SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CX9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1E9L_A_GCSA800_1 (YM1 SECRETORY PROTEIN)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	6 / 9	TYR A 27 PHE A 58 GLY A 98 ASP A 138 ASP A 213 TRP A 360	None CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.0A) CX9 A1398 ( 4.4A) CX9 A1398 ( 3.3A)	0.89A	1e9lA-2ybuA: 61.2	1e9lA-2ybuA: 67.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1E9L_A_GCSA800_1 (YM1 SECRETORY PROTEIN)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	7 / 9	TYR A 27 PHE A 58 GLY A 98 ASP A 138 MET A 210 TYR A 212 ASP A 213	None CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.0A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) CX9 A1398 ( 4.4A)	0.69A	1e9lA-2ybuA: 61.2	1e9lA-2ybuA: 67.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2A3A_A_TEPA1433_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	7 / 11	PHE A 58 GLY A 98 ASP A 138 MET A 210 TYR A 212 TYR A 267 TRP A 360	CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.0A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) None CX9 A1398 ( 3.3A)	0.78A	2a3aA-2ybuA: 11.5	2a3aA-2ybuA: 31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2A3A_A_TEPA1433_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	10 / 11	TYR A 27 PHE A 58 GLY A 98 TRP A 99 GLU A 140 MET A 210 TYR A 212 ASP A 213 TYR A 267 TRP A 360	None CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1399 ( 3.4A) CX9 A1398 (-3.7A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) CX9 A1398 ( 4.4A) None CX9 A1398 ( 3.3A)	0.67A	2a3aA-2ybuA: 11.5	2a3aA-2ybuA: 31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2A3A_A_TEPA1435_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	3 / 3	TRP A 99 GLU A 140 TYR A 141	CX9 A1399 ( 3.4A) CX9 A1398 (-3.7A) None	0.56A	2a3aA-2ybuA: 11.5	2a3aA-2ybuA: 31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2A3A_B_TEPB2433_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	8 / 9	PHE A 58 GLY A 98 GLU A 140 MET A 210 TYR A 212 ASP A 213 TYR A 267 TRP A 360	CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.7A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) CX9 A1398 ( 4.4A) None CX9 A1398 ( 3.3A)	0.44A	2a3aB-2ybuA: 44.5	2a3aB-2ybuA: 31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2A3B_A_CFFA1435_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	7 / 11	PHE A 58 GLY A 98 ASP A 138 MET A 210 TYR A 212 TYR A 267 TRP A 360	CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.0A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) None CX9 A1398 ( 3.3A)	0.84A	2a3bA-2ybuA: 44.5	2a3bA-2ybuA: 31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2A3B_A_CFFA1435_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	7 / 11	TYR A 27 PHE A 58 GLY A 98 GLU A 140 MET A 210 TYR A 212 TRP A 360	None CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.7A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) CX9 A1398 ( 3.3A)	0.84A	2a3bA-2ybuA: 44.5	2a3bA-2ybuA: 31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2A3B_A_CFFA1435_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	8 / 11	TYR A 27 PHE A 58 GLY A 98 MET A 210 TYR A 212 ASP A 213 TYR A 267 TRP A 360	None CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) CX9 A1398 ( 4.4A) None CX9 A1398 ( 3.3A)	0.51A	2a3bA-2ybuA: 44.5	2a3bA-2ybuA: 31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2A3B_B_CFFB2435_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	7 / 10	PHE A 58 GLY A 98 ASP A 138 GLU A 140 MET A 210 TYR A 212 TRP A 360	CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.0A) CX9 A1398 (-3.7A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) CX9 A1398 ( 3.3A)	1.01A	2a3bB-2ybuA: 11.4	2a3bB-2ybuA: 31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2A3B_B_CFFB2435_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	7 / 10	PHE A 58 GLY A 98 ASP A 138 MET A 210 TYR A 212 TYR A 267 TRP A 360	CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.0A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) None CX9 A1398 ( 3.3A)	0.81A	2a3bB-2ybuA: 11.4	2a3bB-2ybuA: 31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2A3B_B_CFFB2435_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	7 / 10	PHE A 58 GLY A 98 MET A 210 TYR A 212 ASP A 213 TYR A 267 TRP A 360	CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) CX9 A1398 ( 4.4A) None CX9 A1398 ( 3.3A)	0.32A	2a3bB-2ybuA: 11.4	2a3bB-2ybuA: 31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2A3C_A_PNXA1434_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	8 / 12	TRP A 31 PHE A 58 GLY A 98 ASP A 138 GLU A 140 MET A 210 TYR A 212 TRP A 360	CX9 A1398 ( 3.4A) CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.0A) CX9 A1398 (-3.7A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) CX9 A1398 ( 3.3A)	1.07A	2a3cA-2ybuA: 11.6	2a3cA-2ybuA: 31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2A3C_A_PNXA1434_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	8 / 12	TRP A 31 PHE A 58 GLY A 98 ASP A 138 MET A 210 TYR A 212 TYR A 267 TRP A 360	CX9 A1398 ( 3.4A) CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.0A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) None CX9 A1398 ( 3.3A)	0.86A	2a3cA-2ybuA: 11.6	2a3cA-2ybuA: 31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2A3C_A_PNXA1434_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	8 / 12	TYR A 27 TRP A 31 PHE A 58 GLY A 98 GLU A 140 MET A 210 TYR A 212 TRP A 360	None CX9 A1398 ( 3.4A) CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.7A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) CX9 A1398 ( 3.3A)	0.91A	2a3cA-2ybuA: 11.6	2a3cA-2ybuA: 31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2A3C_A_PNXA1434_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	9 / 12	TYR A 27 TRP A 31 PHE A 58 GLY A 98 MET A 210 TYR A 212 ASP A 213 TYR A 267 TRP A 360	None CX9 A1398 ( 3.4A) CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) CX9 A1398 ( 4.4A) None CX9 A1398 ( 3.3A)	0.59A	2a3cA-2ybuA: 11.6	2a3cA-2ybuA: 31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2A3C_B_PNXB2433_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	8 / 12	TRP A 31 PHE A 58 GLY A 98 ASP A 138 GLU A 140 MET A 210 TYR A 212 TRP A 360	CX9 A1398 ( 3.4A) CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.0A) CX9 A1398 (-3.7A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) CX9 A1398 ( 3.3A)	1.03A	2a3cB-2ybuA: 44.6	2a3cB-2ybuA: 31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2A3C_B_PNXB2433_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	8 / 12	TRP A 31 PHE A 58 GLY A 98 ASP A 138 MET A 210 TYR A 212 TYR A 267 TRP A 360	CX9 A1398 ( 3.4A) CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.0A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) None CX9 A1398 ( 3.3A)	0.84A	2a3cB-2ybuA: 44.6	2a3cB-2ybuA: 31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2A3C_B_PNXB2433_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	8 / 12	TRP A 31 PHE A 58 GLY A 98 MET A 210 TYR A 212 ASP A 213 TYR A 267 TRP A 360	CX9 A1398 ( 3.4A) CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) CX9 A1398 ( 4.4A) None CX9 A1398 ( 3.3A)	0.43A	2a3cB-2ybuA: 44.6	2a3cB-2ybuA: 31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2UY4_A_AZMA1311_1 (ENDOCHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	7 / 9	TYR A 27 PHE A 58 GLY A 98 ASP A 138 GLU A 140 TYR A 212 TRP A 360	None CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.0A) CX9 A1398 (-3.7A) CX9 A1398 (-4.3A) CX9 A1398 ( 3.3A)	0.53A	2uy4A-2ybuA: 19.9	2uy4A-2ybuA: 22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W9S_D_TOPD1158_1 (DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	5 / 10	ALA A 183 ASP A 136 LEU A 93 ILE A 55 TYR A 212	CX9 A1398 ( 4.6A) None None None CX9 A1398 (-4.3A)	1.17A	2w9sD-2ybuA: undetectable	2w9sD-2ybuA: 18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XTK_A_AZMA1339_1 (CLASS III CHITINASE CHIA1)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	7 / 11	TYR A 27 PHE A 58 GLY A 98 ASP A 138 GLU A 140 TYR A 212 TRP A 360	None CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.0A) CX9 A1398 (-3.7A) CX9 A1398 (-4.3A) CX9 A1398 ( 3.3A)	0.79A	2xtkA-2ybuA: 20.9	2xtkA-2ybuA: 22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XTK_B_AZMB1339_1 (CLASS III CHITINASE CHIA1)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	7 / 10	TYR A 27 PHE A 58 GLY A 98 ASP A 138 GLU A 140 TYR A 212 TRP A 360	None CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.0A) CX9 A1398 (-3.7A) CX9 A1398 (-4.3A) CX9 A1398 ( 3.3A)	0.69A	2xtkB-2ybuA: 20.8	2xtkB-2ybuA: 22.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3G6M_A_CFFA1_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	9 / 11	PHE A 58 GLY A 98 TRP A 99 GLU A 140 MET A 210 TYR A 212 ASP A 213 TYR A 267 TRP A 360	CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1399 ( 3.4A) CX9 A1398 (-3.7A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) CX9 A1398 ( 4.4A) None CX9 A1398 ( 3.3A)	0.63A	3g6mA-2ybuA: 44.5	3g6mA-2ybuA: 30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3G6M_A_CFFA1_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	6 / 11	TYR A 27 PHE A 58 GLY A 98 ASP A 138 TYR A 212 TYR A 267	None CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.0A) CX9 A1398 (-4.3A) None	1.00A	3g6mA-2ybuA: 44.5	3g6mA-2ybuA: 30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3G6M_A_CFFA1_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	9 / 11	TYR A 27 PHE A 58 GLY A 98 GLU A 140 MET A 210 TYR A 212 ASP A 213 TYR A 267 TRP A 360	None CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1398 (-3.7A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) CX9 A1398 ( 4.4A) None CX9 A1398 ( 3.3A)	0.59A	3g6mA-2ybuA: 44.5	3g6mA-2ybuA: 30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3G6M_A_CFFA427_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	5 / 5	TRP A 99 TYR A 141 MET A 210 ASP A 213 TRP A 218	CX9 A1399 ( 3.4A) None CX9 A1398 (-3.3A) CX9 A1398 ( 4.4A) CX9 A1399 (-3.3A)	0.73A	3g6mA-2ybuA: 44.6	3g6mA-2ybuA: 30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3WQV_A_GCSA501_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	10 / 11	PHE A 58 GLY A 98 TRP A 99 ASP A 138 GLU A 140 MET A 210 TYR A 212 ASP A 213 TYR A 267 TRP A 360	CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1399 ( 3.4A) CX9 A1398 (-3.0A) CX9 A1398 (-3.7A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) CX9 A1398 ( 4.4A) None CX9 A1398 ( 3.3A)	0.40A	3wqvA-2ybuA: 55.9	3wqvA-2ybuA: 43.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3WQW_A_GCSA501_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	10 / 11	PHE A 58 GLY A 98 TRP A 99 ASP A 138 GLU A 140 MET A 210 TYR A 212 ASP A 213 TYR A 267 TRP A 360	CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1399 ( 3.4A) CX9 A1398 (-3.0A) CX9 A1398 (-3.7A) CX9 A1398 (-3.3A) CX9 A1398 (-4.3A) CX9 A1398 ( 4.4A) None CX9 A1398 ( 3.3A)	0.43A	3wqwA-2ybuA: 55.8	3wqwA-2ybuA: 43.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KRH_A_SAMA900_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE 2)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	5 / 12	TYR A 141 GLY A 98 GLY A 102 ASP A 136 ALA A 95	None CX9 A1398 (-3.5A) None None None	1.00A	4krhA-2ybuA: 2.5	4krhA-2ybuA: 20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4NSB_A_AINA402_1 (CHITINASE-3-LIKE PROTEIN 1)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	5 / 7	THR A 29 TRP A 31 ARG A 35 TRP A 360 LEU A 364	GOL A1397 ( 4.8A) CX9 A1398 ( 3.4A) GOL A1397 (-4.2A) CX9 A1398 ( 3.3A) None	0.43A	4nsbA-2ybuA: 55.3	4nsbA-2ybuA: 49.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XEY_A_1N1A601_2 (TYROSINE-PROTEIN KINASE ABL1)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	3 / 3	MET A 358 ASP A 138 PHE A 137	None CX9 A1398 (-3.0A) None	0.84A	4xeyA-2ybuA: undetectable	4xeyA-2ybuA: 22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XEY_B_1N1B601_2 (TYROSINE-PROTEIN KINASE ABL1)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	3 / 3	MET A 358 ASP A 138 PHE A 137	None CX9 A1398 (-3.0A) None	0.80A	4xeyB-2ybuA: undetectable	4xeyB-2ybuA: 22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GQB_A_GCSA602_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	3 / 3	TRP A 99 GLU A 140 ASP A 213	CX9 A1399 ( 3.4A) CX9 A1398 (-3.7A) CX9 A1398 ( 4.4A)	0.27A	5gqbA-2ybuA: 43.9	5gqbA-2ybuA: 24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GQB_A_GCSA603_1 (CHITINASE)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	7 / 8	PHE A 58 GLY A 98 TRP A 99 GLU A 140 TYR A 212 ASP A 213 TRP A 360	CX9 A1398 (-4.5A) CX9 A1398 (-3.5A) CX9 A1399 ( 3.4A) CX9 A1398 (-3.7A) CX9 A1398 (-4.3A) CX9 A1398 ( 4.4A) CX9 A1398 ( 3.3A)	0.45A	5gqbA-2ybuA: 43.9	5gqbA-2ybuA: 24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGP_A_ERYA402_0 (MACROLIDE 2'-PHOSPHOTRANSFERAS E)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	5 / 12	ILE A 120 VAL A 180 ALA A 183 ALA A 182 GLY A 98	None None CX9 A1398 ( 4.6A) None CX9 A1398 (-3.5A)	1.39A	5igpA-2ybuA: undetectable	5igpA-2ybuA: 21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGP_A_ERYA402_0 (MACROLIDE 2'-PHOSPHOTRANSFERAS E)	2ybu	ACIDIC MAMMALIAN CHITINASE (Homo sapiens)	5 / 12	MET A 162 ILE A 120 ALA A 183 ALA A 182 GLY A 98	None None CX9 A1398 ( 4.6A) None CX9 A1398 (-3.5A)	1.40A	5igpA-2ybuA: undetectable	5igpA-2ybuA: 21.79

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1E9L_A_GCSA800_1","YM1 SECRETORY PROTEIN","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",6,"TYR A  27;PHE A  58;GLY A  98;ASP A 138;ASP A 213;TRP A 360","None;CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.0A);CX9 A1398 ( 4.4A);CX9 A1398 ( 3.3A)","0.89A","1e9lA-2ybuA:61.2",null],["1E9L_A_GCSA800_1","YM1 SECRETORY PROTEIN","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",7,"TYR A  27;PHE A  58;GLY A  98;ASP A 138;MET A 210;TYR A 212;ASP A 213","None;CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.0A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);CX9 A1398 ( 4.4A)","0.69A","1e9lA-2ybuA:61.2","1e9lA-2ybuA:67.64"],["2A3A_A_TEPA1433_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",7,"PHE A  58;GLY A  98;ASP A 138;MET A 210;TYR A 212;TYR A 267;TRP A 360","CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.0A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);None;CX9 A1398 ( 3.3A)","0.78A","2a3aA-2ybuA:11.5","1e9lA-2ybuA:67.64"],["2A3A_A_TEPA1433_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",10,"TYR A  27;PHE A  58;GLY A  98;TRP A  99;GLU A 140;MET A 210;TYR A 212;ASP A 213;TYR A 267;TRP A 360","None;CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1399 ( 3.4A);CX9 A1398 (-3.7A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);CX9 A1398 ( 4.4A);None;CX9 A1398 ( 3.3A)","0.67A","2a3aA-2ybuA:11.5","2a3aA-2ybuA:31.82"],["2A3A_A_TEPA1435_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",3,"TRP A  99;GLU A 140;TYR A 141","CX9 A1399 ( 3.4A);CX9 A1398 (-3.7A);None","0.56A","2a3aA-2ybuA:11.5","2a3aA-2ybuA:31.82"],["2A3A_B_TEPB2433_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",8,"PHE A  58;GLY A  98;GLU A 140;MET A 210;TYR A 212;ASP A 213;TYR A 267;TRP A 360","CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.7A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);CX9 A1398 ( 4.4A);None;CX9 A1398 ( 3.3A)","0.44A","2a3aB-2ybuA:44.5","2a3aA-2ybuA:31.82"],["2A3B_A_CFFA1435_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",7,"PHE A  58;GLY A  98;ASP A 138;MET A 210;TYR A 212;TYR A 267;TRP A 360","CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.0A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);None;CX9 A1398 ( 3.3A)","0.84A","2a3bA-2ybuA:44.5","2a3aB-2ybuA:31.82"],["2A3B_A_CFFA1435_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",7,"TYR A  27;PHE A  58;GLY A  98;GLU A 140;MET A 210;TYR A 212;TRP A 360","None;CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.7A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);CX9 A1398 ( 3.3A)","0.84A","2a3bA-2ybuA:44.5","2a3bA-2ybuA:31.82"],["2A3B_A_CFFA1435_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",8,"TYR A  27;PHE A  58;GLY A  98;MET A 210;TYR A 212;ASP A 213;TYR A 267;TRP A 360","None;CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);CX9 A1398 ( 4.4A);None;CX9 A1398 ( 3.3A)","0.51A","2a3bA-2ybuA:44.5","2a3bA-2ybuA:31.82"],["2A3B_B_CFFB2435_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",7,"PHE A  58;GLY A  98;ASP A 138;GLU A 140;MET A 210;TYR A 212;TRP A 360","CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.0A);CX9 A1398 (-3.7A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);CX9 A1398 ( 3.3A)","1.01A","2a3bB-2ybuA:11.4","2a3bA-2ybuA:31.82"],["2A3B_B_CFFB2435_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",7,"PHE A  58;GLY A  98;ASP A 138;MET A 210;TYR A 212;TYR A 267;TRP A 360","CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.0A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);None;CX9 A1398 ( 3.3A)","0.81A","2a3bB-2ybuA:11.4","2a3bB-2ybuA:31.82"],["2A3B_B_CFFB2435_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",7,"PHE A  58;GLY A  98;MET A 210;TYR A 212;ASP A 213;TYR A 267;TRP A 360","CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);CX9 A1398 ( 4.4A);None;CX9 A1398 ( 3.3A)","0.32A","2a3bB-2ybuA:11.4","2a3bB-2ybuA:31.82"],["2A3C_A_PNXA1434_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",8,"TRP A  31;PHE A  58;GLY A  98;ASP A 138;GLU A 140;MET A 210;TYR A 212;TRP A 360","CX9 A1398 ( 3.4A);CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.0A);CX9 A1398 (-3.7A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);CX9 A1398 ( 3.3A)","1.07A","2a3cA-2ybuA:11.6","2a3bB-2ybuA:31.82"],["2A3C_A_PNXA1434_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",8,"TRP A  31;PHE A  58;GLY A  98;ASP A 138;MET A 210;TYR A 212;TYR A 267;TRP A 360","CX9 A1398 ( 3.4A);CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.0A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);None;CX9 A1398 ( 3.3A)","0.86A","2a3cA-2ybuA:11.6","2a3cA-2ybuA:31.82"],["2A3C_A_PNXA1434_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",8,"TYR A  27;TRP A  31;PHE A  58;GLY A  98;GLU A 140;MET A 210;TYR A 212;TRP A 360","None;CX9 A1398 ( 3.4A);CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.7A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);CX9 A1398 ( 3.3A)","0.91A","2a3cA-2ybuA:11.6","2a3cA-2ybuA:31.82"],["2A3C_A_PNXA1434_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",9,"TYR A  27;TRP A  31;PHE A  58;GLY A  98;MET A 210;TYR A 212;ASP A 213;TYR A 267;TRP A 360","None;CX9 A1398 ( 3.4A);CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);CX9 A1398 ( 4.4A);None;CX9 A1398 ( 3.3A)","0.59A","2a3cA-2ybuA:11.6","2a3cA-2ybuA:31.82"],["2A3C_B_PNXB2433_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",8,"TRP A  31;PHE A  58;GLY A  98;ASP A 138;GLU A 140;MET A 210;TYR A 212;TRP A 360","CX9 A1398 ( 3.4A);CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.0A);CX9 A1398 (-3.7A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);CX9 A1398 ( 3.3A)","1.03A","2a3cB-2ybuA:44.6","2a3cA-2ybuA:31.82"],["2A3C_B_PNXB2433_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",8,"TRP A  31;PHE A  58;GLY A  98;ASP A 138;MET A 210;TYR A 212;TYR A 267;TRP A 360","CX9 A1398 ( 3.4A);CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.0A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);None;CX9 A1398 ( 3.3A)","0.84A","2a3cB-2ybuA:44.6","2a3cB-2ybuA:31.82"],["2A3C_B_PNXB2433_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",8,"TRP A  31;PHE A  58;GLY A  98;MET A 210;TYR A 212;ASP A 213;TYR A 267;TRP A 360","CX9 A1398 ( 3.4A);CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);CX9 A1398 ( 4.4A);None;CX9 A1398 ( 3.3A)","0.43A","2a3cB-2ybuA:44.6","2a3cB-2ybuA:31.82"],["2UY4_A_AZMA1311_1","ENDOCHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",7,"TYR A  27;PHE A  58;GLY A  98;ASP A 138;GLU A 140;TYR A 212;TRP A 360","None;CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.0A);CX9 A1398 (-3.7A);CX9 A1398 (-4.3A);CX9 A1398 ( 3.3A)","0.53A","2uy4A-2ybuA:19.9","2a3cB-2ybuA:31.82"],["2W9S_D_TOPD1158_1","DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",5,"ALA A 183;ASP A 136;LEU A  93;ILE A  55;TYR A 212","CX9 A1398 ( 4.6A);None;None;None;CX9 A1398 (-4.3A)","1.17A","2w9sD-2ybuA:undetectable","2uy4A-2ybuA:22.81"],["2XTK_A_AZMA1339_1","CLASS III CHITINASE CHIA1","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",7,"TYR A  27;PHE A  58;GLY A  98;ASP A 138;GLU A 140;TYR A 212;TRP A 360","None;CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.0A);CX9 A1398 (-3.7A);CX9 A1398 (-4.3A);CX9 A1398 ( 3.3A)","0.79A","2xtkA-2ybuA:20.9","2w9sD-2ybuA:18.28"],["2XTK_B_AZMB1339_1","CLASS III CHITINASE CHIA1","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",7,"TYR A  27;PHE A  58;GLY A  98;ASP A 138;GLU A 140;TYR A 212;TRP A 360","None;CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.0A);CX9 A1398 (-3.7A);CX9 A1398 (-4.3A);CX9 A1398 ( 3.3A)","0.69A","2xtkB-2ybuA:20.8","2xtkA-2ybuA:22.66"],["3G6M_A_CFFA1_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",9,"PHE A  58;GLY A  98;TRP A  99;GLU A 140;MET A 210;TYR A 212;ASP A 213;TYR A 267;TRP A 360","CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1399 ( 3.4A);CX9 A1398 (-3.7A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);CX9 A1398 ( 4.4A);None;CX9 A1398 ( 3.3A)","0.63A","3g6mA-2ybuA:44.5","2xtkB-2ybuA:22.66"],["3G6M_A_CFFA1_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",6,"TYR A  27;PHE A  58;GLY A  98;ASP A 138;TYR A 212;TYR A 267","None;CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.0A);CX9 A1398 (-4.3A);None","1.00A","3g6mA-2ybuA:44.5","3g6mA-2ybuA:30.09"],["3G6M_A_CFFA1_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",9,"TYR A  27;PHE A  58;GLY A  98;GLU A 140;MET A 210;TYR A 212;ASP A 213;TYR A 267;TRP A 360","None;CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1398 (-3.7A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);CX9 A1398 ( 4.4A);None;CX9 A1398 ( 3.3A)","0.59A","3g6mA-2ybuA:44.5","3g6mA-2ybuA:30.09"],["3G6M_A_CFFA427_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",5,"TRP A  99;TYR A 141;MET A 210;ASP A 213;TRP A 218","CX9 A1399 ( 3.4A);None;CX9 A1398 (-3.3A);CX9 A1398 ( 4.4A);CX9 A1399 (-3.3A)","0.73A","3g6mA-2ybuA:44.6","3g6mA-2ybuA:30.09"],["3WQV_A_GCSA501_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",10,"PHE A  58;GLY A  98;TRP A  99;ASP A 138;GLU A 140;MET A 210;TYR A 212;ASP A 213;TYR A 267;TRP A 360","CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1399 ( 3.4A);CX9 A1398 (-3.0A);CX9 A1398 (-3.7A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);CX9 A1398 ( 4.4A);None;CX9 A1398 ( 3.3A)","0.40A","3wqvA-2ybuA:55.9","3g6mA-2ybuA:30.09"],["3WQW_A_GCSA501_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",10,"PHE A  58;GLY A  98;TRP A  99;ASP A 138;GLU A 140;MET A 210;TYR A 212;ASP A 213;TYR A 267;TRP A 360","CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1399 ( 3.4A);CX9 A1398 (-3.0A);CX9 A1398 (-3.7A);CX9 A1398 (-3.3A);CX9 A1398 (-4.3A);CX9 A1398 ( 4.4A);None;CX9 A1398 ( 3.3A)","0.43A","3wqwA-2ybuA:55.8","3wqvA-2ybuA:43.25"],["4KRH_A_SAMA900_0","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE 2","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",5,"TYR A 141;GLY A  98;GLY A 102;ASP A 136;ALA A  95","None;CX9 A1398 (-3.5A);None;None;None","1.00A","4krhA-2ybuA:2.5","3wqwA-2ybuA:43.25"],["4NSB_A_AINA402_1","CHITINASE-3-LIKE PROTEIN 1","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",5,"THR A  29;TRP A  31;ARG A  35;TRP A 360;LEU A 364","GOL A1397 ( 4.8A);CX9 A1398 ( 3.4A);GOL A1397 (-4.2A);CX9 A1398 ( 3.3A);None","0.43A","4nsbA-2ybuA:55.3","4krhA-2ybuA:20.38"],["4XEY_A_1N1A601_2","TYROSINE-PROTEIN KINASE ABL1","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",3,"MET A 358;ASP A 138;PHE A 137","None;CX9 A1398 (-3.0A);None","0.84A","4xeyA-2ybuA:undetectable","4nsbA-2ybuA:49.21"],["4XEY_B_1N1B601_2","TYROSINE-PROTEIN KINASE ABL1","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",3,"MET A 358;ASP A 138;PHE A 137","None;CX9 A1398 (-3.0A);None","0.80A","4xeyB-2ybuA:undetectable","4xeyA-2ybuA:22.85"],["5GQB_A_GCSA602_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",3,"TRP A  99;GLU A 140;ASP A 213","CX9 A1399 ( 3.4A);CX9 A1398 (-3.7A);CX9 A1398 ( 4.4A)","0.27A","5gqbA-2ybuA:43.9","4xeyB-2ybuA:22.85"],["5GQB_A_GCSA603_1","CHITINASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",7,"PHE A  58;GLY A  98;TRP A  99;GLU A 140;TYR A 212;ASP A 213;TRP A 360","CX9 A1398 (-4.5A);CX9 A1398 (-3.5A);CX9 A1399 ( 3.4A);CX9 A1398 (-3.7A);CX9 A1398 (-4.3A);CX9 A1398 ( 4.4A);CX9 A1398 ( 3.3A)","0.45A","5gqbA-2ybuA:43.9","5gqbA-2ybuA:24.33"],["5IGP_A_ERYA402_0","MACROLIDE 2'-PHOSPHOTRANSFERASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",5,"ILE A 120;VAL A 180;ALA A 183;ALA A 182;GLY A  98","None;None;CX9 A1398 ( 4.6A);None;CX9 A1398 (-3.5A)","1.39A","5igpA-2ybuA:undetectable","5gqbA-2ybuA:24.33"],["5IGP_A_ERYA402_0","MACROLIDE 2'-PHOSPHOTRANSFERASE","2ybu","ACIDIC MAMMALIAN CHITINASE","Homo sapiens",5,"MET A 162;ILE A 120;ALA A 183;ALA A 182;GLY A  98","None;None;CX9 A1398 ( 4.6A);None;CX9 A1398 (-3.5A)","1.40A","5igpA-2ybuA:undetectable","5igpA-2ybuA:21.79"]]