SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CQ7'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		5 / 6 ILE A 531
VAL A 539
ILE A 585
ILE A 643
ASP A 664
 CQ7  A 801 (-3.6A)
CQ7  A 801 ( 4.8A)
None
None
None
 0.84A 1uwhA-6b4wA:
24.7		 1uwhA-6b4wA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		4 / 7 ILE A 531
LEU A 575
ILE A 585
ASP A 664
 CQ7  A 801 (-3.6A)
None
None
None
 0.79A 1uwjA-6b4wA:
10.7		 1uwjA-6b4wA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		4 / 7 ILE A 531
LYS A 553
LEU A 575
ILE A 585
 CQ7  A 801 (-3.6A)
CQ7  A 801 (-3.2A)
None
None
 0.82A 1uwjA-6b4wA:
10.7		 1uwjA-6b4wA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		5 / 10 ALA A 551
ILE A 586
ASP A 608
LEU A 654
ILE A 663
 CQ7  A 801 (-3.2A)
CQ7  A 801 ( 4.5A)
CQ7  A 801 (-4.7A)
CQ7  A 801 (-4.5A)
CQ7  A 801 (-3.7A)
 0.84A 1yi4A-6b4wA:
22.8		 1yi4A-6b4wA:
28.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		4 / 6 VAL A 539
LYS A 553
LEU A 654
ASP A 664
 CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 (-4.5A)
None
 0.74A 3cs9D-6b4wA:
21.0		 3cs9D-6b4wA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		4 / 4 LEU A 654
MET A 727
ILE A 638
ASP A 647
 CQ7  A 801 (-4.5A)
None
None
None
 1.40A 3hecA-6b4wA:
22.2		 3hecA-6b4wA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		5 / 12 ILE A 531
VAL A 539
ALA A 551
LYS A 553
PHE A 665
 CQ7  A 801 (-3.6A)
CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 (-3.2A)
None
 0.74A 3og7A-6b4wA:
23.9		 3og7A-6b4wA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		6 / 12 GLY A 532
VAL A 539
ALA A 551
LYS A 553
LEU A 575
ILE A 586
 CQ7  A 801 ( 4.0A)
CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 (-3.2A)
None
CQ7  A 801 ( 4.5A)
 0.84A 3ohtA-6b4wA:
5.3		 3ohtA-6b4wA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		6 / 12 GLY A 532
VAL A 539
ALA A 551
LYS A 553
LEU A 575
ILE A 586
 CQ7  A 801 ( 4.0A)
CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 (-3.2A)
None
CQ7  A 801 ( 4.5A)
 0.80A 3ohtB-6b4wA:
5.4		 3ohtB-6b4wA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		4 / 8 VAL A 539
LYS A 553
ILE A 586
ILE A 663
 CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 ( 4.5A)
CQ7  A 801 (-3.7A)
 0.52A 3warA-6b4wA:
21.3		 3warA-6b4wA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		6 / 12 VAL A 539
ALA A 551
ILE A 586
MET A 600
LEU A 654
ASP A 664
 CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 ( 4.5A)
None
CQ7  A 801 (-4.5A)
None
 0.71A 4bkjA-6b4wA:
23.3		 4bkjA-6b4wA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		6 / 12 VAL A 539
ALA A 551
ILE A 586
MET A 600
LEU A 654
ASP A 664
 CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 ( 4.5A)
None
CQ7  A 801 (-4.5A)
None
 0.75A 4bkjB-6b4wA:
23.4		 4bkjB-6b4wA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		6 / 11 VAL A 539
ALA A 551
LYS A 553
ASP A 608
LEU A 654
ILE A 663
 CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 (-3.2A)
CQ7  A 801 (-4.7A)
CQ7  A 801 (-4.5A)
CQ7  A 801 (-3.7A)
 0.80A 4iaaA-6b4wA:
22.4		 4iaaA-6b4wA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		6 / 11 VAL A 539
ALA A 551
LYS A 553
VAL A 656
LEU A 654
ILE A 663
 CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 (-3.2A)
None
CQ7  A 801 (-4.5A)
CQ7  A 801 (-3.7A)
 1.46A 4iaaA-6b4wA:
22.4		 4iaaA-6b4wA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		5 / 8 ILE A 531
VAL A 539
ALA A 551
ASP A 608
LEU A 654
 CQ7  A 801 (-3.6A)
CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 (-4.7A)
CQ7  A 801 (-4.5A)
 0.63A 4ogrA-6b4wA:
23.2		 4ogrA-6b4wA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		6 / 12 ILE A 531
GLY A 532
VAL A 539
ALA A 551
MET A 602
LEU A 654
 CQ7  A 801 (-3.6A)
CQ7  A 801 ( 4.0A)
CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 (-3.4A)
CQ7  A 801 (-4.5A)
 0.80A 4qmzA-6b4wA:
24.4		 4qmzA-6b4wA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		5 / 10 ILE A 531
ALA A 551
LYS A 553
ILE A 586
LEU A 654
 CQ7  A 801 (-3.6A)
CQ7  A 801 (-3.2A)
CQ7  A 801 (-3.2A)
CQ7  A 801 ( 4.5A)
CQ7  A 801 (-4.5A)
 0.73A 4rz7A-6b4wA:
14.2		 4rz7A-6b4wA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		4 / 7 GLY A 532
GLY A 534
VAL A 539
LYS A 553
 CQ7  A 801 ( 4.0A)
None
CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
 0.39A 5izjA-6b4wA:
24.1		 5izjA-6b4wA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		4 / 7 GLY A 532
GLY A 534
VAL A 539
LYS A 553
 CQ7  A 801 ( 4.0A)
None
CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
 0.43A 5j5xA-6b4wA:
23.4		 5j5xA-6b4wA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		6 / 9 ILE A 531
GLY A 532
VAL A 539
ALA A 551
ILE A 586
MET A 602
 CQ7  A 801 (-3.6A)
CQ7  A 801 ( 4.0A)
CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 ( 4.5A)
CQ7  A 801 (-3.4A)
 0.55A 5lw1B-6b4wA:
23.3		 5lw1B-6b4wA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		5 / 10 GLY A 532
VAL A 539
ALA A 551
ILE A 586
MET A 602
 CQ7  A 801 ( 4.0A)
CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 ( 4.5A)
CQ7  A 801 (-3.4A)
 0.59A 5lw1E-6b4wA:
23.1		 5lw1E-6b4wA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		4 / 7 VAL A 539
LYS A 553
ILE A 586
ILE A 663
 CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 ( 4.5A)
CQ7  A 801 (-3.7A)
 0.43A 5ywmX-6b4wA:
16.4		 5ywmX-6b4wA:
15.56