SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CXT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		5 / 10 LEU A 127
SER A 126
ILE A 183
SER A 118
GLY A 119
 CXT  A 401 (-4.1A)
CXT  A 401 ( 4.9A)
CXT  A 401 (-4.8A)
None
None
 1.32A 3iluB-1okcA:
undetectable
3iluE-1okcA:
undetectable		 3iluB-1okcA:
23.49
3iluE-1okcA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		5 / 11 ILE A 183
SER A 118
GLY A 119
LEU A 127
SER A 126
 CXT  A 401 (-4.8A)
None
None
CXT  A 401 (-4.1A)
CXT  A 401 ( 4.9A)
 1.35A 3iluB-1okcA:
undetectable
3iluE-1okcA:
undetectable		 3iluB-1okcA:
23.49
3iluE-1okcA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		5 / 10 GLN A  84
ALA A  18
ALA A  19
THR A  23
LEU A  74
 CXT  A 401 ( 4.5A)
None
None
CDL  A 800 ( 4.1A)
CDL  A 800 ( 3.9A)
 1.18A 4j6cB-1okcA:
3.8		 4j6cB-1okcA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		3 / 3 MET A 238
ASP A 231
PHE A 230
 None
CXT  A 401 (-3.6A)
LDM  A 904 ( 4.7A)
 1.06A 4xeyA-1okcA:
undetectable		 4xeyA-1okcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		3 / 3 MET A 238
ASP A 231
PHE A 230
 None
CXT  A 401 (-3.6A)
LDM  A 904 ( 4.7A)
 1.06A 4xeyB-1okcA:
undetectable		 4xeyB-1okcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		4 / 5 PHE A 129
THR A  83
ASP A 134
ASN A 177
 None
CXT  A 401 ( 3.9A)
CXT  A 401 ( 4.7A)
CDL  A 802 (-3.0A)
 1.00A 5ybbA-1okcA:
undetectable		 5ybbA-1okcA:
18.77