SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CZH'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 3kpx APOPHOTOPROTEIN
CLYTIN-3
(Clytia
gregaria) 		4 / 6 TYR A 193
ILE A 133
TYR A 141
GLY A 142
 None
None
CZH  A 201 (-4.6A)
None
 1.03A 1maaB-3kpxA:
undetectable
1maaD-3kpxA:
undetectable		 1maaB-3kpxA:
15.40
1maaD-3kpxA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 1jf0 OBELIN
(Obelia
longissima) 		4 / 7 PHE A  72
TYR A  28
ILE A  50
TRP A 114
 CZH  A 197 ( 4.6A)
None
None
CZH  A 197 (-3.7A)
 0.82A 1tdnA-1jf0A:
undetectable		 1tdnA-1jf0A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 1qv0 OBELIN
(Obelia
longissima) 		5 / 12 TYR A 190
ALA A 186
GLY A 188
ARG A 173
HIS A 175
 CZH  A 201 (-4.3A)
None
None
None
CZH  A 201 (-3.5A)
 1.09A 1ve3A-1qv0A:
undetectable		 1ve3A-1qv0A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 1qv0 OBELIN
(Obelia
longissima) 		5 / 12 TYR A 190
ALA A 186
GLY A 188
ARG A 173
HIS A 175
 CZH  A 201 (-4.3A)
None
None
None
CZH  A 201 (-3.5A)
 1.05A 1ve3B-1qv0A:
undetectable		 1ve3B-1qv0A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 3kpx APOPHOTOPROTEIN
CLYTIN-3
(Clytia
gregaria) 		5 / 12 TYR A 193
ALA A 189
GLY A 191
ARG A 176
HIS A 178
 None
None
None
None
CZH  A 201 (-3.3A)
 1.07A 1ve3B-3kpxA:
undetectable		 1ve3B-3kpxA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 3kpx APOPHOTOPROTEIN
CLYTIN-3
(Clytia
gregaria) 		4 / 6 THR A 140
GLU A 137
PHE A 122
ILE A 124
 None
None
CZH  A 201 (-4.6A)
None
 1.16A 2w98B-3kpxA:
undetectable		 2w98B-3kpxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1jf0 OBELIN
(Obelia
longissima) 		4 / 8 HIS A 175
ILE A 144
TRP A 179
TYR A 138
 CZH  A 197 (-3.5A)
CZH  A 197 ( 4.5A)
CZH  A 197 (-3.7A)
CZH  A 197 (-4.3A)
 1.28A 3ccfB-1jf0A:
undetectable		 3ccfB-1jf0A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1qv0 OBELIN
(Obelia
longissima) 		4 / 8 HIS A 175
ILE A 144
TRP A 179
TYR A 138
 CZH  A 201 (-3.5A)
CZH  A 201 ( 3.8A)
CZH  A 201 (-3.7A)
CZH  A 201 (-4.5A)
 1.16A 3ccfB-1qv0A:
undetectable		 3ccfB-1qv0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4nqg MITROCOMIN
(Mitrocoma
cellularia) 		4 / 7 LEU A  56
LYS A 126
VAL A 132
LEU A 120
 None
None
None
CZH  A 201 (-4.9A)
 1.00A 4b3qA-4nqgA:
undetectable		 4b3qA-4nqgA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 3kpx APOPHOTOPROTEIN
CLYTIN-3
(Clytia
gregaria) 		4 / 6 PHE A  91
HIS A  25
TYR A 183
PHE A  74
 CZH  A 201 (-4.2A)
CZH  A 201 (-3.8A)
None
None
 1.46A 4o7gB-3kpxA:
undetectable		 4o7gB-3kpxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4nqg MITROCOMIN
(Mitrocoma
cellularia) 		5 / 12 LEU A  56
LYS A 126
VAL A 132
PHE A 121
LEU A 120
 None
None
None
None
CZH  A 201 (-4.9A)
 1.43A 5cymA-4nqgA:
undetectable		 5cymA-4nqgA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 1qv0 OBELIN
(Obelia
longissima) 		4 / 6 ILE A  83
PHE A  85
PHE A  72
TRP A 114
 None
None
CZH  A 201 ( 4.9A)
CZH  A 201 (-3.9A)
 1.37A 5g08A-1qv0A:
3.2		 5g08A-1qv0A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 3kpx APOPHOTOPROTEIN
CLYTIN-3
(Clytia
gregaria) 		3 / 3 TRP A 117
ILE A 147
SER A 145
 CZH  A 201 (-3.8A)
CZH  A 201 (-4.1A)
CZH  A 201 ( 4.5A)
 1.03A 5gqbA-3kpxA:
undetectable		 5gqbA-3kpxA:
16.27