SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CXA'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NW5_A_SAMA401_1 (MODIFICATION METHYLASE RSRI)	5j1q	CARBOXYPEPTIDASE B (Sus scrofa)	3 / 3	ASP A 255 HIS A 196 ASP A 65	CXA A 402 (-3.5A) ZN A 401 ( 3.2A) None	0.71A	1nw5A-5j1qA: undetectable	1nw5A-5j1qA: 22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2C8A_A_NCAA1252_0 (MONO-ADP-RIBOSYLTRAN SFERASE C3)	5j1q	CARBOXYPEPTIDASE B (Sus scrofa)	4 / 7	SER A 199 SER A 197 PHE A 279 GLU A 270	None None None CXA A 402 (-3.0A)	1.26A	2c8aA-5j1qA: undetectable	2c8aA-5j1qA: 21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2C8A_B_NCAB1246_0 (MONO-ADP-RIBOSYLTRAN SFERASE C3)	5j1q	CARBOXYPEPTIDASE B (Sus scrofa)	5 / 7	GLY A 278 SER A 199 SER A 197 PHE A 279 GLU A 270	None None None None CXA A 402 (-3.0A)	1.30A	2c8aB-5j1qA: undetectable	2c8aB-5j1qA: 21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2C8A_C_NCAC1252_0 (MONO-ADP-RIBOSYLTRAN SFERASE C3)	5j1q	CARBOXYPEPTIDASE B (Sus scrofa)	4 / 6	SER A 199 SER A 197 PHE A 279 GLU A 270	None None None CXA A 402 (-3.0A)	1.31A	2c8aC-5j1qA: undetectable	2c8aC-5j1qA: 21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X45_B_HSMB1162_1 (ALLERGEN ARG R 1)	5j1q	CARBOXYPEPTIDASE B (Sus scrofa)	3 / 3	GLU A 270 HIS A 69 GLU A 72	CXA A 402 (-3.0A) ZN A 401 ( 3.2A) ZN A 401 ( 1.9A)	0.78A	2x45B-5j1qA: undetectable	2x45B-5j1qA: 18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X45_C_HSMC1162_1 (ALLERGEN ARG R 1)	5j1q	CARBOXYPEPTIDASE B (Sus scrofa)	3 / 3	GLU A 270 HIS A 69 GLU A 72	CXA A 402 (-3.0A) ZN A 401 ( 3.2A) ZN A 401 ( 1.9A)	0.81A	2x45C-5j1qA: undetectable	2x45C-5j1qA: 18.89

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1NW5_A_SAMA401_1","MODIFICATION METHYLASE RSRI","5j1q","CARBOXYPEPTIDASE B","Sus scrofa",3,"ASP A 255;HIS A 196;ASP A  65","CXA A 402 (-3.5A); ZN A 401 ( 3.2A);None","0.71A","1nw5A-5j1qA:undetectable",null],["2C8A_A_NCAA1252_0","MONO-ADP-RIBOSYLTRANSFERASE C3","5j1q","CARBOXYPEPTIDASE B","Sus scrofa",4,"SER A 199;SER A 197;PHE A 279;GLU A 270","None;None;None;CXA A 402 (-3.0A)","1.26A","2c8aA-5j1qA:undetectable","1nw5A-5j1qA:22.61"],["2C8A_B_NCAB1246_0","MONO-ADP-RIBOSYLTRANSFERASE C3","5j1q","CARBOXYPEPTIDASE B","Sus scrofa",5,"GLY A 278;SER A 199;SER A 197;PHE A 279;GLU A 270","None;None;None;None;CXA A 402 (-3.0A)","1.30A","2c8aB-5j1qA:undetectable","2c8aA-5j1qA:21.57"],["2C8A_C_NCAC1252_0","MONO-ADP-RIBOSYLTRANSFERASE C3","5j1q","CARBOXYPEPTIDASE B","Sus scrofa",4,"SER A 199;SER A 197;PHE A 279;GLU A 270","None;None;None;CXA A 402 (-3.0A)","1.31A","2c8aC-5j1qA:undetectable","2c8aB-5j1qA:21.57"],["2X45_B_HSMB1162_1","ALLERGEN ARG R 1","5j1q","CARBOXYPEPTIDASE B","Sus scrofa",3,"GLU A 270;HIS A  69;GLU A  72","CXA A 402 (-3.0A); ZN A 401 ( 3.2A); ZN A 401 ( 1.9A)","0.78A","2x45B-5j1qA:undetectable","2c8aC-5j1qA:21.57"],["2X45_C_HSMC1162_1","ALLERGEN ARG R 1","5j1q","CARBOXYPEPTIDASE B","Sus scrofa",3,"GLU A 270;HIS A  69;GLU A  72","CXA A 402 (-3.0A); ZN A 401 ( 3.2A); ZN A 401 ( 1.9A)","0.81A","2x45C-5j1qA:undetectable","2x45B-5j1qA:18.89"]]