SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CY8'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 5 SER A 387
GLU A 518
TYR A 394
ASP A 473
 None
CY8  A1201 (-3.3A)
CY8  A1201 (-4.3A)
CY8  A1201 (-4.2A)
 1.32A 3zs3A-4o9rA:
undetectable		 3zs3A-4o9rA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5kzy SMOOTHENED
(Xenopus
laevis) 		5 / 12 PRO A 137
LEU A 140
TYR A 103
VAL A 102
SER A  69
 CY8  A1201 ( 4.9A)
None
None
None
None
 1.40A 4a84A-5kzyA:
undetectable		 4a84A-5kzyA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TYR A 394
ASP A 473
VAL A 404
PHE A 391
GLY A 393
 CY8  A1201 (-4.3A)
CY8  A1201 (-4.2A)
None
None
None
 1.17A 4mm4A-4o9rA:
undetectable		 4mm4A-4o9rA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TYR A 394
ASP A 473
VAL A 404
PHE A 391
GLY A 393
 CY8  A1201 (-4.3A)
CY8  A1201 (-4.2A)
None
None
None
 1.17A 4mm4B-4o9rA:
undetectable		 4mm4B-4o9rA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		 5kzy SMOOTHENED
(Xenopus
laevis) 		5 / 9 ILE A  95
LEU A  99
TYR A 103
PHE A 139
ASP A  68
 None
None
None
None
CY8  A1201 (-4.2A)
 1.42A 4qopA-5kzyA:
undetectable		 4qopA-5kzyA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)		 5kzy SMOOTHENED
(Xenopus
laevis) 		5 / 9 ILE A  95
LEU A  99
TYR A 103
PHE A 139
ASP A  68
 None
None
None
None
CY8  A1201 (-4.2A)
 1.43A 4qopB-5kzyA:
undetectable		 4qopB-5kzyA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_D_HQED503_1
(CATALASE)		 5kzy SMOOTHENED
(Xenopus
laevis) 		5 / 9 ILE A  95
LEU A  99
TYR A 103
PHE A 139
ASP A  68
 None
None
None
None
CY8  A1201 (-4.2A)
 1.43A 4qopD-5kzyA:
undetectable		 4qopD-5kzyA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5kzy SMOOTHENED
(Xenopus
laevis) 		5 / 12 GLY A 135
PRO A 137
LEU A 140
ARG A  90
LEU A  85
 None
CY8  A1201 ( 4.9A)
None
None
CY8  A1201 (-4.1A)
 1.47A 5emlA-5kzyA:
undetectable		 5emlA-5kzyA:
10.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		6 / 12 ASN A 219
TRP A 281
ASP A 384
SER A 387
LEU A 522
MET A 525
 CY8  A1201 (-3.3A)
None
CY8  A1201 (-3.2A)
None
None
None
 1.04A 5l7iA-4o9rA:
44.5		 5l7iA-4o9rA:
74.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		10 / 12 ASN A 219
TRP A 281
ASP A 384
SER A 387
TYR A 394
ARG A 400
GLN A 477
GLU A 518
ASN A 521
LEU A 522
 CY8  A1201 (-3.3A)
None
CY8  A1201 (-3.2A)
None
CY8  A1201 (-4.3A)
CY8  A1201 (-3.9A)
CY8  A1201 (-3.7A)
CY8  A1201 (-3.3A)
None
None
 0.85A 5l7iA-4o9rA:
44.5		 5l7iA-4o9rA:
74.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TYR A 394
ARG A 400
GLN A 477
PHE A 484
LEU A 522
 CY8  A1201 (-4.3A)
CY8  A1201 (-3.9A)
CY8  A1201 (-3.7A)
CY8  A1201 (-3.9A)
None
 0.89A 5l7iA-4o9rA:
44.5		 5l7iA-4o9rA:
74.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L7I_B_VISB1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TRP A 281
ASP A 384
SER A 387
LEU A 522
MET A 525
 None
CY8  A1201 (-3.2A)
None
None
None
 1.13A 5l7iB-4o9rA:
37.4		 5l7iB-4o9rA:
74.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L7I_B_VISB1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens) 		11 / 12 TRP A 281
ASP A 384
SER A 387
TYR A 394
ARG A 400
ASP A 473
GLN A 477
PRO A 513
GLU A 518
ASN A 521
LEU A 522
 None
CY8  A1201 (-3.2A)
None
CY8  A1201 (-4.3A)
CY8  A1201 (-3.9A)
CY8  A1201 (-4.2A)
CY8  A1201 (-3.7A)
CY8  A1201 ( 4.9A)
CY8  A1201 (-3.3A)
None
None
 0.79A 5l7iB-4o9rA:
37.4		 5l7iB-4o9rA:
74.96