SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CUA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 3s38 CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 7 HIS B 114
LEU B  84
SER B 109
ASP B 111
 CUA  B 802 (-3.0A)
None
None
None
 1.25A 1ismB-3s38B:
undetectable		 1ismB-3s38B:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1598_0
(NITROUS OXIDE
REDUCTASE)		 1cyx CYOA
(Escherichia
coli) 		4 / 4 HIS A 172
CYH A 207
CYH A 211
MET A 218
 CUA  A 316 (-2.9A)
CUA  A 316 (-2.1A)
CUA  A 316 (-2.2A)
CUA  A 316 (-3.0A)
 0.39A 2iwkA-1cyxA:
0.1		 2iwkA-1cyxA:
14.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IWK_A_CUA1598_0
(NITROUS OXIDE
REDUCTASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 4 HIS A 526
CYH A 561
CYH A 565
MET A 572
 CUA  A4701 (-3.1A)
CUA  A4701 (-2.2A)
CUA  A4701 (-2.2A)
CUA  A4701 (-2.4A)
 0.10A 2iwkA-1fwxA:
70.4		 2iwkA-1fwxA:
85.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1598_0
(NITROUS OXIDE
REDUCTASE)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE II
(Paracoccus
denitrificans) 		4 / 4 HIS B 181
CYH B 216
CYH B 220
MET B 227
 CUA  B 301 (-3.2A)
CUA  B 301 (-2.1A)
CUA  B 301 (-2.0A)
CUA  B 301 (-2.5A)
 0.50A 2iwkA-1qleB:
9.4		 2iwkA-1qleB:
17.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IWK_A_CUA1598_0
(NITROUS OXIDE
REDUCTASE)		 1qni NITROUS-OXIDE
REDUCTASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 4 HIS A 526
CYH A 561
CYH A 565
MET A 572
 CUA  A 701 (-3.1A)
CUA  A 701 (-2.2A)
CUA  A 701 (-2.2A)
CUA  A 701 (-2.4A)
 0.19A 2iwkA-1qniA:
62.7		 2iwkA-1qniA:
59.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1598_0
(NITROUS OXIDE
REDUCTASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 HIS B 162
CYH B 197
CYH B 201
MET B 208
 CUA  B 585 (-3.0A)
CUA  B 585 (-2.4A)
CUA  B 585 (-2.3A)
CUA  B 585 (-2.3A)
 0.23A 2iwkA-2yevB:
8.5		 2iwkA-2yevB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1598_0
(NITROUS OXIDE
REDUCTASE)		 3s38 CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 HIS B 114
CYH B 149
CYH B 153
MET B 160
 CUA  B 802 (-3.0A)
CUA  B 802 (-1.9A)
CUA  B 802 (-2.0A)
CUA  B 802 (-2.0A)
 0.47A 2iwkA-3s38B:
11.7		 2iwkA-3s38B:
14.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IWK_A_CUA1598_0
(NITROUS OXIDE
REDUCTASE)		 3sbq NITROUS-OXIDE
REDUCTASE
(Pseudomonas
stutzeri) 		4 / 4 HIS A 583
CYH A 618
CYH A 622
MET A 629
 CUA  A 701 (-4.3A)
CUA  A 701 (-2.2A)
CUA  A 701 (-2.3A)
CUA  A 701 (-2.3A)
 0.44A 2iwkA-3sbqA:
64.2		 2iwkA-3sbqA:
56.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 1cyx CYOA
(Escherichia
coli) 		3 / 3 CYH A 207
CYH A 211
HIS A 215
 CUA  A 316 (-2.1A)
CUA  A 316 (-2.2A)
CUA  A 316 (-2.8A)
 0.29A 2iwkA-1cyxA:
0.1		 2iwkA-1cyxA:
14.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 CYH A 561
CYH A 565
HIS A 569
 CUA  A4701 (-2.2A)
CUA  A4701 (-2.2A)
CUA  A4701 (-3.0A)
 0.09A 2iwkA-1fwxA:
70.4		 2iwkA-1fwxA:
85.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE II
(Paracoccus
denitrificans) 		3 / 3 CYH B 216
CYH B 220
HIS B 224
 CUA  B 301 (-2.1A)
CUA  B 301 (-2.0A)
CUA  B 301 (-3.1A)
 0.35A 2iwkA-1qleB:
9.4		 2iwkA-1qleB:
17.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 1qni NITROUS-OXIDE
REDUCTASE
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 CYH A 561
CYH A 565
HIS A 569
 CUA  A 701 (-2.2A)
CUA  A 701 (-2.2A)
CUA  A 701 (-3.0A)
 0.13A 2iwkA-1qniA:
62.7		 2iwkA-1qniA:
59.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		3 / 3 CYH B 197
CYH B 201
HIS B 205
 CUA  B 585 (-2.4A)
CUA  B 585 (-2.3A)
CUA  B 585 (-3.1A)
 0.16A 2iwkA-2yevB:
8.5		 2iwkA-2yevB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 3s38 CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		3 / 3 CYH B 149
CYH B 153
HIS B 157
 CUA  B 802 (-1.9A)
CUA  B 802 (-2.0A)
CUA  B 802 (-2.7A)
 0.41A 2iwkA-3s38B:
11.7		 2iwkA-3s38B:
14.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 3sbq NITROUS-OXIDE
REDUCTASE
(Pseudomonas
stutzeri) 		3 / 3 CYH A 618
CYH A 622
HIS A 626
 CUA  A 701 (-2.2A)
CUA  A 701 (-2.3A)
CUA  A 701 (-3.0A)
 0.11A 2iwkA-3sbqA:
64.2		 2iwkA-3sbqA:
56.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1598_0
(NITROUS OXIDE
REDUCTASE)		 1cyx CYOA
(Escherichia
coli) 		4 / 4 HIS A 172
CYH A 207
CYH A 211
MET A 218
 CUA  A 316 (-2.9A)
CUA  A 316 (-2.1A)
CUA  A 316 (-2.2A)
CUA  A 316 (-3.0A)
 0.39A 2iwkB-1cyxA:
0.1		 2iwkB-1cyxA:
14.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IWK_B_CUB1598_0
(NITROUS OXIDE
REDUCTASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 4 HIS A 526
CYH A 561
CYH A 565
MET A 572
 CUA  A4701 (-3.1A)
CUA  A4701 (-2.2A)
CUA  A4701 (-2.2A)
CUA  A4701 (-2.4A)
 0.11A 2iwkB-1fwxA:
70.6		 2iwkB-1fwxA:
85.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1598_0
(NITROUS OXIDE
REDUCTASE)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE II
(Paracoccus
denitrificans) 		4 / 4 HIS B 181
CYH B 216
CYH B 220
MET B 227
 CUA  B 301 (-3.2A)
CUA  B 301 (-2.1A)
CUA  B 301 (-2.0A)
CUA  B 301 (-2.5A)
 0.51A 2iwkB-1qleB:
9.4		 2iwkB-1qleB:
17.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IWK_B_CUB1598_0
(NITROUS OXIDE
REDUCTASE)		 1qni NITROUS-OXIDE
REDUCTASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 4 HIS A 526
CYH A 561
CYH A 565
MET A 572
 CUA  A 701 (-3.1A)
CUA  A 701 (-2.2A)
CUA  A 701 (-2.2A)
CUA  A 701 (-2.4A)
 0.19A 2iwkB-1qniA:
62.8		 2iwkB-1qniA:
59.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1598_0
(NITROUS OXIDE
REDUCTASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 HIS B 162
CYH B 197
CYH B 201
MET B 208
 CUA  B 585 (-3.0A)
CUA  B 585 (-2.4A)
CUA  B 585 (-2.3A)
CUA  B 585 (-2.3A)
 0.21A 2iwkB-2yevB:
8.4		 2iwkB-2yevB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1598_0
(NITROUS OXIDE
REDUCTASE)		 3s38 CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 HIS B 114
CYH B 149
CYH B 153
MET B 160
 CUA  B 802 (-3.0A)
CUA  B 802 (-1.9A)
CUA  B 802 (-2.0A)
CUA  B 802 (-2.0A)
 0.47A 2iwkB-3s38B:
13.9		 2iwkB-3s38B:
14.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IWK_B_CUB1598_0
(NITROUS OXIDE
REDUCTASE)		 3sbq NITROUS-OXIDE
REDUCTASE
(Pseudomonas
stutzeri) 		4 / 4 HIS A 583
CYH A 618
CYH A 622
MET A 629
 CUA  A 701 (-4.3A)
CUA  A 701 (-2.2A)
CUA  A 701 (-2.3A)
CUA  A 701 (-2.3A)
 0.42A 2iwkB-3sbqA:
64.2		 2iwkB-3sbqA:
56.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 1cyx CYOA
(Escherichia
coli) 		3 / 3 CYH A 207
CYH A 211
HIS A 215
 CUA  A 316 (-2.1A)
CUA  A 316 (-2.2A)
CUA  A 316 (-2.8A)
 0.29A 2iwkB-1cyxA:
0.1		 2iwkB-1cyxA:
14.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 CYH A 561
CYH A 565
HIS A 569
 CUA  A4701 (-2.2A)
CUA  A4701 (-2.2A)
CUA  A4701 (-3.0A)
 0.11A 2iwkB-1fwxA:
70.6		 2iwkB-1fwxA:
85.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE II
(Paracoccus
denitrificans) 		3 / 3 CYH B 216
CYH B 220
HIS B 224
 CUA  B 301 (-2.1A)
CUA  B 301 (-2.0A)
CUA  B 301 (-3.1A)
 0.36A 2iwkB-1qleB:
9.4		 2iwkB-1qleB:
17.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 1qni NITROUS-OXIDE
REDUCTASE
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 CYH A 561
CYH A 565
HIS A 569
 CUA  A 701 (-2.2A)
CUA  A 701 (-2.2A)
CUA  A 701 (-3.0A)
 0.17A 2iwkB-1qniA:
62.8		 2iwkB-1qniA:
59.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		3 / 3 CYH B 197
CYH B 201
HIS B 205
 CUA  B 585 (-2.4A)
CUA  B 585 (-2.3A)
CUA  B 585 (-3.1A)
 0.16A 2iwkB-2yevB:
8.4		 2iwkB-2yevB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 3s38 CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		3 / 3 CYH B 149
CYH B 153
HIS B 157
 CUA  B 802 (-1.9A)
CUA  B 802 (-2.0A)
CUA  B 802 (-2.7A)
 0.41A 2iwkB-3s38B:
13.9		 2iwkB-3s38B:
14.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 3sbq NITROUS-OXIDE
REDUCTASE
(Pseudomonas
stutzeri) 		3 / 3 CYH A 618
CYH A 622
HIS A 626
 CUA  A 701 (-2.2A)
CUA  A 701 (-2.3A)
CUA  A 701 (-3.0A)
 0.12A 2iwkB-3sbqA:
64.2		 2iwkB-3sbqA:
56.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 1cyx CYOA
(Escherichia
coli) 		4 / 8 HIS A 172
SER A 167
ASP A 135
ALA A 187
 CUA  A 316 (-2.9A)
None
None
None
 1.14A 2rk8A-1cyxA:
undetectable		 2rk8A-1cyxA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 1yew PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylococcus
capsulatus) 		4 / 8 HIS A 139
TYR A 336
TRP A  54
THR A 334
 CUA  A   3 (-3.1A)
None
None
None
 1.50A 2vxaF-1yewA:
undetectable
2vxaG-1yewA:
undetectable
2vxaI-1yewA:
undetectable		 2vxaF-1yewA:
10.21
2vxaG-1yewA:
10.21
2vxaI-1yewA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1004_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1cyx CYOA
(Escherichia
coli) 		4 / 4 HIS A 172
CYH A 207
CYH A 211
MET A 218
 CUA  A 316 (-2.9A)
CUA  A 316 (-2.1A)
CUA  A 316 (-2.2A)
CUA  A 316 (-3.0A)
 0.38A 3dtuB-1cyxA:
14.4		 3dtuB-1cyxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1004_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 4 HIS A 526
CYH A 561
CYH A 565
MET A 572
 CUA  A4701 (-3.1A)
CUA  A4701 (-2.2A)
CUA  A4701 (-2.2A)
CUA  A4701 (-2.4A)
 0.45A 3dtuB-1fwxA:
9.7		 3dtuB-1fwxA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DTU_B_CUB1004_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE II
(Paracoccus
denitrificans) 		4 / 4 HIS B 181
CYH B 216
CYH B 220
MET B 227
 CUA  B 301 (-3.2A)
CUA  B 301 (-2.1A)
CUA  B 301 (-2.0A)
CUA  B 301 (-2.5A)
 0.29A 3dtuB-1qleB:
29.3		 3dtuB-1qleB:
56.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1004_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1qni NITROUS-OXIDE
REDUCTASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 4 HIS A 526
CYH A 561
CYH A 565
MET A 572
 CUA  A 701 (-3.1A)
CUA  A 701 (-2.2A)
CUA  A 701 (-2.2A)
CUA  A 701 (-2.4A)
 0.44A 3dtuB-1qniA:
9.8		 3dtuB-1qniA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1004_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 HIS B 162
CYH B 197
CYH B 201
MET B 208
 CUA  B 585 (-3.0A)
CUA  B 585 (-2.4A)
CUA  B 585 (-2.3A)
CUA  B 585 (-2.3A)
 0.44A 3dtuB-2yevB:
17.1		 3dtuB-2yevB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1004_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3s38 CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 HIS B 114
CYH B 149
CYH B 153
MET B 160
 CUA  B 802 (-3.0A)
CUA  B 802 (-1.9A)
CUA  B 802 (-2.0A)
CUA  B 802 (-2.0A)
 0.58A 3dtuB-3s38B:
9.3		 3dtuB-3s38B:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1004_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3sbq NITROUS-OXIDE
REDUCTASE
(Pseudomonas
stutzeri) 		4 / 4 HIS A 583
CYH A 618
CYH A 622
MET A 629
 CUA  A 701 (-4.3A)
CUA  A 701 (-2.2A)
CUA  A 701 (-2.3A)
CUA  A 701 (-2.3A)
 0.68A 3dtuB-3sbqA:
8.0		 3dtuB-3sbqA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1cyx CYOA
(Escherichia
coli) 		3 / 3 CYH A 207
CYH A 211
HIS A 215
 CUA  A 316 (-2.1A)
CUA  A 316 (-2.2A)
CUA  A 316 (-2.8A)
 0.26A 3dtuB-1cyxA:
14.4		 3dtuB-1cyxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 CYH A 561
CYH A 565
HIS A 569
 CUA  A4701 (-2.2A)
CUA  A4701 (-2.2A)
CUA  A4701 (-3.0A)
 0.20A 3dtuB-1fwxA:
9.7		 3dtuB-1fwxA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE II
(Paracoccus
denitrificans) 		3 / 3 CYH B 216
CYH B 220
HIS B 224
 CUA  B 301 (-2.1A)
CUA  B 301 (-2.0A)
CUA  B 301 (-3.1A)
 0.26A 3dtuB-1qleB:
29.3		 3dtuB-1qleB:
56.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1qni NITROUS-OXIDE
REDUCTASE
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 CYH A 561
CYH A 565
HIS A 569
 CUA  A 701 (-2.2A)
CUA  A 701 (-2.2A)
CUA  A 701 (-3.0A)
 0.23A 3dtuB-1qniA:
9.8		 3dtuB-1qniA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		3 / 3 CYH B 197
CYH B 201
HIS B 205
 CUA  B 585 (-2.4A)
CUA  B 585 (-2.3A)
CUA  B 585 (-3.1A)
 0.17A 3dtuB-2yevB:
17.1		 3dtuB-2yevB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3s38 CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		3 / 3 CYH B 149
CYH B 153
HIS B 157
 CUA  B 802 (-1.9A)
CUA  B 802 (-2.0A)
CUA  B 802 (-2.7A)
 0.38A 3dtuB-3s38B:
9.3		 3dtuB-3s38B:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3sbq NITROUS-OXIDE
REDUCTASE
(Pseudomonas
stutzeri) 		3 / 3 CYH A 618
CYH A 622
HIS A 626
 CUA  A 701 (-2.2A)
CUA  A 701 (-2.3A)
CUA  A 701 (-3.0A)
 0.25A 3dtuB-3sbqA:
8.0		 3dtuB-3sbqA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1cyx CYOA
(Escherichia
coli) 		3 / 3 CYH A 207
CYH A 211
HIS A 215
 CUA  A 316 (-2.1A)
CUA  A 316 (-2.2A)
CUA  A 316 (-2.8A)
 0.23A 3dtuD-1cyxA:
13.4		 3dtuD-1cyxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		3 / 3 CYH A 561
CYH A 565
HIS A 569
 CUA  A4701 (-2.2A)
CUA  A4701 (-2.2A)
CUA  A4701 (-3.0A)
 0.19A 3dtuD-1fwxA:
9.2		 3dtuD-1fwxA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE II
(Paracoccus
denitrificans) 		3 / 3 CYH B 216
CYH B 220
HIS B 224
 CUA  B 301 (-2.1A)
CUA  B 301 (-2.0A)
CUA  B 301 (-3.1A)
 0.22A 3dtuD-1qleB:
29.5		 3dtuD-1qleB:
56.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1qni NITROUS-OXIDE
REDUCTASE
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 CYH A 561
CYH A 565
HIS A 569
 CUA  A 701 (-2.2A)
CUA  A 701 (-2.2A)
CUA  A 701 (-3.0A)
 0.20A 3dtuD-1qniA:
9.3		 3dtuD-1qniA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		3 / 3 CYH B 197
CYH B 201
HIS B 205
 CUA  B 585 (-2.4A)
CUA  B 585 (-2.3A)
CUA  B 585 (-3.1A)
 0.17A 3dtuD-2yevB:
17.0		 3dtuD-2yevB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3s38 CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		3 / 3 CYH B 149
CYH B 153
HIS B 157
 CUA  B 802 (-1.9A)
CUA  B 802 (-2.0A)
CUA  B 802 (-2.7A)
 0.36A 3dtuD-3s38B:
8.9		 3dtuD-3s38B:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3sbq NITROUS-OXIDE
REDUCTASE
(Pseudomonas
stutzeri) 		3 / 3 CYH A 618
CYH A 622
HIS A 626
 CUA  A 701 (-2.2A)
CUA  A 701 (-2.3A)
CUA  A 701 (-3.0A)
 0.24A 3dtuD-3sbqA:
7.6		 3dtuD-3sbqA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD4_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1cyx CYOA
(Escherichia
coli) 		4 / 4 HIS A 172
CYH A 207
CYH A 211
MET A 218
 CUA  A 316 (-2.9A)
CUA  A 316 (-2.1A)
CUA  A 316 (-2.2A)
CUA  A 316 (-3.0A)
 0.37A 3dtuD-1cyxA:
13.4		 3dtuD-1cyxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD4_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		4 / 4 HIS A 526
CYH A 561
CYH A 565
MET A 572
 CUA  A4701 (-3.1A)
CUA  A4701 (-2.2A)
CUA  A4701 (-2.2A)
CUA  A4701 (-2.4A)
 0.46A 3dtuD-1fwxA:
9.2		 3dtuD-1fwxA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DTU_D_CUD4_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE II
(Paracoccus
denitrificans) 		4 / 4 HIS B 181
CYH B 216
CYH B 220
MET B 227
 CUA  B 301 (-3.2A)
CUA  B 301 (-2.1A)
CUA  B 301 (-2.0A)
CUA  B 301 (-2.5A)
 0.30A 3dtuD-1qleB:
29.5		 3dtuD-1qleB:
56.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD4_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1qni NITROUS-OXIDE
REDUCTASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 4 HIS A 526
CYH A 561
CYH A 565
MET A 572
 CUA  A 701 (-3.1A)
CUA  A 701 (-2.2A)
CUA  A 701 (-2.2A)
CUA  A 701 (-2.4A)
 0.44A 3dtuD-1qniA:
9.3		 3dtuD-1qniA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD4_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2yev CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 HIS B 162
CYH B 197
CYH B 201
MET B 208
 CUA  B 585 (-3.0A)
CUA  B 585 (-2.4A)
CUA  B 585 (-2.3A)
CUA  B 585 (-2.3A)
 0.46A 3dtuD-2yevB:
17.0		 3dtuD-2yevB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD4_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3s38 CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 HIS B 114
CYH B 149
CYH B 153
MET B 160
 CUA  B 802 (-3.0A)
CUA  B 802 (-1.9A)
CUA  B 802 (-2.0A)
CUA  B 802 (-2.0A)
 0.58A 3dtuD-3s38B:
8.9		 3dtuD-3s38B:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD4_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3sbq NITROUS-OXIDE
REDUCTASE
(Pseudomonas
stutzeri) 		4 / 4 HIS A 583
CYH A 618
CYH A 622
MET A 629
 CUA  A 701 (-4.3A)
CUA  A 701 (-2.2A)
CUA  A 701 (-2.3A)
CUA  A 701 (-2.3A)
 0.73A 3dtuD-3sbqA:
7.6		 3dtuD-3sbqA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1fwx NITROUS OXIDE
REDUCTASE
(Paracoccus
denitrificans) 		5 / 9 SER A 492
ASN A 517
ILE A 539
GLY A 527
CYH A 561
 None
None
None
None
CUA  A4701 (-2.2A)
 1.43A 4fxsA-1fwxA:
undetectable		 4fxsA-1fwxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
CYTOCHROME C OXIDASE
POLYPEPTIDE II
(Paracoccus
denitrificans) 		5 / 12 THR A 405
LEU A  57
ARG A  54
HIS B 224
PRO B  13
 None
None
HEA  A 601 (-3.1A)
CUA  B 301 (-3.1A)
None
 1.31A 4xi3A-1qleA:
2.1		 4xi3A-1qleA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 1yew PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylococcus
capsulatus) 		3 / 3 LYS A  33
HIS A 139
HIS A  33
 CUA  A   3 (-3.9A)
CUA  A   3 (-3.1A)
CUA  A   3 (-2.9A)
 1.19A 5oexA-1yewA:
undetectable		 5oexA-1yewA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 1yew PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylococcus
capsulatus) 		3 / 3 LYS A  33
HIS A 139
HIS A  33
 CUA  A   3 (-3.9A)
CUA  A   3 (-3.1A)
CUA  A   3 (-2.9A)
 1.13A 5oexB-1yewA:
undetectable		 5oexB-1yewA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 1yew PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylococcus
capsulatus) 		3 / 3 LYS A  33
HIS A 139
HIS A  33
 CUA  A   3 (-3.9A)
CUA  A   3 (-3.1A)
CUA  A   3 (-2.9A)
 1.12A 5oexC-1yewA:
undetectable		 5oexC-1yewA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 1yew PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylococcus
capsulatus) 		3 / 3 LYS A  33
HIS A 139
HIS A  33
 CUA  A   3 (-3.9A)
CUA  A   3 (-3.1A)
CUA  A   3 (-2.9A)
 1.16A 5oexD-1yewA:
undetectable		 5oexD-1yewA:
22.48