SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CYG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE
(Salmonella
enterica) 		4 / 6 PHE A1094
ASN A1136
ASN A 474
GLN A1048
 CYG  A1135 ( 3.1A)
CYG  A1135 ( 4.4A)
None
None
 1.21A 1t9uA-3ummA:
5.0		 1t9uA-3ummA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 12 MET D 184
ALA D 171
SER D 166
ASN D 164
GLY D 172
 CYG  D  86 ( 3.4A)
None
None
None
None
 1.38A 2dcfA-3d54D:
undetectable		 2dcfA-3d54D:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)
(Escherichia
coli) 		4 / 6 HIS B1812
ASP B1862
THR B1808
HIS B1772
 CYG  B1769 ( 4.9A)
None
None
CYG  B1769 ( 4.9A)
 1.28A 2dysA-1a9xB:
undetectable
2dysC-1a9xB:
undetectable		 2dysA-1a9xB:
20.72
2dysC-1a9xB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)
(Escherichia
coli) 		4 / 7 HIS B1812
ASP B1862
THR B1808
HIS B1772
 CYG  B1769 ( 4.9A)
None
None
CYG  B1769 ( 4.9A)
 1.27A 2eilA-1a9xB:
undetectable
2eilC-1a9xB:
undetectable		 2eilA-1a9xB:
20.72
2eilC-1a9xB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)
(Escherichia
coli) 		4 / 6 HIS B1812
ASP B1862
THR B1808
HIS B1772
 CYG  B1769 ( 4.9A)
None
None
CYG  B1769 ( 4.9A)
 1.22A 2eimN-1a9xB:
undetectable
2eimP-1a9xB:
undetectable		 2eimN-1a9xB:
20.72
2eimP-1a9xB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE
(Salmonella
enterica) 		5 / 12 TYR A1222
ILE A1192
HIS A1260
GLY A1197
ASN A 378
 None
None
CYG  A1135 ( 3.6A)
CYG  A1135 ( 3.8A)
None
 1.49A 2nyrB-3ummA:
3.3		 2nyrB-3ummA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)
(Escherichia
coli) 		3 / 3 SER B1547
TYR B1548
HIS B1576
 CYG  B1769 (-3.2A)
None
None
 0.67A 2r2vD-1a9xB:
0.0		 2r2vD-1a9xB:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)
(Escherichia
coli) 		4 / 8 GLN B1574
GLN B1551
ASP B1545
SER B1547
 None
None
None
CYG  B1769 (-3.2A)
 1.23A 2xz5C-1a9xB:
0.0
2xz5D-1a9xB:
0.0		 2xz5C-1a9xB:
19.74
2xz5D-1a9xB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB8_A_IMNA800_1
(PROSTAGLANDIN
REDUCTASE 2)		 3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE
(Salmonella
enterica) 		5 / 9 THR A1175
PHE A1287
TYR A1222
VAL A1134
LEU A1132
 None
None
None
CYG  A1135 ( 2.9A)
None
 1.41A 2zb8A-3ummA:
0.9		 2zb8A-3ummA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 11 MET D 184
ALA D 171
SER D 166
ASN D 164
GLY D 172
 CYG  D  86 ( 3.4A)
None
None
None
None
 1.36A 2zmaA-3d54D:
undetectable		 2zmaA-3d54D:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)
(Escherichia
coli) 		5 / 12 LEU B1837
GLY B1852
ILE B1705
ASN B1740
PHE B1870
 None
None
None
CYG  B1769 ( 4.6A)
None
 1.43A 2zznB-1a9xB:
undetectable		 2zznB-1a9xB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 12 MET D 184
ALA D 171
SER D 166
ASN D 164
GLY D 172
 CYG  D  86 ( 3.4A)
None
None
None
None
 1.35A 3a65A-3d54D:
undetectable		 3a65A-3d54D:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A66_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 10 MET D 184
ALA D 171
SER D 166
ASN D 164
GLY D 172
 CYG  D  86 ( 3.4A)
None
None
None
None
 1.34A 3a66A-3d54D:
0.0		 3a66A-3d54D:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I
(Burkholderia
lata) 		5 / 12 HIS A 455
GLY A 493
ASP A 451
ILE A 505
VAL A 476
 None
CYG  A 526 ( 3.9A)
None
None
None
 1.00A 3bwcB-3r75A:
undetectable		 3bwcB-3r75A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)
(Escherichia
coli) 		5 / 11 GLY B1700
ALA B1701
ILE B1768
GLY B1771
LEU B1774
 None
None
CYG  B1769 ( 3.8A)
CYG  B1769 ( 4.1A)
None
 0.94A 3em4A-1a9xB:
undetectable		 3em4A-1a9xB:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 12 LEU D  92
GLY D  49
GLY D  84
LEU D 183
ALA D 141
 None
CYG  D  86 ( 3.5A)
None
None
CYG  D  86 ( 4.6A)
 0.96A 3ou6A-3d54D:
undetectable		 3ou6A-3d54D:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWP_A_ACAA503_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 10 MET D 184
ALA D 171
SER D 166
ASN D 164
GLY D 172
 CYG  D  86 ( 3.4A)
None
None
None
None
 1.35A 3vwpA-3d54D:
0.0		 3vwpA-3d54D:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 12 MET D 184
ALA D 171
SER D 166
ASN D 164
GLY D 172
 CYG  D  86 ( 3.4A)
None
None
None
None
 1.35A 3vwqA-3d54D:
undetectable		 3vwqA-3d54D:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1
(Thermotoga
maritima) 		5 / 11 MET D 184
ALA D 171
SER D 166
ASN D 164
GLY D 172
 CYG  D  86 ( 3.4A)
None
None
None
None
 1.35A 3vwrA-3d54D:
undetectable		 3vwrA-3d54D:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)
(Escherichia
coli) 		4 / 6 LEU B1770
LEU B1774
ILE B1752
THR B1783
 CYG  B1769 ( 4.1A)
None
None
None
 0.65A 4do3B-1a9xB:
2.3		 4do3B-1a9xB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)
(Escherichia
coli) 		5 / 12 ASP B1698
PRO B1745
TYR B1750
SER B1739
GLY B1771
 None
None
None
None
CYG  B1769 ( 4.1A)
 1.11A 4mmdB-1a9xB:
undetectable		 4mmdB-1a9xB:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)
(Escherichia
coli) 		5 / 11 PHE B1814
LEU B1825
LEU B1774
GLY B1771
ALA B1778
 CYG  B1769 (-4.8A)
None
None
CYG  B1769 ( 4.1A)
None
 1.35A 5fctA-1a9xB:
0.0		 5fctA-1a9xB:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)
(Escherichia
coli) 		4 / 6 HIS B1812
HIS B1790
LEU B1837
THR B1836
 CYG  B1769 ( 4.9A)
None
None
None
 1.16A 5ogjB-1a9xB:
undetectable		 5ogjB-1a9xB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)
(Escherichia
coli) 		4 / 5 HIS B1812
HIS B1790
LEU B1837
THR B1836
 CYG  B1769 ( 4.9A)
None
None
None
 1.15A 5ohhA-1a9xB:
undetectable		 5ohhA-1a9xB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)
(Escherichia
coli) 		4 / 6 HIS B1812
HIS B1790
LEU B1837
THR B1836
 CYG  B1769 ( 4.9A)
None
None
None
 1.15A 5ohhB-1a9xB:
undetectable		 5ohhB-1a9xB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)
(Escherichia
coli) 		5 / 11 PHE B1814
LEU B1825
LEU B1774
GLY B1771
ALA B1778
 CYG  B1769 (-4.8A)
None
None
CYG  B1769 ( 4.1A)
None
 1.30A 6r2eF-1a9xB:
0.0		 6r2eF-1a9xB:
21.07