SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CSX'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 4ii0 CRATABL
(Crateva
tapia) 		4 / 8 THR A  54
ASN A  70
THR A  73
ASP A  76
 None
None
CSX  A  74 ( 3.6A)
None
 0.99A 1bu5B-4ii0A:
undetectable		 1bu5B-4ii0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ako SPORE COAT PROTEIN A
(Bacillus
subtilis) 		4 / 8 GLY A 237
GLY A  50
LEU A  48
GLY A 167
 None
None
CSX  A  35 ( 4.4A)
None
 0.69A 1d0vA-4akoA:
undetectable		 1d0vA-4akoA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ako SPORE COAT PROTEIN A
(Bacillus
subtilis) 		4 / 8 GLY A 237
GLY A  50
LEU A  48
GLY A 167
 None
None
CSX  A  35 ( 4.4A)
None
 0.72A 1jhaA-4akoA:
undetectable		 1jhaA-4akoA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 2wan PULLULANASE
(Bacillus
acidopullulyticu
s) 		7 / 12 TYR A 509
HIS A 556
ARG A 620
ASP A 622
GLU A 651
HIS A 735
ASP A 736
 None
CSX  A 588 ( 4.0A)
None
None
None
None
None
 0.50A 1mxdA-2wanA:
25.5		 1mxdA-2wanA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3urz UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		4 / 7 LYS A  97
LEU A 100
GLN A 101
LEU A 110
 None
CSX  A 109 ( 4.3A)
None
CSX  A 109 ( 4.4A)
 0.98A 1v55P-3urzA:
4.3
1v55W-3urzA:
undetectable		 1v55P-3urzA:
17.78
1v55W-3urzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3urz UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		4 / 7 LYS A  97
LEU A 100
GLN A 101
LEU A 110
 None
CSX  A 109 ( 4.3A)
None
CSX  A 109 ( 4.4A)
 0.97A 2eijP-3urzA:
4.3
2eijW-3urzA:
undetectable		 2eijP-3urzA:
17.78
2eijW-3urzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3urz UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		4 / 7 LYS A  97
LEU A 100
GLN A 101
LEU A 110
 None
CSX  A 109 ( 4.3A)
None
CSX  A 109 ( 4.4A)
 1.03A 2einC-3urzA:
4.3
2einJ-3urzA:
undetectable		 2einC-3urzA:
17.78
2einJ-3urzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 4gvo LMO2349 PROTEIN
(Listeria
monocytogenes) 		4 / 7 HIS A 101
ASN A  86
THR A  43
GLY A  42
 CSX  A 704 ( 4.5A)
None
None
None
 1.03A 2f6dA-4gvoA:
undetectable		 2f6dA-4gvoA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 4uou FUCOSE-SPECIFIC
LECTIN FLEA
(Aspergillus
fumigatus) 		5 / 12 LEU A 202
ILE A 205
ILE A 231
GLY A 162
ILE A 161
 None
None
None
None
CSX  A 111 ( 4.7A)
 0.59A 2hs1B-4uouA:
undetectable		 2hs1B-4uouA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 5 LEU A  91
ASP A 149
LEU A  78
HIS A 116
 None
None
None
CSX  A 115 ( 3.9A)
 1.31A 2jfaA-2p1fA:
undetectable		 2jfaA-2p1fA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 4upe NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT
(Desulfovibrio
fructosivorans) 		5 / 12 ALA Q 472
ASP Q 114
PRO Q 498
GLY Q 384
ASP Q 473
 None
CSX  Q  75 ( 4.5A)
FCO  Q1550 (-3.5A)
None
None
 1.35A 2nv4B-4upeQ:
undetectable		 2nv4B-4upeQ:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 4uou FUCOSE-SPECIFIC
LECTIN FLEA
(Aspergillus
fumigatus) 		5 / 12 LEU A 202
ILE A 205
ILE A 231
GLY A 162
ILE A 161
 None
None
None
None
CSX  A 111 ( 4.7A)
 0.76A 2o4nA-4uouA:
undetectable		 2o4nA-4uouA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 4uou FUCOSE-SPECIFIC
LECTIN FLEA
(Aspergillus
fumigatus) 		4 / 6 ILE A 136
PRO A  61
LEU A  83
ILE A 112
 None
PEG  A 900 (-4.1A)
None
CSX  A 111 ( 3.8A)
 0.89A 2q83B-4uouA:
undetectable		 2q83B-4uouA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		5 / 10 TYR A 149
ALA A 193
ALA A 214
THR A 267
VAL A 263
 None
CSX  A 194 ( 3.1A)
None
None
None
 1.44A 2wuzB-4d3yA:
undetectable		 2wuzB-4d3yA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		5 / 8 LEU A  48
ALA A 139
GLY A  43
LEU A  60
ASP A  56
 None
None
CSX  A  42 ( 2.6A)
None
None
 1.31A 2yfxA-2cduA:
undetectable		 2yfxA-2cduA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 4gvo LMO2349 PROTEIN
(Listeria
monocytogenes) 		5 / 12 MET A 103
PHE A  45
VAL A  48
ILE A 195
THR A 182
 CSX  A 704 ( 4.4A)
HIS  A 703 ( 4.0A)
None
None
None
 1.25A 3dl9A-4gvoA:
undetectable		 3dl9A-4gvoA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 4ii0 CRATABL
(Crateva
tapia) 		4 / 7 LEU A  24
ASP A  36
TRP A  78
SER A  75
 None
None
None
CSX  A  74 ( 4.3A)
 1.48A 3dzgA-4ii0A:
undetectable		 3dzgA-4ii0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3fmf DETHIOBIOTIN
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 133
ALA A 134
ALA A 132
VAL A  33
ILE A  31
 None
CSX  A 163 ( 4.9A)
None
None
None
 1.05A 3falA-3fmfA:
undetectable		 3falA-3fmfA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1
(Arabidopsis
thaliana) 		5 / 12 LEU A 176
ALA A  54
ASP A 159
GLY A 153
VAL A 162
 None
None
None
CSX  A 154 ( 2.4A)
None
 1.18A 3gguA-6gbcA:
undetectable		 3gguA-6gbcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		4 / 8 GLU A 192
SER A 312
ALA A 214
ALA A 215
 None
CSX  A 194 ( 3.8A)
None
CSX  A 194 ( 4.6A)
 0.84A 3ns1L-4d3yA:
undetectable		 3ns1L-4d3yA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5vgm DIHYDROOROTASE
(Vibrio
cholerae) 		5 / 12 ASP A 246
HIS A  13
HIS A  15
ALA A 262
CYH A 217
 ZN  A 402 (-2.7A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.3A)
CSX  A 261 ( 3.6A)
None
 1.07A 3r2jC-5vgmA:
2.1		 3r2jC-5vgmA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		5 / 12 ASP A 251
HIS A  17
HIS A  19
ALA A 267
CYH A 222
 ZN  A 402 ( 2.8A)
ZN  A 402 (-3.4A)
ZN  A 402 ( 3.3A)
CSX  A 266 (-3.6A)
None
 1.10A 3r2jC-6ctyA:
undetectable		 3r2jC-6ctyA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 3fse TWO-DOMAIN PROTEIN
CONTAINING
DJ-1/THIJ/PFPI-LIKE
AND FERRITIN-LIKE
DOMAINS
(Trichormus
variabilis) 		5 / 12 GLU A  24
PHE A 168
GLY A 113
GLY A 130
GLY A  80
 CSX  A 111 ( 3.0A)
None
CSX  A 111 ( 4.5A)
CSX  A 111 ( 3.5A)
CSX  A 111 ( 3.6A)
 1.08A 3tegA-3fseA:
undetectable		 3tegA-3fseA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 3fse TWO-DOMAIN PROTEIN
CONTAINING
DJ-1/THIJ/PFPI-LIKE
AND FERRITIN-LIKE
DOMAINS
(Trichormus
variabilis) 		4 / 6 TYR A 145
GLY A 130
VAL A 151
THR A 158
 None
CSX  A 111 ( 3.5A)
None
None
 0.97A 3tj7A-3fseA:
undetectable
3tj7B-3fseA:
undetectable		 3tj7A-3fseA:
20.06
3tj7B-3fseA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 3fse TWO-DOMAIN PROTEIN
CONTAINING
DJ-1/THIJ/PFPI-LIKE
AND FERRITIN-LIKE
DOMAINS
(Trichormus
variabilis) 		4 / 6 TYR A 145
GLY A 130
VAL A 151
THR A 158
 None
CSX  A 111 ( 3.5A)
None
None
 0.96A 3tj7C-3fseA:
undetectable
3tj7D-3fseA:
undetectable		 3tj7C-3fseA:
20.06
3tj7D-3fseA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 3fse TWO-DOMAIN PROTEIN
CONTAINING
DJ-1/THIJ/PFPI-LIKE
AND FERRITIN-LIKE
DOMAINS
(Trichormus
variabilis) 		4 / 6 VAL A 151
THR A 158
TYR A 145
GLY A 130
 None
None
None
CSX  A 111 ( 3.5A)
 0.99A 3tj7C-3fseA:
undetectable
3tj7D-3fseA:
undetectable		 3tj7C-3fseA:
20.06
3tj7D-3fseA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVY_B_TOYB201_1
(AMINOGLYCOSIDE
N(6')-ACETYLTRANSFER
ASE TYPE 1)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 10 ASN B 339
GLU B 318
ASP B 217
GLU B 199
GLY B 355
 None
None
None
None
CSX  B  88 ( 4.3A)
 1.47A 4evyA-5f38B:
undetectable
4evyB-5f38B:
undetectable		 4evyA-5f38B:
18.73
4evyB-5f38B:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 4gvo LMO2349 PROTEIN
(Listeria
monocytogenes) 		4 / 9 PHE A  84
HIS A 101
PHE A 123
ILE A 195
 HIS  A 703 ( 3.7A)
CSX  A 704 ( 4.5A)
CSX  A 704 ( 3.4A)
None
 1.30A 4jvlA-4gvoA:
undetectable		 4jvlA-4gvoA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 5irc RHO
GTPASE-ACTIVATING
PROTEIN 35
(Rattus
norvegicus) 		3 / 3 PRO A1433
ASN A1380
HIS A1384
 CSX  A1432 ( 2.6A)
CSX  A1432 ( 4.0A)
None
 0.56A 4ma3H-5ircA:
undetectable
4ma3L-5ircA:
undetectable		 4ma3H-5ircA:
20.83
4ma3L-5ircA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 4uou FUCOSE-SPECIFIC
LECTIN FLEA
(Aspergillus
fumigatus) 		5 / 11 LEU A 202
ILE A 205
ILE A 231
GLY A 162
ILE A 161
 None
None
None
None
CSX  A 111 ( 4.7A)
 0.85A 4q1xA-4uouA:
undetectable		 4q1xA-4uouA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 4uou FUCOSE-SPECIFIC
LECTIN FLEA
(Aspergillus
fumigatus) 		5 / 12 LEU A 202
ILE A 205
ILE A 231
GLY A 162
ILE A 161
 None
None
None
None
CSX  A 111 ( 4.7A)
 0.65A 4q1yB-4uouA:
undetectable		 4q1yB-4uouA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 9 ALA B 112
ILE B 386
GLY B 355
ALA B 356
ILE B 259
 None
MLY  B  86 ( 4.8A)
CSX  B  88 ( 4.3A)
None
None
 1.04A 4r21B-5f38B:
undetectable		 4r21B-5f38B:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLU B 318
LEU B 375
GLY B 355
ALA B 353
GLU B 116
 None
None
CSX  B  88 ( 4.3A)
None
None
 1.29A 4retC-5f38B:
undetectable		 4retC-5f38B:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_B_QDNB602_1
(CYTOCHROME P450 2D6)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 9 LEU B 378
PHE B 320
ALA B 344
SER B 248
ALA B 247
 CSX  B  88 ( 4.0A)
COZ  B 401 (-4.6A)
None
COZ  B 401 (-3.9A)
COZ  B 401 ( 4.4A)
 1.40A 4wnuB-5f38B:
undetectable		 4wnuB-5f38B:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2wan PULLULANASE
(Bacillus
acidopullulyticu
s) 		4 / 5 ALA A 522
TYR A 521
HIS A 556
PHE A 494
 None
None
CSX  A 588 ( 4.0A)
None
 1.21A 4ze2A-2wanA:
undetectable		 4ze2A-2wanA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		4 / 7 ALA A 256
LYS A 260
GLU A 261
HIS A 258
 None
CSX  A 266 ( 2.7A)
None
None
 1.21A 5ecnA-6ctyA:
0.0		 5ecnA-6ctyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5f38 ACETYL-COA
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ILE B 102
VAL B 258
ALA B 255
ALA B 256
GLY B 355
 None
None
None
None
CSX  B  88 ( 4.3A)
 1.47A 5igpA-5f38B:
undetectable		 5igpA-5f38B:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		5 / 10 ALA A 215
THR A 213
ALA A 155
GLY A 154
ASP A 236
 CSX  A 194 ( 4.6A)
None
None
CSX  A 194 ( 3.5A)
None
 0.99A 5lf3H-4d3yA:
undetectable
5lf3I-4d3yA:
undetectable		 5lf3H-4d3yA:
20.44
5lf3I-4d3yA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		5 / 10 ALA A 215
THR A 213
ALA A 155
GLY A 154
ASP A 236
 CSX  A 194 ( 4.6A)
None
None
CSX  A 194 ( 3.5A)
None
 0.97A 5lf3V-4d3yA:
undetectable
5lf3W-4d3yA:
undetectable		 5lf3V-4d3yA:
20.44
5lf3W-4d3yA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3cs1 FLAGELLAR
CALCIUM-BINDING
PROTEIN
(Trypanosoma
cruzi) 		3 / 3 LYS A  59
LYS A  67
SER A  72
 None
CSX  A  66 ( 2.8A)
None
 1.08A 5odiA-3cs1A:
undetectable		 5odiA-3cs1A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3ot1 4-METHYL-5(B-HYDROXY
ETHYL)-THIAZOLE
MONOPHOSPHATE
BIOSYNTHESIS ENZYME
(Vibrio
cholerae) 		4 / 6 LEU B 141
PHE B 133
ASP B 134
HIS B 129
 None
None
None
CSX  B 108 ( 4.3A)
 1.21A 5om3A-3ot1B:
undetectable
5om3B-3ot1B:
undetectable		 5om3A-3ot1B:
19.70
5om3B-3ot1B:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 4upe NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT
(Desulfovibrio
fructosivorans) 		4 / 8 ARG Q 388
TRP Q 442
VAL Q 435
ASP Q 114
 None
GOL  Q1561 ( 4.4A)
None
CSX  Q  75 ( 4.5A)
 1.10A 5vlmF-4upeQ:
1.8		 5vlmF-4upeQ:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3fmf DETHIOBIOTIN
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 215
LEU A 196
VAL A 192
GLY A 165
LEU A 224
 None
None
None
CSX  A 163 ( 3.7A)
None
 1.08A 5x24A-3fmfA:
undetectable		 5x24A-3fmfA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		3 / 3 SER A  41
HIS A  10
TYR A  62
 FAD  A 500 (-4.5A)
CSX  A  42 (-3.6A)
None
 0.97A 5y2tA-2cduA:
undetectable		 5y2tA-2cduA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_B_ASCB501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 3fse TWO-DOMAIN PROTEIN
CONTAINING
DJ-1/THIJ/PFPI-LIKE
AND FERRITIN-LIKE
DOMAINS
(Trichormus
variabilis) 		5 / 12 PRO A  84
ILE A 134
GLN A 115
ALA A 128
ILE A  78
 None
CSX  A 111 ( 4.9A)
None
None
None
 1.40A 5zovB-3fseA:
undetectable		 5zovB-3fseA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 2wan PULLULANASE
(Bacillus
acidopullulyticu
s) 		5 / 12 TYR A 509
HIS A 556
ASP A 622
HIS A 735
ASP A 736
 None
CSX  A 588 ( 4.0A)
None
None
None
 0.52A 6ag0A-2wanA:
24.3		 6ag0A-2wanA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 4d3y LEGUMAIN
(Cricetulus
griseus) 		3 / 3 ARG A 408
LYS A 195
ARG A 347
 None
CSX  A 194 ( 3.0A)
None
 1.31A 6az3C-4d3yA:
undetectable
6az3L-4d3yA:
undetectable
6az3M-4d3yA:
undetectable		 6az3C-4d3yA:
12.13
6az3L-4d3yA:
9.07
6az3M-4d3yA:
12.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 3ot1 4-METHYL-5(B-HYDROXY
ETHYL)-THIAZOLE
MONOPHOSPHATE
BIOSYNTHESIS ENZYME
(Vibrio
cholerae) 		8 / 10 GLU B  21
GLY B  76
GLY B  77
ILE B 107
ALA B 109
PRO B 111
HIS B 129
GLY B 159
 CSX  B 108 ( 3.0A)
CSX  B 108 ( 3.2A)
CSX  B 108 (-3.4A)
CSX  B 108 ( 3.4A)
CSX  B 108 ( 3.7A)
CSX  B 108 ( 4.2A)
CSX  B 108 ( 4.3A)
CSX  B 108 ( 3.6A)
 0.34A 6e5zA-3ot1B:
30.5		 6e5zA-3ot1B:
39.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1p1v SUPEROXIDE DISMUTASE
[CU-ZN]
(Homo
sapiens) 		5 / 12 ILE A 149
GLY A 150
ILE A 151
ILE A 104
ILE A 112
 None
None
None
None
CSX  A 111 ( 4.0A)
 0.99A 6emuA-1p1vA:
undetectable		 6emuA-1p1vA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3urz UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		4 / 6 TYR A 130
ILE A 133
ALA A 112
MET A 116
 None
None
CSX  A 109 ( 3.8A)
None
 0.98A 6hu9m-3urzA:
undetectable
6hu9q-3urzA:
undetectable		 6hu9m-3urzA:
15.40
6hu9q-3urzA:
22.75