SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CYR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 400
GLN A 162
ILE A  46
ARG A 399
GLY A 398
 CYR  A 406 ( 4.9A)
None
None
None
None
 1.47A 1fohA-2aafA:
undetectable		 1fohA-2aafA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 400
GLN A 162
ILE A  46
ARG A 399
GLY A 398
 CYR  A 406 ( 4.9A)
None
None
None
None
 1.47A 1fohB-2aafA:
undetectable		 1fohB-2aafA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 239
ALA A 268
VAL A 297
ASP A 227
ALA A 278
 None
None
None
None
CYR  A 406 ( 4.7A)
 0.97A 3n3iA-2aafA:
undetectable		 3n3iA-2aafA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		4 / 6 THR A 281
ASN A 360
GLY A 358
ASP A 357
 None
CYR  A 406 ( 3.0A)
None
None
 0.83A 3w9tE-2aafA:
undetectable		 3w9tE-2aafA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		4 / 6 THR A 281
ASN A 360
GLY A 358
ASP A 357
 None
CYR  A 406 ( 3.0A)
None
None
 0.83A 3w9tF-2aafA:
undetectable		 3w9tF-2aafA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		5 / 9 ASN A 360
GLY A 403
GLY A 402
PHE A 163
GLY A 404
 CYR  A 406 ( 3.0A)
CYR  A 406 ( 4.6A)
CYR  A 406 ( 3.7A)
CYR  A 406 ( 3.9A)
CYR  A 406 ( 4.3A)
 1.23A 3ztvA-2aafA:
undetectable		 3ztvA-2aafA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  41
THR A 167
ASN A 178
 CYR  A 406 ( 4.5A)
None
None
 0.72A 6baaE-2aafA:
undetectable		 6baaE-2aafA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  41
THR A 167
ASN A 178
 CYR  A 406 ( 4.5A)
None
None
 0.72A 6baaF-2aafA:
undetectable		 6baaF-2aafA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  41
THR A 167
ASN A 178
 CYR  A 406 ( 4.5A)
None
None
 0.73A 6baaG-2aafA:
undetectable		 6baaG-2aafA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  41
THR A 167
ASN A 178
 CYR  A 406 ( 4.5A)
None
None
 0.72A 6baaH-2aafA:
undetectable		 6baaH-2aafA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 2aaf ARGININE DEIMINASE
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 398
HIS A 405
ASN A 360
GLY A 371
 None
CYR  A 406 ( 4.9A)
CYR  A 406 ( 3.0A)
None
 0.97A 6n7fA-2aafA:
undetectable		 6n7fA-2aafA:
12.18