SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CSA'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YY8_B_SAMB500_0 (UPF0106 PROTEIN PH0461)	3npf	PUTATIVE DIPEPTIDYL-PEPTIDASE VI (Bacteroides ovatus)	5 / 11	LEU A 206 VAL A 201 GLY A 195 HIS A 263 ALA A 276	CSA A 203 ( 4.4A) None None CSA A 203 ( 4.1A) CSA A 203 ( 4.1A)	1.17A	2yy8A-3npfA: undetectable 2yy8B-3npfA: undetectable	2yy8A-3npfA: 20.19 2yy8B-3npfA: 20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ARC_A_LEUA1001_0 (LEUCINE--TRNA LIGASE)	3npf	PUTATIVE DIPEPTIDYL-PEPTIDASE VI (Bacteroides ovatus)	4 / 7	TYR A 191 ASP A 202 SER A 204 HIS A 263	CSA A 203 ( 4.5A) GOL A 329 (-3.3A) GOL A 329 (-3.5A) CSA A 203 ( 4.1A)	1.34A	4arcA-3npfA: undetectable	4arcA-3npfA: 15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ARC_A_LEUA1001_0 (LEUCINE--TRNA LIGASE)	4r0k	DIPEPTIDYL-PEPTIDASE VI (Bacteroides thetaiotaomicron)	4 / 7	TYR A 191 ASP A 202 SER A 204 HIS A 263	CSA A 203 ( 4.5A) EDO A 404 (-2.9A) EDO A 404 (-3.1A) CSA A 203 ( 4.0A)	1.32A	4arcA-4r0kA: undetectable	4arcA-4r0kA: 16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZBQ_A_ACTA605_0 (SERUM ALBUMIN)	3npf	PUTATIVE DIPEPTIDYL-PEPTIDASE VI (Bacteroides ovatus)	4 / 6	HIS A 263 GLY A 250 ARG A 299 ASN A 296	CSA A 203 ( 4.1A) None None None	1.32A	4zbqA-3npfA: undetectable	4zbqA-3npfA: 18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZBQ_A_ACTA605_0 (SERUM ALBUMIN)	4r0k	DIPEPTIDYL-PEPTIDASE VI (Bacteroides thetaiotaomicron)	4 / 6	HIS A 263 GLY A 250 ARG A 299 ASN A 296	CSA A 203 ( 4.0A) CL A 401 ( 4.8A) CL A 401 (-4.4A) CL A 401 (-3.9A)	1.36A	4zbqA-4r0kA: undetectable	4zbqA-4r0kA: 19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IEN_A_VDYA201_2 (CDL2.2)	3npf	PUTATIVE DIPEPTIDYL-PEPTIDASE VI (Bacteroides ovatus)	5 / 12	VAL A 201 ILE A 274 LEU A 206 GLY A 205 TYR A 184	None None CSA A 203 ( 4.4A) CSA A 203 ( 4.5A) GOL A 332 ( 4.1A)	1.16A	5ienA-3npfA: undetectable	5ienA-3npfA: 18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IEN_A_VDYA201_2 (CDL2.2)	4r0k	DIPEPTIDYL-PEPTIDASE VI (Bacteroides thetaiotaomicron)	5 / 12	VAL A 201 ILE A 274 LEU A 206 GLY A 205 TYR A 184	None None CSA A 203 ( 4.4A) CSA A 203 ( 4.5A) None	1.15A	5ienA-4r0kA: undetectable	5ienA-4r0kA: 19.81

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2YY8_B_SAMB500_0","UPF0106 PROTEIN PH0461","3npf","PUTATIVE DIPEPTIDYL-PEPTIDASE VI","Bacteroides ovatus",5,"LEU A 206;VAL A 201;GLY A 195;HIS A 263;ALA A 276","CSA A 203 ( 4.4A);None;None;CSA A 203 ( 4.1A);CSA A 203 ( 4.1A)","1.17A","2yy8A-3npfA:undetectable;2yy8B-3npfA:undetectable",null],["4ARC_A_LEUA1001_0","LEUCINE--TRNA LIGASE","3npf","PUTATIVE DIPEPTIDYL-PEPTIDASE VI","Bacteroides ovatus",4,"TYR A 191;ASP A 202;SER A 204;HIS A 263","CSA A 203 ( 4.5A);GOL A 329 (-3.3A);GOL A 329 (-3.5A);CSA A 203 ( 4.1A)","1.34A","4arcA-3npfA:undetectable","2yy8A-3npfA:20.19;2yy8B-3npfA:20.19"],["4ARC_A_LEUA1001_0","LEUCINE--TRNA LIGASE","4r0k","DIPEPTIDYL-PEPTIDASE VI","Bacteroides thetaiotaomicron",4,"TYR A 191;ASP A 202;SER A 204;HIS A 263","CSA A 203 ( 4.5A);EDO A 404 (-2.9A);EDO A 404 (-3.1A);CSA A 203 ( 4.0A)","1.32A","4arcA-4r0kA:undetectable","4arcA-3npfA:15.38"],["4ZBQ_A_ACTA605_0","SERUM ALBUMIN","3npf","PUTATIVE DIPEPTIDYL-PEPTIDASE VI","Bacteroides ovatus",4,"HIS A 263;GLY A 250;ARG A 299;ASN A 296","CSA A 203 ( 4.1A);None;None;None","1.32A","4zbqA-3npfA:undetectable","4arcA-4r0kA:16.25"],["4ZBQ_A_ACTA605_0","SERUM ALBUMIN","4r0k","DIPEPTIDYL-PEPTIDASE VI","Bacteroides thetaiotaomicron",4,"HIS A 263;GLY A 250;ARG A 299;ASN A 296","CSA A 203 ( 4.0A); CL A 401 ( 4.8A); CL A 401 (-4.4A); CL A 401 (-3.9A)","1.36A","4zbqA-4r0kA:undetectable","4zbqA-3npfA:18.01"],["5IEN_A_VDYA201_2","CDL2.2","3npf","PUTATIVE DIPEPTIDYL-PEPTIDASE VI","Bacteroides ovatus",5,"VAL A 201;ILE A 274;LEU A 206;GLY A 205;TYR A 184","None;None;CSA A 203 ( 4.4A);CSA A 203 ( 4.5A);GOL A 332 ( 4.1A)","1.16A","5ienA-3npfA:undetectable","4zbqA-4r0kA:19.81"],["5IEN_A_VDYA201_2","CDL2.2","4r0k","DIPEPTIDYL-PEPTIDASE VI","Bacteroides thetaiotaomicron",5,"VAL A 201;ILE A 274;LEU A 206;GLY A 205;TYR A 184","None;None;CSA A 203 ( 4.4A);CSA A 203 ( 4.5A);None","1.15A","5ienA-4r0kA:undetectable","5ienA-3npfA:18.24"]]