SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CYS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 4zu9 ELONGATION FACTOR
SELB
(Aquifex
aeolicus) 		5 / 12 ARG A 198
GLY A 199
LEU A 246
VAL A 223
ALA A 236
 CYS  A2006 (-3.8A)
None
None
None
None
 1.16A 1gseA-4zu9A:
undetectable		 1gseA-4zu9A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 8 ARG A 105
SER A 102
SER A  75
LYS A  46
 PLP  A 403 ( 4.9A)
None
CYS  A 401 ( 2.6A)
PLP  A 403 ( 1.4A)
 1.02A 1hwiB-4lmbA:
undetectable		 1hwiB-4lmbA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 8 ARG A 105
SER A 102
SER A  75
LYS A  46
 PLP  A 403 ( 4.9A)
None
CYS  A 401 ( 2.6A)
PLP  A 403 ( 1.4A)
 1.01A 1hwkA-4lmbA:
undetectable		 1hwkA-4lmbA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 8 ARG A 105
SER A 102
SER A  75
LYS A  46
 PLP  A 403 ( 4.9A)
None
CYS  A 401 ( 2.6A)
PLP  A 403 ( 1.4A)
 1.04A 1hwkC-4lmbA:
undetectable		 1hwkC-4lmbA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 8 ARG A 105
SER A 102
SER A  75
LYS A  46
 PLP  A 403 ( 4.9A)
None
CYS  A 401 ( 2.6A)
PLP  A 403 ( 1.4A)
 1.05A 1hwkD-4lmbA:
undetectable		 1hwkD-4lmbA:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NKI_A_PPFA5001_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 4jh8 METALLOTHIOL
TRANSFERASE FOSB
(Bacillus
cereus) 		5 / 9 TYR A  64
HIS A  66
TYR A 105
GLU A 115
ARG A 124
 CYS  A 205 ( 4.3A)
ZN  A 201 ( 3.2A)
FCN  A 204 (-4.8A)
ZN  A 201 ( 2.5A)
FCN  A 204 (-2.9A)
 0.37A 1nkiA-4jh8A:
17.7
1nkiB-4jh8A:
17.5		 1nkiA-4jh8A:
35.25
1nkiB-4jh8A:
35.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NKI_B_PPFB5002_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 4jh8 METALLOTHIOL
TRANSFERASE FOSB
(Bacillus
cereus) 		5 / 9 TYR A  64
HIS A  66
TYR A 105
GLU A 115
ARG A 124
 CYS  A 205 ( 4.3A)
ZN  A 201 ( 3.2A)
FCN  A 204 (-4.8A)
ZN  A 201 ( 2.5A)
FCN  A 204 (-2.9A)
 0.39A 1nkiA-4jh8A:
17.7
1nkiB-4jh8A:
17.5		 1nkiA-4jh8A:
35.25
1nkiB-4jh8A:
35.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		5 / 8 GLY A  26
ALA A 223
LEU A 334
ILE A 305
HIS A 373
 CYS  A2002 (-4.8A)
None
None
None
None
 1.06A 1yajC-1n31A:
undetectable		 1yajC-1n31A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		5 / 8 GLY A  29
GLY A  26
ALA A 223
ILE A 305
HIS A 373
 None
CYS  A2002 (-4.8A)
None
None
None
 1.09A 1yajC-1n31A:
undetectable		 1yajC-1n31A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 5 LEU A 352
ASP A 349
GLY A 165
ALA A 356
 None
None
CYS  A 371 (-3.4A)
None
 0.95A 2aohA-3pzrA:
undetectable		 2aohA-3pzrA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		5 / 12 GLY A  26
PHE A  25
TYR A 358
ALA A 199
ALA A 223
 CYS  A2002 (-4.8A)
None
None
PLP  A2001 (-3.4A)
None
 1.06A 2avdB-1n31A:
3.8		 2avdB-1n31A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		5 / 12 GLY A  27
PHE A  25
TYR A 358
ALA A 199
ALA A 223
 CYS  A2002 (-3.3A)
None
None
PLP  A2001 (-3.4A)
None
 1.40A 2avdB-1n31A:
3.8		 2avdB-1n31A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		5 / 12 THR A 170
GLY A 171
GLY A 333
GLN A 200
ILE A 362
 None
None
None
CYS  A2002 ( 4.2A)
None
 1.33A 2azxA-1n31A:
2.4		 2azxA-1n31A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1n31 L-CYSTEINE/CYSTINE
LYASE C-DES
(Synechocystis
sp.
PCC
6714) 		5 / 12 THR A 170
GLY A 171
GLY A 333
GLN A 200
ILE A 362
 None
None
None
CYS  A2002 ( 4.2A)
None
 1.35A 2azxB-1n31A:
2.2		 2azxB-1n31A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 168
ALA A 171
ALA A 204
SER A 162
VAL A 159
 None
None
None
CYS  A 401 ( 4.6A)
None
 1.13A 2bxeB-3tz6A:
undetectable		 2bxeB-3tz6A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		3 / 3 SER A 275
TYR A 160
HIS A 274
 None
None
CYS  A 371 (-3.9A)
 0.71A 2r2vD-3pzrA:
undetectable		 2r2vD-3pzrA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 SER A 257
TYR A 156
HIS A 256
 None
None
CYS  A 401 (-3.9A)
 0.76A 2r2vD-3tz6A:
undetectable		 2r2vD-3tz6A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 8 LEU A 180
ALA A 140
ALA A  71
PHE A  27
 None
None
CYS  A 401 ( 4.7A)
CYS  A 401 (-4.6A)
 0.88A 2vcvF-1xt8A:
undetectable		 2vcvF-1xt8A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 VAL A  54
GLY A  79
TYR A  91
TYR A 112
SER A  75
 None
None
None
None
CYS  A 401 ( 2.6A)
 1.23A 2zthA-4lmbA:
3.5		 2zthA-4lmbA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 HIS A 234
ASP A  69
THR A  68
HIS A 224
 ZN  A 963 ( 3.1A)
None
CYS  A1000 (-3.3A)
None
 1.42A 3ag1A-1li7A:
0.0
3ag1C-1li7A:
0.0		 3ag1A-1li7A:
21.22
3ag1C-1li7A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 HIS A 234
ASP A  69
THR A  68
HIS A 224
 ZN  A 963 ( 3.1A)
None
CYS  A1000 (-3.3A)
None
 1.41A 3ag4N-1li7A:
0.0
3ag4P-1li7A:
undetectable		 3ag4N-1li7A:
21.22
3ag4P-1li7A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 6 LEU A  93
ILE A  80
ALA A  81
THR A  74
 None
None
None
CYS  A 401 (-3.6A)
 1.09A 3mdrA-4lmbA:
undetectable		 3mdrA-4lmbA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 5 GLY A 227
GLU A 206
GLY A 229
PRO A 207
 CYS  A 402 ( 4.9A)
None
None
None
 1.08A 3onnA-4lmbA:
2.1		 3onnA-4lmbA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1pqu ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 ARG A 270
SER A 166
ALA A 168
LEU A 176
ILE A 271
 CYS  A1374 (-2.5A)
NAP  A1372 (-4.8A)
CYS  A1374 ( 4.8A)
None
None
 1.38A 3qt0A-1pquA:
0.0		 3qt0A-1pquA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ARG A 350
ILE A 155
ALA A 148
VAL A 334
LEU A 335
 CYS  A 502 (-2.4A)
None
None
None
None
 1.26A 3s79A-1ecxA:
undetectable		 3s79A-1ecxA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 4h7o SERINE
ACETYLTRANSFERASE
(Vibrio
cholerae) 		5 / 11 GLY A 165
ALA A 168
ILE A 154
LEU A 156
ILE A 176
 CYS  A 301 ( 4.6A)
None
None
None
None
 1.10A 4dt8A-4h7oA:
undetectable		 4dt8A-4h7oA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 3gvd SERINE
ACETYLTRANSFERASE
(Yersinia
pestis) 		5 / 10 GLY A 165
ALA A 168
ILE A 154
LEU A 156
ILE A 176
 CYS  A 501 ( 4.5A)
None
None
None
None
 1.10A 4dt8B-3gvdA:
undetectable		 4dt8B-3gvdA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 4h7o SERINE
ACETYLTRANSFERASE
(Vibrio
cholerae) 		5 / 10 GLY A 165
ALA A 168
ILE A 154
LEU A 156
ILE A 176
 CYS  A 301 ( 4.6A)
None
None
None
None
 1.00A 4dt8B-4h7oA:
undetectable		 4dt8B-4h7oA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1ssq SERINE
ACETYLTRANSFERASE
(Haemophilus
influenzae) 		4 / 4 ALA A  90
VAL A  91
ASP A  88
LEU A 101
 CYS  A2000 (-3.5A)
None
CYS  A2000 (-3.1A)
None
 0.95A 4e7gA-1ssqA:
0.0		 4e7gA-1ssqA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3gvd SERINE
ACETYLTRANSFERASE
(Yersinia
pestis) 		4 / 4 ALA A  94
VAL A  95
ASP A  92
LEU A 105
 CYS  A 276 (-3.5A)
None
CYS  A 276 (-2.7A)
None
 0.93A 4e7gA-3gvdA:
undetectable		 4e7gA-3gvdA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4h7o SERINE
ACETYLTRANSFERASE
(Vibrio
cholerae) 		4 / 4 ALA A  94
VAL A  95
ASP A  92
LEU A 105
 CYS  A 303 ( 3.7A)
None
CYS  A 303 (-2.9A)
None
 0.92A 4e7gA-4h7oA:
undetectable		 4e7gA-4h7oA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		4 / 7 ASN L  68
GLY L  70
THR L  74
ILE L   9
 None
SF4  L 423 (-3.9A)
CYS  L 432 (-3.3A)
None
 0.88A 4ejjA-1hfeL:
undetectable		 4ejjA-1hfeL:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 GLY A 233
GLY A 231
VAL A 116
LEU A 118
SER A 130
 None
GOL  A1283 (-3.4A)
CYS  A 500 (-3.6A)
None
None
 0.87A 4f84A-2ylnA:
undetectable		 4f84A-2ylnA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		4 / 7 VAL A 181
SER A 165
GLN A 161
LEU A 184
 None
CYS  A 600 ( 4.1A)
None
CYS  A 600 (-4.3A)
 1.22A 4hxyB-2ylnA:
undetectable		 4hxyB-2ylnA:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IR0_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 4jh8 METALLOTHIOL
TRANSFERASE FOSB
(Bacillus
cereus) 		6 / 11 TYR A  64
HIS A  66
ARG A  94
TYR A 105
GLU A 115
ARG A 124
 CYS  A 205 ( 4.3A)
ZN  A 201 ( 3.2A)
FCN  A 204 ( 3.9A)
FCN  A 204 (-4.8A)
ZN  A 201 ( 2.5A)
FCN  A 204 (-2.9A)
 0.20A 4ir0A-4jh8A:
20.7
4ir0B-4jh8A:
21.4		 4ir0A-4jh8A:
67.63
4ir0B-4jh8A:
67.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IR0_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 4jh8 METALLOTHIOL
TRANSFERASE FOSB
(Bacillus
cereus) 		6 / 11 TYR A  64
HIS A  66
ARG A  94
TYR A 105
GLU A 115
ARG A 124
 CYS  A 205 ( 4.3A)
ZN  A 201 ( 3.2A)
FCN  A 204 ( 3.9A)
FCN  A 204 (-4.8A)
ZN  A 201 ( 2.5A)
FCN  A 204 (-2.9A)
 0.17A 4ir0A-4jh8A:
20.7
4ir0B-4jh8A:
21.4		 4ir0A-4jh8A:
67.63
4ir0B-4jh8A:
67.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 4jh8 METALLOTHIOL
TRANSFERASE FOSB
(Bacillus
cereus) 		6 / 12 TYR A  64
HIS A  66
ARG A  94
TYR A 105
GLU A 115
ARG A 124
 CYS  A 205 ( 4.3A)
ZN  A 201 ( 3.2A)
FCN  A 204 ( 3.9A)
FCN  A 204 (-4.8A)
ZN  A 201 ( 2.5A)
FCN  A 204 (-2.9A)
 0.21A 4jd1A-4jh8A:
20.7
4jd1B-4jh8A:
20.6		 4jd1A-4jh8A:
67.63
4jd1B-4jh8A:
67.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 4jh8 METALLOTHIOL
TRANSFERASE FOSB
(Bacillus
cereus) 		6 / 12 TYR A  64
HIS A  66
ARG A  94
TYR A 105
GLU A 115
ARG A 124
 CYS  A 205 ( 4.3A)
ZN  A 201 ( 3.2A)
FCN  A 204 ( 3.9A)
FCN  A 204 (-4.8A)
ZN  A 201 ( 2.5A)
FCN  A 204 (-2.9A)
 0.20A 4jd1A-4jh8A:
20.7
4jd1B-4jh8A:
20.6		 4jd1A-4jh8A:
67.63
4jd1B-4jh8A:
67.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4jh8 METALLOTHIOL
TRANSFERASE FOSB
(Bacillus
cereus) 		6 / 12 TYR A  64
HIS A  66
ARG A  94
TYR A 105
GLU A 115
ARG A 124
 CYS  A 205 ( 4.3A)
ZN  A 201 ( 3.2A)
FCN  A 204 ( 3.9A)
FCN  A 204 (-4.8A)
ZN  A 201 ( 2.5A)
FCN  A 204 (-2.9A)
 0.07A 4jh3A-4jh8A:
23.6
4jh3B-4jh8A:
24.4		 4jh3A-4jh8A:
100.00
4jh3B-4jh8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH3_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4jh8 METALLOTHIOL
TRANSFERASE FOSB
(Bacillus
cereus) 		6 / 11 TYR A  64
HIS A  66
ARG A  94
TYR A 105
GLU A 115
ARG A 124
 CYS  A 205 ( 4.3A)
ZN  A 201 ( 3.2A)
FCN  A 204 ( 3.9A)
FCN  A 204 (-4.8A)
ZN  A 201 ( 2.5A)
FCN  A 204 (-2.9A)
 0.10A 4jh3A-4jh8A:
23.6
4jh3B-4jh8A:
24.4		 4jh3A-4jh8A:
100.00
4jh3B-4jh8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH4_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4jh8 METALLOTHIOL
TRANSFERASE FOSB
(Bacillus
cereus) 		6 / 11 TYR A  64
HIS A  66
ARG A  94
TYR A 105
GLU A 115
ARG A 124
 CYS  A 205 ( 4.3A)
ZN  A 201 ( 3.2A)
FCN  A 204 ( 3.9A)
FCN  A 204 (-4.8A)
ZN  A 201 ( 2.5A)
FCN  A 204 (-2.9A)
 0.13A 4jh4A-4jh8A:
24.3
4jh4B-4jh8A:
23.5		 4jh4A-4jh8A:
100.00
4jh4B-4jh8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH4_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4jh8 METALLOTHIOL
TRANSFERASE FOSB
(Bacillus
cereus) 		6 / 11 TYR A  64
HIS A  66
ARG A  94
TYR A 105
GLU A 115
ARG A 124
 CYS  A 205 ( 4.3A)
ZN  A 201 ( 3.2A)
FCN  A 204 ( 3.9A)
FCN  A 204 (-4.8A)
ZN  A 201 ( 2.5A)
FCN  A 204 (-2.9A)
 0.11A 4jh4A-4jh8A:
24.3
4jh4B-4jh8A:
23.5		 4jh4A-4jh8A:
100.00
4jh4B-4jh8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH5_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4jh8 METALLOTHIOL
TRANSFERASE FOSB
(Bacillus
cereus) 		6 / 11 TYR A  64
HIS A  66
ARG A  94
TYR A 105
GLU A 115
ARG A 124
 CYS  A 205 ( 4.3A)
ZN  A 201 ( 3.2A)
FCN  A 204 ( 3.9A)
FCN  A 204 (-4.8A)
ZN  A 201 ( 2.5A)
FCN  A 204 (-2.9A)
 0.10A 4jh5A-4jh8A:
24.3
4jh5B-4jh8A:
23.5		 4jh5A-4jh8A:
100.00
4jh5B-4jh8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH5_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4jh8 METALLOTHIOL
TRANSFERASE FOSB
(Bacillus
cereus) 		6 / 11 TYR A  64
HIS A  66
ARG A  94
TYR A 105
GLU A 115
ARG A 124
 CYS  A 205 ( 4.3A)
ZN  A 201 ( 3.2A)
FCN  A 204 ( 3.9A)
FCN  A 204 (-4.8A)
ZN  A 201 ( 2.5A)
FCN  A 204 (-2.9A)
 0.06A 4jh5A-4jh8A:
24.3
4jh5B-4jh8A:
23.5		 4jh5A-4jh8A:
100.00
4jh5B-4jh8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH6_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4jh8 METALLOTHIOL
TRANSFERASE FOSB
(Bacillus
cereus) 		6 / 10 TYR A  64
HIS A  66
ARG A  94
TYR A 105
GLU A 115
ARG A 124
 CYS  A 205 ( 4.3A)
ZN  A 201 ( 3.2A)
FCN  A 204 ( 3.9A)
FCN  A 204 (-4.8A)
ZN  A 201 ( 2.5A)
FCN  A 204 (-2.9A)
 0.12A 4jh6A-4jh8A:
24.4
4jh6B-4jh8A:
23.6		 4jh6A-4jh8A:
100.00
4jh6B-4jh8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH6_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4jh8 METALLOTHIOL
TRANSFERASE FOSB
(Bacillus
cereus) 		6 / 10 TYR A  64
HIS A  66
ARG A  94
TYR A 105
GLU A 115
ARG A 124
 CYS  A 205 ( 4.3A)
ZN  A 201 ( 3.2A)
FCN  A 204 ( 3.9A)
FCN  A 204 (-4.8A)
ZN  A 201 ( 2.5A)
FCN  A 204 (-2.9A)
 0.09A 4jh6A-4jh8A:
24.4
4jh6B-4jh8A:
23.6		 4jh6A-4jh8A:
100.00
4jh6B-4jh8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_F_ACTF701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 4 PHE A  44
HIS A  40
GLY A  29
ILE A  30
 None
None
CYS  A1000 (-4.3A)
CYS  A1000 (-4.9A)
 1.27A 4k50E-1li7A:
0.0		 4k50E-1li7A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_M_ACTM503_0
(RNA POLYMERASE
3D-POL)		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 4 PHE A  44
HIS A  40
GLY A  29
ILE A  30
 None
None
CYS  A1000 (-4.3A)
CYS  A1000 (-4.9A)
 1.26A 4k50M-1li7A:
0.0		 4k50M-1li7A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 7 THR A  78
ILE A  49
THR A 185
GLY A 183
 CYS  A 401 (-3.9A)
None
PLP  A 403 (-3.5A)
PLP  A 403 (-3.4A)
 0.88A 4l39B-4lmbA:
2.2		 4l39B-4lmbA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 8 ILE A 195
HIS A 176
THR A 138
THR A 139
 None
CYS  A 401 ( 4.7A)
CYS  A 401 (-4.4A)
CYS  A 401 (-3.4A)
 0.86A 4n16A-1xt8A:
undetectable		 4n16A-1xt8A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		4 / 8 ILE A 223
HIS A 204
THR A 166
THR A 167
 None
CYS  A 350 (-4.7A)
CYS  A 350 (-4.5A)
CYS  A 350 (-3.4A)
 0.81A 4n16A-2yjpA:
undetectable		 4n16A-2yjpA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		7 / 11 HIS A 102
ASP A 137
GLU A 171
GLU A 172
GLY A 420
GLY A 421
HIS A 450
 None
ZN  A 501 (-2.3A)
GLY  A 503 (-3.2A)
ZN  A 501 ( 2.0A)
None
CYS  A 504 ( 4.6A)
ZN  A 501 ( 3.2A)
 0.67A 4pqaA-4g1pA:
31.4		 4pqaA-4g1pA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 3gvd SERINE
ACETYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 LEU A 156
ILE A 202
ILE A 208
GLY A 183
ILE A 176
 None
None
None
CYS  A 501 ( 3.9A)
None
 0.94A 4q1yB-3gvdA:
undetectable		 4q1yB-3gvdA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 4h7o SERINE
ACETYLTRANSFERASE
(Vibrio
cholerae) 		5 / 12 LEU A 156
ILE A 202
ILE A 208
GLY A 183
ILE A 176
 None
None
None
CYS  A 301 ( 4.1A)
None
 0.96A 4q1yB-4h7oA:
undetectable		 4q1yB-4h7oA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1pqu ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 9 SER A 166
ALA A 168
LEU A 176
LEU A 223
ILE A 271
 NAP  A1372 (-4.8A)
CYS  A1374 ( 4.8A)
None
None
None
 1.23A 4xtaA-1pquA:
undetectable		 4xtaA-1pquA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 8 ALA A   9
HIS A  99
ASN A 150
LYS A 203
ARG A 350
 CYS  A 502 ( 4.2A)
PLP  A 500 ( 3.6A)
CYS  A 502 ( 3.3A)
PLP  A 500 (-2.4A)
CYS  A 502 (-2.4A)
 0.53A 5db5A-1ecxA:
42.7
5db5B-1ecxA:
42.4		 5db5A-1ecxA:
27.38
5db5B-1ecxA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ARG A 350
ILE A 155
ALA A 148
VAL A 334
LEU A 335
 CYS  A 502 (-2.4A)
None
None
None
None
 1.26A 5jkvA-1ecxA:
undetectable		 5jkvA-1ecxA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 ALA A 132
ILE A 240
GLY A 178
PHE A 230
THR A  74
 None
None
None
None
CYS  A 401 (-3.6A)
 1.13A 5jlcA-4lmbA:
undetectable		 5jlcA-4lmbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 ILE A 226
MET A 101
ALA A 255
SER A 266
PRO A 296
 PLP  A 403 ( 4.7A)
CYS  A 402 (-4.5A)
None
None
PLP  A 403 (-4.1A)
 1.38A 5mlmA-4lmbA:
undetectable		 5mlmA-4lmbA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		4 / 4 GLY L 123
ALA L 113
MET L 391
THR L 260
 None
None
CYS  L 432 (-3.7A)
None
 1.34A 5n0sB-1hfeL:
0.8		 5n0sB-1hfeL:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 GLY A 183
GLY A 229
GLY A 227
GLY A 181
GLU A 206
 PLP  A 403 (-3.4A)
None
CYS  A 402 ( 4.9A)
PLP  A 403 (-3.6A)
None
 0.92A 5njvC-4lmbA:
undetectable		 5njvC-4lmbA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 207
VAL A 250
TYR A 156
GLN A 157
 None
None
None
CYS  A 401 (-4.1A)
 1.07A 5qggA-3tz6A:
undetectable		 5qggA-3tz6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 250
TYR A 156
GLN A 157
 None
None
CYS  A 401 (-4.1A)
 0.60A 5qgkA-3tz6A:
undetectable		 5qgkA-3tz6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 207
VAL A 250
TYR A 156
GLN A 157
 None
None
None
CYS  A 401 (-4.1A)
 1.09A 5qgoA-3tz6A:
undetectable		 5qgoA-3tz6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 207
VAL A 250
TYR A 156
GLN A 157
 None
None
None
CYS  A 401 (-4.1A)
 1.07A 5qgpA-3tz6A:
undetectable		 5qgpA-3tz6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 207
VAL A 250
TYR A 156
GLN A 157
 None
None
None
CYS  A 401 (-4.1A)
 1.09A 5qgqA-3tz6A:
undetectable		 5qgqA-3tz6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 250
TYR A 156
GLN A 157
 None
None
CYS  A 401 (-4.1A)
 0.58A 5qgrA-3tz6A:
undetectable		 5qgrA-3tz6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 250
TYR A 156
GLN A 157
 None
None
CYS  A 401 (-4.1A)
 0.57A 5qgtA-3tz6A:
undetectable		 5qgtA-3tz6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 207
VAL A 250
TYR A 156
GLN A 157
 None
None
None
CYS  A 401 (-4.1A)
 1.07A 5qhbA-3tz6A:
undetectable		 5qhbA-3tz6A:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V3D_A_FCNA205_1
(FOSFOMYCIN
RESISTANCE PROTEIN)		 4jh8 METALLOTHIOL
TRANSFERASE FOSB
(Bacillus
cereus) 		5 / 10 TYR A  64
HIS A  66
TYR A 105
GLU A 115
ARG A 124
 CYS  A 205 ( 4.3A)
ZN  A 201 ( 3.2A)
FCN  A 204 (-4.8A)
ZN  A 201 ( 2.5A)
FCN  A 204 (-2.9A)
 0.40A 5v3dA-4jh8A:
17.4
5v3dB-4jh8A:
17.5		 5v3dA-4jh8A:
38.57
5v3dB-4jh8A:
38.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 GLY A 183
GLY A 229
GLY A 227
GLY A 181
GLU A 206
 PLP  A 403 (-3.4A)
None
CYS  A 402 ( 4.9A)
PLP  A 403 (-3.6A)
None
 0.96A 5vimA-4lmbA:
undetectable		 5vimA-4lmbA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1li7 CYSTEINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 THR A  68
GLU A 208
HIS A 206
 CYS  A1000 (-3.3A)
CYS  A1000 ( 4.9A)
None
 0.90A 5xiqD-1li7A:
2.2		 5xiqD-1li7A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 4h7o SERINE
ACETYLTRANSFERASE
(Vibrio
cholerae) 		4 / 5 THR A 167
ARG A 192
THR A 130
GLN A 133
 None
CYS  A 301 (-3.8A)
None
None
 1.37A 6ectA-4h7oA:
undetectable		 6ectA-4h7oA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 4h7o SERINE
ACETYLTRANSFERASE
(Vibrio
cholerae) 		4 / 5 THR A 167
ARG A 192
THR A 130
GLN A 133
 None
CYS  A 301 (-3.8A)
None
None
 1.45A 6ecxA-4h7oA:
undetectable		 6ecxA-4h7oA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 1pqu ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Haemophilus
influenzae) 		4 / 7 VAL A  16
LEU A 328
GLY A 326
GLY A 167
 None
None
None
CYS  A1374 (-3.1A)
 0.71A 6eu9D-1pquA:
0.0		 6eu9D-1pquA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 7 VAL A  15
LEU A 325
GLY A 323
GLY A 165
 None
None
None
CYS  A 371 (-3.4A)
 0.76A 6eu9D-3pzrA:
undetectable		 6eu9D-3pzrA:
12.36