SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CU4'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		5 / 12 SER A 291
ALA A 466
GLY A 467
LEU A 445
PHE A 483
 None
None
None
None
CU4  A 601 (-4.2A)
 1.22A 1vpoH-6b5iA:
undetectable
1vpoL-6b5iA:
undetectable		 1vpoH-6b5iA:
13.49
1vpoL-6b5iA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		3 / 3 GLN A 310
HIS A 309
ARG A 346
 CU4  A 601 (-3.6A)
None
None
 1.09A 1zlqA-6b5iA:
undetectable		 1zlqA-6b5iA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FR8_A_TNGA601_1
(ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		6 / 11 ASN A 187
PHE A 188
LEU A 191
MET A 192
TRP A 195
CYH A 320
 CU4  A 601 (-4.2A)
CU4  A 601 (-3.6A)
None
CU4  A 601 ( 4.7A)
CU4  A 601 (-4.2A)
CU4  A 601 (-4.2A)
 0.62A 4fr8A-6b5iA:
65.0		 4fr8A-6b5iA:
55.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		9 / 12 GLY A 142
THR A 146
ASN A 187
PHE A 188
LEU A 191
MET A 192
CYH A 319
CYH A 320
THR A 321
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.4A)
CU4  A 601 (-4.2A)
CU4  A 601 (-3.6A)
None
CU4  A 601 ( 4.7A)
CU4  A 601 ( 4.5A)
CU4  A 601 (-4.2A)
CU4  A 601 (-3.0A)
 0.78A 5fhzA-6b5iA:
62.8		 5fhzA-6b5iA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		9 / 12 GLY A 142
THR A 146
ASN A 187
PHE A 188
LEU A 191
MET A 192
TRP A 195
CYH A 319
THR A 321
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.4A)
CU4  A 601 (-4.2A)
CU4  A 601 (-3.6A)
None
CU4  A 601 ( 4.7A)
CU4  A 601 (-4.2A)
CU4  A 601 ( 4.5A)
CU4  A 601 (-3.0A)
 0.71A 5fhzA-6b5iA:
62.8		 5fhzA-6b5iA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		6 / 12 GLY A 142
THR A 146
ASN A 315
LEU A 191
TRP A 195
THR A 321
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.4A)
None
None
CU4  A 601 (-4.2A)
CU4  A 601 (-3.0A)
 1.46A 5fhzA-6b5iA:
62.8		 5fhzA-6b5iA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		7 / 9 GLY A 142
THR A 146
LEU A 191
TRP A 195
GLN A 310
ASN A 475
LEU A 477
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.4A)
None
CU4  A 601 (-4.2A)
CU4  A 601 (-3.6A)
CU4  A 601 (-3.7A)
CU4  A 601 (-3.8A)
 0.71A 5fhzB-6b5iA:
59.6		 5fhzB-6b5iA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		6 / 9 GLY A 142
THR A 146
TRP A 195
GLN A 307
ASN A 475
LEU A 477
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.4A)
CU4  A 601 (-4.2A)
None
CU4  A 601 (-3.7A)
CU4  A 601 (-3.8A)
 1.43A 5fhzB-6b5iA:
59.6		 5fhzB-6b5iA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		8 / 10 GLY A 142
THR A 146
LEU A 191
TRP A 195
GLN A 310
PHE A 314
ASN A 475
LEU A 477
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.4A)
None
CU4  A 601 (-4.2A)
CU4  A 601 (-3.6A)
CU4  A 601 (-3.7A)
CU4  A 601 (-3.7A)
CU4  A 601 (-3.8A)
 0.66A 5fhzC-6b5iA:
62.4		 5fhzC-6b5iA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		6 / 12 GLY A 142
ASN A 187
MET A 192
CYH A 319
CYH A 320
THR A 321
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.2A)
CU4  A 601 ( 4.7A)
CU4  A 601 ( 4.5A)
CU4  A 601 (-4.2A)
CU4  A 601 (-3.0A)
 0.96A 5fhzD-6b5iA:
61.8		 5fhzD-6b5iA:
63.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens) 		7 / 12 GLY A 142
ASN A 187
MET A 192
TRP A 195
CYH A 319
THR A 321
LEU A 477
 CU4  A 601 (-3.6A)
CU4  A 601 (-4.2A)
CU4  A 601 ( 4.7A)
CU4  A 601 (-4.2A)
CU4  A 601 ( 4.5A)
CU4  A 601 (-3.0A)
CU4  A 601 (-3.8A)
 0.79A 5fhzD-6b5iA:
61.8		 5fhzD-6b5iA:
63.75