SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CSJ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 12 MET A 225
LEU A 193
PHE A 218
HIS A 257
VAL A 282
 COW  A 350 (-3.7A)
CSJ  A 112 (-4.5A)
CSJ  A 112 ( 4.0A)
COW  A 350 (-4.2A)
None
 1.35A 1hrkB-3h77A:
2.6		 1hrkB-3h77A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 284
ASN A 287
ARG A  40
VAL A 282
 None
CSJ  A 112 ( 3.8A)
None
None
 1.11A 1u1jA-3h77A:
undetectable		 1u1jA-3h77A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  77
GLY A 114
VAL A 166
VAL A 134
VAL A 136
 None
CSJ  A 112 ( 4.5A)
None
None
None
 0.84A 2ieoB-3h77A:
undetectable		 2ieoB-3h77A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 12 MET A 225
LEU A 193
PHE A 218
HIS A 257
VAL A 282
 COW  A 350 (-3.7A)
CSJ  A 112 (-4.5A)
CSJ  A 112 ( 4.0A)
COW  A 350 (-4.2A)
None
 1.36A 2pnjB-3h77A:
undetectable		 2pnjB-3h77A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA1_0
(FERROCHELATASE)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 11 MET A 225
LEU A 193
PHE A 218
HIS A 257
VAL A 282
 COW  A 350 (-3.7A)
CSJ  A 112 (-4.5A)
CSJ  A 112 ( 4.0A)
COW  A 350 (-4.2A)
None
 1.38A 3aqiA-3h77A:
undetectable		 3aqiA-3h77A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 316
LEU A 119
GLY A 114
ALA A 323
ALA A 324
 CSJ  A 112 ( 3.2A)
None
CSJ  A 112 ( 4.5A)
None
None
 0.92A 3sufA-3h77A:
undetectable		 3sufA-3h77A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 12 MET A 225
LEU A 193
PHE A 218
HIS A 257
VAL A 282
 COW  A 350 (-3.7A)
CSJ  A 112 (-4.5A)
CSJ  A 112 ( 4.0A)
COW  A 350 (-4.2A)
None
 1.41A 3w1wB-3h77A:
undetectable		 3w1wB-3h77A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 109
TYR A 315
ASN A 287
 None
None
CSJ  A 112 ( 3.8A)
 0.85A 4ffwB-3h77A:
undetectable		 4ffwB-3h77A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 11 MET A 225
LEU A 193
PHE A 218
HIS A 257
VAL A 282
 COW  A 350 (-3.7A)
CSJ  A 112 (-4.5A)
CSJ  A 112 ( 4.0A)
COW  A 350 (-4.2A)
None
 1.38A 4mk4B-3h77A:
undetectable		 4mk4B-3h77A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 10 SER A  82
LEU A 193
LEU A 155
SER A 143
ASN A 287
 None
CSJ  A 112 (-4.5A)
None
None
CSJ  A 112 ( 3.8A)
 1.21A 4yiaA-3h77A:
undetectable		 4yiaA-3h77A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 161
LEU A 155
SER A 156
PHE A 218
 None
None
None
CSJ  A 112 ( 4.0A)
 1.19A 6ekuA-3h77A:
undetectable		 6ekuA-3h77A:
19.37