SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CSF'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		4 / 5 ALA A 181
PHE A 196
ILE A 258
ASP A 257
 None
CSF  A1001 (-3.5A)
None
None
 1.14A 1yc2D-2p2vA:
undetectable		 1yc2D-2p2vA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 4r84 SIALYLTRANSFERASE
0160
(Photobacterium
damselae) 		4 / 8 HIS A 120
ASP A 119
SER A 426
ASP A 229
 None
None
CSF  A 501 ( 3.8A)
None
 0.94A 2obvA-4r84A:
undetectable		 2obvA-4r84A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 4r84 SIALYLTRANSFERASE
0160
(Photobacterium
damselae) 		4 / 8 HIS A 120
ASP A 119
SER A 426
ASP A 229
 None
None
CSF  A 501 ( 3.8A)
None
 0.92A 2p02A-4r84A:
undetectable		 2p02A-4r84A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		4 / 8 GLY A  25
ASN A  24
ILE A  60
TYR A  86
 CSF  A1001 (-3.4A)
CSF  A1001 (-4.5A)
None
None
 0.96A 2yoeB-2p2vA:
undetectable
2yoeC-2p2vA:
undetectable		 2yoeB-2p2vA:
22.38
2yoeC-2p2vA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2wqq ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		5 / 12 GLY A 152
GLY A   8
PRO A  11
ALA A 163
ILE A   6
 None
CSF  A1259 (-2.9A)
None
None
None
 1.10A 3jayA-2wqqA:
undetectable		 3jayA-2wqqA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2wqq ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		6 / 12 ILE A 153
GLY A 152
GLY A   8
PRO A  11
ALA A 163
TYR A  18
 CSF  A1259 (-4.4A)
None
CSF  A1259 (-2.9A)
None
None
None
 1.21A 3jayA-2wqqA:
undetectable		 3jayA-2wqqA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2iy8 PROTEIN PM0188
(Pasteurella
multocida) 		3 / 3 ASP A  33
ARG A  63
ALA A  39
 None
CSF  A1415 ( 3.1A)
None
 0.73A 3mbgC-2iy8A:
undetectable		 3mbgC-2iy8A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		4 / 8 ILE A 168
ILE A 222
SER A 203
GLU A 209
 CSF  A1001 (-4.3A)
None
None
None
 0.83A 3ua5A-2p2vA:
undetectable		 3ua5A-2p2vA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2p2v ALPHA-2,3-SIALYLTRAN
SFERASE
(Campylobacter
jejuni) 		5 / 11 LEU A 211
GLY A 148
ILE A 156
PHE A  92
LEU A 231
 None
CSF  A1001 (-3.8A)
None
None
None
 1.14A 3zosA-2p2vA:
undetectable
3zosB-2p2vA:
undetectable		 3zosA-2p2vA:
18.73
3zosB-2p2vA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2wqq ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		4 / 8 ASP A 154
ILE A 153
GLY A 152
SER A  79
 None
CSF  A1259 (-4.4A)
None
None
 0.92A 4acbB-2wqqA:
undetectable
4acbC-2wqqA:
undetectable		 4acbB-2wqqA:
21.15
4acbC-2wqqA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4r84 SIALYLTRANSFERASE
0160
(Photobacterium
damselae) 		4 / 8 HIS A 120
ASP A 119
SER A 426
ASP A 229
 None
None
CSF  A 501 ( 3.8A)
None
 1.02A 4kttA-4r84A:
undetectable		 4kttA-4r84A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4r84 SIALYLTRANSFERASE
0160
(Photobacterium
damselae) 		4 / 8 HIS A 120
ASP A 119
SER A 426
ASP A 229
 None
None
CSF  A 501 ( 3.8A)
None
 0.99A 4ndnA-4r84A:
undetectable		 4ndnA-4r84A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4r84 SIALYLTRANSFERASE
0160
(Photobacterium
damselae) 		4 / 7 HIS A 120
ASP A 119
SER A 426
ASP A 229
 None
None
CSF  A 501 ( 3.8A)
None
 0.97A 4ndnC-4r84A:
undetectable		 4ndnC-4r84A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2iy8 PROTEIN PM0188
(Pasteurella
multocida) 		3 / 3 SER A 356
ALA A 354
VAL A 353
 CSF  A1415 (-2.6A)
None
None
 0.49A 4o2bA-2iy8A:
5.3		 4o2bA-2iy8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2iy8 PROTEIN PM0188
(Pasteurella
multocida) 		3 / 3 SER A 356
ALA A 354
VAL A 353
 CSF  A1415 (-2.6A)
None
None
 0.58A 4o2bC-2iy8A:
5.4		 4o2bC-2iy8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4r84 SIALYLTRANSFERASE
0160
(Photobacterium
damselae) 		4 / 8 HIS A 120
ASP A 119
SER A 426
ASP A 229
 None
None
CSF  A 501 ( 3.8A)
None
 0.93A 5a1iA-4r84A:
undetectable		 5a1iA-4r84A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4r84 SIALYLTRANSFERASE
0160
(Photobacterium
damselae) 		4 / 7 HIS A 120
ASP A 119
SER A 426
ASP A 229
 None
None
CSF  A 501 ( 3.8A)
None
 0.93A 5a1iA-4r84A:
undetectable		 5a1iA-4r84A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 2iy8 PROTEIN PM0188
(Pasteurella
multocida) 		5 / 12 THR A 267
THR A 268
THR A 269
SER A 356
MET A 144
 None
None
None
CSF  A1415 (-2.6A)
CSF  A1415 ( 3.8A)
 1.16A 5lf3b-2iy8A:
undetectable		 5lf3b-2iy8A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 2iy8 PROTEIN PM0188
(Pasteurella
multocida) 		5 / 12 THR A 267
THR A 268
THR A 269
SER A 356
MET A 144
 None
None
None
CSF  A1415 (-2.6A)
CSF  A1415 ( 3.8A)
 1.17A 5lf3N-2iy8A:
undetectable		 5lf3N-2iy8A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2iy8 PROTEIN PM0188
(Pasteurella
multocida) 		4 / 6 TYR A 358
ASP A 140
LEU A 200
GLY A 142
 None
None
None
CSF  A1415 (-3.4A)
 1.06A 5nooC-2iy8A:
undetectable		 5nooC-2iy8A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4r84 SIALYLTRANSFERASE
0160
(Photobacterium
damselae) 		4 / 5 ALA A 381
VAL A 377
PHE A 353
ILE A 443
 None
None
None
CSF  A 501 (-4.8A)
 0.83A 5of1A-4r84A:
undetectable		 5of1A-4r84A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4r84 SIALYLTRANSFERASE
0160
(Photobacterium
damselae) 		4 / 5 ALA A 381
VAL A 377
PHE A 353
ILE A 443
 None
None
None
CSF  A 501 (-4.8A)
 0.78A 5of1B-4r84A:
undetectable		 5of1B-4r84A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4r84 SIALYLTRANSFERASE
0160
(Photobacterium
damselae) 		4 / 8 HIS A 120
ASP A 119
SER A 426
ASP A 229
 None
None
CSF  A 501 ( 3.8A)
None
 0.94A 6fboA-4r84A:
undetectable		 6fboA-4r84A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4r84 SIALYLTRANSFERASE
0160
(Photobacterium
damselae) 		4 / 8 HIS A 120
ASP A 119
SER A 426
ASP A 229
 None
None
CSF  A 501 ( 3.8A)
None
 0.95A 6fcbA-4r84A:
undetectable		 6fcbA-4r84A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4r84 SIALYLTRANSFERASE
0160
(Photobacterium
damselae) 		4 / 8 HIS A 120
ASP A 119
SER A 426
ASP A 229
 None
None
CSF  A 501 ( 3.8A)
None
 0.93A 6fcdA-4r84A:
undetectable		 6fcdA-4r84A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4r84 SIALYLTRANSFERASE
0160
(Photobacterium
damselae) 		4 / 7 HIS A 120
ASP A 119
SER A 426
ASP A 229
 None
None
CSF  A 501 ( 3.8A)
None
 0.94A 6g6rA-4r84A:
undetectable		 6g6rA-4r84A:
21.54