SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CR9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1AQ7_B_AG2B4_1 (TRYPSIN AERUGINOSIN 98-B)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	6 / 8	HIS H 57 ASP H 189 SER H 195 VAL H 213 GLY H 216 GLY H 226	CR9 H 256 (-3.9A) CR9 H 256 (-2.4A) CR9 H 256 (-1.5A) CR9 H 256 (-4.3A) CR9 H 256 ( 3.8A) CR9 H 256 (-3.0A)	0.51A	1aq7A-1o5fH: 34.9	1aq7A-1o5fH: 41.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1BCU_H_PRLH280_0 (ALPHA-THROMBIN)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	7 / 9	ASP H 189 ALA H 190 SER H 195 VAL H 213 TRP H 215 GLY H 216 GLY H 226	CR9 H 256 (-2.4A) CR9 H 256 (-2.9A) CR9 H 256 (-1.5A) CR9 H 256 (-4.3A) None CR9 H 256 ( 3.8A) CR9 H 256 (-3.0A)	0.32A	1bcuH-1o5fH: 35.7	1bcuH-1o5fH: 40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	5 / 9	HIS H 57 ASP H 189 SER H 195 TRP H 215 GLY H 226	CR9 H 256 (-3.9A) CR9 H 256 (-2.4A) CR9 H 256 (-1.5A) None CR9 H 256 (-3.0A)	0.45A	1dwcH-1o5fH: 34.7	1dwcH-1o5fH: 40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	7 / 12	HIS H 57 ASP H 189 SER H 195 VAL H 213 TRP H 215 GLY H 216 GLY H 226	CR9 H 256 (-3.9A) CR9 H 256 (-2.4A) CR9 H 256 (-1.5A) CR9 H 256 (-4.3A) None CR9 H 256 ( 3.8A) CR9 H 256 (-3.0A)	0.56A	1etrH-1o5fH: 35.0	1etrH-1o5fH: 39.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1F5L_A_AMRA301_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	6 / 8	ASP H 189 GLN H 192 SER H 195 VAL H 213 GLY H 216 GLY H 226	CR9 H 256 (-2.4A) CR9 H 256 ( 4.4A) CR9 H 256 (-1.5A) CR9 H 256 (-4.3A) CR9 H 256 ( 3.8A) CR9 H 256 (-3.0A)	0.43A	1f5lA-1o5fH: 35.7	1f5lA-1o5fH: 37.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P6K_A_ACTA860_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	4 / 6	GLY H 142 GLN H 156 VAL H 138 ALA H 190	None None None CR9 H 256 (-2.9A)	0.93A	1p6kA-1o5fH: undetectable	1p6kA-1o5fH: 20.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	5 / 6	ASP H 189 SER H 195 VAL H 213 GLY H 216 GLY H 226	CR9 H 256 (-2.4A) CR9 H 256 (-1.5A) CR9 H 256 (-4.3A) CR9 H 256 ( 3.8A) CR9 H 256 (-3.0A)	0.23A	1tnlA-1o5fH: 19.2	1tnlA-1o5fH: 41.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2OTV_A_NCAA1301_0 (CATIONIC TRYPSIN)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	5 / 6	ASP H 189 SER H 195 VAL H 213 GLY H 216 GLY H 226	CR9 H 256 (-2.4A) CR9 H 256 (-1.5A) CR9 H 256 (-4.3A) CR9 H 256 ( 3.8A) CR9 H 256 (-3.0A)	0.18A	2otvA-1o5fH: 19.2	2otvA-1o5fH: 41.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	8 / 12	ASP H 189 ALA H 190 SER H 195 VAL H 213 TRP H 215 GLY H 216 GLY H 226 TYR H 228	CR9 H 256 (-2.4A) CR9 H 256 (-2.9A) CR9 H 256 (-1.5A) CR9 H 256 (-4.3A) None CR9 H 256 ( 3.8A) CR9 H 256 (-3.0A) None	0.25A	2p16A-1o5fH: 34.8	2p16A-1o5fH: 36.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	6 / 8	ASP H 189 GLN H 192 SER H 195 VAL H 213 GLY H 216 GLY H 226	CR9 H 256 (-2.4A) CR9 H 256 ( 4.4A) CR9 H 256 (-1.5A) CR9 H 256 (-4.3A) CR9 H 256 ( 3.8A) CR9 H 256 (-3.0A)	0.44A	2vinA-1o5fH: 36.2	2vinA-1o5fH: 37.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2W26_A_RIVA1001_1 (ACTIVATED FACTOR XA HEAVY CHAIN)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	9 / 12	ASP H 189 ALA H 190 SER H 195 VAL H 213 TRP H 215 GLY H 216 GLY H 219 GLY H 226 TYR H 228	CR9 H 256 (-2.4A) CR9 H 256 (-2.9A) CR9 H 256 (-1.5A) CR9 H 256 (-4.3A) None CR9 H 256 ( 3.8A) CR9 H 256 (-4.3A) CR9 H 256 (-3.0A) None	0.28A	2w26A-1o5fH: 34.7	2w26A-1o5fH: 36.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3GY3_A_PNTA246_0 (CATIONIC TRYPSIN)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	7 / 11	HIS H 57 GLN H 175 ASP H 189 SER H 195 TRP H 215 GLY H 216 GLY H 226	CR9 H 256 (-3.9A) None CR9 H 256 (-2.4A) CR9 H 256 (-1.5A) None CR9 H 256 ( 3.8A) CR9 H 256 (-3.0A)	0.63A	3gy3A-1o5fH: 18.6	3gy3A-1o5fH: 41.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L8L_D_DVAD8_0 (GRAMICIDIN D)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	3 / 3	VAL H 227 VAL H 213 TRP H 215	None CR9 H 256 (-4.3A) None	0.95A	3l8lC-1o5fH: undetectable 3l8lD-1o5fH: undetectable	3l8lC-1o5fH: 5.80 3l8lD-1o5fH: 5.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RXF_A_4APA9_1 (CATIONIC TRYPSIN)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	5 / 6	SER H 195 VAL H 213 TRP H 215 GLY H 216 GLY H 226	CR9 H 256 (-1.5A) CR9 H 256 (-4.3A) None CR9 H 256 ( 3.8A) CR9 H 256 (-3.0A)	0.22A	3rxfA-1o5fH: 19.1	3rxfA-1o5fH: 41.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RXH_A_HSMA7_1 (CATIONIC TRYPSIN)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	4 / 5	ASP H 189 SER H 195 VAL H 213 GLY H 226	CR9 H 256 (-2.4A) CR9 H 256 (-1.5A) CR9 H 256 (-4.3A) CR9 H 256 (-3.0A)	0.22A	3rxhA-1o5fH: 19.2	3rxhA-1o5fH: 41.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4FU8_A_ACTA302_0 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	4 / 5	HIS H 57 GLN H 192 GLY H 193 SER H 195	CR9 H 256 (-3.9A) CR9 H 256 ( 4.4A) None CR9 H 256 (-1.5A)	0.39A	4fu8A-1o5fH: 35.8	4fu8A-1o5fH: 37.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HFP_D_15UD402_1 (PROTHROMBIN)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	6 / 12	HIS H 57 ASP H 189 ALA H 190 VAL H 213 TRP H 215 GLY H 226	CR9 H 256 (-3.9A) CR9 H 256 (-2.4A) CR9 H 256 (-2.9A) CR9 H 256 (-4.3A) None CR9 H 256 (-3.0A)	0.36A	4hfpD-1o5fH: 34.8	4hfpD-1o5fH: 39.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LRH_B_FOLB301_1 (FOLATE RECEPTOR ALPHA)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	3 / 3	ASP H 102 TRP H 65 SER H 195	None None CR9 H 256 (-1.5A)	1.06A	4lrhB-1o5fH: 0.0	4lrhB-1o5fH: 17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LRH_F_FOLF301_1 (FOLATE RECEPTOR ALPHA)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	3 / 3	ASP H 102 TRP H 65 SER H 195	None None CR9 H 256 (-1.5A)	1.10A	4lrhF-1o5fH: 0.0	4lrhF-1o5fH: 17.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RN6_B_15UB301_1 (THROMBIN HEAVY CHAIN)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	6 / 12	HIS H 57 ALA H 190 VAL H 213 TRP H 215 GLY H 216 GLY H 226	CR9 H 256 (-3.9A) CR9 H 256 (-2.9A) CR9 H 256 (-4.3A) None CR9 H 256 ( 3.8A) CR9 H 256 (-3.0A)	0.66A	4rn6B-1o5fH: 29.9	4rn6B-1o5fH: 39.64

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AQ7_B_AG2B4_1","TRYPSIN;AERUGINOSIN 98-B","1o5f","SERINE PROTEASE HEPSIN","Homo sapiens",6,"HIS H  57;ASP H 189;SER H 195;VAL H 213;GLY H 216;GLY H 226","CR9 H 256 (-3.9A);CR9 H 256 (-2.4A);CR9 H 256 (-1.5A);CR9 H 256 (-4.3A);CR9 H 256 ( 3.8A);CR9 H 256 (-3.0A)","0.51A","1aq7A-1o5fH:34.9",null],["1BCU_H_PRLH280_0","ALPHA-THROMBIN","1o5f","SERINE PROTEASE HEPSIN","Homo sapiens",7,"ASP H 189;ALA H 190;SER H 195;VAL H 213;TRP H 215;GLY H 216;GLY H 226","CR9 H 256 (-2.4A);CR9 H 256 (-2.9A);CR9 H 256 (-1.5A);CR9 H 256 (-4.3A);None;CR9 H 256 ( 3.8A);CR9 H 256 (-3.0A)","0.32A","1bcuH-1o5fH:35.7","1aq7A-1o5fH:41.11"],["1DWC_H_MITH1_1","ALPHA-THROMBIN (LARGE SUBUNIT)","1o5f","SERINE PROTEASE HEPSIN","Homo sapiens",5,"HIS H  57;ASP H 189;SER H 195;TRP H 215;GLY H 226","CR9 H 256 (-3.9A);CR9 H 256 (-2.4A);CR9 H 256 (-1.5A);None;CR9 H 256 (-3.0A)","0.45A","1dwcH-1o5fH:34.7","1bcuH-1o5fH:40.00"],["1ETR_H_MITH1_1","EPSILON-THROMBIN","1o5f","SERINE PROTEASE HEPSIN","Homo sapiens",7,"HIS H  57;ASP H 189;SER H 195;VAL H 213;TRP H 215;GLY H 216;GLY H 226","CR9 H 256 (-3.9A);CR9 H 256 (-2.4A);CR9 H 256 (-1.5A);CR9 H 256 (-4.3A);None;CR9 H 256 ( 3.8A);CR9 H 256 (-3.0A)","0.56A","1etrH-1o5fH:35.0","1dwcH-1o5fH:40.00"],["1F5L_A_AMRA301_1","UROKINASE-TYPE PLASMINOGEN ACTIVATOR","1o5f","SERINE PROTEASE HEPSIN","Homo sapiens",6,"ASP H 189;GLN H 192;SER H 195;VAL H 213;GLY H 216;GLY H 226","CR9 H 256 (-2.4A);CR9 H 256 ( 4.4A);CR9 H 256 (-1.5A);CR9 H 256 (-4.3A);CR9 H 256 ( 3.8A);CR9 H 256 (-3.0A)","0.43A","1f5lA-1o5fH:35.7","1etrH-1o5fH:39.93"],["1P6K_A_ACTA860_0","NITRIC-OXIDE SYNTHASE, BRAIN","1o5f","SERINE PROTEASE HEPSIN","Homo sapiens",4,"GLY H 142;GLN H 156;VAL H 138;ALA H 190","None;None;None;CR9 H 256 (-2.9A)","0.93A","1p6kA-1o5fH:undetectable","1f5lA-1o5fH:37.23"],["1TNL_A_TPAA900_1","TRYPSIN","1o5f","SERINE PROTEASE HEPSIN","Homo sapiens",5,"ASP H 189;SER H 195;VAL H 213;GLY H 216;GLY H 226","CR9 H 256 (-2.4A);CR9 H 256 (-1.5A);CR9 H 256 (-4.3A);CR9 H 256 ( 3.8A);CR9 H 256 (-3.0A)","0.23A","1tnlA-1o5fH:19.2","1p6kA-1o5fH:20.20"],["2OTV_A_NCAA1301_0","CATIONIC TRYPSIN","1o5f","SERINE PROTEASE HEPSIN","Homo sapiens",5,"ASP H 189;SER H 195;VAL H 213;GLY H 216;GLY H 226","CR9 H 256 (-2.4A);CR9 H 256 (-1.5A);CR9 H 256 (-4.3A);CR9 H 256 ( 3.8A);CR9 H 256 (-3.0A)","0.18A","2otvA-1o5fH:19.2","1tnlA-1o5fH:41.11"],["2P16_A_GG2A298_1","COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR)","1o5f","SERINE PROTEASE HEPSIN","Homo sapiens",8,"ASP H 189;ALA H 190;SER H 195;VAL H 213;TRP H 215;GLY H 216;GLY H 226;TYR H 228","CR9 H 256 (-2.4A);CR9 H 256 (-2.9A);CR9 H 256 (-1.5A);CR9 H 256 (-4.3A);None;CR9 H 256 ( 3.8A);CR9 H 256 (-3.0A);None","0.25A","2p16A-1o5fH:34.8","2otvA-1o5fH:41.11"],["2VIN_A_505A1247_1","UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B","1o5f","SERINE PROTEASE HEPSIN","Homo sapiens",6,"ASP H 189;GLN H 192;SER H 195;VAL H 213;GLY H 216;GLY H 226","CR9 H 256 (-2.4A);CR9 H 256 ( 4.4A);CR9 H 256 (-1.5A);CR9 H 256 (-4.3A);CR9 H 256 ( 3.8A);CR9 H 256 (-3.0A)","0.44A","2vinA-1o5fH:36.2","2p16A-1o5fH:36.40"],["2W26_A_RIVA1001_1","ACTIVATED FACTOR XA HEAVY CHAIN","1o5f","SERINE PROTEASE HEPSIN","Homo sapiens",9,"ASP H 189;ALA H 190;SER H 195;VAL H 213;TRP H 215;GLY H 216;GLY H 219;GLY H 226;TYR H 228","CR9 H 256 (-2.4A);CR9 H 256 (-2.9A);CR9 H 256 (-1.5A);CR9 H 256 (-4.3A);None;CR9 H 256 ( 3.8A);CR9 H 256 (-4.3A);CR9 H 256 (-3.0A);None","0.28A","2w26A-1o5fH:34.7","2vinA-1o5fH:37.23"],["3GY3_A_PNTA246_0","CATIONIC TRYPSIN","1o5f","SERINE PROTEASE HEPSIN","Homo sapiens",7,"HIS H  57;GLN H 175;ASP H 189;SER H 195;TRP H 215;GLY H 216;GLY H 226","CR9 H 256 (-3.9A);None;CR9 H 256 (-2.4A);CR9 H 256 (-1.5A);None;CR9 H 256 ( 3.8A);CR9 H 256 (-3.0A)","0.63A","3gy3A-1o5fH:18.6","2w26A-1o5fH:36.40"],["3L8L_D_DVAD8_0","GRAMICIDIN D","1o5f","SERINE PROTEASE HEPSIN","Homo sapiens",3,"VAL H 227;VAL H 213;TRP H 215","None;CR9 H 256 (-4.3A);None","0.95A","3l8lC-1o5fH:undetectable;3l8lD-1o5fH:undetectable","3gy3A-1o5fH:41.11"],["3RXF_A_4APA9_1","CATIONIC TRYPSIN","1o5f","SERINE PROTEASE HEPSIN","Homo sapiens",5,"SER H 195;VAL H 213;TRP H 215;GLY H 216;GLY H 226","CR9 H 256 (-1.5A);CR9 H 256 (-4.3A);None;CR9 H 256 ( 3.8A);CR9 H 256 (-3.0A)","0.22A","3rxfA-1o5fH:19.1","3l8lC-1o5fH:5.80;3l8lD-1o5fH:5.80"],["3RXH_A_HSMA7_1","CATIONIC TRYPSIN","1o5f","SERINE PROTEASE HEPSIN","Homo sapiens",4,"ASP H 189;SER H 195;VAL H 213;GLY H 226","CR9 H 256 (-2.4A);CR9 H 256 (-1.5A);CR9 H 256 (-4.3A);CR9 H 256 (-3.0A)","0.22A","3rxhA-1o5fH:19.2","3rxfA-1o5fH:41.11"],["4FU8_A_ACTA302_0","UROKINASE-TYPE PLASMINOGEN ACTIVATOR","1o5f","SERINE PROTEASE HEPSIN","Homo sapiens",4,"HIS H  57;GLN H 192;GLY H 193;SER H 195","CR9 H 256 (-3.9A);CR9 H 256 ( 4.4A);None;CR9 H 256 (-1.5A)","0.39A","4fu8A-1o5fH:35.8","3rxhA-1o5fH:41.11"],["4HFP_D_15UD402_1","PROTHROMBIN","1o5f","SERINE PROTEASE HEPSIN","Homo sapiens",6,"HIS H  57;ASP H 189;ALA H 190;VAL H 213;TRP H 215;GLY H 226","CR9 H 256 (-3.9A);CR9 H 256 (-2.4A);CR9 H 256 (-2.9A);CR9 H 256 (-4.3A);None;CR9 H 256 (-3.0A)","0.36A","4hfpD-1o5fH:34.8","4fu8A-1o5fH:37.40"],["4LRH_B_FOLB301_1","FOLATE RECEPTOR ALPHA","1o5f","SERINE PROTEASE HEPSIN","Homo sapiens",3,"ASP H 102;TRP H  65;SER H 195","None;None;CR9 H 256 (-1.5A)","1.06A","4lrhB-1o5fH:0.0","4hfpD-1o5fH:39.64"],["4LRH_F_FOLF301_1","FOLATE RECEPTOR ALPHA","1o5f","SERINE PROTEASE HEPSIN","Homo sapiens",3,"ASP H 102;TRP H  65;SER H 195","None;None;CR9 H 256 (-1.5A)","1.10A","4lrhF-1o5fH:0.0","4lrhB-1o5fH:17.62"],["4RN6_B_15UB301_1","THROMBIN HEAVY CHAIN","1o5f","SERINE PROTEASE HEPSIN","Homo sapiens",6,"HIS H  57;ALA H 190;VAL H 213;TRP H 215;GLY H 216;GLY H 226","CR9 H 256 (-3.9A);CR9 H 256 (-2.9A);CR9 H 256 (-4.3A);None;CR9 H 256 ( 3.8A);CR9 H 256 (-3.0A)","0.66A","4rn6B-1o5fH:29.9","4lrhF-1o5fH:17.62"]]