SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CS2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		4 / 6 GLY A   9
ALA A  30
TYR A   8
GLU A  63
 None
None
None
CS2  A 402 (-3.6A)
 0.90A 1dmaB-4eayA:
undetectable		 1dmaB-4eayA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		4 / 7 VAL A 224
SER A 218
LEU A 215
ALA A  37
 None
None
CS2  A 401 (-4.2A)
None
 0.88A 1j8uA-4pc9A:
undetectable		 1j8uA-4pc9A:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2W_A_MTLA5600_0
(MANNITOL
DEHYDROGENASE)		 4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI
(Escherichia
coli) 		7 / 9 ASN A 185
ASP A 224
LYS A 289
LEU A 293
ASN A 294
HIS A 297
LYS A 374
 NAI  A 502 ( 3.3A)
CS2  A 501 (-3.6A)
CS2  A 501 (-2.7A)
CS2  A 501 ( 4.5A)
CS2  A 501 (-3.0A)
CS2  A 501 (-3.7A)
CS2  A 501 (-2.8A)
 0.49A 1m2wA-4im7A:
51.6		 1m2wA-4im7A:
38.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2W_B_MTLB6600_0
(MANNITOL
DEHYDROGENASE)		 4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI
(Escherichia
coli) 		7 / 9 ASN A 185
ASP A 224
LYS A 289
LEU A 293
ASN A 294
HIS A 297
LYS A 374
 NAI  A 502 ( 3.3A)
CS2  A 501 (-3.6A)
CS2  A 501 (-2.7A)
CS2  A 501 ( 4.5A)
CS2  A 501 (-3.0A)
CS2  A 501 (-3.7A)
CS2  A 501 (-2.8A)
 0.51A 1m2wB-4im7A:
51.9		 1m2wB-4im7A:
38.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 ASN A 174
VAL A 175
ILE A 238
LEU A 215
ALA A 107
 None
CS2  A 401 (-4.6A)
CS2  A 401 (-4.9A)
CS2  A 401 (-4.2A)
None
 1.31A 2iyfB-4pc9A:
undetectable		 2iyfB-4pc9A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI
(Escherichia
coli) 		4 / 6 ALA A 301
TYR A 302
MET A 379
HIS A 297
 None
None
None
CS2  A 501 (-3.7A)
 1.27A 2pncB-4im7A:
undetectable		 2pncB-4im7A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		5 / 12 VAL A  28
GLU A  63
HIS A 233
ASP A 236
ASP A 351
 None
CS2  A 402 (-3.6A)
MN  A 403 ( 3.4A)
CS2  A 402 (-3.7A)
CS2  A 402 (-2.7A)
 1.27A 2xinC-4eayA:
20.2		 2xinC-4eayA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		3 / 3 GLU A  63
VAL A  62
CYH A 101
 CS2  A 402 (-3.6A)
None
CS2  A 402 ( 4.3A)
 1.01A 3fbxA-4eayA:
undetectable		 3fbxA-4eayA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 ARG A 151
GLU A  94
LEU A 106
GLU A  75
ARG A 171
 CS2  A 401 (-3.0A)
CS2  A 401 (-2.5A)
None
CS2  A 401 (-2.8A)
CS2  A 401 (-2.9A)
 1.35A 3k37B-4pc9A:
undetectable		 3k37B-4pc9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 GLU A  94
LEU A 106
ALA A  37
GLU A  75
ARG A 171
 CS2  A 401 (-2.5A)
None
None
CS2  A 401 (-2.8A)
CS2  A 401 (-2.9A)
 1.17A 3k37B-4pc9A:
undetectable		 3k37B-4pc9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 GLU A  94
LEU A 106
ALA A  37
GLU A  75
ARG A 171
 CS2  A 401 (-2.5A)
None
None
CS2  A 401 (-2.8A)
CS2  A 401 (-2.9A)
 1.15A 3k39D-4pc9A:
undetectable		 3k39D-4pc9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 GLU A  94
LEU A 106
ALA A  37
GLU A  75
ARG A 171
 CS2  A 401 (-2.5A)
None
None
CS2  A 401 (-2.8A)
CS2  A 401 (-2.9A)
 1.14A 3k39N-4pc9A:
undetectable		 3k39N-4pc9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 ARG A 151
GLU A  94
LEU A 106
GLU A  75
ARG A 171
 CS2  A 401 (-3.0A)
CS2  A 401 (-2.5A)
None
CS2  A 401 (-2.8A)
CS2  A 401 (-2.9A)
 1.31A 3k39O-4pc9A:
undetectable		 3k39O-4pc9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 GLU A  94
LEU A 106
ALA A  37
GLU A  75
ARG A 171
 CS2  A 401 (-2.5A)
None
None
CS2  A 401 (-2.8A)
CS2  A 401 (-2.9A)
 1.12A 3k39O-4pc9A:
undetectable		 3k39O-4pc9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 GLU A  94
LEU A 106
ALA A  37
GLU A  75
ARG A 171
 CS2  A 401 (-2.5A)
None
None
CS2  A 401 (-2.8A)
CS2  A 401 (-2.9A)
 1.15A 3k39P-4pc9A:
undetectable		 3k39P-4pc9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI
(Escherichia
coli) 		4 / 7 TYR A 347
MET A 288
ASN A 294
LEU A 293
 None
None
CS2  A 501 (-3.0A)
CS2  A 501 ( 4.5A)
 1.41A 3lslA-4im7A:
undetectable
3lslD-4im7A:
undetectable		 3lslA-4im7A:
19.01
3lslD-4im7A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI
(Escherichia
coli) 		4 / 7 TYR A 347
MET A 288
ASN A 294
LEU A 293
 None
None
CS2  A 501 (-3.0A)
CS2  A 501 ( 4.5A)
 1.45A 3lslA-4im7A:
undetectable
3lslD-4im7A:
undetectable		 3lslA-4im7A:
19.01
3lslD-4im7A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI
(Escherichia
coli) 		4 / 7 TYR A 347
MET A 292
ASN A 294
LEU A 293
 None
None
CS2  A 501 (-3.0A)
CS2  A 501 ( 4.5A)
 1.43A 3lslA-4im7A:
undetectable
3lslD-4im7A:
undetectable		 3lslA-4im7A:
19.01
3lslD-4im7A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI
(Escherichia
coli) 		4 / 6 TYR A 347
MET A 288
ASN A 294
LEU A 293
 None
None
CS2  A 501 (-3.0A)
CS2  A 501 ( 4.5A)
 1.43A 3lslG-4im7A:
undetectable		 3lslG-4im7A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI
(Escherichia
coli) 		4 / 6 TYR A 347
MET A 292
ASN A 294
LEU A 293
 None
None
CS2  A 501 (-3.0A)
CS2  A 501 ( 4.5A)
 1.41A 3lslG-4im7A:
undetectable		 3lslG-4im7A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		3 / 3 VAL A 175
VAL A 234
SER A 236
 CS2  A 401 (-4.6A)
None
None
 0.68A 3n8xB-4pc9A:
undetectable		 3n8xB-4pc9A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		4 / 7 GLY A   9
ALA A  30
TYR A   8
GLU A  63
 None
None
None
CS2  A 402 (-3.6A)
 0.83A 4hyfA-4eayA:
undetectable		 4hyfA-4eayA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		4 / 8 GLY A   9
ALA A  30
TYR A   8
GLU A  63
 None
None
None
CS2  A 402 (-3.6A)
 0.89A 4hyfB-4eayA:
undetectable		 4hyfB-4eayA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 4eay MANNONATE
DEHYDRATASE
(Escherichia
coli) 		4 / 8 GLY A   9
ALA A  30
TYR A   8
GLU A  63
 None
None
None
CS2  A 402 (-3.6A)
 0.84A 4hyfC-4eayA:
undetectable		 4hyfC-4eayA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 11 ASN A 174
VAL A 175
ILE A 238
LEU A 215
ALA A 107
 None
CS2  A 401 (-4.6A)
CS2  A 401 (-4.9A)
CS2  A 401 (-4.2A)
None
 1.34A 4m83A-4pc9A:
undetectable		 4m83A-4pc9A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		3 / 3 ARG A 151
HIS A 233
SER A 236
 CS2  A 401 (-3.0A)
None
None
 1.02A 4mjwA-4pc9A:
undetectable
4mjwB-4pc9A:
undetectable		 4mjwA-4pc9A:
23.97
4mjwB-4pc9A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 LEU A 215
ILE A  91
VAL A  66
LEU A 273
ALA A  42
 CS2  A 401 (-4.2A)
None
None
None
None
 1.18A 6djzA-4pc9A:
undetectable		 6djzA-4pc9A:
22.91