SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CRZ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		5 / 12 PHE A  16
TYR A  19
ALA A  33
THR A  60
PHE A  70
 CRZ  A 501 (-4.5A)
None
CRZ  A 501 ( 4.1A)
None
None
 1.26A 1mx8A-1towA:
16.8		 1mx8A-1towA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		7 / 12 PHE A  16
VAL A  23
SER A  53
THR A  60
ALA A  75
ARG A 126
TYR A 128
 CRZ  A 501 (-4.5A)
None
CRZ  A 501 ( 3.8A)
None
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-3.8A)
CRZ  A 501 (-4.8A)
 1.32A 2qm9A-1towA:
25.6		 2qm9A-1towA:
91.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		12 / 12 PHE A  16
VAL A  25
ALA A  33
SER A  53
SER A  55
THR A  60
ALA A  75
ASP A  76
ARG A  78
CYH A 117
ARG A 126
TYR A 128
 CRZ  A 501 (-4.5A)
None
CRZ  A 501 ( 4.1A)
CRZ  A 501 ( 3.8A)
CRZ  A 501 ( 4.8A)
None
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-4.0A)
CRZ  A 501 (-4.7A)
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-3.8A)
CRZ  A 501 (-4.8A)
 0.45A 2qm9A-1towA:
25.6		 2qm9A-1towA:
91.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		4 / 4 TYR A  19
MET A  20
PRO A  38
ILE A 104
 None
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-4.5A)
CRZ  A 501 ( 4.8A)
 0.27A 2qm9A-1towA:
25.6		 2qm9A-1towA:
91.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		12 / 12 PHE A  16
TYR A  19
VAL A  25
SER A  53
SER A  55
THR A  60
ALA A  75
ARG A  78
ILE A 104
CYH A 117
ARG A 126
TYR A 128
 CRZ  A 501 (-4.5A)
None
None
CRZ  A 501 ( 3.8A)
CRZ  A 501 ( 4.8A)
None
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-4.7A)
CRZ  A 501 ( 4.8A)
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-3.8A)
CRZ  A 501 (-4.8A)
 0.48A 2qm9B-1towA:
26.2		 2qm9B-1towA:
91.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		7 / 12 PHE A  16
VAL A  23
SER A  53
THR A  60
ALA A  75
ARG A 126
TYR A 128
 CRZ  A 501 (-4.5A)
None
CRZ  A 501 ( 3.8A)
None
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-3.8A)
CRZ  A 501 (-4.8A)
 1.27A 2qm9B-1towA:
26.2		 2qm9B-1towA:
91.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		4 / 4 MET A  20
PRO A  38
ASP A  76
ARG A 106
 CRZ  A 501 ( 3.8A)
CRZ  A 501 (-4.5A)
CRZ  A 501 (-4.0A)
None
 0.32A 2qm9B-1towA:
26.2		 2qm9B-1towA:
91.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		5 / 12 ILE A  51
THR A  74
CYH A 117
VAL A 115
PHE A  16
 None
None
CRZ  A 501 ( 3.8A)
None
CRZ  A 501 (-4.5A)
 1.21A 2qo5A-1towA:
20.1		 2qo5A-1towA:
29.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		12 / 12 PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  76
ARG A  78
ILE A 104
ARG A 106
VAL A 115
CYH A 117
ARG A 126
TYR A 128
 CRZ  A 501 (-4.5A)
CRZ  A 501 ( 3.8A)
None
CRZ  A 501 (-4.5A)
CRZ  A 501 (-4.0A)
CRZ  A 501 (-4.7A)
CRZ  A 501 ( 4.8A)
None
None
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-3.8A)
CRZ  A 501 (-4.8A)
 0.43A 3p6gA-1towA:
26.1		 3p6gA-1towA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		5 / 12 PHE A  16
VAL A  23
PRO A  38
ARG A 126
TYR A 128
 CRZ  A 501 (-4.5A)
None
CRZ  A 501 (-4.5A)
CRZ  A 501 (-3.8A)
CRZ  A 501 (-4.8A)
 1.19A 3p6gA-1towA:
26.1		 3p6gA-1towA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		7 / 7 PHE A  16
MET A  20
ASP A  76
ILE A 104
VAL A 115
ARG A 126
TYR A 128
 CRZ  A 501 (-4.5A)
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-4.0A)
CRZ  A 501 ( 4.8A)
None
CRZ  A 501 (-3.8A)
CRZ  A 501 (-4.8A)
 0.27A 3p6hA-1towA:
26.2		 3p6hA-1towA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		5 / 12 PHE A  16
TYR A  19
ALA A  33
ILE A  51
SER A  55
 CRZ  A 501 (-4.5A)
None
CRZ  A 501 ( 4.1A)
None
CRZ  A 501 ( 4.8A)
 0.80A 5h8tA-1towA:
20.4		 5h8tA-1towA:
35.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		6 / 12 PHE A  16
TYR A  19
VAL A  25
ALA A  33
ILE A  51
SER A  55
 CRZ  A 501 (-4.5A)
None
None
CRZ  A 501 ( 4.1A)
None
CRZ  A 501 ( 4.8A)
 0.89A 5hbsA-1towA:
20.2		 5hbsA-1towA:
35.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens) 		6 / 12 TYR A  19
VAL A  25
ALA A  33
PRO A  38
ILE A  51
SER A  55
 None
None
CRZ  A 501 ( 4.1A)
CRZ  A 501 (-4.5A)
None
CRZ  A 501 ( 4.8A)
 0.96A 5hbsA-1towA:
20.2		 5hbsA-1towA:
35.34