SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CYT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5buv PUTATIVE EPIMERASE
(Yersinia
enterocolitica) 		4 / 8 TYR A  50
HIS A  63
HIS A 120
LYS A  73
 CYT  A 203 (-4.6A)
PO4  A 201 ( 3.8A)
PO4  A 202 (-3.9A)
PO4  A 202 (-2.8A)
 1.18A 1eqbA-5buvA:
undetectable
1eqbB-5buvA:
undetectable		 1eqbA-5buvA:
17.83
1eqbB-5buvA:
17.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 GLU A 203
VAL A 219
GLY A 220
MET A 221
HIS A 259
 CYT  A 301 (-2.9A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
None
 0.90A 1pwyE-5ko5A:
39.6		 1pwyE-5ko5A:
46.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 GLY A 120
VAL A 219
GLY A 220
MET A 221
ASN A 245
 CYT  A 301 (-3.3A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
CYT  A 301 (-3.2A)
 0.54A 1pwyE-5ko5A:
39.6		 1pwyE-5ko5A:
46.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 GLY A 120
VAL A 219
GLY A 220
MET A 221
HIS A 259
 CYT  A 301 (-3.3A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
None
 0.59A 1pwyE-5ko5A:
39.6		 1pwyE-5ko5A:
46.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 GLU A 203
VAL A 219
GLY A 220
MET A 221
HIS A 259
 CYT  A 301 (-2.9A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
None
 0.89A 1v3qE-5ko5A:
40.4		 1v3qE-5ko5A:
46.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 GLY A 120
VAL A 219
GLY A 220
MET A 221
ASN A 245
 CYT  A 301 (-3.3A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
CYT  A 301 (-3.2A)
 0.41A 1v3qE-5ko5A:
40.4		 1v3qE-5ko5A:
46.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 GLY A 120
VAL A 219
GLY A 220
MET A 221
HIS A 259
 CYT  A 301 (-3.3A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
None
 0.36A 1v3qE-5ko5A:
40.4		 1v3qE-5ko5A:
46.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 7 GLY A 120
GLY A 121
ASP A 250
VAL A 262
 CYT  A 301 (-3.3A)
None
None
None
 0.77A 2oa1B-5ko5A:
undetectable		 2oa1B-5ko5A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 5buv PUTATIVE EPIMERASE
(Yersinia
enterocolitica) 		4 / 8 HIS A 139
PRO A 141
ASP A 144
SER A 164
 CYT  A 203 (-3.7A)
None
None
None
 1.23A 2p02A-5buvA:
undetectable		 2p02A-5buvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfohalobium
retbaense) 		4 / 6 GLU A 462
PHE A 464
GLN A 489
PRO A 490
 CYT  A 602 (-2.8A)
None
None
None
 1.39A 2qqtA-5ereA:
0.1		 2qqtA-5ereA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		6 / 6 GLY A 120
TYR A 202
GLU A 203
GLY A 220
MET A 221
ASN A 245
 CYT  A 301 (-3.3A)
CYT  A 301 (-4.6A)
CYT  A 301 (-2.9A)
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
CYT  A 301 (-3.2A)
 1.06A 3e9rA-5ko5A:
43.9		 3e9rA-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		6 / 6 GLY A 120
TYR A 202
GLU A 203
GLY A 220
MET A 221
ASN A 245
 CYT  A 301 (-3.3A)
CYT  A 301 (-4.6A)
CYT  A 301 (-2.9A)
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
CYT  A 301 (-3.2A)
 1.02A 3e9rC-5ko5A:
44.4		 3e9rC-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		8 / 12 GLY A 120
TYR A 202
GLU A 203
VAL A 219
GLY A 220
MET A 221
ASN A 245
VAL A 262
 CYT  A 301 (-3.3A)
CYT  A 301 (-4.6A)
CYT  A 301 (-2.9A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
CYT  A 301 (-3.2A)
None
 1.05A 3f8wA-5ko5A:
44.1		 3f8wA-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		10 / 12 SER A  35
TYR A  90
GLY A 120
TYR A 202
GLU A 203
VAL A 219
GLY A 220
MET A 221
HIS A 259
VAL A 262
 EDO  A 302 (-3.6A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.6A)
CYT  A 301 (-2.9A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
None
None
 0.92A 3f8wA-5ko5A:
44.1		 3f8wA-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		8 / 12 GLY A 120
TYR A 202
VAL A 219
GLY A 220
MET A 221
ASN A 245
HIS A 259
VAL A 262
 CYT  A 301 (-3.3A)
CYT  A 301 (-4.6A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
CYT  A 301 (-3.2A)
None
None
 0.61A 3f8wB-5ko5A:
43.8		 3f8wB-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		10 / 12 SER A  35
HIS A  88
TYR A  90
GLY A 120
TYR A 202
VAL A 219
GLY A 220
MET A 221
HIS A 259
VAL A 262
 EDO  A 302 (-3.6A)
EDO  A 302 (-4.5A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.6A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
None
None
 0.56A 3f8wB-5ko5A:
43.8		 3f8wB-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		10 / 12 SER A  35
HIS A  88
TYR A  90
TYR A 202
GLU A 203
VAL A 219
GLY A 220
MET A 221
HIS A 259
VAL A 262
 EDO  A 302 (-3.6A)
EDO  A 302 (-4.5A)
None
CYT  A 301 (-4.6A)
CYT  A 301 (-2.9A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
None
None
 0.90A 3f8wB-5ko5A:
43.8		 3f8wB-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		8 / 12 TYR A 202
GLU A 203
VAL A 219
GLY A 220
MET A 221
ASN A 245
HIS A 259
VAL A 262
 CYT  A 301 (-4.6A)
CYT  A 301 (-2.9A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
CYT  A 301 (-3.2A)
None
None
 1.02A 3f8wB-5ko5A:
43.8		 3f8wB-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		7 / 12 GLY A 120
TYR A 202
VAL A 219
GLY A 220
MET A 221
ASN A 245
VAL A 262
 CYT  A 301 (-3.3A)
CYT  A 301 (-4.6A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
CYT  A 301 (-3.2A)
None
 0.64A 3f8wC-5ko5A:
44.1		 3f8wC-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		9 / 12 SER A  35
HIS A  88
TYR A  90
GLY A 120
TYR A 202
VAL A 219
GLY A 220
MET A 221
VAL A 262
 EDO  A 302 (-3.6A)
EDO  A 302 (-4.5A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.6A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
None
 0.56A 3f8wC-5ko5A:
44.1		 3f8wC-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		9 / 12 SER A  35
HIS A  88
TYR A  90
TYR A 202
GLU A 203
VAL A 219
GLY A 220
MET A 221
VAL A 262
 EDO  A 302 (-3.6A)
EDO  A 302 (-4.5A)
None
CYT  A 301 (-4.6A)
CYT  A 301 (-2.9A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
None
 0.93A 3f8wC-5ko5A:
44.1		 3f8wC-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		7 / 12 TYR A 202
GLU A 203
VAL A 219
GLY A 220
MET A 221
ASN A 245
VAL A 262
 CYT  A 301 (-4.6A)
CYT  A 301 (-2.9A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
CYT  A 301 (-3.2A)
None
 1.08A 3f8wC-5ko5A:
44.1		 3f8wC-5ko5A:
62.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5buv PUTATIVE EPIMERASE
(Yersinia
enterocolitica) 		4 / 7 HIS A 139
PRO A 141
ASP A 144
SER A 164
 CYT  A 203 (-3.7A)
None
None
None
 1.24A 4ndnC-5buvA:
undetectable		 4ndnC-5buvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5buv PUTATIVE EPIMERASE
(Yersinia
enterocolitica) 		4 / 7 HIS A 139
PRO A 141
ASP A 144
SER A 164
 CYT  A 203 (-3.7A)
None
None
None
 1.27A 4odjA-5buvA:
undetectable		 4odjA-5buvA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5buv PUTATIVE EPIMERASE
(Yersinia
enterocolitica) 		4 / 7 HIS A 139
PRO A 141
ASP A 144
SER A 164
 CYT  A 203 (-3.7A)
None
None
None
 1.25A 5a1iA-5buvA:
undetectable		 5a1iA-5buvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfohalobium
retbaense) 		5 / 12 ALA A 382
GLY A 389
SER A 485
ASP A 375
PRO A 472
 None
None
CYT  A 602 (-3.5A)
None
None
 1.13A 5zvgA-5ereA:
undetectable		 5zvgA-5ereA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfohalobium
retbaense) 		5 / 12 ALA A 382
GLY A 389
SER A 485
ASP A 375
PRO A 472
 None
None
CYT  A 602 (-3.5A)
None
None
 1.16A 5zvgB-5ereA:
2.2		 5zvgB-5ereA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfohalobium
retbaense) 		5 / 12 HIS A 447
VAL A 453
VAL A 461
THR A 420
GLY A 419
 None
None
CYT  A 602 (-3.7A)
None
None
 1.10A 6brdA-5ereA:
undetectable		 6brdA-5ereA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5buv PUTATIVE EPIMERASE
(Yersinia
enterocolitica) 		4 / 7 HIS A 139
PRO A 141
ASP A 144
SER A 164
 CYT  A 203 (-3.7A)
None
None
None
 1.25A 6g6rA-5buvA:
undetectable		 6g6rA-5buvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfohalobium
retbaense) 		4 / 7 ILE A 443
GLN A 440
GLU A 435
VAL A 415
 None
CYT  A 602 (-2.9A)
None
None
 1.12A 6j20A-5ereA:
undetectable		 6j20A-5ereA:
22.56