SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'COW'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HRK_B_CHDB2501_0 (FERROCHELATASE)	3h77	PQS BIOSYNTHETIC ENZYME (Pseudomonas aeruginosa)	5 / 12	MET A 225 LEU A 193 PHE A 218 HIS A 257 VAL A 282	COW A 350 (-3.7A) CSJ A 112 (-4.5A) CSJ A 112 ( 4.0A) COW A 350 (-4.2A) None	1.35A	1hrkB-3h77A: 2.6	1hrkB-3h77A: 23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PNJ_B_CHDB501_0 (FERROCHELATASE, MITOCHONDRIAL)	3h77	PQS BIOSYNTHETIC ENZYME (Pseudomonas aeruginosa)	5 / 12	MET A 225 LEU A 193 PHE A 218 HIS A 257 VAL A 282	COW A 350 (-3.7A) CSJ A 112 (-4.5A) CSJ A 112 ( 4.0A) COW A 350 (-4.2A) None	1.36A	2pnjB-3h77A: undetectable	2pnjB-3h77A: 23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AQI_A_CHDA1_0 (FERROCHELATASE)	3h77	PQS BIOSYNTHETIC ENZYME (Pseudomonas aeruginosa)	5 / 11	MET A 225 LEU A 193 PHE A 218 HIS A 257 VAL A 282	COW A 350 (-3.7A) CSJ A 112 (-4.5A) CSJ A 112 ( 4.0A) COW A 350 (-4.2A) None	1.38A	3aqiA-3h77A: undetectable	3aqiA-3h77A: 23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W1W_B_CHDB504_0 (FERROCHELATASE, MITOCHONDRIAL)	3h77	PQS BIOSYNTHETIC ENZYME (Pseudomonas aeruginosa)	5 / 12	MET A 225 LEU A 193 PHE A 218 HIS A 257 VAL A 282	COW A 350 (-3.7A) CSJ A 112 (-4.5A) CSJ A 112 ( 4.0A) COW A 350 (-4.2A) None	1.41A	3w1wB-3h77A: undetectable	3w1wB-3h77A: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G24_A_ACAA1004_1 (PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN AT2G32230, MITOCHONDRIAL)	3h77	PQS BIOSYNTHETIC ENZYME (Pseudomonas aeruginosa)	4 / 6	ALA A 229 LEU A 233 VAL A 234 GLU A 269	COW A 350 (-3.6A) None None None	1.00A	4g24A-3h77A: undetectable	4g24A-3h77A: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MK4_B_CHDB503_0 (FERROCHELATASE, MITOCHONDRIAL)	3h77	PQS BIOSYNTHETIC ENZYME (Pseudomonas aeruginosa)	5 / 11	MET A 225 LEU A 193 PHE A 218 HIS A 257 VAL A 282	COW A 350 (-3.7A) CSJ A 112 (-4.5A) CSJ A 112 ( 4.0A) COW A 350 (-4.2A) None	1.38A	4mk4B-3h77A: undetectable	4mk4B-3h77A: 23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AG0_A_ACRA607_0 (ALPHA-AMYLASE)	3h77	PQS BIOSYNTHETIC ENZYME (Pseudomonas aeruginosa)	4 / 4	ARG A 153 SER A 149 ASP A 150 ASN A 154	COW A 350 (-3.6A) None None COW A 350 (-3.0A)	1.32A	6ag0A-3h77A: 0.3	6ag0A-3h77A: 13.24

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HRK_B_CHDB2501_0","FERROCHELATASE","3h77","PQS BIOSYNTHETIC ENZYME","Pseudomonas aeruginosa",5,"MET A 225;LEU A 193;PHE A 218;HIS A 257;VAL A 282","COW A 350 (-3.7A);CSJ A 112 (-4.5A);CSJ A 112 ( 4.0A);COW A 350 (-4.2A);None","1.35A","1hrkB-3h77A:2.6",null],["2PNJ_B_CHDB501_0","FERROCHELATASE, MITOCHONDRIAL","3h77","PQS BIOSYNTHETIC ENZYME","Pseudomonas aeruginosa",5,"MET A 225;LEU A 193;PHE A 218;HIS A 257;VAL A 282","COW A 350 (-3.7A);CSJ A 112 (-4.5A);CSJ A 112 ( 4.0A);COW A 350 (-4.2A);None","1.36A","2pnjB-3h77A:undetectable","1hrkB-3h77A:23.51"],["3AQI_A_CHDA1_0","FERROCHELATASE","3h77","PQS BIOSYNTHETIC ENZYME","Pseudomonas aeruginosa",5,"MET A 225;LEU A 193;PHE A 218;HIS A 257;VAL A 282","COW A 350 (-3.7A);CSJ A 112 (-4.5A);CSJ A 112 ( 4.0A);COW A 350 (-4.2A);None","1.38A","3aqiA-3h77A:undetectable","2pnjB-3h77A:23.51"],["3W1W_B_CHDB504_0","FERROCHELATASE, MITOCHONDRIAL","3h77","PQS BIOSYNTHETIC ENZYME","Pseudomonas aeruginosa",5,"MET A 225;LEU A 193;PHE A 218;HIS A 257;VAL A 282","COW A 350 (-3.7A);CSJ A 112 (-4.5A);CSJ A 112 ( 4.0A);COW A 350 (-4.2A);None","1.41A","3w1wB-3h77A:undetectable","3aqiA-3h77A:23.51"],["4G24_A_ACAA1004_1","PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN AT2G32230, MITOCHONDRIAL","3h77","PQS BIOSYNTHETIC ENZYME","Pseudomonas aeruginosa",4,"ALA A 229;LEU A 233;VAL A 234;GLU A 269","COW A 350 (-3.6A);None;None;None","1.00A","4g24A-3h77A:undetectable","3w1wB-3h77A:21.34"],["4MK4_B_CHDB503_0","FERROCHELATASE, MITOCHONDRIAL","3h77","PQS BIOSYNTHETIC ENZYME","Pseudomonas aeruginosa",5,"MET A 225;LEU A 193;PHE A 218;HIS A 257;VAL A 282","COW A 350 (-3.7A);CSJ A 112 (-4.5A);CSJ A 112 ( 4.0A);COW A 350 (-4.2A);None","1.38A","4mk4B-3h77A:undetectable","4g24A-3h77A:21.58"],["6AG0_A_ACRA607_0","ALPHA-AMYLASE","3h77","PQS BIOSYNTHETIC ENZYME","Pseudomonas aeruginosa",4,"ARG A 153;SER A 149;ASP A 150;ASN A 154","COW A 350 (-3.6A);None;None;COW A 350 (-3.0A)","1.32A","6ag0A-3h77A:0.3","4mk4B-3h77A:23.27"]]