hB:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD6_0
(GRAMICIDIN D)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 TRP D  48
TRP D 111
ALA D 177
VAL D  78
 PHO  D1039 ( 3.5A)
None
None
None
 1.50A 1w5uC-3a0hD:
undetectable
1w5uD-3a0hD:
undetectable		 1w5uC-3a0hD:
4.00
1w5uD-3a0hD:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 1vrq SARCOSINE OXIDASE
DELTA SUBUNIT
(Corynebacterium
sp.
U-96) 		3 / 3 CYH D   6
CYH D  63
HIS D  59
 ZN  D1006 (-2.4A)
ZN  D1006 (-2.4A)
ZN  D1006 (-3.2A)
 0.67A 2iwkA-1vrqD:
2.2		 2iwkA-1vrqD:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 1vrq SARCOSINE OXIDASE
DELTA SUBUNIT
(Corynebacterium
sp.
U-96) 		3 / 3 CYH D   9
CYH D  63
HIS D  59
 ZN  D1006 (-2.3A)
ZN  D1006 (-2.4A)
ZN  D1006 (-3.2A)
 0.60A 2iwkA-1vrqD:
2.2		 2iwkA-1vrqD:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 1vrq SARCOSINE OXIDASE
DELTA SUBUNIT
(Corynebacterium
sp.
U-96) 		3 / 3 CYH D   6
CYH D  63
HIS D  59
 ZN  D1006 (-2.4A)
ZN  D1006 (-2.4A)
ZN  D1006 (-3.2A)
 0.68A 2iwkB-1vrqD:
2.1		 2iwkB-1vrqD:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 1vrq SARCOSINE OXIDASE
DELTA SUBUNIT
(Corynebacterium
sp.
U-96) 		3 / 3 CYH D   9
CYH D  63
HIS D  59
 ZN  D1006 (-2.3A)
ZN  D1006 (-2.4A)
ZN  D1006 (-3.2A)
 0.57A 2iwkB-1vrqD:
2.1		 2iwkB-1vrqD:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC6_0
(GRAMICIDIN D)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 ALA D 177
VAL D  78
TRP D  48
TRP D 111
 None
None
PHO  D1039 ( 3.5A)
None
 1.48A 2izqC-3a0hD:
undetectable
2izqD-3a0hD:
undetectable		 2izqC-3a0hD:
4.00
2izqD-3a0hD:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5knh DARPIN 6G9
(synthetic
construct) 		4 / 6 GLN D 122
ASN D 156
ASN D 107
LEU D 132
 ACT  D1001 (-2.9A)
None
None
None
 1.21A 2nyrA-5knhD:
undetectable		 2nyrA-5knhD:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1vrq SARCOSINE OXIDASE
DELTA SUBUNIT
(Corynebacterium
sp.
U-96) 		3 / 3 CYH D   6
CYH D  63
HIS D  59
 ZN  D1006 (-2.4A)
ZN  D1006 (-2.4A)
ZN  D1006 (-3.2A)
 0.54A 3dtuB-1vrqD:
undetectable		 3dtuB-1vrqD:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1vrq SARCOSINE OXIDASE
DELTA SUBUNIT
(Corynebacterium
sp.
U-96) 		3 / 3 CYH D   9
CYH D  63
HIS D  59
 ZN  D1006 (-2.3A)
ZN  D1006 (-2.4A)
ZN  D1006 (-3.2A)
 0.68A 3dtuB-1vrqD:
undetectable		 3dtuB-1vrqD:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1vrq SARCOSINE OXIDASE
DELTA SUBUNIT
(Corynebacterium
sp.
U-96) 		3 / 3 CYH D   6
CYH D  63
HIS D  59
 ZN  D1006 (-2.4A)
ZN  D1006 (-2.4A)
ZN  D1006 (-3.2A)
 0.51A 3dtuD-1vrqD:
undetectable		 3dtuD-1vrqD:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1vrq SARCOSINE OXIDASE
DELTA SUBUNIT
(Corynebacterium
sp.
U-96) 		3 / 3 CYH D   9
CYH D  63
HIS D  59
 ZN  D1006 (-2.3A)
ZN  D1006 (-2.4A)
ZN  D1006 (-3.2A)
 0.68A 3dtuD-1vrqD:
undetectable		 3dtuD-1vrqD:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 PHE B 464
TYR D 141
ARG D 128
LEU D 122
 MGE  B1060 ( 3.9A)
None
None
PHO  D1039 (-4.7A)
 1.31A 3sueA-3a0hB:
0.0		 3sueA-3a0hB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 TRP D 191
LEU D 279
GLY D 278
VAL D 152
ALA D 151
 CLA  D1004 (-4.8A)
PHO  D1039 ( 4.0A)
PQ9  D1042 ( 4.9A)
CLA  D1004 (-3.9A)
None
 1.05A 4fqsA-3a0hD:
undetectable		 4fqsA-3a0hD:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 TRP D 191
LEU D 279
GLY D 278
VAL D 152
ALA D 151
 CLA  D1004 (-4.8A)
PHO  D1039 ( 4.0A)
PQ9  D1042 ( 4.9A)
CLA  D1004 (-3.9A)
None
 1.07A 4fqsB-3a0hD:
undetectable		 4fqsB-3a0hD:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 3a0h PHOTOSYSTEM II CP43
PROTEIN
PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus;
Thermosynechococ
cus
vulcanus) 		4 / 4 VAL C 466
ALA D 249
ILE C 459
THR D 221
 None
PQ9  D1042 (-3.2A)
None
None
 1.07A 5e4dB-3a0hC:
undetectable		 5e4dB-3a0hC:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 6 HIS D 197
VAL D 286
TYR D 160
HIS D 189
 CLA  D1004 ( 4.3A)
CLA  D1004 (-4.1A)
IOD  D1068 (-3.7A)
None
 1.35A 5kkzA-3a0hD:
undetectable
5kkzG-3a0hD:
undetectable		 5kkzA-3a0hD:
23.06
5kkzG-3a0hD:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 7 HIS D 189
HIS D 197
VAL D 286
TYR D 160
 None
CLA  D1004 ( 4.3A)
CLA  D1004 (-4.1A)
IOD  D1068 (-3.7A)
 1.32A 5kkzM-3a0hD:
undetectable
5kkzO-3a0hD:
undetectable		 5kkzM-3a0hD:
19.76
5kkzO-3a0hD:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5oy9 GLYCOPROTEIN G
LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens;
Indiana
vesiculovirus) 		4 / 5 ASP A 334
GLU D 119
ARG A 354
THR A 352
 None
CA  D1001 (-2.9A)
None
None
 0.87A 5uxcA-5oy9A:
undetectable		 5uxcA-5oy9A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 5ax0 RHODOPSIN I
(Acetabularia
acetabulum) 		5 / 12 ALA A  50
MET A 122
ALA A 149
ALA A 152
LEU A 181
 D10  A 309 ( 3.8A)
RET  A 301 (-3.7A)
R16  A 308 ( 3.8A)
None
None
 1.35A 6aycA-5ax0A:
undetectable		 6aycA-5ax0A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 3a0h PHOTOSYSTEM II CP43
PROTEIN
PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus;
Thermosynechococ
cus
vulcanus) 		5 / 12 ILE C 459
LEU C 467
VAL D 247
PHE D 223
THR D 217
 None
None
None
None
PQ9  D1042 (-2.8A)
 1.08A 6b54A-3a0hC:
undetectable		 6b54A-3a0hC:
19.12