SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CTO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		5 / 10 LEU A 191
VAL A 320
TYR A 121
GLY A 321
TYR A 213
 CTO  A 404 (-4.7A)
None
CTO  A 404 (-4.4A)
None
CTO  A 404 (-4.6A)
 1.38A 1ikwA-5i1tA:
undetectable		 1ikwA-5i1tA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 5xsx CHITINASE
(Thermococcus
chitonophagus) 		5 / 12 TYR A 655
ALA A 514
GLY A 510
LEU A 511
PHE A 507
 CTO  A1001 (-3.8A)
None
None
None
None
 1.20A 1vpoH-5xsxA:
2.5
1vpoL-5xsxA:
2.8		 1vpoH-5xsxA:
19.14
1vpoL-5xsxA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		3 / 3 LEU A 191
HIS A 128
LYS A 125
 CTO  A 404 (-4.7A)
None
CTO  A 404 ( 4.9A)
 1.05A 1y7iA-5i1tA:
undetectable		 1y7iA-5i1tA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		4 / 7 ALA A 117
TYR A 194
TYR A 124
TYR A 213
 None
CTO  A 404 (-3.5A)
None
CTO  A 404 (-4.6A)
 1.18A 2ajvH-5i1tA:
undetectable
2ajvL-5i1tA:
undetectable		 2ajvH-5i1tA:
21.35
2ajvL-5i1tA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		5 / 11 LEU A  98
ALA A 110
ALA A 327
TYR A 194
GLN A 147
 None
None
None
CTO  A 404 (-3.5A)
None
 1.50A 3bszF-5i1tA:
undetectable		 3bszF-5i1tA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 2r0h CGL3 LECTIN
(Coprinopsis
cinerea) 		4 / 6 HIS A  60
ARG A  64
ASN A  73
GLU A  84
 CTO  A 165 (-3.6A)
CTO  A 165 (-2.6A)
CTO  A 165 (-4.1A)
CTO  A 165 (-2.7A)
 0.45A 3galA-2r0hA:
15.8		 3galA-2r0hA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 2r0h CGL3 LECTIN
(Coprinopsis
cinerea) 		4 / 6 HIS A  60
ARG A  64
ASN A  73
GLU A  84
 CTO  A 165 (-3.6A)
CTO  A 165 (-2.6A)
CTO  A 165 (-4.1A)
CTO  A 165 (-2.7A)
 0.40A 3galB-2r0hA:
15.3		 3galB-2r0hA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HVT_A_NVPA557_1
(HIV-1 REVERSE
TRANSCRIPTASE
(SUBUNIT P66))		 5i1t STAGE II SPORULATION
PROTEIN D
(Clostridioides
difficile) 		5 / 9 LEU A 191
VAL A 320
TYR A 121
GLY A 321
TYR A 213
 CTO  A 404 (-4.7A)
None
CTO  A 404 (-4.4A)
None
CTO  A 404 (-4.6A)
 1.33A 3hvtA-5i1tA:
undetectable		 3hvtA-5i1tA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 2r0h CGL3 LECTIN
(Coprinopsis
cinerea) 		3 / 3 PRO A  76
SER A  80
ASN A  73
 None
None
CTO  A 165 (-4.1A)
 0.93A 3lslG-2r0hA:
undetectable		 3lslG-2r0hA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 2r0h CGL3 LECTIN
(Coprinopsis
cinerea) 		5 / 12 LEU A   5
HIS A  60
PRO A 143
PHE A 145
ILE A  63
 None
CTO  A 165 (-3.6A)
None
None
None
 1.42A 5dv4A-2r0hA:
undetectable		 5dv4A-2r0hA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 2r0h CGL3 LECTIN
(Coprinopsis
cinerea) 		5 / 7 HIS A  60
ARG A  64
ASN A  73
GLU A  84
ARG A  86
 CTO  A 165 (-3.6A)
CTO  A 165 (-2.6A)
CTO  A 165 (-4.1A)
CTO  A 165 (-2.7A)
CTO  A 165 ( 4.0A)
 0.37A 6b8kA-2r0hA:
16.3		 6b8kA-2r0hA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 2r0h CGL3 LECTIN
(Coprinopsis
cinerea) 		5 / 8 HIS A  60
ARG A  64
ASN A  73
GLU A  84
ARG A  86
 CTO  A 165 (-3.6A)
CTO  A 165 (-2.6A)
CTO  A 165 (-4.1A)
CTO  A 165 (-2.7A)
CTO  A 165 ( 4.0A)
 0.55A 6b94A-2r0hA:
14.4		 6b94A-2r0hA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 2r0h CGL3 LECTIN
(Coprinopsis
cinerea) 		5 / 10 HIS A  60
ARG A  64
ASN A  73
GLU A  84
ARG A  86
 CTO  A 165 (-3.6A)
CTO  A 165 (-2.6A)
CTO  A 165 (-4.1A)
CTO  A 165 (-2.7A)
CTO  A 165 ( 4.0A)
 0.39A 6b94A-2r0hA:
14.4
6b94B-2r0hA:
13.8		 6b94A-2r0hA:
18.54
6b94B-2r0hA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 2r0h CGL3 LECTIN
(Coprinopsis
cinerea) 		4 / 4 ARG A  64
GLU A  67
GLU A  84
ARG A  86
 CTO  A 165 (-2.6A)
CTO  A 165 ( 4.7A)
CTO  A 165 (-2.7A)
CTO  A 165 ( 4.0A)
 0.51A 6fk2A-2r0hA:
16.1		 6fk2A-2r0hA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 2r0h CGL3 LECTIN
(Coprinopsis
cinerea) 		4 / 4 ARG A  86
GLU A  84
GLU A  67
ARG A  64
 CTO  A 165 ( 4.0A)
CTO  A 165 (-2.7A)
CTO  A 165 ( 4.7A)
CTO  A 165 (-2.6A)
 1.00A 6fk2A-2r0hA:
16.1		 6fk2A-2r0hA:
25.00