SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CTS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		6 / 12 ASN A 191
GLU A 192
HIS A 253
TYR A 255
GLU A 292
TRP A 363
 CTS  A 401 (-3.1A)
CTS  A 401 (-3.3A)
None
CTS  A 401 (-3.7A)
CTS  A 401 (-2.8A)
CTS  A 401 (-3.5A)
 0.69A 2v3dA-1eqcA:
16.5		 2v3dA-1eqcA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		5 / 11 ASN A 191
GLU A 192
TYR A 255
GLU A 292
TRP A 363
 CTS  A 401 (-3.1A)
CTS  A 401 (-3.3A)
CTS  A 401 (-3.7A)
CTS  A 401 (-2.8A)
CTS  A 401 (-3.5A)
 0.77A 2v3dB-1eqcA:
13.9		 2v3dB-1eqcA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 7 TYR A 284
LEU A 277
ASN A 384
TYR A 478
 None
None
CTS  A1544 (-3.9A)
None
 1.37A 4f8yC-2vl8A:
undetectable
4f8yD-2vl8A:
undetectable		 4f8yC-2vl8A:
14.63
4f8yD-2vl8A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		3 / 3 GLU A 292
TYR A  29
GLU A  27
 CTS  A 401 (-2.8A)
CTS  A 401 (-4.6A)
CTS  A 401 (-2.7A)
 0.65A 4ryaA-1eqcA:
0.0		 4ryaA-1eqcA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 4 ILE A 375
ASN A 384
ILE A 274
VAL A 399
 None
CTS  A1544 (-3.9A)
None
None
 1.11A 4uy87-2vl8A:
undetectable		 4uy87-2vl8A:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		5 / 9 ASN A 264
ALA A 267
ILE A 403
GLY A 470
ILE A 466
 None
None
None
CTS  A1544 ( 3.7A)
None
 1.20A 5kr2A-2vl8A:
undetectable		 5kr2A-2vl8A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		5 / 9 ASN A 264
ALA A 267
ILE A 403
GLY A 470
ILE A 466
 None
None
None
CTS  A1544 ( 3.7A)
None
 0.97A 5kr2C-2vl8A:
undetectable		 5kr2C-2vl8A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		5 / 12 ILE A  15
VAL A 289
ASN A 191
ASP A 133
ILE A 224
 None
None
CTS  A 401 (-3.1A)
None
None
 1.00A 5lg3E-1eqcA:
0.0		 5lg3E-1eqcA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		5 / 12 ILE A  15
VAL A 289
ASN A 191
ASP A 133
ILE A 224
 None
None
CTS  A 401 (-3.1A)
None
None
 0.97A 5lg3J-1eqcA:
undetectable		 5lg3J-1eqcA:
21.01