SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CRM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1kzl RIBOFLAVIN SYNTHASE
(Schizosaccharomy
ces
pombe) 		6 / 11 SER A  41
CYH A  48
LEU A  49
THR A  50
THR A  71
VAL A 103
 CRM  A 502 ( 4.0A)
HG  A1001 ( 2.5A)
CRM  A 502 (-4.4A)
CRM  A 502 (-3.9A)
None
CRM  A 502 (-4.0A)
 0.21A 1pkvA-1kzlA:
16.1
1pkvB-1kzlA:
16.3		 1pkvA-1kzlA:
45.54
1pkvB-1kzlA:
45.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1kzl RIBOFLAVIN SYNTHASE
(Schizosaccharomy
ces
pombe) 		6 / 11 VAL A 103
SER A  41
CYH A  48
LEU A  49
THR A  50
THR A  71
 CRM  A 502 (-4.0A)
CRM  A 502 ( 4.0A)
HG  A1001 ( 2.5A)
CRM  A 502 (-4.4A)
CRM  A 502 (-3.9A)
None
 0.23A 1pkvA-1kzlA:
16.1
1pkvB-1kzlA:
16.3		 1pkvA-1kzlA:
45.54
1pkvB-1kzlA:
45.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1kzl RIBOFLAVIN SYNTHASE
(Schizosaccharomy
ces
pombe) 		3 / 3 ILE A 140
ILE A 149
THR A 145
 None
None
CRM  A 501 (-4.0A)
 0.64A 1rg7A-1kzlA:
undetectable		 1rg7A-1kzlA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 1kzl RIBOFLAVIN SYNTHASE
(Schizosaccharomy
ces
pombe) 		5 / 12 VAL A   6
ASN A  72
LEU A  73
ALA A 141
ASP A  80
 CRM  A 501 (-4.0A)
None
None
None
None
 1.41A 2iyfB-1kzlA:
undetectable		 2iyfB-1kzlA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1kzl RIBOFLAVIN SYNTHASE
(Schizosaccharomy
ces
pombe) 		4 / 6 THR A  47
ILE A  63
LEU A  73
THR A  71
 CRM  A 502 (-4.0A)
CRM  A 502 (-4.6A)
None
None
 0.72A 3deuB-1kzlA:
undetectable		 3deuB-1kzlA:
22.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1kzl RIBOFLAVIN SYNTHASE
(Schizosaccharomy
ces
pombe) 		8 / 11 SER A  41
CYH A  48
LEU A  49
THR A  50
GLU A  66
THR A  71
HIS A 102
VAL A 103
 CRM  A 502 ( 4.0A)
HG  A1001 ( 2.5A)
CRM  A 502 (-4.4A)
CRM  A 502 (-3.9A)
None
None
CRM  A 502 (-4.2A)
CRM  A 502 (-4.0A)
 0.70A 4e0fA-1kzlA:
29.1		 4e0fA-1kzlA:
36.92