SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CQL'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P91_B_SAMB2401_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE A)	3kcx	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR (Homo sapiens)	5 / 12	LEU A 187 GLY A 266 GLY A 268 ILE A 291 THR A 196	None None None None CQL A 1 (-3.8A)	1.05A	1p91B-3kcxA: undetectable	1p91B-3kcxA: 19.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3KCX_A_CQLA1_0 (HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR)	3kcx	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR (Homo sapiens)	10 / 10	TYR A 145 LEU A 188 THR A 196 HIS A 199 ASP A 201 LYS A 214 ILE A 273 HIS A 279 ILE A 281 TRP A 296	None CQL A 1 (-4.7A) CQL A 1 (-3.8A) FE2 A1350 ( 3.2A) FE2 A1350 (-2.5A) CQL A 1 (-3.6A) CQL A 1 (-4.8A) CQL A 1 ( 3.2A) CQL A 1 (-3.4A) CQL A 1 (-4.7A)	0.02A	3kcxA-3kcxA: 54.5	3kcxA-3kcxA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BAA_E_GBME2001_1 (ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8)	3kcx	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR (Homo sapiens)	5 / 12	ASN A 294 THR A 149 LEU A 186 SER A 240 ARG A 238	CQL A 1 ( 4.8A) None None None None	1.34A	6baaE-3kcxA: undetectable	6baaE-3kcxA: 12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BAA_F_GBMF2001_1 (ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8)	3kcx	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR (Homo sapiens)	5 / 12	ASN A 294 THR A 149 LEU A 186 SER A 240 ARG A 238	CQL A 1 ( 4.8A) None None None None	1.34A	6baaF-3kcxA: undetectable	6baaF-3kcxA: 12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BAA_G_GBMG2001_1 (ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8)	3kcx	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR (Homo sapiens)	5 / 12	ASN A 294 THR A 149 LEU A 186 SER A 240 ARG A 238	CQL A 1 ( 4.8A) None None None None	1.35A	6baaG-3kcxA: undetectable	6baaG-3kcxA: 12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BAA_H_GBMH2001_1 (ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8)	3kcx	HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR (Homo sapiens)	5 / 12	ASN A 294 THR A 149 LEU A 186 SER A 240 ARG A 238	CQL A 1 ( 4.8A) None None None None	1.35A	6baaH-3kcxA: undetectable	6baaH-3kcxA: 12.96

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1P91_B_SAMB2401_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE A","3kcx","HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR","Homo sapiens",5,"LEU A 187;GLY A 266;GLY A 268;ILE A 291;THR A 196","None;None;None;None;CQL A   1 (-3.8A)","1.05A","1p91B-3kcxA:undetectable",null],["3KCX_A_CQLA1_0","HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR","3kcx","HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR","Homo sapiens",10,"TYR A 145;LEU A 188;THR A 196;HIS A 199;ASP A 201;LYS A 214;ILE A 273;HIS A 279;ILE A 281;TRP A 296","None;CQL A   1 (-4.7A);CQL A   1 (-3.8A);FE2 A1350 ( 3.2A);FE2 A1350 (-2.5A);CQL A   1 (-3.6A);CQL A   1 (-4.8A);CQL A   1 ( 3.2A);CQL A   1 (-3.4A);CQL A   1 (-4.7A)","0.02A","3kcxA-3kcxA:54.5","1p91B-3kcxA:19.79"],["6BAA_E_GBME2001_1","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","3kcx","HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR","Homo sapiens",5,"ASN A 294;THR A 149;LEU A 186;SER A 240;ARG A 238","CQL A   1 ( 4.8A);None;None;None;None","1.34A","6baaE-3kcxA:undetectable","3kcxA-3kcxA:100.00"],["6BAA_F_GBMF2001_1","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","3kcx","HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR","Homo sapiens",5,"ASN A 294;THR A 149;LEU A 186;SER A 240;ARG A 238","CQL A   1 ( 4.8A);None;None;None;None","1.34A","6baaF-3kcxA:undetectable","6baaE-3kcxA:12.96"],["6BAA_G_GBMG2001_1","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","3kcx","HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR","Homo sapiens",5,"ASN A 294;THR A 149;LEU A 186;SER A 240;ARG A 238","CQL A   1 ( 4.8A);None;None;None;None","1.35A","6baaG-3kcxA:undetectable","6baaF-3kcxA:12.96"],["6BAA_H_GBMH2001_1","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","3kcx","HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR","Homo sapiens",5,"ASN A 294;THR A 149;LEU A 186;SER A 240;ARG A 238","CQL A   1 ( 4.8A);None;None;None;None","1.35A","6baaH-3kcxA:undetectable","6baaG-3kcxA:12.96"]]