SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CR2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 4dkn AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPA1
(Branchiostoma
floridae) 		4 / 8 GLY A  25
GLY A  26
TYR A  61
VAL A 199
 None
None
CR2  A  60 ( 3.5A)
None
 0.91A 1dbbH-4dknA:
undetectable
1dbbL-4dknA:
undetectable		 1dbbH-4dknA:
20.58
1dbbL-4dknA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		6 / 11 ALA A 110
LEU A  64
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
CR2  A  66 ( 4.4A)
None
None
None
None
 1.40A 1dhiB-3akoA:
undetectable		 1dhiB-3akoA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		6 / 12 ALA A 110
LEU A  64
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
CR2  A  66 ( 4.4A)
None
None
None
None
 1.43A 1dyiA-3akoA:
undetectable		 1dyiA-3akoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		6 / 12 ALA A 163
LEU A 117
ILE A  67
LEU A  95
TYR A 145
THR A 161
 None
CR2  A 118 ( 4.1A)
None
None
None
None
 1.43A 1dyiA-4ndkA:
undetectable		 1dyiA-4ndkA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		6 / 12 ALA A 163
LEU A 117
ILE A  67
LEU A  95
TYR A 145
THR A 161
 None
CR2  A 118 ( 4.1A)
None
None
None
None
 1.37A 1dyiB-4ndkA:
undetectable		 1dyiB-4ndkA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		4 / 7 TYR D 260
GLN D  73
TYR D 112
GLN D 297
 None
CR2  D  70 ( 4.9A)
CR2  D  70 ( 4.8A)
None
 1.21A 1eiiA-5mwcD:
undetectable		 1eiiA-5mwcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		5 / 11 ALA A 163
LEU A 117
ILE A  67
LEU A  95
THR A 161
 None
CR2  A 118 ( 4.1A)
None
None
None
 1.23A 1jomA-4ndkA:
undetectable		 1jomA-4ndkA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 4dkn AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPA1
(Branchiostoma
floridae) 		4 / 7 TYR A 175
HIS A   7
TYR A  61
GLY A  28
 None
None
CR2  A  60 ( 3.5A)
None
 1.33A 1mxgA-4dknA:
undetectable		 1mxgA-4dknA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		6 / 12 ALA A 163
LEU A 117
ILE A  67
LEU A  95
TYR A 145
THR A 161
 None
CR2  A 118 ( 4.1A)
None
None
None
None
 1.42A 1ra2A-4ndkA:
undetectable		 1ra2A-4ndkA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		6 / 12 ALA A 163
LEU A 117
ILE A  67
LEU A  95
TYR A 145
THR A 161
 None
CR2  A 118 ( 4.1A)
None
None
None
None
 1.42A 1ra8A-4ndkA:
undetectable		 1ra8A-4ndkA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		6 / 12 ALA A 110
LEU A  64
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
CR2  A  66 ( 4.4A)
None
None
None
None
 1.44A 1rb2A-3akoA:
undetectable		 1rb2A-3akoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		6 / 12 ALA A 163
LEU A 117
ILE A  67
LEU A  95
TYR A 145
THR A 161
 None
CR2  A 118 ( 4.1A)
None
None
None
None
 1.42A 1rb2A-4ndkA:
undetectable		 1rb2A-4ndkA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_B_AZMB401_1
(CARBONIC ANHYDRASE
XIV)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		5 / 10 HIS B 181
LEU A  53
LEU A  64
THR A  62
THR A  63
 None
None
CR2  A  66 ( 4.4A)
CR2  A  66 ( 4.5A)
None
 1.43A 1rj6B-3akoB:
undetectable		 1rj6B-3akoB:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_B_AZMB401_1
(CARBONIC ANHYDRASE
XIV)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Aequorea
victoria;
Eimeria
acervulina) 		5 / 10 HIS A 234
LEU A 106
LEU A 117
THR A 115
THR A 116
 None
None
CR2  A 118 ( 4.1A)
CR2  A 118 ( 4.7A)
None
 1.42A 1rj6B-4ndkA:
undetectable		 1rj6B-4ndkA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		6 / 12 ALA A 163
LEU A 117
ILE A  67
LEU A  95
TYR A 145
THR A 161
 None
CR2  A 118 ( 4.1A)
None
None
None
None
 1.40A 1rx2A-4ndkA:
undetectable		 1rx2A-4ndkA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		6 / 12 ALA A 110
LEU A  64
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
CR2  A  66 ( 4.4A)
None
None
None
None
 1.34A 1rx7A-3akoA:
undetectable		 1rx7A-3akoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		6 / 12 ALA A 110
LEU A  64
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
CR2  A  66 ( 4.4A)
None
None
None
None
 1.39A 1rx8A-3akoA:
undetectable		 1rx8A-3akoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		6 / 12 ALA A 163
LEU A 117
ILE A  67
LEU A  95
TYR A 145
THR A 161
 None
CR2  A 118 ( 4.1A)
None
None
None
None
 1.36A 1rx8A-4ndkA:
undetectable		 1rx8A-4ndkA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2g6y GREEN FLUORESCENT
PROTEIN 2
(Pontellina
plumata) 		3 / 3 SER A 172
GLY A 152
ARG A 195
 None
None
CR2  A  58 ( 4.9A)
 0.63A 1t9wA-2g6yA:
undetectable		 1t9wA-2g6yA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4hvf GREEN FLUORESCENT
PROTEIN BLFP-Y6
(Branchiostoma
lanceolatum) 		4 / 8 PHE A 209
GLU A 211
TYR A 103
TYR A 105
 CR2  A  58 ( 4.5A)
CR2  A  58 ( 2.8A)
None
CR2  A  58 ( 4.5A)
 1.25A 2aoxA-4hvfA:
undetectable		 2aoxA-4hvfA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3
(Branchiostoma
lanceolatum) 		4 / 8 PHE A 208
GLU A 210
TYR A 102
TYR A 104
 CR2  A  59 ( 4.6A)
CR2  A  59 ( 3.2A)
None
CR2  A  59 ( 4.6A)
 1.34A 2aoxA-5ltqA:
undetectable		 2aoxA-5ltqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		4 / 8 PHE D 293
GLU D 295
TYR D 112
TYR D 114
 CR2  D  70 ( 4.5A)
CR2  D  70 ( 2.9A)
CR2  D  70 ( 4.8A)
CR2  D  70 ( 4.5A)
 1.26A 2aoxA-5mwcD:
undetectable		 2aoxA-5mwcD:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4z4m GREEN FLUORESCENT
PROTEIN,TAX1-BINDING
PROTEIN 1
(Aequorea
victoria;
Homo
sapiens) 		5 / 10 VAL A 150
TYR A  74
THR A 203
GLY A  40
ALA A  72
 CR2  A  66 ( 4.9A)
None
CR2  A  66 ( 3.6A)
None
None
 1.49A 2coiA-4z4mA:
undetectable
2coiB-4z4mA:
undetectable		 2coiA-4z4mA:
21.48
2coiB-4z4mA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		6 / 12 ALA A 163
LEU A 117
ILE A  67
LEU A  95
TYR A 145
THR A 161
 None
CR2  A 118 ( 4.1A)
None
None
None
None
 1.45A 2d0kB-4ndkA:
undetectable		 2d0kB-4ndkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 5ktg GREEN FLUORESCENT
PROTEIN, BCL-2
HOMOLOGOUS
ANTAGONIST/KILLER
(Aequorea
victoria;
Mus
musculus) 		3 / 3 THR A  62
PRO A  58
TYR A 145
 None
None
CR2  A  66 ( 4.1A)
 0.94A 2dxrA-5ktgA:
undetectable		 2dxrA-5ktgA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 4jge RED FLUORESCENT
PROTEIN BLFP-R5
(Branchiostoma
lanceolatum) 		4 / 6 ARG A 196
GLY A 154
THR A 174
ARG A  89
 CR2  A  58 ( 3.9A)
None
None
CR2  A  58 ( 2.7A)
 1.16A 2f7fA-4jgeA:
undetectable		 2f7fA-4jgeA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 4dkn AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPA1
(Branchiostoma
floridae) 		4 / 6 LEU A 208
SER A 141
PHE A 155
GLU A 210
 CR2  A  60 ( 4.9A)
CR2  A  60 ( 4.0A)
CR2  A  60 ( 4.0A)
CR2  A  60 ( 3.0A)
 1.14A 2vn1B-4dknA:
undetectable		 2vn1B-4dknA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_A_C2FA401_0
(AMINOMETHYLTRANSFERA
SE)		 4jge RED FLUORESCENT
PROTEIN BLFP-R5
(Branchiostoma
lanceolatum) 		5 / 12 ILE A 152
TYR A 146
PHE A 178
TYR A  62
ARG A 196
 None
None
None
CR2  A  58 ( 3.5A)
CR2  A  58 ( 3.9A)
 1.10A 3a8iA-4jgeA:
undetectable		 3a8iA-4jgeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_B_C2FB401_0
(AMINOMETHYLTRANSFERA
SE)		 4jge RED FLUORESCENT
PROTEIN BLFP-R5
(Branchiostoma
lanceolatum) 		5 / 12 ILE A 152
TYR A 146
PHE A 178
TYR A  62
ARG A 196
 None
None
None
CR2  A  58 ( 3.5A)
CR2  A  58 ( 3.9A)
 1.13A 3a8iB-4jgeA:
undetectable		 3a8iB-4jgeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_C_C2FC401_0
(AMINOMETHYLTRANSFERA
SE)		 4jge RED FLUORESCENT
PROTEIN BLFP-R5
(Branchiostoma
lanceolatum) 		5 / 12 ILE A 152
TYR A 146
PHE A 178
TYR A  62
ARG A 196
 None
None
None
CR2  A  58 ( 3.5A)
CR2  A  58 ( 3.9A)
 1.18A 3a8iC-4jgeA:
undetectable		 3a8iC-4jgeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 4jge RED FLUORESCENT
PROTEIN BLFP-R5
(Branchiostoma
lanceolatum) 		5 / 12 ILE A 152
TYR A 146
PHE A 178
TYR A  62
ARG A 196
 None
None
None
CR2  A  58 ( 3.5A)
CR2  A  58 ( 3.9A)
 1.12A 3a8iD-4jgeA:
undetectable		 3a8iD-4jgeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3
(Branchiostoma
lanceolatum) 		5 / 12 ILE A  57
LEU A  98
SER A  49
ILE A  11
TYR A 102
 CR2  A  59 ( 4.2A)
None
None
None
None
 1.18A 3cd2A-5ltqA:
undetectable		 3cd2A-5ltqA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Streptococcus
pyogenes;
Aequorea
victoria) 		4 / 7 VAL A 224
ILE A 152
VAL A 163
GLN A  94
 None
None
None
CR2  A  66 ( 3.3A)
 0.86A 3fi0E-5fguA:
undetectable		 3fi0E-5fguA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 4dkm AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPC1A
(Branchiostoma
floridae) 		3 / 3 ARG A 166
VAL A  54
THR A 197
 None
None
CR2  A  60 ( 4.7A)
 0.81A 3ndtA-4dkmA:
undetectable		 3ndtA-4dkmA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		5 / 12 ALA A 163
LEU A 117
ILE A  67
LEU A  95
TYR A 145
 None
CR2  A 118 ( 4.1A)
None
None
None
 1.20A 3ql0A-4ndkA:
undetectable		 3ql0A-4ndkA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 4dkm AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPC1A
(Branchiostoma
floridae) 		4 / 7 ILE A  57
LYS A  43
PHE A  20
GLY A  13
 CR2  A  60 ( 3.6A)
None
None
None
 1.00A 3sj0X-4dkmA:
undetectable		 3sj0X-4dkmA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 4hvf GREEN FLUORESCENT
PROTEIN BLFP-Y6
(Branchiostoma
lanceolatum) 		4 / 7 ILE A  57
LYS A  43
PHE A  20
GLY A  13
 CR2  A  58 ( 4.0A)
None
None
None
 1.19A 3sj0X-4hvfA:
undetectable		 3sj0X-4hvfA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3
(Branchiostoma
lanceolatum) 		5 / 9 ILE A  57
LEU A  53
LYS A  43
PHE A  20
GLY A  13
 CR2  A  59 ( 4.2A)
None
None
None
None
 1.39A 3sj4X-5ltqA:
undetectable		 3sj4X-5ltqA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4bdu GREEN FLUORESCENT
PROTEIN, APOPTOSIS
REGULATOR BAX
(Aequorea
victoria;
Homo
sapiens) 		5 / 11 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  65 ( 4.3A)
None
None
 1.17A 3t3rA-4bduA:
undetectable		 3t3rA-4bduA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5ktg GREEN FLUORESCENT
PROTEIN, BCL-2
HOMOLOGOUS
ANTAGONIST/KILLER
(Aequorea
victoria;
Mus
musculus) 		5 / 11 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 4.1A)
None
None
 1.17A 3t3rA-5ktgA:
undetectable		 3t3rA-5ktgA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CR2  A  66 ( 4.9A)
CR2  A  66 ( 3.7A)
None
None
 1.19A 3t3rB-3ai5A:
undetectable		 3t3rB-3ai5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 3.6A)
None
None
 1.17A 3t3rB-3akoA:
undetectable		 3t3rB-3akoA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4bdu GREEN FLUORESCENT
PROTEIN, APOPTOSIS
REGULATOR BAX
(Aequorea
victoria;
Homo
sapiens) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  65 ( 4.3A)
None
None
 1.14A 3t3rB-4bduA:
undetectable		 3t3rB-4bduA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4jrb GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Blattella
germanica) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CR2  A  66 ( 4.8A)
CR2  A  66 ( 3.6A)
None
None
 1.15A 3t3rB-4jrbA:
undetectable		 3t3rB-4jrbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Aequorea
victoria;
Eimeria
acervulina) 		5 / 9 PHE A 124
VAL A 165
ASN A 174
ILE A  67
PHE A  61
 None
None
CR2  A 118 ( 4.5A)
None
None
 1.15A 3t3rB-4ndkA:
undetectable		 3t3rB-4ndkA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Aequorea
victoria;
Streptococcus
pyogenes) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 3.7A)
None
None
 1.15A 3t3rB-5fguA:
undetectable		 3t3rB-5fguA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5ktg GREEN FLUORESCENT
PROTEIN, BCL-2
HOMOLOGOUS
ANTAGONIST/KILLER
(Aequorea
victoria;
Mus
musculus) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 4.1A)
None
None
 1.15A 3t3rB-5ktgA:
undetectable		 3t3rB-5ktgA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CR2  A  66 ( 4.9A)
CR2  A  66 ( 3.7A)
None
None
 1.22A 3t3rC-3ai5A:
undetectable		 3t3rC-3ai5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 3.6A)
None
None
 1.20A 3t3rC-3akoA:
undetectable		 3t3rC-3akoA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4bdu GREEN FLUORESCENT
PROTEIN, APOPTOSIS
REGULATOR BAX
(Aequorea
victoria;
Homo
sapiens) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  65 ( 4.3A)
None
None
 1.18A 3t3rC-4bduA:
undetectable		 3t3rC-4bduA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4jrb GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Blattella
germanica) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CR2  A  66 ( 4.8A)
CR2  A  66 ( 3.6A)
None
None
 1.19A 3t3rC-4jrbA:
undetectable		 3t3rC-4jrbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Aequorea
victoria;
Eimeria
acervulina) 		5 / 9 PHE A 124
VAL A 165
ASN A 174
ILE A  67
PHE A  61
 None
None
CR2  A 118 ( 4.5A)
None
None
 1.18A 3t3rC-4ndkA:
undetectable		 3t3rC-4ndkA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Aequorea
victoria;
Streptococcus
pyogenes) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 3.7A)
None
None
 1.19A 3t3rC-5fguA:
undetectable		 3t3rC-5fguA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5ktg GREEN FLUORESCENT
PROTEIN, BCL-2
HOMOLOGOUS
ANTAGONIST/KILLER
(Aequorea
victoria;
Mus
musculus) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 4.1A)
None
None
 1.17A 3t3rC-5ktgA:
undetectable		 3t3rC-5ktgA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		5 / 10 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CR2  A  66 ( 4.9A)
CR2  A  66 ( 3.7A)
None
None
 1.17A 3t3rD-3ai5A:
undetectable		 3t3rD-3ai5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		5 / 10 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 3.6A)
None
None
 1.15A 3t3rD-3akoA:
undetectable		 3t3rD-3akoA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4bdu GREEN FLUORESCENT
PROTEIN, APOPTOSIS
REGULATOR BAX
(Aequorea
victoria;
Homo
sapiens) 		5 / 10 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  65 ( 4.3A)
None
None
 1.13A 3t3rD-4bduA:
undetectable		 3t3rD-4bduA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4jrb GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Blattella
germanica) 		5 / 10 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CR2  A  66 ( 4.8A)
CR2  A  66 ( 3.6A)
None
None
 1.14A 3t3rD-4jrbA:
undetectable		 3t3rD-4jrbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Aequorea
victoria;
Eimeria
acervulina) 		5 / 10 PHE A 124
VAL A 165
ASN A 174
ILE A  67
PHE A  61
 None
None
CR2  A 118 ( 4.5A)
None
None
 1.13A 3t3rD-4ndkA:
undetectable		 3t3rD-4ndkA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Aequorea
victoria;
Streptococcus
pyogenes) 		5 / 10 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 3.7A)
None
None
 1.14A 3t3rD-5fguA:
undetectable		 3t3rD-5fguA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5ktg GREEN FLUORESCENT
PROTEIN, BCL-2
HOMOLOGOUS
ANTAGONIST/KILLER
(Aequorea
victoria;
Mus
musculus) 		5 / 10 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 4.1A)
None
None
 1.13A 3t3rD-5ktgA:
undetectable		 3t3rD-5ktgA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4dkm AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPC1A
(Branchiostoma
floridae) 		4 / 7 ILE A  90
ARG A  88
GLY A 100
VAL A 117
 None
CR2  A  60 ( 2.8A)
None
None
 0.99A 4a3uB-4dkmA:
undetectable		 4a3uB-4dkmA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		5 / 11 ALA A 163
LEU A 117
LEU A  95
TYR A 145
THR A 161
 None
CR2  A 118 ( 4.1A)
None
None
None
 1.37A 4i1nA-4ndkA:
undetectable		 4i1nA-4ndkA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Aequorea
victoria;
Streptococcus
pyogenes) 		4 / 6 LYS A  68
LEU A  42
ALA A  72
THR A 225
 CR2  A  66 ( 3.5A)
None
None
None
 1.02A 4ikiB-5fguA:
undetectable		 4ikiB-5fguA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 2g6y GREEN FLUORESCENT
PROTEIN 2
(Pontellina
plumata) 		4 / 8 ARG A  87
PHE A 154
GLN A 212
THR A 138
 CR2  A  58 ( 3.5A)
CR2  A  58 ( 4.3A)
None
CR2  A  58 ( 2.7A)
 0.94A 4k87A-2g6yA:
undetectable		 4k87A-2g6yA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN
(Aequorea
victoria;
Mus
musculus) 		4 / 6 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
CR2  A  66 ( 4.3A)
 0.94A 4o1zA-3ai5A:
undetectable		 4o1zA-3ai5A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		4 / 6 VAL A  55
LEU A  53
LEU A 125
PHE B 165
 None
None
None
CR2  A  66 ( 4.5A)
 0.94A 4o1zA-3akoA:
undetectable		 4o1zA-3akoA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Sus
scrofa) 		4 / 6 VAL A1055
LEU A1053
LEU A1125
PHE A1165
 None
None
None
CR2  A1065 ( 4.2A)
 0.84A 4o1zA-4anjA:
undetectable		 4o1zA-4anjA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4jrb GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Blattella
germanica) 		4 / 6 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
CR2  A  66 ( 4.4A)
 1.01A 4o1zA-4jrbA:
undetectable		 4o1zA-4jrbA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Aequorea
victoria;
Eimeria
acervulina) 		4 / 6 VAL A 108
LEU A 106
LEU A 178
PHE A 218
 None
None
None
CR2  A 118 ( 4.9A)
 0.99A 4o1zA-4ndkA:
undetectable		 4o1zA-4ndkA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4z4m GREEN FLUORESCENT
PROTEIN,TAX1-BINDING
PROTEIN 1
(Aequorea
victoria;
Homo
sapiens) 		4 / 6 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
CR2  A  66 ( 4.1A)
 0.93A 4o1zA-4z4mA:
undetectable		 4o1zA-4z4mA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Aequorea
victoria;
Streptococcus
pyogenes) 		4 / 6 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
CR2  A  66 (-4.8A)
 0.95A 4o1zA-5fguA:
undetectable		 4o1zA-5fguA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		6 / 12 ALA A 110
LEU A  64
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
CR2  A  66 ( 4.4A)
None
None
None
None
 1.49A 4qi9A-3akoA:
undetectable		 4qi9A-3akoA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		6 / 12 ALA A 163
LEU A 117
ILE A  67
LEU A  95
TYR A 145
THR A 161
 None
CR2  A 118 ( 4.1A)
None
None
None
None
 1.42A 4qleA-4ndkA:
undetectable		 4qleA-4ndkA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		6 / 11 ALA A 163
LEU A 117
ILE A  67
LEU A  95
TYR A 145
THR A 161
 None
CR2  A 118 ( 4.1A)
None
None
None
None
 1.42A 4qleB-4ndkA:
undetectable		 4qleB-4ndkA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		6 / 12 ALA A 110
LEU A  64
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
CR2  A  66 ( 4.4A)
None
None
None
None
 1.39A 4qlgA-3akoA:
undetectable		 4qlgA-3akoA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		6 / 12 ALA A 163
LEU A 117
ILE A  67
LEU A  95
TYR A 145
THR A 161
 None
CR2  A 118 ( 4.1A)
None
None
None
None
 1.39A 4qlgA-4ndkA:
undetectable		 4qlgA-4ndkA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 4dkn AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPA1
(Branchiostoma
floridae) 		5 / 12 PHE A 102
ILE A   9
LEU A  57
LEU A  98
LEU A 117
 None
None
CR2  A  60 ( 4.4A)
None
None
 1.32A 4qynB-4dknA:
undetectable		 4qynB-4dknA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 2g6y GREEN FLUORESCENT
PROTEIN 2
(Pontellina
plumata) 		4 / 8 ASN A  85
PHE A 101
PHE A  74
TYR A 105
 None
CR2  A  58 ( 4.3A)
None
None
 1.47A 4v2zC-2g6yA:
undetectable		 4v2zC-2g6yA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4hvf GREEN FLUORESCENT
PROTEIN BLFP-Y6
(Branchiostoma
lanceolatum) 		5 / 12 TYR A  64
TYR A 105
GLY A 114
GLU A   8
PHE A 209
 None
CR2  A  58 ( 4.5A)
None
None
CR2  A  58 ( 4.5A)
 1.24A 4wcxC-4hvfA:
undetectable		 4wcxC-4hvfA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4hvf GREEN FLUORESCENT
PROTEIN BLFP-Y6
(Branchiostoma
lanceolatum) 		5 / 12 TYR A 105
GLY A 114
GLU A   8
PRO A  30
ALA A  78
 CR2  A  58 ( 4.5A)
None
None
None
None
 1.24A 4wcxC-4hvfA:
undetectable		 4wcxC-4hvfA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3
(Branchiostoma
lanceolatum) 		5 / 12 TYR A  64
TYR A 104
GLY A 113
GLU A   8
HIS A  62
 None
CR2  A  59 ( 4.6A)
None
None
CR2  A  59 (-4.1A)
 1.02A 4wcxC-5ltqA:
undetectable		 4wcxC-5ltqA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3
(Branchiostoma
lanceolatum) 		5 / 12 TYR A  64
TYR A 104
GLY A 113
PHE A 208
HIS A  62
 None
CR2  A  59 ( 4.6A)
None
CR2  A  59 ( 4.6A)
CR2  A  59 (-4.1A)
 1.06A 4wcxC-5ltqA:
undetectable		 4wcxC-5ltqA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3
(Branchiostoma
lanceolatum) 		5 / 12 TYR A 104
GLY A 113
GLU A   8
PRO A  30
ALA A  77
 CR2  A  59 ( 4.6A)
None
None
None
None
 1.21A 4wcxC-5ltqA:
undetectable		 4wcxC-5ltqA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		6 / 12 TYR D  74
TYR D 114
GLY D 123
GLU D  18
PHE D 293
HIS D  72
 None
CR2  D  70 ( 4.5A)
None
None
CR2  D  70 ( 4.5A)
CR2  D  70 ( 4.1A)
 1.22A 4wcxC-5mwcD:
undetectable		 4wcxC-5mwcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		5 / 12 TYR D 114
GLY D 123
GLU D  18
PRO D  40
ALA D  87
 CR2  D  70 ( 4.5A)
None
None
None
None
 1.23A 4wcxC-5mwcD:
undetectable		 4wcxC-5mwcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		6 / 12 ALA A 163
LEU A 117
ILE A  67
LEU A  95
TYR A 145
THR A 161
 None
CR2  A 118 ( 4.1A)
None
None
None
None
 1.40A 4x5fB-4ndkA:
undetectable		 4x5fB-4ndkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		6 / 12 ALA A 163
LEU A 117
ILE A  67
LEU A  95
TYR A 145
THR A 161
 None
CR2  A 118 ( 4.1A)
None
None
None
None
 1.41A 4x5gB-4ndkA:
undetectable		 4x5gB-4ndkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		6 / 12 ALA A 163
LEU A 117
ILE A  67
LEU A  95
TYR A 145
THR A 161
 None
CR2  A 118 ( 4.1A)
None
None
None
None
 1.43A 4x5hA-4ndkA:
undetectable		 4x5hA-4ndkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		6 / 12 ALA A 163
LEU A 117
ILE A  67
LEU A  95
TYR A 145
THR A 161
 None
CR2  A 118 ( 4.1A)
None
None
None
None
 1.44A 4x5iA-4ndkA:
undetectable		 4x5iA-4ndkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 2g6y GREEN FLUORESCENT
PROTEIN 2
(Pontellina
plumata) 		5 / 10 VAL A 110
TYR A 105
TYR A 103
GLY A  64
PHE A  63
 None
None
CR2  A  58 ( 4.5A)
None
None
 1.46A 4xpbA-2g6yA:
undetectable		 4xpbA-2g6yA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2dd7 GREEN FLUORESCENT
PROTEIN
(Chiridius
poppei) 		4 / 5 ALA A 153
TYR A 152
HIS A 198
PRO A 135
 None
CR2  A  56 ( 4.7A)
None
None
 1.29A 4ze2A-2dd7A:
undetectable		 4ze2A-2dd7A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3
(Branchiostoma
lanceolatum) 		4 / 6 LEU A 206
ILE A  57
THR A 197
ALA A 136
 None
CR2  A  59 ( 4.2A)
CR2  A  59 ( 4.7A)
None
 0.78A 4zf8A-5ltqA:
undetectable		 4zf8A-5ltqA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4jge RED FLUORESCENT
PROTEIN BLFP-R5
(Branchiostoma
lanceolatum) 		5 / 12 VAL A 176
GLN A 211
PHE A 209
HIS A 103
TYR A 105
 None
CR2  A  58 ( 3.4A)
CR2  A  58 ( 4.6A)
None
CR2  A  58 ( 4.6A)
 1.31A 4zj8A-4jgeA:
undetectable		 4zj8A-4jgeA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		6 / 12 ALA A 163
LEU A 117
ILE A  67
LEU A  95
TYR A 145
THR A 161
 None
CR2  A 118 ( 4.1A)
None
None
None
None
 1.44A 5eajA-4ndkA:
undetectable		 5eajA-4ndkA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		6 / 12 ALA A 163
LEU A 117
ILE A  67
LEU A  95
TYR A 145
THR A 161
 None
CR2  A 118 ( 4.1A)
None
None
None
None
 1.38A 5eajB-4ndkA:
undetectable		 5eajB-4ndkA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2dd7 GREEN FLUORESCENT
PROTEIN
(Chiridius
poppei) 		5 / 12 TYR A 101
PHE A  45
ILE A 125
PHE A  19
GLY A 116
 CR2  A  56 ( 4.5A)
None
None
None
None
 1.36A 5esgA-2dd7A:
undetectable		 5esgA-2dd7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		4 / 7 LEU D 291
ILE D  62
LEU D 143
MET D 146
 None
None
None
CR2  D  70 ( 4.4A)
 0.98A 5fxtA-5mwcD:
undetectable		 5fxtA-5mwcD:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4hvf GREEN FLUORESCENT
PROTEIN BLFP-Y6
(Branchiostoma
lanceolatum) 		4 / 5 PHE A  61
LEU A  39
GLY A  24
ILE A 112
 CR2  A  58 ( 3.5A)
None
None
None
 0.94A 5ik1A-4hvfA:
undetectable		 5ik1A-4hvfA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4jge RED FLUORESCENT
PROTEIN BLFP-R5
(Branchiostoma
lanceolatum) 		4 / 5 PHE A  61
LEU A  39
GLY A  24
ILE A 112
 CR2  A  58 ( 3.6A)
None
None
None
 0.95A 5ik1A-4jgeA:
undetectable		 5ik1A-4jgeA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3
(Branchiostoma
lanceolatum) 		4 / 5 PHE A  61
LEU A  39
GLY A  24
ILE A 111
 CR2  A  59 ( 3.6A)
None
None
None
 0.96A 5ik1A-5ltqA:
undetectable		 5ik1A-5ltqA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		4 / 5 PHE D  71
LEU D  49
GLY D  34
ILE D 121
 CR2  D  70 ( 3.5A)
None
None
None
 1.00A 5ik1A-5mwcD:
undetectable		 5ik1A-5mwcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2dd7 GREEN FLUORESCENT
PROTEIN
(Chiridius
poppei) 		5 / 12 ALA A 155
TYR A  59
PHE A 182
ILE A  71
TYR A  72
 None
CR2  A  56 ( 4.4A)
None
None
None
 1.16A 5jlcA-2dd7A:
undetectable		 5jlcA-2dd7A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,
(Eimeria
acervulina;
Aequorea
victoria) 		6 / 12 ALA A 163
LEU A 117
ILE A  67
LEU A  95
TYR A 145
THR A 161
 None
CR2  A 118 ( 4.1A)
None
None
None
None
 1.43A 5ujxA-4ndkA:
undetectable		 5ujxA-4ndkA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 4dkm AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPC1A
(Branchiostoma
floridae) 		4 / 6 PHE A 115
GLY A 113
GLN A  63
TYR A 106
 CR2  A  60 ( 4.7A)
None
CR2  A  60 ( 4.7A)
None
 1.15A 6ag0A-4dkmA:
undetectable		 6ag0A-4dkmA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 4hvf GREEN FLUORESCENT
PROTEIN BLFP-Y6
(Branchiostoma
lanceolatum) 		4 / 6 PHE A 116
GLY A 114
GLN A  63
TYR A 107
 CR2  A  58 ( 4.4A)
None
CR2  A  58 ( 4.9A)
None
 1.25A 6ag0A-4hvfA:
undetectable		 6ag0A-4hvfA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3
(Branchiostoma
lanceolatum) 		4 / 6 PHE A 115
GLY A 113
GLN A  63
TYR A 106
 CR2  A  59 ( 4.5A)
None
None
None
 1.25A 6ag0A-5ltqA:
undetectable		 6ag0A-5ltqA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 4dkm AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPC1A
(Branchiostoma
floridae) 		4 / 6 PHE A 115
GLY A 113
GLN A  63
TYR A 106
 CR2  A  60 ( 4.7A)
None
CR2  A  60 ( 4.7A)
None
 1.13A 6ag0C-4dkmA:
undetectable		 6ag0C-4dkmA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 4hvf GREEN FLUORESCENT
PROTEIN BLFP-Y6
(Branchiostoma
lanceolatum) 		4 / 6 PHE A 116
GLY A 114
GLN A  63
TYR A 107
 CR2  A  58 ( 4.4A)
None
CR2  A  58 ( 4.9A)
None
 1.23A 6ag0C-4hvfA:
undetectable		 6ag0C-4hvfA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3
(Branchiostoma
lanceolatum) 		4 / 6 PHE A 115
GLY A 113
GLN A  63
TYR A 106
 CR2  A  59 ( 4.5A)
None
None
None
 1.23A 6ag0C-5ltqA:
undetectable		 6ag0C-5ltqA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D
(Aequorea
victoria;
Streptococcus
pyogenes) 		4 / 7 PHE A 165
SER A 202
VAL A 224
ARG A  96
 CR2  A  66 (-4.8A)
None
None
CR2  A  66 ( 3.1A)
 1.42A 6av6C-5fguA:
undetectable
6av6D-5fguA:
undetectable		 6av6C-5fguA:
9.40
6av6D-5fguA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		5 / 12 HIS A 148
ILE B 161
PHE A  84
THR A  63
THR A  62
 CR2  A  66 ( 3.8A)
None
None
None
CR2  A  66 ( 4.5A)
 1.22A 6bbsA-3akoA:
undetectable		 6bbsA-3akoA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 4bdu GREEN FLUORESCENT
PROTEIN, APOPTOSIS
REGULATOR BAX
(Aequorea
victoria;
Homo
sapiens) 		5 / 12 HIS A 148
ILE A 161
PHE A  84
THR A  63
THR A  62
 CR2  A  65 ( 4.3A)
None
None
None
None
 1.20A 6bbsA-4bduA:
undetectable		 6bbsA-4bduA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 4jrb GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Blattella
germanica) 		5 / 12 HIS A 148
ILE A 161
PHE A  84
THR A  63
THR A  62
 CR2  A  66 ( 4.0A)
None
None
None
CR2  A  66 ( 4.8A)
 1.24A 6bbsA-4jrbA:
undetectable		 6bbsA-4jrbA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 5ktg GREEN FLUORESCENT
PROTEIN, BCL-2
HOMOLOGOUS
ANTAGONIST/KILLER
(Aequorea
victoria;
Mus
musculus) 		5 / 12 HIS A 148
ILE A 161
PHE A  84
THR A  63
THR A  62
 CR2  A  66 ( 3.9A)
None
None
None
None
 1.21A 6bbsA-5ktgA:
undetectable		 6bbsA-5ktgA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		4 / 8 HIS D  66
PRO D  65
SER D 107
PHE D 102
 None
CR2  D  70 ( 4.5A)
None
None
 1.21A 6fcbA-5mwcD:
undetectable		 6fcbA-5mwcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 4dkn AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPA1
(Branchiostoma
floridae) 		5 / 12 GLY A  26
HIS A 110
TYR A 104
PRO A   4
GLY A  28
 None
None
CR2  A  60 ( 4.5A)
None
None
 1.14A 6gngA-4dknA:
undetectable		 6gngA-4dknA:
16.20