SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CTR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		11 / 12 ALA A 143
TYR A 145
TYR A 171
ASP A 173
GLN A 175
GLU A 212
ASP A 214
GLU A 217
THR A 246
ARG A 251
ASP A 368
 CTR  A 431 ( 4.6A)
CTR  A 431 (-3.8A)
None
CTR  A 431 (-3.0A)
CTR  A 431 (-3.3A)
CTR  A 431 (-3.3A)
CTR  A 431 (-4.2A)
CTR  A 431 (-3.1A)
CTR  A 431 (-4.2A)
CTR  A 431 (-3.4A)
None
 0.72A 1dy4A-2rfzA:
61.9		 1dy4A-2rfzA:
50.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 5w11 GLUCANASE
(Thermothelomyces
thermophila) 		9 / 12 ALA A 144
SER A 175
GLN A 176
GLU A 213
ASP A 215
GLU A 218
THR A 247
ARG A 252
ASP A 374
 None
None
CTR  A 506 (-4.1A)
CTR  A 506 ( 4.5A)
None
CTR  A 506 ( 4.3A)
CTR  A 506 (-2.7A)
CTR  A 506 (-3.0A)
CTR  A 506 ( 3.0A)
 0.64A 1dy4A-5w11A:
65.6		 1dy4A-5w11A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 5w11 GLUCANASE
(Thermothelomyces
thermophila) 		11 / 12 ALA A 144
TYR A 146
TYR A 172
ASP A 174
SER A 175
GLN A 176
GLU A 213
ASP A 215
GLU A 218
ARG A 252
ASP A 374
 None
None
None
CTR  A 506 ( 4.6A)
None
CTR  A 506 (-4.1A)
CTR  A 506 ( 4.5A)
None
CTR  A 506 ( 4.3A)
CTR  A 506 (-3.0A)
CTR  A 506 ( 3.0A)
 0.29A 1dy4A-5w11A:
65.6		 1dy4A-5w11A:
14.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_2
(EXOGLUCANASE 1)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		4 / 5 HIS A 228
TRP A 366
ALA A 371
TRP A 375
 CTR  A 431 (-4.1A)
CTR  A 432 (-4.6A)
None
CTR  A 431 (-4.0A)
 0.44A 1dy4A-2rfzA:
61.9		 1dy4A-2rfzA:
50.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5w11 GLUCANASE
(Thermothelomyces
thermophila) 		5 / 9 ASP A 180
LEU A 181
ILE A  73
THR A 109
ILE A  34
 CTR  A 505 (-3.8A)
None
PCA  A   1 ( 4.8A)
None
None
 1.46A 1hzeA-5w11A:
undetectable
1hzeB-5w11A:
undetectable		 1hzeA-5w11A:
21.18
1hzeB-5w11A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5w11 GLUCANASE
(Thermothelomyces
thermophila) 		5 / 9 THR A 109
ILE A  34
ASP A 180
LEU A 181
ILE A  73
 None
None
CTR  A 505 (-3.8A)
None
PCA  A   1 ( 4.8A)
 1.46A 1hzeA-5w11A:
undetectable
1hzeB-5w11A:
undetectable		 1hzeA-5w11A:
21.18
1hzeB-5w11A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		3 / 3 GLU A 217
ASN A 141
TRP A 375
 CTR  A 431 (-3.1A)
None
CTR  A 431 (-4.0A)
 0.94A 1r15C-2rfzA:
undetectable		 1r15C-2rfzA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		3 / 3 GLU A 217
ASN A 141
TRP A 375
 CTR  A 431 (-3.1A)
None
CTR  A 431 (-4.0A)
 0.97A 1r15D-2rfzA:
undetectable		 1r15D-2rfzA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		3 / 3 GLU A 217
ASN A 141
TRP A 375
 CTR  A 431 (-3.1A)
None
CTR  A 431 (-4.0A)
 0.95A 1r15E-2rfzA:
undetectable		 1r15E-2rfzA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		3 / 3 GLU A 217
ASN A 141
TRP A 375
 CTR  A 431 (-3.1A)
None
CTR  A 431 (-4.0A)
 0.98A 1r15F-2rfzA:
undetectable		 1r15F-2rfzA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 4n2z GH62
ARABINOFURANOSIDASE
(Podospora
anserina) 		4 / 8 SER A  64
TYR A  71
TYR A 320
HIS A 285
 TRS  A 402 ( 4.4A)
TRS  A 402 (-4.6A)
CTR  A 405 ( 3.8A)
CA  A 401 ( 3.3A)
 1.21A 2bteA-4n2zA:
undetectable		 2bteA-4n2zA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 3a3h ENDOGLUCANASE
(Salipaludibacill
us
agaradhaerens) 		5 / 12 ASN A 138
GLU A 139
HIS A 200
GLU A 228
TRP A 262
 CTR  A   1 (-3.1A)
CTR  A   1 ( 2.4A)
None
CTR  A   1 ( 2.7A)
CTR  A   1 (-3.5A)
 0.55A 2v3dA-3a3hA:
16.1		 2v3dA-3a3hA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 5gly GLYCOSIDE HYDROLASE
FAMILY 45 PROTEIN
(Thielavia
terrestris) 		4 / 7 ASP A 115
SER A 118
SER A   7
ASP A 179
 None
None
None
CTR  A 302 (-2.6A)
 1.33A 3bc9A-5glyA:
undetectable		 3bc9A-5glyA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 3a3h ENDOGLUCANASE
(Salipaludibacill
us
agaradhaerens) 		5 / 12 ARG A  62
GLU A 135
TYR A 202
ASN A 138
HIS A 101
 None
None
CTR  A   1 (-4.5A)
CTR  A   1 (-3.1A)
CTR  A   1 (-4.0A)
 1.49A 3bjmA-3a3hA:
undetectable		 3bjmA-3a3hA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 3a3h ENDOGLUCANASE
(Salipaludibacill
us
agaradhaerens) 		5 / 12 ARG A  62
GLU A 135
TYR A 202
ASN A 138
HIS A 101
 None
None
CTR  A   1 (-4.5A)
CTR  A   1 (-3.1A)
CTR  A   1 (-4.0A)
 1.45A 3bjmB-3a3hA:
undetectable		 3bjmB-3a3hA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5gly GLYCOSIDE HYDROLASE
FAMILY 45 PROTEIN
(Thielavia
terrestris) 		3 / 3 GLY A 129
GLY A 145
GLY A 150
 CTR  A 302 (-3.5A)
None
None
 0.31A 3bogC-5glyA:
undetectable		 3bogC-5glyA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5gly GLYCOSIDE HYDROLASE
FAMILY 45 PROTEIN
(Thielavia
terrestris) 		3 / 3 GLY A 129
GLY A 145
GLY A 150
 CTR  A 302 (-3.5A)
None
None
 0.30A 3bogD-5glyA:
undetectable		 3bogD-5glyA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 12 VAL A 183
GLY A 168
TYR A 171
ILE A  34
TRP A  38
 None
None
None
None
CTR  A 432 (-3.8A)
 1.49A 3bwmA-2rfzA:
undetectable		 3bwmA-2rfzA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 12 VAL A 183
GLY A 168
TYR A 171
ILE A  34
TRP A  38
 None
None
None
None
CTR  A 432 (-3.8A)
 1.49A 3bwyA-2rfzA:
undetectable		 3bwyA-2rfzA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4n2z GH62
ARABINOFURANOSIDASE
(Podospora
anserina) 		3 / 3 GLU A 216
GLU A 233
TRP A 325
 CTR  A 405 ( 2.8A)
None
None
 1.23A 3hrdA-4n2zA:
undetectable
3hrdE-4n2zA:
undetectable
3hrdF-4n2zA:
undetectable		 3hrdA-4n2zA:
23.33
3hrdE-4n2zA:
23.33
3hrdF-4n2zA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5w11 GLUCANASE
(Thermothelomyces
thermophila) 		3 / 3 ARG A 398
ASP A 258
GLN A 332
 CTR  A 506 (-3.5A)
None
None
 0.91A 3lcvB-5w11A:
undetectable		 3lcvB-5w11A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 3a3h ENDOGLUCANASE
(Salipaludibacill
us
agaradhaerens) 		3 / 3 HIS A 101
PHE A 118
PHE A 119
 CTR  A   1 (-4.0A)
None
None
 0.57A 3lk0D-3a3hA:
undetectable		 3lk0D-3a3hA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		4 / 6 GLU A 212
THR A 246
ALA A 174
ALA A 258
 CTR  A 431 (-3.3A)
CTR  A 431 (-4.2A)
None
None
 1.23A 3ns1C-2rfzA:
undetectable		 3ns1C-2rfzA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		4 / 7 TYR A 145
ASP A 179
ALA A 177
TYR A 171
 CTR  A 431 (-3.8A)
CTR  A 432 (-2.3A)
None
None
 1.19A 3rodD-2rfzA:
undetectable		 3rodD-2rfzA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 5w11 GLUCANASE
(Thermothelomyces
thermophila) 		4 / 8 ASP A 215
GLY A 261
GLU A 218
ARG A 252
 None
None
CTR  A 506 ( 4.3A)
CTR  A 506 (-3.0A)
 0.97A 3s3nA-5w11A:
undetectable		 3s3nA-5w11A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 3a3h ENDOGLUCANASE
(Salipaludibacill
us
agaradhaerens) 		4 / 8 PRO A 140
HIS A 101
ILE A 102
ILE A 136
 None
CTR  A   1 (-4.0A)
None
None
 0.88A 3sfeB-3a3hA:
undetectable
3sfeC-3a3hA:
undetectable		 3sfeB-3a3hA:
19.57
3sfeC-3a3hA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 3a3h ENDOGLUCANASE
(Salipaludibacill
us
agaradhaerens) 		4 / 6 HIS A 200
GLU A 228
ASP A  99
SER A  33
 None
CTR  A   1 ( 2.7A)
None
None
 1.08A 4apjA-3a3hA:
undetectable
4apjP-3a3hA:
undetectable		 4apjA-3a3hA:
19.90
4apjP-3a3hA:
4.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		8 / 9 ASN A 141
ALA A 143
TYR A 145
TYR A 171
ASP A 173
GLU A 212
ASP A 214
TRP A 366
 None
CTR  A 431 ( 4.6A)
CTR  A 431 (-3.8A)
None
CTR  A 431 (-3.0A)
CTR  A 431 (-3.3A)
CTR  A 431 (-4.2A)
CTR  A 432 (-4.6A)
 0.43A 4ipmA-2rfzA:
59.8		 4ipmA-2rfzA:
49.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		8 / 9 ASN A 141
TYR A 145
TYR A 171
ASP A 173
GLU A 212
ASP A 214
GLU A 217
TRP A 366
 None
CTR  A 431 (-3.8A)
None
CTR  A 431 (-3.0A)
CTR  A 431 (-3.3A)
CTR  A 431 (-4.2A)
CTR  A 431 (-3.1A)
CTR  A 432 (-4.6A)
 0.63A 4ipmA-2rfzA:
59.8		 4ipmA-2rfzA:
49.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 5w11 GLUCANASE
(Thermothelomyces
thermophila) 		9 / 9 ASN A 142
ALA A 144
TYR A 146
TYR A 172
ASP A 174
GLU A 213
ASP A 215
GLU A 218
TRP A 372
 None
None
None
None
CTR  A 506 ( 4.6A)
CTR  A 506 ( 4.5A)
None
CTR  A 506 ( 4.3A)
None
 0.52A 4ipmA-5w11A:
63.3		 4ipmA-5w11A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3a3h ENDOGLUCANASE
(Salipaludibacill
us
agaradhaerens) 		5 / 12 PHE A 201
GLU A 139
ALA A 198
ALA A 260
ALA A  64
 None
CTR  A   1 ( 2.4A)
None
None
None
 1.05A 4oaeA-3a3hA:
undetectable		 4oaeA-3a3hA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5w11 GLUCANASE
(Thermothelomyces
thermophila) 		5 / 7 THR A 247
THR A 227
LEU A 382
ASN A 142
SER A 175
 CTR  A 506 (-2.7A)
CTR  A 506 ( 4.9A)
None
None
None
 1.42A 4pfjA-5w11A:
undetectable		 4pfjA-5w11A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		4 / 5 TYR A 171
SER A 364
ASP A 214
ASP A 262
 None
None
CTR  A 431 (-4.2A)
CTR  A 431 ( 4.5A)
 1.18A 4qtuB-2rfzA:
undetectable		 4qtuB-2rfzA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5w11 GLUCANASE
(Thermothelomyces
thermophila) 		4 / 5 TYR A 172
SER A 370
ASP A 215
ASP A 263
 None
None
None
CTR  A 506 ( 3.8A)
 1.11A 4qtuB-5w11A:
undetectable		 4qtuB-5w11A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 3a3h ENDOGLUCANASE
(Salipaludibacill
us
agaradhaerens) 		4 / 4 THR A 265
GLY A 236
ASP A 237
SER A 263
 None
CTR  A   1 (-3.5A)
None
None
 1.34A 4rfqA-3a3hA:
undetectable		 4rfqA-3a3hA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5gly GLYCOSIDE HYDROLASE
FAMILY 45 PROTEIN
(Thielavia
terrestris) 		5 / 12 GLY A 129
GLY A 149
ALA A  75
THR A 110
ALA A 124
 CTR  A 302 (-3.5A)
CTR  A 302 (-3.7A)
CTT  A 301 (-3.5A)
None
None
 1.15A 4uckB-5glyA:
undetectable		 4uckB-5glyA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 3a3h ENDOGLUCANASE
(Salipaludibacill
us
agaradhaerens) 		5 / 9 SER A  33
GLY A 174
SER A 179
GLU A 139
ALA A 155
 None
None
None
CTR  A   1 ( 2.4A)
None
 1.37A 5entC-3a3hA:
undetectable		 5entC-3a3hA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5w11 GLUCANASE
(Thermothelomyces
thermophila) 		5 / 12 ASP A 251
ALA A 254
PRO A 259
SER A 249
TYR A 248
 None
None
None
None
CTR  A 505 ( 4.4A)
 1.26A 5hfjA-5w11A:
undetectable		 5hfjA-5w11A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5w11 GLUCANASE
(Thermothelomyces
thermophila) 		5 / 12 ASP A 251
ALA A 254
PRO A 259
SER A 249
TYR A 248
 None
None
None
None
CTR  A 505 ( 4.4A)
 1.26A 5hfjC-5w11A:
undetectable		 5hfjC-5w11A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGJ_A_X6XA402_1
(PREDICTED
ACETYLTRANSFERASE)		 4n2z GH62
ARABINOFURANOSIDASE
(Podospora
anserina) 		4 / 5 ARG A 241
GLU A 233
ASP A  49
TRP A 325
 CTR  A 405 (-3.0A)
None
TRS  A 402 (-2.7A)
None
 1.48A 5kgjA-4n2zA:
undetectable		 5kgjA-4n2zA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 12 VAL A 183
GLY A 168
TYR A 171
ILE A  34
TRP A  38
 None
None
None
None
CTR  A 432 (-3.8A)
 1.48A 5lsaA-2rfzA:
undetectable		 5lsaA-2rfzA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 12 VAL A 147
GLU A 212
LEU A  90
LEU A  14
LEU A  92
 None
CTR  A 431 (-3.3A)
None
None
None
 1.08A 6ew0B-2rfzA:
undetectable		 6ew0B-2rfzA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 12 VAL A 147
GLU A 212
LEU A  90
LEU A  14
LEU A  92
 None
CTR  A 431 (-3.3A)
None
None
None
 1.08A 6ew0D-2rfzA:
undetectable		 6ew0D-2rfzA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 12 VAL A 147
GLU A 212
LEU A  90
LEU A  14
LEU A  92
 None
CTR  A 431 (-3.3A)
None
None
None
 1.08A 6ew0H-2rfzA:
undetectable		 6ew0H-2rfzA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Melanocarpus
albomyces) 		5 / 12 VAL A 147
GLU A 212
LEU A  90
LEU A  14
LEU A  92
 None
CTR  A 431 (-3.3A)
None
None
None
 1.08A 6ew0I-2rfzA:
undetectable		 6ew0I-2rfzA:
12.53