SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CRK'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W3M_A_FOLA1188_0 (DIHYDROFOLATE REDUCTASE)	3u0k	RCAMP (Entacmaea quadricolor)	5 / 12	LEU A 117 GLN A 257 LEU A 166 TYR A 247 THR A 76	CRK A 214 ( 4.2A) NFA A 213 ( 3.8A) NFA A 213 ( 3.7A) None CRK A 214 ( 4.6A)	1.04A	2w3mA-3u0kA: undetectable	2w3mA-3u0kA: 18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W3M_B_FOLB1188_0 (DIHYDROFOLATE REDUCTASE)	3u0k	RCAMP (Entacmaea quadricolor)	5 / 12	LEU A 117 GLN A 257 LEU A 166 TYR A 247 THR A 76	CRK A 214 ( 4.2A) NFA A 213 ( 3.8A) NFA A 213 ( 3.7A) None CRK A 214 ( 4.6A)	0.99A	2w3mB-3u0kA: undetectable	2w3mB-3u0kA: 18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BA0_A_HAEA477_1 (MACROPHAGE METALLOELASTASE)	3u0k	RCAMP (Entacmaea quadricolor)	3 / 3	HIS A 134 GLU A 133 HIS A 115	None ACT A 443 (-2.7A) CRK A 214 (-3.4A)	0.87A	3ba0A-3u0kA: undetectable	3ba0A-3u0kA: 21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KEB_B_FOLB202_0 (DIHYDROFOLATE REDUCTASE)	3u0k	RCAMP (Entacmaea quadricolor)	5 / 12	LEU A 117 GLN A 257 LEU A 166 TYR A 247 THR A 76	CRK A 214 ( 4.2A) NFA A 213 ( 3.8A) NFA A 213 ( 3.7A) None CRK A 214 ( 4.6A)	1.03A	4kebB-3u0kA: undetectable	4kebB-3u0kA: 17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_D_SORD1343_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	3u0k	RCAMP (Entacmaea quadricolor)	4 / 5	ALA A 135 ARG A 218 ALA A 137 GLU A 63	ACT A 443 (-3.5A) ACT A 443 (-3.6A) None CRK A 214 ( 4.1A)	1.06A	5a06C-3u0kA: undetectable 5a06D-3u0kA: undetectable	5a06C-3u0kA: 21.56 5a06D-3u0kA: 21.56

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2W3M_A_FOLA1188_0","DIHYDROFOLATE REDUCTASE","3u0k","RCAMP","Entacmaea quadricolor",5,"LEU A 117;GLN A 257;LEU A 166;TYR A 247;THR A  76","CRK A 214 ( 4.2A);NFA A 213 ( 3.8A);NFA A 213 ( 3.7A);None;CRK A 214 ( 4.6A)","1.04A","2w3mA-3u0kA:undetectable",null],["2W3M_B_FOLB1188_0","DIHYDROFOLATE REDUCTASE","3u0k","RCAMP","Entacmaea quadricolor",5,"LEU A 117;GLN A 257;LEU A 166;TYR A 247;THR A  76","CRK A 214 ( 4.2A);NFA A 213 ( 3.8A);NFA A 213 ( 3.7A);None;CRK A 214 ( 4.6A)","0.99A","2w3mB-3u0kA:undetectable","2w3mA-3u0kA:18.08"],["3BA0_A_HAEA477_1","MACROPHAGE METALLOELASTASE","3u0k","RCAMP","Entacmaea quadricolor",3,"HIS A 134;GLU A 133;HIS A 115","None;ACT A 443 (-2.7A);CRK A 214 (-3.4A)","0.87A","3ba0A-3u0kA:undetectable","2w3mB-3u0kA:18.08"],["4KEB_B_FOLB202_0","DIHYDROFOLATE REDUCTASE","3u0k","RCAMP","Entacmaea quadricolor",5,"LEU A 117;GLN A 257;LEU A 166;TYR A 247;THR A  76","CRK A 214 ( 4.2A);NFA A 213 ( 3.8A);NFA A 213 ( 3.7A);None;CRK A 214 ( 4.6A)","1.03A","4kebB-3u0kA:undetectable","3ba0A-3u0kA:21.37"],["5A06_D_SORD1343_0","ALDOSE-ALDOSE OXIDOREDUCTASE","3u0k","RCAMP","Entacmaea quadricolor",4,"ALA A 135;ARG A 218;ALA A 137;GLU A  63","ACT A 443 (-3.5A);ACT A 443 (-3.6A);None;CRK A 214 ( 4.1A)","1.06A","5a06C-3u0kA:undetectable;5a06D-3u0kA:undetectable","4kebB-3u0kA:17.89"]]