SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'COZ'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VCV_F_ASDF1224_1 (GLUTATHIONE S-TRANSFERASE A3)	2c6x	CITRATE SYNTHASE 1 (Bacillus subtilis)	5 / 8	LEU A 237 LEU A 247 LEU A 224 ALA A 282 PHE A 308	None COZ A1365 (-4.3A) None None None	1.42A	2vcvF-2c6xA: undetectable	2vcvF-2c6xA: 22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VMY_A_FFOA505_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	5f38	ACETYL-COA ACETYLTRANSFERASE (Escherichia coli)	5 / 12	GLY B 348 SER B 248 ALA B 344 ASN B 317 GLY B 91	None COZ B 401 (-3.9A) None None None	1.13A	2vmyB-5f38B: undetectable	2vmyB-5f38B: 23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_L_CLML221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	5f38	ACETYL-COA ACETYLTRANSFERASE (Escherichia coli)	5 / 12	PHE B 236 HIS B 157 PHE B 320 SER B 248 LEU B 145	COZ B 401 (-4.4A) COZ B 401 (-4.6A) COZ B 401 (-4.6A) COZ B 401 (-3.9A) None	1.39A	3u9fJ-5f38B: undetectable 3u9fL-5f38B: undetectable	3u9fJ-5f38B: 18.72 3u9fL-5f38B: 18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_B_QDNB602_1 (CYTOCHROME P450 2D6)	5f38	ACETYL-COA ACETYLTRANSFERASE (Escherichia coli)	5 / 9	LEU B 378 PHE B 320 ALA B 344 SER B 248 ALA B 247	CSX B 88 ( 4.0A) COZ B 401 (-4.6A) None COZ B 401 (-3.9A) COZ B 401 ( 4.4A)	1.40A	4wnuB-5f38B: undetectable	4wnuB-5f38B: 23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KPC_A_SAMA401_0 (PAVINE N-METHYLTRANSFERASE)	2c6x	CITRATE SYNTHASE 1 (Bacillus subtilis)	6 / 12	GLY A 249 GLY A 251 VAL A 220 THR A 221 ALA A 262 ALA A 310	None COZ A1365 (-3.6A) None None None None	1.28A	5kpcA-2c6xA: undetectable	5kpcA-2c6xA: 21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MRA_B_DM2B204_1 (SORCIN)	5f38	ACETYL-COA ACETYLTRANSFERASE (Escherichia coli)	4 / 6	PHE B 320 THR B 161 ASP B 237 GLY B 240	COZ B 401 (-4.6A) None None None	1.22A	5mraA-5f38B: undetectable 5mraB-5f38B: undetectable	5mraA-5f38B: 17.60 5mraB-5f38B: 17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UHD_C_RFPC1201_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	5f38	ACETYL-COA ACETYLTRANSFERASE (Escherichia coli)	5 / 12	GLN B 184 ARG B 357 PRO B 350 ASN B 251 ILE B 14	COZ B 401 ( 4.7A) None None None None	1.23A	5uhdC-5f38B: 0.0	5uhdC-5f38B: 16.96

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2VCV_F_ASDF1224_1","GLUTATHIONE S-TRANSFERASE A3","2c6x","CITRATE SYNTHASE 1","Bacillus subtilis",5,"LEU A 237;LEU A 247;LEU A 224;ALA A 282;PHE A 308","None;COZ A1365 (-4.3A);None;None;None","1.42A","2vcvF-2c6xA:undetectable",null],["2VMY_A_FFOA505_1","SERINE HYDROXYMETHYLTRANSFERASE","5f38","ACETYL-COA ACETYLTRANSFERASE","Escherichia coli",5,"GLY B 348;SER B 248;ALA B 344;ASN B 317;GLY B  91","None;COZ B 401 (-3.9A);None;None;None","1.13A","2vmyB-5f38B:undetectable","2vcvF-2c6xA:22.47"],["3U9F_L_CLML221_0","CHLORAMPHENICOL ACETYLTRANSFERASE","5f38","ACETYL-COA ACETYLTRANSFERASE","Escherichia coli",5,"PHE B 236;HIS B 157;PHE B 320;SER B 248;LEU B 145","COZ B 401 (-4.4A);COZ B 401 (-4.6A);COZ B 401 (-4.6A);COZ B 401 (-3.9A);None","1.39A","3u9fJ-5f38B:undetectable;3u9fL-5f38B:undetectable","2vmyB-5f38B:23.98"],["4WNU_B_QDNB602_1","CYTOCHROME P450 2D6","5f38","ACETYL-COA ACETYLTRANSFERASE","Escherichia coli",5,"LEU B 378;PHE B 320;ALA B 344;SER B 248;ALA B 247","CSX B  88 ( 4.0A);COZ B 401 (-4.6A);None;COZ B 401 (-3.9A);COZ B 401 ( 4.4A)","1.40A","4wnuB-5f38B:undetectable","3u9fJ-5f38B:18.72;3u9fL-5f38B:18.72"],["5KPC_A_SAMA401_0","PAVINE N-METHYLTRANSFERASE","2c6x","CITRATE SYNTHASE 1","Bacillus subtilis",6,"GLY A 249;GLY A 251;VAL A 220;THR A 221;ALA A 262;ALA A 310","None;COZ A1365 (-3.6A);None;None;None;None","1.28A","5kpcA-2c6xA:undetectable","4wnuB-5f38B:23.17"],["5MRA_B_DM2B204_1","SORCIN;SORCIN","5f38","ACETYL-COA ACETYLTRANSFERASE","Escherichia coli",4,"PHE B 320;THR B 161;ASP B 237;GLY B 240","COZ B 401 (-4.6A);None;None;None","1.22A","5mraA-5f38B:undetectable;5mraB-5f38B:undetectable","5kpcA-2c6xA:21.41"],["5UHD_C_RFPC1201_1","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","5f38","ACETYL-COA ACETYLTRANSFERASE","Escherichia coli",5,"GLN B 184;ARG B 357;PRO B 350;ASN B 251;ILE B  14","COZ B 401 ( 4.7A);None;None;None;None","1.23A","5uhdC-5f38B:0.0","5mraA-5f38B:17.60;5mraB-5f38B:17.60"]]