SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CR8'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4dxo LEA X(6) GFP-LIKE
PROTEINS
(synthetic
construct) 		4 / 7 TYR A  71
SER A  82
TYR A 177
GLN A  38
 None
None
None
CR8  A  63 ( 3.7A)
 1.48A 1eiiA-4dxoA:
undetectable		 1eiiA-4dxoA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 2gw3 KAEDE
(Trachyphyllia
geoffroyi) 		5 / 12 GLU A 212
ARG A  66
MET A  14
GLY A  27
LEU A  42
 CR8  A  63 ( 3.6A)
CR8  A  63 ( 3.0A)
None
None
None
 1.08A 2jfaB-2gw3A:
undetectable		 2jfaB-2gw3A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 2vzx GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002) 		5 / 12 GLU A 211
ARG A  66
MET A  14
GLY A  27
LEU A  42
 CR8  A  64 ( 3.6A)
CR8  A  64 ( 4.3A)
None
None
None
 0.86A 2jfaB-2vzxA:
undetectable		 2jfaB-2vzxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 4dxo LEA X(6) GFP-LIKE
PROTEINS
(synthetic
construct) 		5 / 12 GLU A 211
ARG A  66
MET A  14
GLY A  27
LEU A  42
 CR8  A  63 ( 4.0A)
CR8  A  63 ( 3.1A)
None
None
None
 1.11A 2jfaB-4dxoA:
undetectable		 2jfaB-4dxoA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		5 / 12 GLU A 219
ARG A 306
MET A 254
GLY A 267
LEU A 282
 CR8  A 303 ( 3.6A)
CR8  A 303 ( 2.9A)
None
None
None
 1.03A 2jfaB-4oy4A:
undetectable		 2jfaB-4oy4A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 2gw3 KAEDE
(Trachyphyllia
geoffroyi) 		3 / 3 PHE A 114
ASN A  65
PHE A  87
 None
CR8  A  63 ( 4.8A)
None
 0.87A 2zbuD-2gw3A:
undetectable		 2zbuD-2gw3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		4 / 4 GLU A 330
ARG A 344
ASN A 345
ASP A 346
 GOL  A 504 (-4.7A)
None
CR8  A 303 ( 4.1A)
None
 1.46A 2zq9A-4oy4A:
undetectable		 2zq9A-4oy4A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 2gw3 KAEDE
(Trachyphyllia
geoffroyi) 		3 / 3 HIS A 213
GLU A 212
HIS A 194
 None
CR8  A  63 ( 3.6A)
CR8  A  63 ( 3.6A)
 0.80A 3ba0A-2gw3A:
undetectable		 3ba0A-2gw3A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 2vzx GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002) 		3 / 3 HIS A 212
GLU A 211
HIS A 193
 None
CR8  A  64 ( 3.6A)
CR8  A  64 ( 3.5A)
 0.76A 3ba0A-2vzxA:
undetectable		 3ba0A-2vzxA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 4dxo LEA X(6) GFP-LIKE
PROTEINS
(synthetic
construct) 		3 / 3 HIS A 212
GLU A 211
HIS A 193
 None
CR8  A  63 ( 4.0A)
CR8  A  63 ( 3.4A)
 0.79A 3ba0A-4dxoA:
undetectable		 3ba0A-4dxoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		3 / 3 HIS A 220
GLU A 219
HIS A 201
 GOL  A 503 (-3.8A)
CR8  A 303 ( 3.6A)
CR8  A 303 ( 3.8A)
 0.77A 3ba0A-4oy4A:
undetectable		 3ba0A-4oy4A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2vzx GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002) 		4 / 5 LYS A  65
ILE A 195
VAL A 191
LEU A 146
 CR8  A  64 ( 3.6A)
CR8  A  64 ( 3.6A)
None
None
 1.11A 3wzdA-2vzxA:
undetectable		 3wzdA-2vzxA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Rattus
norvegicus;
Lobophyllia
hemprichii) 		3 / 3 ASP A 346
ARG A 306
ARG A 331
 None
CR8  A 303 ( 2.9A)
CR8  A 303 ( 3.0A)
 0.95A 4x5iA-4oy4A:
undetectable		 4x5iA-4oy4A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 2gw3 KAEDE
(Trachyphyllia
geoffroyi) 		4 / 5 ARG A  66
GLY A  36
GLU A 212
SER A   2
 CR8  A  63 ( 3.0A)
None
CR8  A  63 ( 3.6A)
None
 1.24A 4z3oA-2gw3A:
undetectable
4z3oB-2gw3A:
undetectable		 4z3oA-2gw3A:
14.85
4z3oB-2gw3A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2gw3 KAEDE
(Trachyphyllia
geoffroyi) 		4 / 5 SER A   2
ARG A  66
GLY A  36
GLU A 212
 None
CR8  A  63 ( 3.0A)
None
CR8  A  63 ( 3.6A)
 1.21A 5btiA-2gw3A:
undetectable
5btiB-2gw3A:
undetectable		 5btiA-2gw3A:
20.12
5btiB-2gw3A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2gw3 KAEDE
(Trachyphyllia
geoffroyi) 		4 / 5 SER A   2
ARG A  66
GLY A  36
GLU A 212
 None
CR8  A  63 ( 3.0A)
None
CR8  A  63 ( 3.6A)
 1.14A 5btiC-2gw3A:
undetectable
5btiD-2gw3A:
undetectable		 5btiC-2gw3A:
20.12
5btiD-2gw3A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2gw3 KAEDE
(Trachyphyllia
geoffroyi) 		4 / 5 SER A   2
ARG A  66
GLY A  36
GLU A 212
 None
CR8  A  63 ( 3.0A)
None
CR8  A  63 ( 3.6A)
 1.18A 5cdqR-2gw3A:
undetectable
5cdqS-2gw3A:
undetectable
5cdqT-2gw3A:
undetectable		 5cdqR-2gw3A:
21.81
5cdqS-2gw3A:
24.90
5cdqT-2gw3A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 2gw3 KAEDE
(Trachyphyllia
geoffroyi) 		5 / 10 TYR A 177
ARG A  91
VAL A  67
TYR A  71
ILE A 196
 None
CR8  A  63 ( 3.0A)
None
None
CR8  A  63 ( 3.6A)
 1.31A 5hw8C-2gw3A:
undetectable
5hw8H-2gw3A:
undetectable		 5hw8C-2gw3A:
21.79
5hw8H-2gw3A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 2vzx GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002) 		5 / 10 TYR A 177
ARG A  91
VAL A  67
TYR A  71
ILE A 195
 None
CR8  A  64 ( 3.0A)
None
None
CR8  A  64 ( 3.6A)
 1.36A 5hw8C-2vzxA:
undetectable
5hw8H-2vzxA:
undetectable		 5hw8C-2vzxA:
18.22
5hw8H-2vzxA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		5 / 10 TYR A 184
ARG A 331
VAL A 307
TYR A 311
ILE A 203
 None
CR8  A 303 ( 3.0A)
None
None
CR8  A 303 ( 3.7A)
 1.33A 5hw8C-4oy4A:
undetectable
5hw8H-4oy4A:
undetectable		 5hw8C-4oy4A:
15.59
5hw8H-4oy4A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2gw3 KAEDE
(Trachyphyllia
geoffroyi) 		5 / 12 LEU A 210
LYS A 209
ASP A  28
GLY A  27
ALA A  60
 CR8  A  63 ( 3.8A)
None
None
None
None
 1.40A 5kbwB-2gw3A:
undetectable		 5kbwB-2gw3A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 4dxo LEA X(6) GFP-LIKE
PROTEINS
(synthetic
construct) 		4 / 8 VAL A  67
GLY A  29
GLN A  38
THR A  39
 None
None
CR8  A  63 ( 3.7A)
None
 0.98A 5syjB-4dxoA:
undetectable		 5syjB-4dxoA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2vzx GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002) 		4 / 8 THR A 176
TYR A 177
ARG A 104
TRP A  89
 None
None
None
CR8  A  64 ( 3.8A)
 1.08A 5tzoA-2vzxA:
undetectable		 5tzoA-2vzxA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 2vzx GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002) 		5 / 12 THR A  58
MET A 159
PHE A 173
ILE A 157
THR A 175
 None
CR8  A  64 ( 3.4A)
None
CR8  A  64 ( 4.8A)
None
 1.25A 5w8aA-2vzxA:
undetectable		 5w8aA-2vzxA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Rattus
norvegicus;
Lobophyllia
hemprichii) 		5 / 12 THR A 298
MET A 166
PHE A 180
ILE A 164
THR A 182
 None
CR8  A 303 ( 3.4A)
None
CR8  A 303 ( 4.7A)
None
 1.25A 5w8aA-4oy4A:
undetectable		 5w8aA-4oy4A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE
(Gallus
gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		5 / 9 GLU A 219
ARG A 306
MET A 254
GLY A 267
LEU A 282
 CR8  A 303 ( 3.6A)
CR8  A 303 ( 2.9A)
None
None
None
 1.48A 5wgqA-4oy4A:
undetectable		 5wgqA-4oy4A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2gw3 KAEDE
(Trachyphyllia
geoffroyi) 		5 / 12 TRP A  89
LEU A  93
HIS A 194
THR A  58
LEU A  57
 CR8  A  63 ( 4.0A)
None
CR8  A  63 ( 3.6A)
None
None
 1.19A 6djzB-2gw3A:
undetectable		 6djzB-2gw3A:
20.91