SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CTP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		5 / 11 HIS A  14
GLY A  16
HIS A  17
GLY A  92
ASP A  94
 CTP  A 130 (-4.2A)
CTP  A 130 ( 4.1A)
CTP  A 130 (-3.7A)
CTP  A 130 (-3.3A)
CTP  A 130 (-3.9A)
 0.72A 1pg2A-1cozA:
5.4		 1pg2A-1cozA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		4 / 7 ASP A 309
VAL A 314
GLY A 326
ILE A 350
 CTP  A 500 (-4.1A)
None
CTP  A 500 (-3.6A)
None
 0.77A 1t7iB-1u7wA:
undetectable		 1t7iB-1u7wA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		4 / 7 ASP A 309
VAL A 314
GLY A 326
ILE A 350
 CTP  A 500 (-4.1A)
None
CTP  A 500 (-3.6A)
None
 0.79A 1t7jB-1u7wA:
undetectable		 1t7jB-1u7wA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE
(Homo
sapiens) 		3 / 3 TYR A  31
ARG A  43
GLN A  44
 CTP  A 402 ( 3.9A)
None
None
 0.87A 1tw4A-4xsvA:
undetectable		 1tw4A-4xsvA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		5 / 12 LEU A  21
THR A   6
LEU A 111
GLY A  92
PHE A  10
 None
None
None
CTP  A 130 (-3.3A)
CTP  A 130 (-4.3A)
 1.14A 1xwfA-1cozA:
2.4		 1xwfA-1cozA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		5 / 12 LEU A  21
THR A   6
LEU A 111
GLY A  92
PHE A  10
 None
None
None
CTP  A 130 (-3.3A)
CTP  A 130 (-4.3A)
 1.14A 1xwfB-1cozA:
3.3		 1xwfB-1cozA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 277
ALA A 196
PHE A 332
ALA A 278
ILE A 405
 CTP  A 500 (-4.8A)
None
None
None
None
 1.00A 2aclA-4qjiA:
undetectable
2aclE-4qjiA:
undetectable		 2aclA-4qjiA:
23.08
2aclE-4qjiA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ALA A 277
ALA A 196
PHE A 332
ALA A 278
ILE A 405
 CTP  A 500 (-4.8A)
None
None
None
None
 1.05A 2aclC-4qjiA:
undetectable		 2aclC-4qjiA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A 277
ALA A 196
PHE A 332
ALA A 278
ILE A 405
 CTP  A 500 (-4.8A)
None
None
None
None
 1.04A 2aclE-4qjiA:
undetectable		 2aclE-4qjiA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		6 / 12 ALA A 328
GLY A 326
MET A 216
GLY A 389
LEU A 392
LEU A 391
 CTP  A 500 ( 4.0A)
CTP  A 500 (-3.6A)
None
None
None
None
 1.33A 2hw2A-1u7wA:
undetectable		 2hw2A-1u7wA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		4 / 4 ASP A  94
LEU A 111
GLY A  92
ARG A  23
 CTP  A 130 (-3.9A)
None
CTP  A 130 (-3.3A)
None
 1.44A 2j2pD-1cozA:
0.0
2j2pE-1cozA:
0.0		 2j2pD-1cozA:
20.18
2j2pE-1cozA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 277
GLY A 197
LEU A 311
VAL A 330
LEU A 359
 CTP  A 500 (-4.8A)
None
CTP  A 500 (-3.9A)
None
None
 1.04A 2nyuA-4qjiA:
5.2		 2nyuA-4qjiA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		4 / 7 PHE A  10
PHE A  89
ILE A  81
GLY A   8
 CTP  A 130 (-4.3A)
None
None
CTP  A 130 ( 3.8A)
 0.86A 2v0mB-1cozA:
0.0		 2v0mB-1cozA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		5 / 11 HIS A  14
GLY A  16
HIS A  17
GLY A  92
ASP A  94
 CTP  A 130 (-4.2A)
CTP  A 130 ( 4.1A)
CTP  A 130 (-3.7A)
CTP  A 130 (-3.3A)
CTP  A 130 (-3.9A)
 0.94A 2x1lA-1cozA:
6.1		 2x1lA-1cozA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 313
ARG A 260
LEU A 259
VAL A 279
MET A 275
 None
None
None
CTP  A 500 (-4.1A)
CTP  A 500 (-4.4A)
 0.88A 3adxB-4qjiA:
undetectable		 3adxB-4qjiA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 9 ALA A   9
ASP A  95
ILE A  45
VAL A  57
ILE A  30
 CTP  A1233 (-4.4A)
MG  A1234 ( 2.6A)
None
None
None
 1.04A 3ekvB-2y6pA:
undetectable		 3ekvB-2y6pA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ALA A 277
ALA A 196
PHE A 332
ALA A 278
ILE A 405
 CTP  A 500 (-4.8A)
None
None
None
None
 1.04A 3falA-4qjiA:
undetectable		 3falA-4qjiA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ALA A 277
ALA A 196
PHE A 332
ALA A 278
ILE A 405
 CTP  A 500 (-4.8A)
None
None
None
None
 0.99A 3falC-4qjiA:
undetectable		 3falC-4qjiA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A 277
ALA A 196
PHE A 332
ALA A 278
ILE A 405
 CTP  A 500 (-4.8A)
None
None
None
None
 0.99A 3fc6A-4qjiA:
undetectable		 3fc6A-4qjiA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5guf CDP-ARCHAEOL
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 SER A 104
ASP A 100
ASP A  41
 CTP  A 201 (-2.3A)
CTP  A 201 ( 3.4A)
None
 0.85A 3iv6A-5gufA:
undetectable		 3iv6A-5gufA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5guf CDP-ARCHAEOL
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 SER A 104
ASP A 100
ASP A  41
 CTP  A 201 (-2.3A)
CTP  A 201 ( 3.4A)
None
 0.85A 3iv6C-5gufA:
undetectable		 3iv6C-5gufA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KD5_E_PPFE914_1
(DNA POLYMERASE)		 5guf CDP-ARCHAEOL
SYNTHASE
(Aeropyrum
pernix) 		4 / 5 ASP A 100
LEU A 121
ARG A 108
ASP A 125
 CTP  A 201 ( 3.4A)
None
CTP  A 201 (-2.9A)
K  A 205 ( 3.8A)
 1.50A 3kd5E-5gufA:
1.5		 3kd5E-5gufA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 9 ALA A   9
ASP A  95
ILE A  45
VAL A  57
ILE A  30
 CTP  A1233 (-4.4A)
MG  A1234 ( 2.6A)
None
None
None
 0.98A 3nu4A-2y6pA:
undetectable		 3nu4A-2y6pA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		4 / 8 ASP A 309
VAL A 314
GLY A 326
ILE A 350
 CTP  A 500 (-4.1A)
None
CTP  A 500 (-3.6A)
None
 0.75A 3nu9A-1u7wA:
undetectable		 3nu9A-1u7wA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 9 ALA A   9
ASP A  95
ILE A  45
VAL A  57
ILE A  30
 CTP  A1233 (-4.4A)
MG  A1234 ( 2.6A)
None
None
None
 1.02A 3nuoA-2y6pA:
undetectable		 3nuoA-2y6pA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 ASP A 219
ASP A  95
GLY A  94
GLY A  73
TYR A 170
 MG  A1234 ( 2.3A)
MG  A1234 ( 2.6A)
CTP  A1233 (-3.5A)
CTP  A1233 (-3.4A)
IPA  A1236 ( 4.0A)
 0.92A 3prsA-2y6pA:
undetectable		 3prsA-2y6pA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4wop ATP-DEPENDENT
DETHIOBIOTIN
SYNTHETASE BIOD
(Mycobacterium
tuberculosis) 		4 / 7 PRO A 197
GLY A 199
ALA A 200
ASP A 207
 None
CTP  A 301 (-3.0A)
CTP  A 301 (-3.6A)
None
 0.72A 3ur0B-4wopA:
undetectable		 3ur0B-4wopA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4wop ATP-DEPENDENT
DETHIOBIOTIN
SYNTHETASE BIOD
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 200
LEU A  56
PHE A 208
SER A 170
VAL A   6
 CTP  A 301 (-3.6A)
None
None
CTP  A 301 ( 4.2A)
None
 1.27A 4claA-4wopA:
undetectable		 4claA-4wopA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4wop ATP-DEPENDENT
DETHIOBIOTIN
SYNTHETASE BIOD
(Mycobacterium
tuberculosis) 		4 / 7 ALA A  21
PHE A 216
ALA A 194
LEU A 196
 None
None
None
CTP  A 301 ( 4.4A)
 0.85A 4du2A-4wopA:
undetectable		 4du2A-4wopA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4wop ATP-DEPENDENT
DETHIOBIOTIN
SYNTHETASE BIOD
(Mycobacterium
tuberculosis) 		4 / 7 ALA A  21
PHE A 216
ALA A 194
LEU A 196
 None
None
None
CTP  A 301 ( 4.4A)
 0.84A 4du2B-4wopA:
undetectable		 4du2B-4wopA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 10 ALA A   9
ASP A  95
ILE A  45
VAL A  57
ILE A  30
 CTP  A1233 (-4.4A)
MG  A1234 ( 2.6A)
None
None
None
 1.06A 4q1wB-2y6pA:
undetectable		 4q1wB-2y6pA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A 239
SER A 213
ALA A 236
GLY A 237
ALA A 277
 None
None
None
None
CTP  A 500 (-4.8A)
 1.29A 4qw1H-4qjiA:
undetectable
4qw1I-4qjiA:
undetectable		 4qw1H-4qjiA:
23.60
4qw1I-4qjiA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A 239
SER A 213
ALA A 236
GLY A 237
ALA A 277
 None
None
None
None
CTP  A 500 (-4.8A)
 1.28A 4qw1V-4qjiA:
undetectable
4qw1W-4qjiA:
undetectable		 4qw1V-4qjiA:
23.60
4qw1W-4qjiA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5guf CDP-ARCHAEOL
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 LYS A  57
ARG A 109
VAL A 106
 CTP  A 201 (-2.4A)
None
None
 0.68A 4x3uA-5gufA:
undetectable
4x3uB-5gufA:
undetectable		 4x3uA-5gufA:
20.35
4x3uB-5gufA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 5guf CDP-ARCHAEOL
SYNTHASE
(Aeropyrum
pernix) 		4 / 5 ASP A 100
VAL A  40
ASP A  41
GLY A  54
 CTP  A 201 ( 3.4A)
None
None
None
 1.20A 4xp6A-5gufA:
0.1		 4xp6A-5gufA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Aquifex
aeolicus) 		4 / 6 ARG A  15
GLY A 217
ASP A 223
ASP A  95
 CTP  A1233 (-3.7A)
None
None
MG  A1234 ( 2.6A)
 1.15A 5hp1A-2y6pA:
undetectable		 5hp1A-2y6pA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4ee1 DNA PRIMASE
(Staphylococcus
aureus) 		4 / 6 ARG A 146
ASP A 270
GLY A 267
ASP A 343
 CTP  A 501 (-2.9A)
CTP  A 501 ( 3.9A)
CTP  A 501 (-3.0A)
MN  A 504 (-2.7A)
 1.19A 5hp1C-4ee1A:
undetectable		 5hp1C-4ee1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		4 / 5 ALA A 338
ALA A 328
ILE A 350
LEU A 347
 None
CTP  A 500 ( 4.0A)
None
None
 0.78A 5jncD-1u7wA:
undetectable		 5jncD-1u7wA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A 239
SER A 213
ALA A 236
GLY A 237
ALA A 277
 None
None
None
None
CTP  A 500 (-4.8A)
 1.29A 5l5zH-4qjiA:
undetectable
5l5zI-4qjiA:
undetectable		 5l5zH-4qjiA:
23.60
5l5zI-4qjiA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A 239
SER A 213
ALA A 236
GLY A 237
ALA A 277
 None
None
None
None
CTP  A 500 (-4.8A)
 1.29A 5l5zV-4qjiA:
undetectable
5l5zW-4qjiA:
undetectable		 5l5zV-4qjiA:
23.60
5l5zW-4qjiA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A 239
SER A 213
ALA A 236
GLY A 237
ALA A 277
 None
None
None
None
CTP  A 500 (-4.8A)
 1.28A 5l66H-4qjiA:
undetectable
5l66I-4qjiA:
undetectable		 5l66H-4qjiA:
23.60
5l66I-4qjiA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A 239
SER A 213
ALA A 236
GLY A 237
ALA A 277
 None
None
None
None
CTP  A 500 (-4.8A)
 1.28A 5l66V-4qjiA:
undetectable
5l66W-4qjiA:
undetectable		 5l66V-4qjiA:
23.60
5l66W-4qjiA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		6 / 12 CYH A 274
ALA A 276
PRO A 197
GLY A 236
GLY A 326
LEU A 392
 None
None
None
None
CTP  A 500 (-3.6A)
None
 1.17A 5wwsA-1u7wA:
3.4		 5wwsA-1u7wA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		5 / 12 CYH A 274
ALA A 276
PRO A 197
GLY A 236
GLY A 326
 None
None
None
None
CTP  A 500 (-3.6A)
 1.06A 5wwsB-1u7wA:
3.2		 5wwsB-1u7wA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4wop ATP-DEPENDENT
DETHIOBIOTIN
SYNTHETASE BIOD
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 215
LEU A 196
VAL A 192
GLY A 165
LEU A 224
 None
CTP  A 301 ( 4.4A)
None
None
None
 1.07A 5x24A-4wopA:
undetectable		 5x24A-4wopA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE
(Homo
sapiens) 		4 / 8 THR A 125
THR A 117
PRO A  94
LYS A  66
 None
None
None
CTP  A 402 ( 4.8A)
 1.33A 5x2sI-4xsvA:
undetectable
5x2sJ-4xsvA:
undetectable
5x2sK-4xsvA:
undetectable		 5x2sI-4xsvA:
17.72
5x2sJ-4xsvA:
19.69
5x2sK-4xsvA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 LEU A  99
VAL A 113
PRO A 158
THR A 157
THR A 203
 None
None
None
None
CTP  A 500 ( 4.6A)
 1.29A 5xipC-1vpaA:
2.7		 5xipC-1vpaA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 LEU A  99
VAL A 113
PRO A 158
THR A 157
THR A 203
 None
None
None
None
CTP  A 500 ( 4.6A)
 1.28A 5xipD-1vpaA:
3.5		 5xipD-1vpaA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A  55
GLY A  29
THR A 101
TYR A 105
TYR A 126
 None
CTP  A 402 (-3.4A)
None
None
None
 1.02A 5yf0A-4xsvA:
undetectable		 5yf0A-4xsvA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 5 THR A 203
THR A 157
HIS A 101
GLY A  10
 CTP  A 500 ( 4.6A)
None
None
CTP  A 500 (-3.2A)
 1.20A 6gbnC-1vpaA:
2.3		 6gbnC-1vpaA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		4 / 8 GLY A  16
HIS A  17
GLY A  92
ALA A  24
 CTP  A 130 ( 4.1A)
CTP  A 130 (-3.7A)
CTP  A 130 (-3.3A)
None
 0.79A 6hu9H-1cozA:
undetectable
6hu9e-1cozA:
undetectable		 6hu9H-1cozA:
21.58
6hu9e-1cozA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		4 / 5 GLY A   8
THR A   9
HIS A  17
SER A 118
 CTP  A 130 ( 3.8A)
CTP  A 130 (-4.3A)
CTP  A 130 (-3.7A)
CTP  A 130 (-3.9A)
 0.75A 6jmjA-1cozA:
12.9		 6jmjA-1cozA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		5 / 7 GLY A   8
THR A   9
PHE A  10
HIS A  17
SER A 118
 CTP  A 130 ( 3.8A)
CTP  A 130 (-4.3A)
CTP  A 130 (-4.3A)
CTP  A 130 (-3.7A)
CTP  A 130 (-3.9A)
 0.81A 6jnhA-1cozA:
13.0		 6jnhA-1cozA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		4 / 6 GLY A   8
THR A   9
HIS A  17
SER A 118
 CTP  A 130 ( 3.8A)
CTP  A 130 (-4.3A)
CTP  A 130 (-3.7A)
CTP  A 130 (-3.9A)
 0.81A 6jogA-1cozA:
12.9		 6jogA-1cozA:
26.47